• Analytical Science and Technology
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• v.24 no.2
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• pp.142-149
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• 2011

This study was conducted to define metabolite of the resveratrol by gas chromatography- time-offlight mass spectrometric detection. From these results, we suppose that the structure of metabolite is the result of reduction of double-bond attached by two-phenyl groups. Also, validity of method for determining metabolite of resveratrol and endogenous steroids was tested. The recoveries ranged from 96.47 to 114.74%, and intraand inter-day precision ranged 11.40 - 10.87% and 1.10 - 10.93%, accuracy ranged 80.03 - 119.92% and 80.02 - 119.56%, respectively. Resveratrol and endogenous steroids had correlation coefficients above or equal to 0.996. The method was successfully validated for the determination of resveratrol and endogenous steroids. Urinary samples from volunteers dosed resveratrol were analyzed to confirm a correlation resveratrol and its metabolite. From these results, the highest level of resveratrol and its metabolite was excreted in 10 - 15 hr more slowly than common drug, and conversion rate of metabolite was higher in woman than that in man. In addition, endogenous steroids were shown same the highest level of 10 - 15 hr. For estrone and estradiol, sensitivity was relatively higher in female than in man. And there were no significant changes of excretion patterns in the other endogenous steroids. Thus, we assumed that activation of resveratrol has impact on woman than man.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.44 no.11
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• pp.1006-1015
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• 2016

This paper presents preliminary design and performance analysis of a fast and high precision Tracking Mount for 1m Satellite Laser Ranging(SLR) which is development by Korea Astronomy and Space science Institute(KASI). SLR is considered to be the most accurate technique currently available for the precise orbit determination of Earth satellites. The SLR technique measures the time of flight between pulses emitted from laser transmitter and pulses returned from satellites with laser retro-reflector array. It provides millimeter level precision of range measurements between SLR stations and satellites. A fast and high precision Tracking Mount for SLR which is proposed in this research should be capable of day and nighttime laser tracking about the satellites with laser reflectors from 200 km to 36,000 km altitude(geosynchronous orbit). In order to meet this requirement, we performed mechanical design and structural analysis for Tracking Mount. Also we designed the motion control system and conducted pre-performance analysis to obtain good performance results for a fast and high precision Tracking Mount.

• The Korean Journal of Pharmacology
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• v.26 no.1
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• pp.35-49
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• 1990

A highly purified $(Na^+,\;K^+)-ATPase$ from the rectal gland of Squalus acanthias and from the electric organ of Electrophorus electricus has been used to raise antibodies in rabbits. The 97,000 dalton catalytic subunit and glycoprotein derived from the rectal gland of spiny shark were also used as antigens. The two $(Na^+,\;K^+)-ATPase$ holoenzymes and the two shark subunits were antigenic. In Ouchterlony double diffusion experiments, these antibodies formed precipitation bands with their antigens. Antibodies prepared against the two subunits of shark holoenzyme also formed precipitation bands with their antigens and shark holoenzyme, but not with eel holoenzyme. These observations are in good agreement with inhibitory effect of these antibodies on the catalytic activity of $(Na^+,\;K^+)-ATPase$ both from the shark and the eel, since there is very little cross-reaction between the shark anticatalytic subunit antibodies and the eel holoenzyme. The maximum antibodies titer of the anticatalytic subunit antibodies is found to be 6 weeks after the initial single exposure to this antigen. Multiple injections of the antigen increased the antibody titer. However, the time required to produce the maximum antibody titer was approximately the same. These antibodies also inhibit catalytic activity of $(Na^+,\;K^+)-ATPase$ vesicles reconstituted by a slow dialysis of cholate after solubilization of the enzyme in a presonicated mixture of cholate and phospholipid. In these reconstituted $(Na^+,\;K^+)-ATPase$ vesicles, effects of these antibodies on the fluxes of $Na^+$, $Rb^+$, and $K^+$ were investigated. Control or preimmune serum had no effect on the influx of $^{22}Na^+$ or the efflux of $^{86}Rb^+$. Immunized sera against the shark $(Na^+,\;K^+)-ATPase$ holoenzyme, its glycoprotein or catalytic subunit did inhibit the influx of $^{22}Na^+$ and the efflux of $^{86}Rb^+$. It was also demonstrated that these antibodies inhibit the coupled counter-transport of $Na^+$ and $K^+$ as studied by means of dual labeling experiments. However, this inhibitory effect of the antibodies on transport of ions in the $(Na^+,\;K^+)-ATPase$ vesicles is manifested only on the portion of energy and temperature dependent alkali metal fluxes, not on the portion of ATP and ouabain insensitive ion movement. Simultaneous determination of effects of the antibodies on ion fluxes and vesicular catalytic activity indicates that an inhibition of active ion transport in reconstituted $(Na^+,\;K^+)-ATPase$ vesicles appears to be due to the inhibitory action of the antibodies on the enzymatic activity of $(Na^+,\;K^+)-ATPase$ molecules incorporated in the vesicles. These findings that the inhibitory effects of the antibodies specific to $(Na^+,\;K^+)-ATPase$ or to its subunits on ATP and temperature sensitive monovalent cation transport in parallel with the inhibitory effect of vesicular catalytic activity by these antibodies provide direct evidence that $(Na^+,\;K^+)-ATPase$ is the molecular machinery of active cation transport in this reconstituted $(Na^+,\;K^+)-ATPase$ vesicular system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.7
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• pp.337-342
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• 2018

