• Journal of Chest Surgery
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• 제31권3호
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• pp.319-323
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• 1998

흉선의 유암종은 매우 드문 종격동 종양으로, 1972년에 Rosai와 Higa에 의해 기술되었다. 흉선의 유암종은 Kultschizky 세포에서 생기는 종양으로 생각되어지며, 흉선종과 다른 종양으로 간주되어 왔다. 흉선의 유암종의 병리학적인 진단으로 병리학적, 면역조직화학적, 전자현미경적 소견을 이용한다. 유암종의 50% 정도에서는 내분비 질환을 가진다. 재발과 흉곽외 전이가 특징적이다. 발견당시나 재발의 경우에 외과적인 절제가 가장 효과적이라고 생각된다. 그러나 방사선 치료나 항암치료의 역할은 분명하지 않다. 저자들은 수술 및 병리학적으로 증명된 57세 남자의 흉선 유암종 1예를 경험하였기에 간단한 문헌 고찰과 함게 보고하는 바이다.

• Journal of Chest Surgery
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• 제25권11호
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• pp.1236-1239
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• 1992

Carcinoid tumors arising in the thymus are rare. Since Rosai and Higa in 1972 distinguished these neoplasms from thymomas, fewer than 100 cases have been reported in the world literature. The pathologic diagnosis of thymic carcinoids is been on findings from light microscopy, histochemical studies, and electron microscopy. About 50% of thymic carcinoids are seen with endocrinopathies. Recurrence and extrathoracic metastasis are characteristic of thymic carcinoids. Surgical extirpation of the tumor initially and of the subseguent recurrences in the most effective treatment today The role of adjuvant radiotherapy and chemotherapy is still uncertain. Herein we report a case of thymic carcinoid tumor in a 36-year old male with brief review of literatures.

• Journal of Chest Surgery
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• 제35권8호
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• pp.634-637
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• 2002

흉선 유암종 또는 흉선의 신경내분비 종양은 매우 드문 질환이며 재발이나 전이가 많아 예후가 좋지 못하다. 43세 남자 환자로 우측 흉부의 통증과 불편감으로 내원하였다. 단순 흉부 촬영상 우측 전종격동에 $7{\times}8$cm 크기의 종양을 발견하였으며 추가검사 후 수술적 절제를 시행하였다. 절제된 종괴는 조직학적, 면역조직화학적, 전자현미경적 소견상 흉선 낭종을 동반한 흉선의 비정형 유암종으로 진단 되었다. 수술 후 재발이나 전이 소견 없이 3개월째 외래 관찰중이다. 저자들은 흉선 낭종을 동반한 비정형 흉선유암종 1례를 치험하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제19권4호
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• pp.736-743
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• 1986

Thymus gland is a kind of endocrine organ which secretes thymosin and thymoprotein. There can be developed variable lesions like thymoma, thymic hyperplasia, thymic cyst, thymolipoma, and carcinoid tumor of the thymus gland. We have experienced 25 patients of thymic disease: thymoma 12, thymic hyperplasia 11, thymic cyst 1, carcinoid tumor 1. The age distribution were ranged from 3 to 66 years and the sex ratio was 1:1.8 [male to female]. Thymectomy was performed in all cases, but 3 cases with deep infiltration to the adjacent structures were not resectable completely. Malignancy [all thymoma] were 5 and the rest were benign. Two cases were died of recurrence after tumor resection. Myasthenia gravis occurred in 10 cases. Among them, 2 were thymoma and 8 were thymic hyperplasia. We could obtained the result that thymectomized cases reached 2 remission and 5 improvement. Myasthenia gravis treated medically [18 cases] had no remission and only 2 clinical improvement. In the light of these results, early radical thymectomy would be most favorable treatment in not only thymic tumor, but generalized myasthenia gravis.

