• Clinical and Experimental Reproductive Medicine
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• v.38 no.4
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• pp.193-202
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• 2011

Objective: We found previously that $interferon$ $regulatory$ factor ($Irf$)-1 is a germinal vesicle (GV)-selective gene that highly expressed in GV as compared to metaphase II oocytes. To our knowledge, the function of $Irf-1$ in oocytes has yet to be examined. The present study was conducted to determine the relationship between retinoic acid (RA) and RA-mediated expression of $Irf-1$ and the mouse oocyte maturation. Methods: Immature cumulus-oocyte-complexes (COCs) were collected from 17-day-old female mice and cultured $in$ $vitro$ for 16 hours in the presence of varying concentrations of RA (0-10 ${\mu}M$). Rate of oocyte maturation and activation was measured. Gene expression was measured by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) and cytokine secretion in the medium was measured by Bio-Plex analysis. Apoptosis was analyzed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Results: The rates of oocyte maturation to metaphase II and oocyte activation increased significantly with RA treatment (10 nM-1 ${\mu}M$). With 100 nM RA treatment, lowest level of $Irf-1$ mRNA and cumulus cell's apoptosis was found. Among 23 cytokines measured by Bio-Plex system, the substantial changes in secretion of tumor necrosis factor-${\alpha}$, macrophage inflammatory protein-$1{\beta}$, eotaxin and interleukin-12 (p40) from COCs in response to RA were detected. Conclusion: We concluded that the maturation of oocytes and $Irf-1$ expression are negatively correlated, and RA enhances the developmental competence of mouse immature oocytes $in$ $vitro$ by suppressing apoptosis of cumulus cells. Using a mouse model, results of the present study provide insights into improved culture conditions for $in$ $vitro$ oocyte maturation and relevant cytokine production and secretion in assisted reproductive technology.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.38 no.5
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• pp.16-26
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• 2001

In this paper, we present a new scheduling method called CDSS(Carried-Dependence Self-Scheduling) for efficiently execution of the loop with intra dependency between iterations based on the central queue. We also implemented it on shared memory system using Java language. Also, we study the modification that converts the existing self-scheduling method based on the central task queue for parallel loops onto the same form applied to loop with loop-carried dependences. The proposed method is self scheduling and assigns the loops in three-level considering the synchronization point according to the dependence distance of the loops. To adapt the proposed scheme and modified methods into various platforms, including a uni-processor system, we use threads for implementation. Compared to other assignment algorithms with various changes of application and system parameters, CDSS is found to be more efficient than other methods in overall execution time including scheduling overheads. CDSS shows improved performance over modified SS, Factoring, GSS and CSS by about 0.02, 40.5, 46.1 and 53.6%, respectively. In CDSS, we achieve the best performance on varying application programs using a few threads, which equal the dependence distance.

• Geophysics and Geophysical Exploration
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• v.2 no.2
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• pp.86-95
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• 1999

This paper presents an efficient three-dimensional (3-D) modeling algorithm using the extended approximation to an electric field integral equation. Numerical evaluations of Green's tensor integral are performed in the spatial wavenumber domain. This approach makes it possible to reduce computing time, to handle smoothly varying conductivity model and to remove singularity problems encountered in the integration of Green's tensor at a source point. The responses obtained by 3-D modeling algorithm developed in this study are compared with those by the full integral equation for a thin-sheet EM scattering. The extensive analyses on the performance of modeling algorithm are made with the conductivity contrasts and source frequencies. These results show that the modeling algorithm are accurate up to the conductivity contrast of 1:16 and the frequency range of 100 Hz-100 kHz. The extended Born approximation, however, may produce inaccurate results for some source and model configurations in which the electric field is discontinuous across the conductivity boundary. We performed the modeling of a composite model of which conductivity varies continuously and this shows the modeling algorithm developed in this study is efficient for 3-D EM modeling. For a cross-hole source-receiver configuration a composite model of which conductivity varies continuously can be successfully simulated using this algorithm.