A rain water pumping station is a structural countermeasure to inland flooding of domestic water generated in a urban watershed. In this study, the optimal operation water level of the pump with the minimum overflow was determined based on the opinions of the person in charge of the operation of the rain water pump station. A GA (Genetic Algorithm), which is an optimization technique, was used to estimate the optimal operation water level of the rain water pump station and was linked with SWMM (Ver.5.1) DLL, which is a rainfall-runoff model of an urban watershed. Considering the time required to maximize the efficiency of the pump, the optimal operating water level was estimated. As a result, the overall water level decreased at a lower operating water level than the existing water level. For most pumps, the lowest operating water level was selected for the operating range of each pump unit. The operation of the initial pump could reduce the amount of overflow, and there was no change in the overflow reduction, even after changing the operation condition of the pump. Internal water flooding reduction was calculated to be 1%~2%, and the overflow occurring in the downstream area was reduced. The operating point of the pump was judged to be an effective operation from a mechanical and practical point of view. A consideration of the operating conditions of the pump in future, will be helpful for improving the efficiency of the pump and to reducing inland flooding.

• Journal of KIISE:Computing Practices and Letters
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• v.13 no.3
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• pp.165-178
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• 2007

The recent progress in multimedia signal processing and transmission technologies has contributed to the extensive use of multimedia devices to watch sports games with small LCD panel. However, the most of video sequences are captured for normal viewing on standard TV or HDTV, for cost reasons, merely resized and delivered without additional editing. This may give the small-display-viewers uncomfortable experiences in understanding what is happening in a scene. For instance, in a soccer video sequence taken by a long-shot camera techniques, the tiny objects (e.g., soccer ball and players) may not be clearly viewed on the small LCD panel. Moreover, it is also difficult to recognize the contents of the scorebox which contains the elapsed time and scores. This renuires intelligent display technique to provide small-display-viewers with better experience. To this end, one of the key technologies is to determine region of interest (ROI) and display the magnified ROI on the screen, where ROI is a part of the scene that viewers pay more attention to than other regions. Examples include a region surrounding a ball in long-shot and a scorebox located in the comer of each frame. In this paper, we propose a scheme for raising viewing experiences of multimedia mobile device users. Instead of taking generic approaches utilizing visually salient features for extraction of ROI in a scene, we take domain-specific approach to exploit unique attributes of the soccer video. The proposed scheme consists of two modules: ROI determination and scorebox extraction. The experimental results show that the proposed scheme offers useful tools for intelligent video display on multimedia mobile devices.

• Journal of Korean Tunnelling and Underground Space Association
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• v.8 no.2
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• pp.151-163
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• 2006

Although various methods for effective modeling of pre-reinforced zones have been suggested for numerical analysis of large section tunnels, tunnel designers refer to empirical cases and literature reviews rather than engineering methods because ones who use commercial programs are unfamiliar with a macro-scale approach in general. Therefore, this paper suggests a simple micro-scale approach combined with the macro-scale approach to determine equivalent design parameters for effective numerical modeling of pre-reinforced zones in tunnel. This new approach is to determine the equivalent stiffness of pre-reinforced zones with combination of ground, bulb, and steel in series or/and parallel. For verification, 3-D numerical results from the suggested approach are compared with those of a realistic model. The comparison suggests that two cases make best approximation to a realistic solution: One is related to the series-parallel stiffness system (hereafter SPSS) in which bulb and steel are coupled in parallel and then connected to the ground in series, and the other is the series stiffness system (hereafter SSS) in which only bulb and steel are coupled in series. The SPSS is recommended for stiffness calculation of pre-reinforced zones because the SSS is inconvenient and time-consuming. The SPSS provides slightly bigger vertical displacement at tunnel crown in weathered rock than other cases and give almost identical results to a realistic model for horizontal displacement at tunnel spring line and ground surface settlement. Displacement trends on weathered rock and weathered soil are similar. The SPSS which is suggested in this paper represents the behavior mechanism of pre-reinforced area effectively.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.4 no.2
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• pp.95-102
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• 2006

Alpha spectrometry was studied for the determination of $^{237}Np$ in spent nuclear fuel samples. The optimum condition for the electrodeposition of $^{237}Np$ was obtained as follows : for $1{\sim}1.5$ hour of deposition time, at the current intensity of $1.2{\sim}1.5$ A and at sodium sulfate electrolyte without organic additive. The deposition yield and its reproducibility on $^{237}Np$ was decreased as the amount of $^{237}Np$ decreased from 4.16 Bq down to 0.0264 Bq(1ng). The recovery yield of $^{237}Np$ determined by alpha spectrometry after separation in synthetic solution was $98.8{\pm}5.1%$(n=4). The contents of $^{237}Np$ in spent nuclear fuel samples were determined and the result showed an agreement within 10% of a difference between the measurement and the calculation.