• Journal of Chest Surgery
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• 제16권4호
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• pp.571-583
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• 1983

Thymic tumor is the most common neoplasm originating in the anterior mediastinum. Histologically, thymic tumors and tumorlike conditions have been classified into thymic cyst, thymolipoma, true thymic hyperplasia, thymoma and carcinoid tumor of the thymus gland. We have experienced several tumors and a few tumorlike conditions of the thymus gland in 10 patients: thymoma 6, thymic hyperplasia 2, carcinoid tumor 1 and thymic cyst 1. The age distributions were ranging from 30 to 60 years except for one 3 year old child [malignant thymoma, lymphocytic type], and male to female ratio was 1:1.5. In 6 cases, thymic lesions were removed through lateral thoracic incision [right 2, left 4] because the mediastinal masses were growing far into the pleural space, meanwhile, medially located lesions [4 cases] through median sternotomy incision. Among these 10 patients, 3 were malignant thymomas, in which 2 were died of recurrence after tumor resection. Myasthenia gravis was all noted in 3 females [thymoma 2, thymic follicular hyperplasia 1], in which only two revealed remission in symptoms following thymectomy. The authors would like to recommend early radical thymectomy through median sternotomy incision whenever patients demonstrate suspicious thymic tumor lesions on the chest roentgenogram or generalized myasthenic symptoms.

• Journal of Yeungnam Medical Science
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• 제31권2호
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• pp.131-134
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• 2014

Familial isolated primary hyperparathyroidism(FIPH) is associated with multiple endocrine neoplasia type 1 (MEN1) syndrome, primary hyperparathyroidism accompanied by jaw-tumor syndrome, and familial hypocalciuric hypercalcemia. FIPH may be an early stage of MEN1 or an allelic variant of MEN1. Thymic carcinoid tumor is a rare tumor in MEN1 syndrome. Here, the authors report the case of a 40-year-old man diagnosed with recurrent thymic carcinoid tumor and FIPH. Both the patient and his elder sister had been previously diagnosed to have FIPH with a novel frameshift mutation in the MEN1 gene. Initially, the patient underwent thymectomy because of an incidental finding of a mediastinal mass in his chest X-ray, and had remained asymptomatic over the following 4 years. Pancreas computed tomography conducted to evaluate MEN1 syndrome revealed anterior and middle mediastinal masses, and resultantly, massive mass excision was performed. Histological findings disclosed atypical carcinoids with infiltrative margins. In view of the thymic carcinoid tumor relapse that occurred in this patient, the authors recommend that regular pancreas and pituitary imaging studies be conducted for FIPH associated with a MEN1 gene mutation.

• Journal of Chest Surgery
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• 제39권10호
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• pp.795-798
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• 2006

쿠싱증후군과 연관된 흉선 carcinoid종양은 드문 질병으로 그 예후가 나쁜 것으로 알려져 있다. 그중 부신피질자극 호르몬 분비 촉진 호르몬을 생산하는 흉선 carcinoid 종양은 훨씬 더 드물다. 우리는 거대한 전방 종격동 종양을 갖고 있는 58세 여자 환자에 대해 보고하려고 한다. 환자는 흉선제거술 5개월 후 전반적인 부종과 호흡곤란으로 다시 입원하였다. 환자는 재발과 전이가 발견되었고 쿠싱증후군으로 진단 받았다.

• 대한세포병리학회지
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• 제2권2호
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• pp.142-147
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• 1991

Diagnosis of a thymic carcinoid was made on transthoracic fine needle aspiration in a 36-year old woman who had an anterior mediastinal mass on chest X-ray and CT scan. The aspiration smears showed numerous anastomosing ribbons and cords of small round tumor cells. The tumor cells had slightly eccentric nuclei and some granular cytoplasm. The small and uniform nuclei of the tumor cells had finely granular chromatin and thin nuclear membrane. The cytologic diagnosis of a carcinoid was confirmed on histopathologic, immunohistochemical, and electromicroscopic examination of surgical specimen.

• Tuberculosis and Respiratory Diseases
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• 제44권2호
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• pp.425-429
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• 1997

저자들은 68세 여자에서 전종격동에 발생한 흉선 유암종 1예를 광학 및 전자현미경소견들로 확진하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제52권6호
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• pp.420-424
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• 2019

Atypical thymic carcinoid is an extremely rare tumor with a poor prognosis. In addition to its known association with multiple endocrine neoplasia type 1, its hallmark characteristics include local invasion and early distant metastasis. In this report, we share our experience treating atypical thymic carcinoid in a patient with Zollinger-Ellison syndrome.