• Proceedings of the Korea Concrete Institute Conference
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• 1999.04a
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• pp.774-780
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• 1999

The study of bond behavior between concrete and rebar has been performed for a long time. On this study, we tried to analysed variation of bond behaviors quantitatively with varying the strength of concrete. Bond stress which observed below the neutral surface of beam and at connecting part of beam and column is affected by various bond parameters. Resistance of deformed bars which embedded in concrete to the pullout force is divided 1) chemical adhesive force 2) frictional force 3) mechanical resistance of ribs to the concrete and these horizontal components of resistance is being bond strength. We selected the most common and typical variable which is concrete strength among various variables. So we used two kinds of concrete strength like as 25MPa(NSC) and 65MPa(HSC). Tension Test was performed to verify how bond behavior varied with two kinds of concrete strength. Concentration of bond stress was observed at load-end commonly in Tension Test of the initial load stage. At this stage stress distribution was almost coincident at each strength. As tension load added, this stress distribution had difference gradually and movement of pick point of bond stress to free-end and central section was observed. This tendency was observed at first and moving speed was more fast in NSC. At the preceeding result the reason of this phenomenon is considered to discretion of chemical adhesion and local failure of concrete around rebar in load-end direction. Especially, when concrete strength was increased 2.6 times in tension test, ultimate bond strength was increased 1.45 times. In most recent used building codes, bond strength is proportioned to sqare root of concrete compressive strength but comparison of normalized ultimate bond strength was considered that the higher concrete strength is, the lower safety factor of bond strength is in each strength if we use existing building codes. In Tension Test, in case of initial tensile force state, steel tensile stress of central cross section is not different greatly at each strength but tensile force increasing, that of central cross section in NSC was increased remarkably. Namely, tensile force which was shared in concrete in HSC was far greater than that of concrete in NSC at central section.

• The KIPS Transactions:PartB
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• v.8B no.5
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• pp.429-440
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• 2001

To achieve a computer tutor framework with high learning effects as well as practicality, the goal of this research has been set to developing an intelligent tutor for problem-solving in mathematics domain. The maine feature of the CyberTutor, a computer tutor developed in this research, is the facilitation of a learning environment interacting in accordance with the learners differing inferential capabilities and needs. The pedagogical information, the driving force of such an interactive learning, comprises of tutoring strategies used commonly in various domains such as phvsics and mathematics, in which the main contents of learning is the comprehension and the application of principles. These tutoring strategies are those of testing learners hypotheses test, providing hints, and generating explanations. We illustrate the feasibility and the behavior of our propose framework with a sample problem-solving learning in geometry. The proposed tutorial framework is an advancement from previous works in several aspects. Firstly, it is more practical since it supports handing of a wide range of problem types, including not only proof types but also finding-unkown tpes. Secondly, it is aimed at facilitating a personal tutor environment by adapting to learners of varying capabilities. Finally, learning effects are maximized by its tutorial dialogues which are derived from real-time problem-solving inference instead of from built-in procedures.

• The Korean Journal of Financial Management
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• v.20 no.1
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• pp.163-190
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• 2003

This study tests the hypothesis of market efficiency through the information spillover effects over price and volatility across countries by using open-to-close(daytime) returns and close-to-open(overnight) returns of NASDAQ, KOSDAQ and JASDAQ data from January 3, 1997 to December 21, 2000. Based on Granger-causality and time-varying AR(1)-GARCH(1, 1)-M models we document that the evidence of statistically significant conditional mean and volatility spillovers effects from the daytime returns and volatility of NASDAQ to the overnight returns and volatility of KOSDAQ is observed both before and after the IMF foreign currency crisis but not to the close-to-open return before the IMF foreign currency crisis. We can understand the information spillover effect from NASDAQ to KOSDAQ on the overnight rather than the daytime grows more significantly after the IMF foreign currency crisis. We also find the interactive information spillover effect between NASDAQ and JASDAQ both before and after the IMF financial crisis, in particular, to close-to-open return. In addition, the market efficiency between KOSDAQ and NASDAQ is on an increasing trend through IMF foreign currency crisis.

• Journal of the Earthquake Engineering Society of Korea
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• v.12 no.4
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• pp.19-33
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• 2008

Dynamic response measurements from natural excitation were carried out for 25- and 42-story buildings to evaluate their inherent properties, such as natural frequencies, mode shapes and damping ratios. Both are reinforced concrete buildings adopting a core wall, or with shear walls as the major lateral force resisting system, but frames are added in the plan or elevation. In particular, shear walls in a 25-story building are converted to frames from the 4th floor level downwards while maintaining a core wall throughout, resulting in a fairly complex structure. Due to this, along with similar stiffness characteristics in the principal directions, significantly coupled and closely spaced modes of motion are expected in this building, making identification rather difficult. By using various state-of-the-art system identification methods, the modal parameters are extracted, and the results are then compared. Three frequency-domain and four time-domain based operational modal identification methods are considered. Overall, all natural frequencies and damping ratios estimated from the different identification methods showed a greater consistency for both buildings, while mode shapes exhibited some degree of discrepancy, varying from method to method. On the other hand, in comparison with analysis results obtained using the initial finite element(FE) models, test results exhibited a significant difference of about doubled frequencies, at least for the three lower modes in both buildings. To improve the correlation between test and analysis, a few manual schemes of FE model updating based on plausible reasons have been applied, and acceptable results are obtained. The advantages and disadvantages of each identification method used are addressed, and some difficulties that might arise from the updating of FE models, including automatic procedures, for such large structures are carefully discussed.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.2 no.1
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• pp.53-62
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• 1982