• Quality Improvement in Health Care
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• v.9 no.1
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• pp.52-64
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• 2002

Background : Coding of principal diagnosis is essential component for producing reliable health statistics. We performed this study to evaluate the current practice of principal diagnoses determination and coding, and to give some basic data to improve coding of principal diagnosis. Method : Nineteen medical record administrators (MRAs) of 3 university hospitals participated in coding principal Dx. from August 1, 2001 to August 31, 2001. From each hospital, 10 medical records of patients with high frequency disease were selected randomly. Each 10 medical records were grouped into three (A. B, C). Then, these 30 medical records were given to each MRAs for coding. At the same time questionnaire was given to each of them. Questions were to prove how they decide and code the principal diagnosis among many current diagnoses; how they decide and code the principal diagnosis when they see irrelevant diagnosis recorded as the principal diagnosis in medical record, when only tentative diagnoses were recorded without final diagnosis, and when different diagnoses were recorded in different sheets of same record. Agreement of coding among 3 hospitals were compared and survey results were analysed with SAS 6.12. Results : Agreement of coding was found in medical records 5-6 of each 10 medical records. Causes of disagreement were as follows. Difference of clinician's opinion from each hospital; mixed use of guideline from KCD-3 and guideline from DRG; difference in 4th digit classification according to the absence of pathology report in the medical record; difference of abbreviations among hospitals. 57.9% of MRAs selected the principal diagnosis recorded by physician, 42.1% of MRAs decided principal diagnosis after consulting to KCD-3 guideline. When there were difficulties in determining the principal diagnosis, 42.1% of MRAs decided principal diagnosis after discussion with the physician, 26.3% after discussion with fellow MRAs. Conclusion : There were differences in codings among hospitals. To minimize the difference, we suggest the development of disease-specific guidelines for coding in addition to the current general guideline such as KCD-3. To do this, Coding Clinic which can produce guidelines is needed.

• Journal of Astronomy and Space Sciences
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• v.25 no.4
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• pp.425-434
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• 2008

The mean temperature equation is a key factor in calculating GPS meteorological information. A local mean temperature equation should be used to improve accuracy of GPS PWV (Precipitable Water Vapor). In this paper, four local mean temperature equations, HP, $HP_M,\;HPt_Y,\;and\;HPt_M$ from Ha & Park (2008) were used to analyze the effects of local models in determining GPS PWV. Four different sets of GPS PWVs were compared with radiosonde PWV to validate the accuracies of local models. GPS PWVs of four local models have similar trends compared against radiosonde PWV. The bias and RMS error were the same level: the bias is ${\sim}3mm$ and the RMS is ${\sim}3.6mm$ after the bias was removed. Especially, with $HPt_Y\;and\;HPt_M$ models one can obtain accurate PWVs even without surface temperature measurements. And we investigated dry bias of radiosonde measurements depending on sensor types and observation time at Sokcho weather station. After the radiosonde sensor equipment was changed from RS80-15L to GRS DFM-06, dry bias of radiosonde PWV decreased about 18.2% during daytime (KST 09:00), and 16.1% during nighttime (KST 21:00).

• Korean Journal of Fisheries and Aquatic Sciences
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• v.35 no.3
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• pp.273-281
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• 2002

Determination of sediment type is generally based on ground truthing. This method, however, provides information only for the limited sites. Recent developments of remote classification of seafloor sediments made it possible to obtain continuous profiles of sediment types. QTC View system, which is an acoustic instrument providing digital real-time seabed classification, was used to classify seafloor sediment types in the Suyoung Bay, Pusan. QTC View was connected to 50 kHz echo sounder, All parameters of QTC View and echo sounder are uniformly kept during survey. By ground truthing, the sediments are classified into seven types, such as slightly gravelly sand, slightly gravelly sandy mud, gravelly muddy sand, clayey sand, sandy mud, slightly gravelly muddy sand, and rocky bottom. By the first remote classification using QTC View, four sediment types are clearly identified, such as slightly gravelly sand, gravelly mud, slightly gravelly muddy sand, and rocky bottom. These are similar to the result of the second survey. Also the result of remote classification matches well with that of ground truthing, but for sediment type determined by minor component. Therefore, QTC View can effectively be used for remote classification of seafloor sediments.