• Smart Media Journal
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• v.5 no.1
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• pp.137-142
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• 2016

In this paper, a multi-scale model is applied to the simulation of thrombus growth. This model includes macroscale model and microscale model. The former is used to model the plasma flow with Navier-Stokes equations, and the latter is used to model the platelets adhesion and aggregation, thrombus motion, and the surface expansion of thrombus. The force acting on platelets and thrombus from plasma is modeled by the drag force, and the forces from biochemical reactions are modeled by the adhesion force and the aggregation force. As more platelets are merged into the thrombus, the thrombus surface expands. We proposed a thrombus growth model for simulating the expansion of thrombus surface and tracking the surface by Level Set Methods. We implemented the computational model. The model performs well, and the experimental results show that the shape of thrombus in level set expansion form is similar with the thrombus in clinical test.

• 한국전산유체공학회:학술대회논문집
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• 2003.10a
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• pp.147-149
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• 2003

Using computational fluid dynamics with the fluid-structure interaction, structural effects of intra-luminal thrombus were determined in thrombosed axisymmetric abdominal aorta aneurysm (AAA) models under pulsatile flow. Four different models, varying dilatations of the aneurysm and Young's moduli of intra-luminal thrombus, were defmed. Compared with unthrombosed AAA models, both von Mises stress and radial displacements in the aneurysm wall significantly decreased. Stiffer intra-luminal thrombus reduced von Mises stress in the aneUtysm wall. The present study supported that intra-luminal thrombus might reduce wall stress in the aneurysm.

• Journal of Chest Surgery
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• v.46 no.6
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• pp.464-466
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• 2013

Floating thrombi in the aortic arch are very rare and an unusual source of systemic embolism. Herein, a case of a 3-cm thrombus in the aortic arch is reported. It was a floating, highly mobile thrombus attached to the lesser curvature of the aortic arch. The patients had a hypercoagulable disorder induced by protein C and S deficiency. The thrombus was operatively removed with a favorable outcome.

• Journal of Chest Surgery
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• v.33 no.2
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• pp.190-192
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• 2000

A 53-year-old male patient who had suffered from acute myocardial infarction before a week was admitted due to postinfarction angina A mobile pedunculated left ventricular thrombus of 2.0-cm diameter which was overlooked in cardiac catheterization and ventriculographic study was diagnosed with transthoracic two-dimensional echocardiography. There was no exact clinical finding of left ventricular aneurysm and the thrombus was placed in the akinetic and hypokinetic apical portion. For preventing systemic embolism that was removed through a left ventriculotomy just prior to coronary artery bypass grafting.

• Journal of Veterinary Clinics
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• v.34 no.6
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• pp.478-480
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• 2017

A Cocker spaniel (7-year-old, female) was presented with one week of anorexia, halitosis, oral ulcer, intermittent vomiting, acute weight loss and 3-day history of oliguria. The patient was diagnosed with acute on chronic kidney disease and pancreatitis. Hemodialysis was continued three times a week (total 7 sessions) with improved clinical signs and kidney panel, but presented with another episode of abdominal distention, respiratory distress, and large bowel diarrhea. Echocardiography revealed nearly totally occlusive thrombus in the cranial vena cava, as well as a right atrial mass of approximately $2cm{\times}1cm$. The patient was treated with catheter removal, thrombolysis and anticoagulation therapy with recombinant tissue plasminogen activator. During anticoagulation therapy, size of atrial thrombus was not changed and heart function was not improved after treatment. Since clinical signs were deteriorated, the patient was euthanized by owner's request. Catheter-related giant thrombus in right atrium is a rare complication and treatment guideline for atrial thrombus does not exist. This case is first report of hemodialysis catheter-induced thrombus in Korea.

• Journal of Veterinary Clinics
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• v.34 no.3
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• pp.213-217
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• 2017

A 1-year and 8-month-old male, thoroughbred horse showed fever ($39.8^{\circ}C$), cardiac murmur, tachycardia up to 80 beats/min, anorexia, depression and lameness for about 2 months. The dead horse was referred to pathology laboratory at the College of Veterinary Medicine in Jeju National University. At necropsy, Severe protruding multiple rough cauliflower-like yellowish red nodules ranged $5{\sim}6{\times}2{\sim}3cm$ in size were attached on the mitral valve of the left heart. A yellowish red long stick-shaped thrombus $15{\times}3.5{\times}1.5cm$ in size was also present inside the right ventricle. Multifocal infarcts were scattered in the myocardium and renal cortex. Histopathologic examination revealed that morphologic diagnosis were vegetative endocarditis, thrombus in right ventricle, infarcts in myocardium and kidney, pulmonary congestion and edema, and splenic congestion. The isolated bacteria from vegetative lesions and thrombus were confirmed as Escherichia (E.) coli based on the bacterial culture and VITEK 2 system. Based on the gross and histopathologic features, and bacterial test, this case was diagnosed as vegetative endocarditis with thrombus formation associated by E. coli in a thoroughbred horse.