An effort of preliminary type has been made to develope a practical method for the waterway area determination of a drainage outlet in rural or agricultural areas. The Seoul meteorological station was selected as tile index station, and the maximum rainfalls-duration-frequency (R-D-F) relation of short-time intense rainfalls was first established. A frequency analysis of the daily rainfalls for the 75 stations selected throughout the country resulted the 50-year daily rainfall for each station. The rainfall factor, which is defined here as the ration of 50-year daily rainfalls of individual station and the index station, was determined for the 8 climatological regions divided in this study. Following the US SCS method the runoff number of a watershed was given based on the soil type, land-use pattern, and the surface treatment. With this runoff number and the R-D-F relationship the runoff factors for the index station were computed and hence a nomogram could be drawn which makes it possible to determine the runoff factor for a given rainfall number and a rainfall of specific duration and frequency. With this done, the potential runoff of a watershed for a given rainfall duration could be calculated, based on the unit hydrograph theory, by multiplying the rainfall factor, the runoff factor, and the drainage area of the watershed under consideration. Then, the maximum runoff potential was determined by varying the rainfall duration and finding out the duration which results the peak discharge of a gived return period.

• Korean Journal of Poultry Science
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• v.44 no.1
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• pp.59-65
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• 2017

This study examined factors affecting the analysis of motility of chicken semen. The viability of spermatozoa was estimated using varying dilution ratios and supplementation with BSA or fatty acid free (FAF)-BSA as protein sources in semen diluent. Fresh semen was examined after preparing dilutions in beltsvile poultry semen extender (BPSE) of 1/8, 1/16 and 1/32 at $25^{\circ}C$. The motility of incubated semen at each dilution was observed at 3 min (89.9%, 69.9% and 53.2%), 30 min (86.7%, 71.4% and 51.7%), 1 h (89.5%, 74.0% and 53.5%) and 3 h (78.5%, 66.5% and 45.7%), respectively. The addition of BSA or FAF-BSA to BPSE diluent significantly increased the viability of semen in 1/32 dilution with results of 53.2% (control), 84.8% (BSA) and 92.9% (FAF-BSA) (p<0.05). This phenomenon was also observed in the dilution of frozen semen, where FAF-BSA treatment increased the viability of thawed semen from 17.6% to 34.0% in a 1/8 dilution (p<0.05). When the protein sources were used in the dilution, the survival rates of diluted chicken semen were also increased with time lapse. These results show that FAF-BSA may act to protect chicken semen and is suitable as a basic component of chicken semen diluent for the method of analyzing rooster semen after freezing.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.15 no.1
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• pp.165-172
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• 2002

Generally, the steel rigid frame has been analyzed using finite element analysis tools. While many efforts have been poured into the understanding and accurate prediction for the nonlinear behavior of the columns and beam-columns connections, the base of the columns are modeled as simply hinged or fixed. However, the base of the steel columns practically is neither fixed not hinged. It behaves as semi-rigid. In this paper, the supports of the columns we modeled as semi-rigid and the importance of such approach in moment-resisting columns is evaluated. Two typical buildings designed by the US specification are modeled and analyzed by the finite element based on stiffness method and flexibility method. The column bases of three-story buildings are modeled as rotational springs with a varying degree of stiffness and strength that simulates the semi-rigidity of the base. Depending on the degree of stiffness and strength, the semi-rigidity varies from the hinged to the fixed. Buildings with semi-rigid column bases behaves similarly to the building with fixed bases. It has been numerically observed through the pushover and nonlinear time history analyses that the decrease of the stiffness of the column base induces the rotational demand on the int air beams. an increase of rotation demands on the first store connections and lead to a soft-story mechanists Due often to the construction and environmental effects, undesired reduction of column base stiffness may cause an increase of rotation demands on the first store connections and lead to a soft-story mechanism.