• Title/Summary/Keyword: Threshold effect

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Hindlimb Muscle Atrophy of Rat Induced by Neuropathic Pain (말초신경 손상에 의한 신경병증성 통증으로 유발된 쥐 뒷다리근 위축)

  • Choe, Myoung-Ae;Kim, Kyung-Hwa;An, Gyeong-Ju;Lee, Kyung-Sook;Choi, Jung-An
    • Journal of Korean Biological Nursing Science
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    • v.10 no.1
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    • pp.88-95
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    • 2008
  • Purpose: The purpose of this study was to examine the effect of neuropathic pain by peripheral nerve injury on mass and Type I and II fiber cross-sectional areas on hindlimb muscles of the neuropathic pain model rat. Method: Adult male Sprague-Dawley rats (body weight 200-220 g) were assigned to one of two groups: a neuropathic pain group (n=7) that had a ligation of the left L5 spinal nerve, a control group (n=5), a naive rat without any procedures. Withdrawal threshold, activity, body weight and food intake were measured daily. At 8 days after neuropathic pain, all rats were anesthetized and the soleus and plantaris muscles were dissected from the both hindlimbs. Body weight, food intake, muscle weight and Type I and II fiber cross-sectional area of the dissected muscles were determined. Result: The neuropathic pain group showed a significant decreases (p<.05) as compared with the control rats, in diet intake, body weight, muscle weight and Type II fiber cross-sectional area of the left (affected side) soleus and plantaris muscles, and the right (unaffected side) muscle weight of plantaris and Type II fiber cross-sectional area of the soleus muscle. Conclusion: The hindlimb muscle atrophy occurs in both affected and unaffected side due to neuropathic pain by the peripheral nerve injury. The hindlimb muscle atrophy of the affected side is more pronounced than that of the unaffected side.

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Effects of Methylglyoxal on the Growth Dynamics of Secenedesmus quadricauda (Methylglyoxal 이 Scenedesmus quadricauda 의 성장 역학에 미치는 영향)

  • Rhie, Ki-Tae
    • The Korean Journal of Ecology
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    • v.18 no.1
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    • pp.17-30
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    • 1995
  • The growth of Scenedesmus quadricauda (Trup.) Breb. is enhanced by methylyoxal (MG), a general inhibitor of cell division, at threshold concentration in conjunction with reatment timing relative to growth stage. The stimulatory effect of MG on algal cell growth was most significant with 2.27-fold of untreated algal culture in cell number when 0.5 mM of MG was added to the algal culture at the beginning of logarithmic phase with an initial MG concentration of 0.535 mg $MG/10^6cell$. A Specific growth rates (SGRs) of MG-treated cultures were rapidly increased at the beginning of logarithmic phase with 1.89-fold of untreated algal culture. Cultures inoculated with high cell numbers of 2.4 to 4.8 X $10^4$ cells/ml were less sensitive to 0.5 mM of MG treatment. The algal cell division was ranged from 0.392 to 0.924 mg MG/106 cell. If the cell number of an algal culture at the time of inoculation was low (0.6 X $10^4$ cells/ml) and MG was added before logarithmic phase, the cell number of 0.5 mM of MG-treated cultures were lower than those of controls. In algal cultures treated with high concentrations of MG (1.0 mM and 2.0 mM), the algal growth was inhibited. Photosynthetic rate of growth-enhanced algal by 0.5 mM of MG was significantly higher than that of untreated or 1.0 mM of MG-treated algal cell, while there was no significant difference among those groups in respiratory rate. Pyruvate concentration in 0.5 mM of MG-treated culture was incrcased agter methylglyoxal trcatment.

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Modeling and performance analysis of movement-based registration considering implicit registration effect of outgoing calls (발신호의 묵시적 위치등록 효과를 고려한 이동기준 위치등록의 모형화 및 성능 분석)

  • Suh, Jae-Joon;Lee, Tae-Han;Baek, Jang-Hyun
    • Journal of the Korean Data and Information Science Society
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    • v.21 no.6
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    • pp.1155-1169
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    • 2010
  • This study considers movement-based registration (MBR). In MBR, a mobile station (MS) performs location registration whenever the number of entering cells reaches the specified movement threshold M. MBR is simple and its implementation is quite straightforward. However, it may result in more registrations than other similar schemes. An improved MBR scheme called MBIR (MBR with implicit registration) was proposed to reduce registration cost of MBR and its approximated performance was analyzed. In this study, we point out some problems of the previous analysis method and propose an exact analysis method of MBIR. Using the exact analysis method, we show that the previous analysis includes considerable errors and improvement of MBIR in our study seems to be larger than in the previous study.