• Clinical and Experimental Pediatrics
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• v.50 no.6
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• pp.588-591
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• 2007

Left ventricular thrombus is mainly caused by anterior myocardial infarction or severe cardiac wall dysfunction of the apex, and is rarely caused by a complication of acute myocarditis. A 12-year-old female who developed symptoms of motor dysphasia and incomplete hemiparesis of the right side was admitted to the hospital. The brain MRI taken on the day of her admission showed acute cerebral infarction in the left basal ganglia and the frontoparietal lobe. The echocardiogram showed a movable thrombus, which was $19{\times}28mm$ sized and located in the apex of the left ventricle. So in order to prevent further thromboembolic event we performed open cardiac surgery via the atrium and removed the thrombus of the left ventricle. After the removal of the thrombus her symptoms improved and she was discharged from the hospital. Thrombus formation in acute viral myocarditis are considered to be related with endocardial injury and blood flow stasis. Treatment with anticoagulants in left ventricular thrombosis may not be effective and may even cause a major thromboembolism. When the thrombus is laminar and fixed, one should consider anticoagulant therapy. But if the thrombus is pedunculated and movable, which means that there are higher possibilities of major embolism or there may be already one, one should consider surgical removal. We report a 12-year-old girl who required surgical removal of a left ventricular thrombus caused by acute viral myocarditis.

• Journal of Yeungnam Medical Science
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• v.27 no.2
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• pp.133-138
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• 2010

Apical hypertrophic cardiomyopathy is rare disease and a variant of hypertrophic cardiomyopathy with prevalence of 1 in 500 in the general population. Apical hypertrophic cardiomyopathy with apical aneurysm and intramural thrombus is extremely rare. We report a case of apical hypertrophic cardiomyopathy progressing to left ventricular apical aneurysm with intramural thrombus diagnosed by contrast echocardiography.

• Proceedings of the KOSOMBE Conference
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• v.1993 no.11
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• pp.110-113
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• 1993

An in vitro experiment under laminar non-pulsatile blood flow and an acute canine ex vivo femoral A-V series shunt experiment were undertaken to investigate the effectiveness of saline perfusion through pores of porous tubes to prevent formation of mural thrombus. PS/SBR porous tubes were used for the in vitro experiment. Commercially obtained ePTFE porous tubes were etched by sodium naphthalenide, and the etched tubes were used for the ex vivo experiment. According to the results of the in vitro experiment, mural thrombus on the surface of the porous tribe could be prevented by the saline perfusion. Adhered blood cells decreased semi-logarithmically with increased perfusion rate (up to $0.022\;ml/min-cm^2$) of isotonic saline solution. According to results of the ex vivo experiment, mural thrombus decreased with increased perfusion rate (upto $0.060\;ml/min-cm^2$).

• Journal of Biomedical Engineering Research
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• v.23 no.4
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• pp.295-300
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• 2002

Localized hypoxia, due to the diminished $O_2$supply, is reported to cause necrosis of the arterial cell and to significantly decrease resistances to physiologic distending pressures. In the present study, in order to understand the mechanism of localized hypoxia which might result in the rupture of the aneurysm. $O_2$ transport phenomena across intraluminal thrombus in axisymmetric aneurysms under steady laminar flow condition were numerically analyzed using the Fick's law and the analogy with the fluid-solid heat transfer. For computational models, varying the thickness of intraluminal thrombus, numerical results showed that for the axisymmetric aneurysm with intraluminal thrombus. $O_2$ concentration became minimal at the aneurysm wall. With increased thickness of the intraluminal thrombus in the aneurysm. regions of low $O_2$ concentration were widely distributed near the aneurysm wall, which resulted in the possibility of localized hypoxia. The present study verifis that intraluminal thrombus influences $O_2$ transport to the aneurysm wall. depending on its size and structure.