• 대한두경부종양학회지
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• 제14권1호
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• pp.81-87
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• 1998

Fine needle aspiration cytology was used widely to select thyroid nodules for surgery. The result could be highly reliable for most malignancies and for benign nodules. The purpose of this study was to determine the value of frozen biopsy by directly comparing the results of preoperative fine needle aspiration cytology to frozen biopsy examination. In our university hospital, 103 patients with thyroid nodule were operated during the years 1996 through 1997. A comparison of accuracy of the fine needle aspiration cytology with frozen biopsy was made for 85 patients who underwent both procedures. The 85 patients were separated into two groups. The group I included 65 patients, whose preoperative fine needle aspiration cytology results were reported as benign or malignant lesion definitely. The group II included 85 patients, the patients whose reported fine needle aspiration cytologic result was suspicious for malignancy were regarded .as malignant lesion and results for follicular neoplasm were regarded as benign lesion. The accuracy of both procedures was compared on two group also. The sensitivity, specificity, and accuracy of frozen biopsy were 76.7%, 93.5%, and 85.2% in group I and 75.6%, 95.5%, and 85.9% in group II, respectively, compared with 63.3%, 87.1%, and 75.4% in group I and 65.4%, 81.8%, and 72.9% in group II for fine needle aspiration cytology. On benign lesion, the accuracy was 95.5% in frozen biopsy and 68.2% in fine needle aspiration cytology, 75.6% in frozen biopsy and 53.7% in fine needle aspiration cytology on malignant lesion. We conclude that although fine needle aspiration cytology is the reliable diagnostic test in the evaluation of thyroid nodule, frozen biopsy should be performed intraoperatively, because fine needle aspiration cytology is insufficiently sensitive for reliable surgical planning.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4689-4692
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• 2016

Purpose: To study the clinical application value of ultrasound guided thyroid fine needle aspiration biopsy and thinprep cytology testing in diagnosis of thyroid disease. Methods: A total of 78 patients with thyroid nodules were enrolled, 34 males and 44 females, aged 33-64 years old with mean age of 47.6 years. All underwent thyroid module fine needle puncture after surgery to assess cell pathology and histopathological features. Results: Sufficient specimens were obtained from all of 78 patients, the cytological results of 73 cases (93.6 %) being consistent with pathological results. While 20 cases (25.6 %) were malignant tumors, 44 (56.4 %) were benign and 9 (11.5 %) were non-tumor lesions. The sensitivity of benign and malignant thyroid nodule by thyroid fine needle puncture was 90.9 %, specificity was 98.1 % and the positive predictive value was 96.3 %. Conclusions: It is demonstrated that ultrasound-guided thyroid fine needle aspiration biopsy and thinprep cytology testing have diagnostic value in clinical application for thyroid disease,showing good diagnostic coincidence rates with histopathological examination. They can thus be regarded as safe and effective for preoperative diagnosis and providing an appropriate basis for selection of surgery.

• 대한세포병리학회지
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• 제13권1호
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• pp.33-37
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• 2002

We report two different types of thyroid lymphoma associated with Hashimoto's thyroiditis. Both showed autoantibodies and were compatible with Hashimoto's thyroiditis according to their clinical backgrounds. A 76-year-old female noted a painless, rapidly growing mass in her neck which was diagnosed as diffuse non-Hodgkin's lymphoma, large cell type, after the fine needle aspiration cytology of the thyroid. She underwent chemo-radiotherapy and is free of the disease 10 months after diagnosis. The other patient, a 73-year-old female with a diffuse golfer, was diagnosed on fine needle aspiration cytology as having Hashimoto's thyroiditis. Three years later she developed a hard nodular growth in the both lobes of the thyroid. This was subjected to fine needle aspiration cytology and needle biopsy and was diagnosed as a MALT lymphoma. She refused any treatment and died 12 months after the diagnosis.

• 대한두경부종양학회지
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• 제21권2호
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• pp.170-173
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• 2005

Fine needle aspiration cytology (FNAC) of thyroid gland lesions has become a routine diagnostic method. And fine needle aspiration cytology is considered a safe, reliable and cost-effective means of selecting thyroid nodules with risk for malignancy. However, fine needle aspiration cytology of the thyroid may cause hemorrhage, infection, or trauma to adjacent structures. Hemorrhage sufficient to cause tracheal compression has not been reported. So we present a case of anterior neck hematoma causing tracheal compression after FNAC of the thyroid nodule.

• 대한두경부종양학회지
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• 제23권1호
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• pp.54-57
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• 2007

Fine needle aspiration biopsy(FNAB) has been used for many decades in the diagnosis of benign and malignant tumors of thyroid gland. Complications of thyroid fine-needle aspiration biopsy(FNAB) are extremely rare. Hematoma formation is the most commonly encountered complication. However, massive intrathyroid unilateral hemorrhage and hematoma formation inducing upper airway distress rarely occurs. Here, we report two cases diagnosed as having hematoma that caused upper airway distress after FNAB for thyroid nodule.