Brazilian Test of Concrete Specimens Subjected to Different Loading Geometries: Review and New Insights

  • Garcia, Victor J.;Marquez, Carmen O.;Zuniga-Suarez, Alonso R.;Zuniga-Torres, Berenice C.;Villalta-Granda, Luis J.
    • International Journal of Concrete Structures and Materials
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    • v.11 no.2
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    • pp.343-363
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    • 2017
  • The objective of this work was finding out the most advisable testing conditions for an effective and robust characterization of the tensile strength (TS) of concrete disks. The independent variables were the loading geometry, the angle subtended by the contact area, disk diameter and thickness, maximum aggregate size, and the sample compression strength (CS). The effect of the independent variables was studied in a three groups of experiments using a factorial design with two levels and four factors. The likeliest location where failure beginning was calculated using the equations that account for the stress-strain field developed within the disk. The theoretical outcome shows that for failure beginning at the geometric center of the sample, it is necessary for the contact angle in the loading setup to be larger than or equal to a threshold value. Nevertheless, the measured indirect tensile strength must be adjusted to get a close estimate of the uniaxial TS of the material. The correction depends on the loading geometry, and we got their mathematical expression and cross-validated them with the reported in the literature. The experimental results show that a loading geometry with a curved contact area, uniform load distribution over the contact area, loads projected parallel to one another within the disk, and a contact angle bigger of $12^{\circ}$ is the most advisable and robust setup for implementation of BT on concrete disks. This work provides a description of the BT carries on concrete disks and put forward a characterization technique to study costly samples of cement based material that have been enabled to display new and improved properties with nanomaterials.

The Effect of Electrolyte Concentration for Colloid Adsorption toward a Fluid-Fluid Interface (유체 계면에서 콜로이드 흡착에 대한 전해질 농도의 영향)

  • Park, Bum Jun
    • Korean Chemical Engineering Research
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    • v.51 no.4
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    • pp.527-530
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    • 2013
  • I present the behavior of colloidal adsorption to an oil-water interface in the presence of electrolyte in an aqueous subphase. The optical laser tweezers and the piezo controller are used to trap an individual polystyrene microsphere in water and forcibly transfer it to the interface in the vertical direction. Addition of an electrolyte (i.e., NaCl) in the aqueous subphase enables the particle to attach to the interface, whereas the particle escapes from the trap without the adsorption in the absence of the electrolyte. Based on the analytical calculations of the optical trapping force and the electrostatic disjoining pressure between the particle and the oil-water interface, it is found that a critical energy barrier between them should exist. This study will provide a fundamental understanding for applications of colloidal particles as solid surfactants that can stabilize the immiscible fluid-fluid interfaces, such as emulsions (i.e., Pickering emulsions) and foams.

Effect of Hydrogen Addition on Autoignited Methane Lifted Flames (자발화된 메탄 부상화염에 대한 수소 첨가의 영향)

  • Choi, Byung-Chul;Chung, Suk-Ho
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.36 no.1
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    • pp.75-81
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    • 2012
  • Autoignited lifted flames in laminar jets with hydrogen-enriched methane fuels have been investigated experimentally in heated coflow air. The results showed that the autoignited lifted flame of the methane/hydrogen mixture, which had an initial temperature over 920 K, the threshold temperature for autoignition in methane jets, exhibited features typical of either a tribrachial edge or mild combustion depending on fuel mole fraction and the liftoff height increased with jet velocity. The liftoff height in the hydrogen-assisted autoignition regime was dependent on the square of the adiabatic ignition delay time for the addition of small amounts of hydrogen, as was the case for pure methane jets. When the initial temperature was below 920 K, where the methane fuel did not show autoignition behavior, the flame was autoignited by the addition of hydrogen, which is an ignition improver. The liftoff height demonstrated a unique feature in that it decreased nonlinearly as the jet velocity increased. The differential diffusion of hydrogen is expected to play a crucial role in the decrease in the liftoff height with increasing jet velocity.

Performance Analysis of Initial Cell Search in WCDMA System over Rayleigh Fading Channels (레일리 페이딩 채널에서 W-CDMA 시스템의 초기 셀 탐색 성능 해석)

  • Song, Moon-Kyou
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.38 no.4
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    • pp.1-10
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    • 2001
  • The 3-step cell search has been considered for fast acquisition of the scrambling code unique to a cell in the W -CDMA system. In this paper, the performance of the cell search scheme is analyzed in Rayleigh fading channels. And the system parameters for cell search scheme and the design parameters for the receivers are examined. The probabilities of detection, miss and false alarm for each step are derived in closed forms based on the statistics of CDMA noncoherent demodulator output. Through the analysis, the effect of threshold setting and post detection integration for each step is investigated, and the optimal values of the power allocation for the synchronization channels are also considered. The number of post-detection integrations for each step is a design parameter for the receiver, and the optimum values may depend on not only the power allocation for each channel related to the cell search, but the false alarm penalty time. It is shown that optimal values could be determined through the analysis. Also, the cumulative probability distribution of the average cell search time is obtained.

