• Title/Summary/Keyword: Three Rs alternatives

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Searching and review on the Three Rs information in Korea: time for quality assessment and continued education

  • Choe, Byung In;Lee, Gwi Hyang
    • BMB Reports
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    • v.46 no.7
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    • pp.335-337
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    • 2013
  • Scientists planning research that involves the use of animals are required by international and/or national law to examine the possibilities for the implementation of Replacement, Reduction and/or Refinement (the Three Rs principles of Russell and Burch) in experiments for research, testing, and education. There are two Korean laws legislating humane use of animals and ethical review prior to animal experiments. This report reviews current practice of the literature search by the researchers and protocol review by the Institutional Animal Care and Use Committees on the Replacement, Reduction and Refinement alternatives in Korea. The promotion and protection of the laboratory animals are one of the core competencies of investigators exploring the ethical conduct of research and good science.

Promoting and improving three Rs practice: the Korean guidelines

  • Choe, Byung In;Lee, Gwi Hyang
    • BMB Reports
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    • v.50 no.12
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    • pp.610-614
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    • 2017
  • Scientists planning research that involves the use of animals are required to examine the possibilities for replacement, reduction, or refinement (the Three Rs), and their protocol must be reviewed by the Institutional Animal Care and Use Committee. Good scientific practice involving appropriate search techniques on the available Three Rs resources is essential for both ethical and scientific reasons. Appropriate experimental design and statistical analysis techniques are particularly necessary for research involving the use of animals, because this can improve animal welfare and scientific outcomes, as well as saving animal lives. There are a number of resources to help researchers improve their search techniques, experimental design strategies, and their reporting of research involving the use of animals. However, there is little specific information or resources on the Three Rs alternatives that is readily available in the Korean language. This paper outlines the common errors made by submitting researchers that have been repeatedly observed during the ethical review of experimental protocols over the last ten years, and provides information on the Korean resources available to promote good scientific practice. This could help to bridge the gap between Korean scientists and animal welfare advocates assisting scientists to improve ethical considerations and conduct responsible research.

A Genetic Algorithm for Order Picking in Automated Storage and Retrieval Systems with Multiple Stock Locations

  • Ghamari, Yaghoub Khojasteh;Wang, Shouyang
    • Industrial Engineering and Management Systems
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    • v.4 no.2
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    • pp.136-144
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    • 2005
  • This research deals with an order picking problem in automated storage and retrieval systems (AS/RS). When retrieval requests consist of multiple items and the items are in multiple stock locations, the storage/retrieval (S/R) machine must travel to numerous storage locations to complete each order. The aim of this research is to propose algorithms for the resolution of order picking problems with multiple stock locations to minimize the total time traveled by the S/R machine. We present and compare three alternatives for solving the problem based on enumeration, ordinary heuristic and genetic algorithms. We used a set of 180 different problems that are solved by these three algorithms. The results show that our proposed genetic algorithm is more efficient than the other two.

A Comparative Study on Automated Container Terminal according to Stevedoring System (자동화 컨테이너 터미널의 하역 시스템에 따른 경제성 비교)

  • Cho, Sungwoo;Won, Seunghwan;Choi, Sanghei
    • Journal of Korea Port Economic Association
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    • v.30 no.3
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    • pp.121-140
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    • 2014
  • The purpose of this study is to identify economic benefits for analyzing the future port and propose an appropriate estimation model. This research has conducted the empirical analysis in order to examine the developed research model. First of all, several existing economic benefits are reviewed and the list of benefits, are able to quantify and characterizable, is selected for the next step. We test the application possibility of the proposed model applying for the three suggestions(AS/RS, OSS, Sky Rail) which are based on "Development of Smart Green Container Terminal Technology." The results of this paper are as follows: Firstly, all of the alternatives are proved economic validation because the values of B/C analysis are over 1.0. Secondly, sensitive analysis is attempted to test unforeseeable circumstances based on the cost increases. The result of the test is identified economic validation as well. Lastly, we convince that the proposed research model in this study is particularly applicable to future container terminal so-called "eco-friendly and fully automated container terminal with high productivity."

Development of the Regulatory Impact Analysis Framework for the Convergence Industry: Case Study on Regulatory Issues by Emerging Industry (융합산업 규제영향분석 프레임워크 개발: 신산업 분야별 규제이슈 사례 연구)

  • Song, Hye-Lim;Seo, Bong-Goon;Cho, Sung-Min
    • Journal of Intelligence and Information Systems
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    • v.27 no.3
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    • pp.199-230
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    • 2021
  • Innovative new products and services are being launched through the convergence between heterogeneous industries, and social interest and investment in convergence industries such as AI, big data-based future cars, and robots are continuously increasing. However, in the process of commercialization of convergence new products and services, there are many cases where they do not conform to the existing regulatory and legal system, which causes many difficulties in companies launching their products and services into the market. In response to these industrial changes, the current government is promoting the improvement of existing regulatory mechanisms applied to the relevant industry along with the expansion of investment in new industries. This study, in these convergence industry trends, aimed to analysis the existing regulatory system that is an obstacle to market entry of innovative new products and services in order to preemptively predict regulatory issues that will arise in emerging industries. In addition, it was intended to establish a regulatory impact analysis system to evaluate adequacy and prepare improvement measures. The flow of this study is divided into three parts. In the first part, previous studies on regulatory impact analysis and evaluation systems are investigated. This was used as basic data for the development direction of the regulatory impact framework, indicators and items. In the second regulatory impact analysis framework development part, indicators and items are developed based on the previously investigated data, and these are applied to each stage of the framework. In the last part, a case study was presented to solve the regulatory issues faced by actual companies by applying the developed regulatory impact analysis framework. The case study included the autonomous/electric vehicle industry and the Internet of Things (IoT) industry, because it is one of the emerging industries that the Korean government is most interested in recently, and is judged to be most relevant to the realization of an intelligent information society. Specifically, the regulatory impact analysis framework proposed in this study consists of a total of five steps. The first step is to identify the industrial size of the target products and services, related policies, and regulatory issues. In the second stage, regulatory issues are discovered through review of regulatory improvement items for each stage of commercialization (planning, production, commercialization). In the next step, factors related to regulatory compliance costs are derived and costs incurred for existing regulatory compliance are calculated. In the fourth stage, an alternative is prepared by gathering opinions of the relevant industry and experts in the field, and the necessity, validity, and adequacy of the alternative are reviewed. Finally, in the final stage, the adopted alternatives are formulated so that they can be applied to the legislation, and the alternatives are reviewed by legal experts. The implications of this study are summarized as follows. From a theoretical point of view, it is meaningful in that it clearly presents a series of procedures for regulatory impact analysis as a framework. Although previous studies mainly discussed the importance and necessity of regulatory impact analysis, this study presented a systematic framework in consideration of the various factors required for regulatory impact analysis suggested by prior studies. From a practical point of view, this study has significance in that it was applied to actual regulatory issues based on the regulatory impact analysis framework proposed above. The results of this study show that proposals related to regulatory issues were submitted to government departments and finally the current law was revised, suggesting that the framework proposed in this study can be an effective way to resolve regulatory issues. It is expected that the regulatory impact analysis framework proposed in this study will be a meaningful guideline for technology policy researchers and policy makers in the future.