• 대한세포병리학회지
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• 제11권1호
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• pp.41-45
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• 2000

Thymoma is the most common anterior mediastinal tumor in adults. Rarely, it is presented as the anterior neck mass, commonly located in the anterolateral aspect of the neck or adjacent to the thyroid. We experienced two cases of fine needle aspiration cytology of thymoma, mimicking thyroid mass. The first case was an ectopoic cervical thymoma in a 31-year-old female. The fine needle aspiration cytology was misinterpreted as reactive hyperplasia of lymph node. But the histologic diagnosis was thymoma, predominantly lymphocytic type. The second case was an invasive thymoma in a 66-year-old female, who complained a large anterior neck mass. The fine needle aspiration cytology revealed biphasic population of some clusters of epithelial cells and scattered lymphocytes. The cytologic diagnosis was thymoma and was confirmed as invasive thymoma after the biopsy. Therefore, when the cytologic feature of anterior neck mass shows the both lymphocyte and epithelial component, the differential diagnosis should Include the possibility of thymoma.

• 한국콘텐츠학회논문지
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• 제16권5호
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• pp.290-297
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• 2016

본 연구는 직장건강검진 수검자의 갑상샘 초음파 검사에서 발견된 결절 중 1 cm 보다 큰 결절이거나 초음파상 악성을 시사하는 경우의 세침흡인세포검사 결과를 1군으로, 결절의 크기와 상관없이 초음파상 악성을 시사하는 경우의 세침흡인세포검사 결과를 2군으로 나누어 세침흡인세포검사가 필요한 결절 양상에 대해 비교 분석하였다. 1군에서 15.8%가 악성이었고 2군에서는 28%에서 악성으로 나왔다. 악성을 시사하는 소견은 양성과 악성 간의 통계학적으로 유의한 차이가 있었고 결절의 크기가 1 cm 이상이지만 고위험 인자를 동반하지 않으면서 초음파검사 결과 스폰지(spongiform) 형태 소견을 보일 때에는 거의 대부분 양성이므로 세침흡인세포검사가 불필요하다고 사료되었다. 이러한 초음파 소견의 의미는 갑상샘 결절에 대한 세침흡인세포검사가 필요한지 여부를 결정하는데 중요한 근거가 된다. 현재 갑상샘 결절에 대한 세침흡인세포검사 시행은 결절의 크기가 1 cm 이상이면 스폰지 형태라도 환자의 불안감에 편승하여 행하여지는 경우가 흔하다. 그러나 양성과 악성 결절을 감별하는데 있어서 갑상샘 초음파 소견을 정확히 숙지한다면 불필요한 세침흡인세포검사를 줄일 수 있을 것으로 사료된다.

• International journal of thyroidology
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• 제11권2호
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• pp.182-188
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• 2018

Fine-needle aspiration (FNA) with ultrasonography is considered a minimally invasive and safe procedure. Complications of it are infrequent and occur immediately or within a few days after FNA. Such complications may occur mainly in patients with underlying problems. We here report a rare case of thyroid cystic nodule infection occurring 1 month after FNA in an immunocompetent patient and serial sonographic findings in this patient. A 33-year-old woman with a cystic nodule including partially isoechoic solid areas on the right thyroid gland complained of difficulty swallowing and painful sensations in the right neck 1 month after FNA. On follow-up examination, the cystic nodule and perithyroidal soft tissue were suspicious of infection. The possibility of infection after FNA should be considered even if the patient is immunocompetent in order to prompt evaluation and immediate management with empirical antibiotic therapy to avoid life-threatening complications.

• 대한세포병리학회지
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• 제8권1호
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• pp.52-56
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• 1997

Oxyphilic (Hurthle) cells have abundant eosinophilic granular cytoplasms and occur in both benign and malignant neoplasms of the thyroid gland. Most published studies described mainly oxyphilic tumors of follicular type, and reports on oxyphilic papillary thyroid carcinomas are rare. The oxyphilic variant of papillary carcinoma differs from the classic papillary carcinoma in its more aggressive biological behavior. We report a case of oxyphilic papillary carcinoma exhibiting exclusively oxyphilic cells in a follicular pattern without papillary structures. The pattern of papillary carcinoma was confirmed by fine needle aspiration material and lymph nodal metastasis, both of which revealed typicaled papillary structures with characteristic nuclear features, psammoma bodies, and oxyphilic cytoplasm.

• 대한세포병리학회지
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• 제14권1호
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• pp.32-35
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• 2003

Multinucleated giant cells of osteoclast-like appearance can be seen in a type of anaplastic carcinoma of thyroid and only a few case reports for fine needle aspiration cytologic findings are found in the literatures. Recently, we experienced a case of anaplastic carcinoma of thyroid with many osteoclast-like giant cells in a 72-year-old woman. The cytologic features and immunohistochemical results are described with special emphasis on differential diagnosis.