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Analysis of Random Variations and Variation-Robust Advanced Device Structures

  • Nam, Hyohyun;Lee, Gyo Sub;Lee, Hyunjae;Park, In Jun;Shin, Changhwan
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.14 no.1
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    • pp.8-22
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    • 2014
  • In the past few decades, CMOS logic technologies and devices have been successfully developed with the steady miniaturization of the feature size. At the sub-30-nm CMOS technology nodes, one of the main hurdles for continuously and successfully scaling down CMOS devices is the parametric failure caused by random variations such as line edge roughness (LER), random dopant fluctuation (RDF), and work-function variation (WFV). The characteristics of each random variation source and its effect on advanced device structures such as multigate and ultra-thin-body devices (vs. conventional planar bulk MOSFET) are discussed in detail. Further, suggested are suppression methods for the LER-, RDF-, and WFV-induced threshold voltage (VTH) variations in advanced CMOS logic technologies including the double-patterning and double-etching (2P2E) technique and in advanced device structures including the fully depleted silicon-on-insulator (FD-SOI) MOSFET and FinFET/tri-gate MOSFET at the sub-30-nm nodes. The segmented-channel MOSFET (SegFET) and junctionless transistor (JLT) that can suppress the random variations and the SegFET-/JLT-based static random access memory (SRAM) cell that enhance the read and write margins at a time, though generally with a trade-off between the read and the write margins, are introduced.

Small area LDO Regulator with pass transistor using body-driven technique (패스 트랜지스터에 바디 구동 기술을 적용한 저면적 LDO 레귤레이터)

  • Park, Jun-Soo;Yoo, Dae-Yeol;Song, Bo-Bae;Jung, Jun-Mo;Koo, Yong-Seo
    • Journal of IKEEE
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    • v.17 no.2
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    • pp.214-220
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    • 2013
  • Small area LDO (Low drop-out) regulator with pass transistor using body-driven technique is presented in this paper. The body-driven technique can decrease threshold voltage (Vth) and increase the current ID flowing from drain to source in current. The technique is applied to the pass transistor to reduce size of area and maintain the same performance as conventional LDO regulator. A pass transistor using the technique can reduce its size by 5.5 %. The proposed LDO regulator works under the input voltage of 2.7 V ~ 4.5 V and provides up to 150mA load current for an output voltage range of 1.2 V ~ 3.3 V.

Measurement Uncertainty of Nicotine in Environmental Tobacco Smoke (ETS)

  • Lee, Jeong-Il;Lee, Cheol Min;Shim, In-Keun;Kim, Seong-Mi;Lee, Woo-Seok;Kim, Yoon-Shin
    • Bulletin of the Korean Chemical Society
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    • v.34 no.8
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    • pp.2394-2398
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    • 2013
  • Nicotine is the main component of environmental tobacco smoke, and its presence in indoor air is widely used as a secondhand-smoke indicator. Environmental tobacco smoke is a major source of indoor air pollution, but sufficient investigation of the uncertainty of its measurement, which mirrors the reliability of nicotine measurement, has not been performed. We calculated the uncertainty of measurement of indoor air nicotine concentration at low, medium, and high concentrations of 11.3798, 10.1977, $98.3768{\mu}g/m^3$, respectively, and we employed the Guide to the Expression of Uncertainty in Measurements (GUM), proposed by the International Organization for Standardization (ISO). The factors considered in determining the uncertainty were uncertainty of the calibration curve (calibration curve and repeated measurements), desorption efficiency, extraction volume, and sampling airflow (accuracy and acceptable limits of flowmeter). The measurement uncertainty was highest at low concentrations; the expanded measurement uncertainty is $0.9435{\mu}g/m^3$ and is represented as a relative uncertainty of 63.38%. At medium and high (concentrations, the relative uncertainty was 13.1% and 9.1%, respectively. The uncertainty of the calibration curve was largest for low indoor nicotine concentrations. To increase reliability of measurement in assessing the effect of secondhand smoke, measures such as increasing the sample injection rate ($1{\mu}L$ or more), increasing sampling volume to increase collected nicotine, and using gas chromatography-mass spectrometry (GC/MS) or GC/MS/MS, which has a lower quantitation threshold, rather than gas chromatography with nitrogen phosphorous detector, should be considered.