• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6197-6208
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• 2013

Cancers will continue to be a threat to health unless they can be controlled by combinations of treatment modalities. In this review, evaluate the role of resveratrol (RSV) as a radiosensitizing agent was evaluated and underlying mechanisms holistically explored in different cancer models focusing on therapeutic possibilities. The ability of RSV to modify the effect of radiation exposure in normal and cancer cells has indeed been shown quite convincingly, the combination of RSV and IR exhibiting synergistic effects on different cancer cells. This is relevant since controlled exposure to IR is one of the most frequently applied treatments in cancer patients. However, radiotherapy (XRT) treatment regimes are very often not effective in clinical practice as observed in patients with glioma, prostate cancer (PCa), melanoma, for example, largely due to tumour radioresistant properties. Sensitization of IR-induced apoptosis by natural products such as RSV is likely to be relevant in cancer control and treatment. However, all cancers do not respond to RSV+IR in a similar manner. Therefore, for those such as the radioresistant PCa or melanoma cells, the RSV+IR regime has to be very carefully chosen in order to achieve effective and desirable outcomes with minimum toxicity to normal cells. They are reports that the highest concentration of 100 ${\mu}M$ RSV and highest dose of 5 Gy IR are sufficient to kill cells by induction of apoptosis, indicating that RSV is effective in radiosensitizing otherwise radioresistant cells. In general, it has been shown in different cancer cells that RSV+XRT effectively act by enhancing expression of anti-proliferative and pro-apoptotic molecules, and inhibiting pro-proliferative and anti-apoptotic molecules, leading to induction of apoptosis through various pathways, and cell death. If RSV+XRT can suppress the signature of cancer stemness, enhance the radiosensitivity by either targeting the mitochondrial functionality or modulating the tumour necrosis factor-mediated or Fas-FasL-mediated pathways of apoptosis in different cancers, particularly in vivo, its therapeutic use in the control of cancers holds promise in the near future.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.39 no.2
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• pp.11-18
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• 2016

Product liability (PL), which began enforcement in 2002, refers to the legal responsibility of the manufacturers or sellers (wholesales or retailers) for the property damage or bodily harm caused by their product. With a strong enforcement of the Product Liability (PL) Act, companies are required to structure and operate a response system to defend or prevent product accidents efficiently, but small and medium enterprises (SMEs) are unable to respond more aggressively due to limitation of management resources. In this manner, it is important to develop response strategies for SMEs to efficiently cope with the PL Act. In this paper, the PEST (Political, Economic, Social, and Technological) analysis is performed to reveal the impact of the PL Act on SMEs in macro-economic point of view. To formulate SME's PL response strategy, SWOT analysis is performed to categorize each factors from PEST analysis and AHP is applied to identify the intensities of SWOT factors. The prioritized SWOT factor, results of PEST-SWOT-AHP analysis, are used to formulate SME's PL response strategies. The study results are briefly summarized as follows. To reduce product defects, it is necessary for SMEs to formulate PL response strategies for each phase of the product life cycle by continuously collecting and analyzing PL cases in the same industry or for similar products. In addition, SMEs should invest more technological effort to ensure product safety. Further, SMEs should spread PL awareness to all staff members by training internal PL experts. Moreover, a SME should enroll in PL insurance and spread this information to its customers so that they become aware that the company is proactively conforming to the PL law.

• Korean journal of food and cookery science
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• v.32 no.1
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• pp.136-146
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• 2016

The purpose of this study was to investigate whether there was a gender difference in motivating university students to decrease their sodium intake and to identify effective motivating factors. Within the protection motivation theory (PMT) framework, a survey questionnaire was developed to measure participants' perceptions on the severity of and the vulnerability to risk of serious diseases due to the high sodium intake, as well as the effectiveness (response efficacy) and the ability to perform preventive measures (self-efficacy). Behavioral intentions on five specific practices (checking nutrition label, consuming more fruits and vegetables, consuming less soups, avoiding spicy and pungent food, purchasing less instant or restaurant foods) related to decreasing sodium intake were also included. A total of 294 usable response data were collected from university students (92 male, 202 female) in Busan and Gyeongnam in June 2015 and analyzed using IBM SPSS 22. Severity was the highest (4.04) PMT factor followed by response efficacy (3.72), self-efficacy (3.42), and vulnerability (3.26). Compared to male students, female students thought that the threat was more severe (t=6.035, p<0.001) and reducing sodium intake would be effective to prevent serious illnesses (t=4.724, p<0.001), but their vulnerability and self-efficacy perceptions were not different from male students. Among the five items measuring behavioral intention, female students were more likely to increase fruits and vegetables consumption (t=3.811, p<0.001), while male students were more likely to avoid spicy and pungent foods (t=2.336, p=0.020). Based on findings of this study, the recommended strategy to effectively motivate university students to lower their sodium consumption level is the development of campaign focused on increased vulnerability perception, response efficacy, and ease of practicing preventive measures instead of emphasizing the severity of the consequences.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5081-5084
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• 2015

Background: Breast cancer is a malignant tumor that starts from cells of the breast and is seen mainly in women. It's the most common cancer in women worldwide and is a major threat to health. The purpose of this study was to fit a Cox proportional hazards model for prediction and determination of years of survival in Iranian patients. Materials and Methods: A total of 366 patients with breast cancer in the Cancer Research Center were included in the study. A Cox proportional hazard model was used with variables such as tumor grade, number of removed positive lymph nodes, human epidermal growth factor receptor 2 (HER2) expression and several other variables. Kaplan-Meier curves were plotted and multi-years of survival were evaluated. Results: The mean age of patients was 48.1 years. Consumption of fatty foods (p=0.033), recurrence (p<0.001), tumor grade (p=0.046) and age (p=0.017) were significant variables. The overall 1- year, 3-year and 5-year survival rates were found to be 93%, 75% and 52%. Conclusions: Use of covariates and the Cox proportional hazard model are effective in predicting the survival of individuals and this model distinguished 4 effective factors in the survival of patients.

• The Korean Journal of Community Living Science
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• v.18 no.4
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• pp.655-670
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• 2007

The purpose of this study was to develop a brand naming strategy for rural specialty products of Muju. This study was to apply brand development research to the field. The selected investigation subject, a local farming operation producing a specialty product, was chosen from a New Enterprise Support Project of Farm Women ('06). The selected subject was a farming operation producing bokbunja drink in Muju. The data was derived from 137 female consumers. The major results of this study were as follows. First, the process of brand development strategy was advanced by six steps: Step 1, environment analysis; Step 2, brand case study; Step 3, SWOT analysis (Strength Weakness, Opportunity, Threat factor analysis); Step 4, direction design for brand naming development (Targeting, Brand focus concept extraction); Step 5, brand logo and symbol production; and Step6, Evaluation. Second, to extract brand naming development direction, key concepts in association with natural connection, area features, representative resources, and natural friendship were investigated. Namely, the health function concept was selected on the basis of a consumer recognition investigation where results appeared most highly favorable. Also, it was decided that the direction of brand naming should emphasize a green image and the location name of Muju. Finally, the brand name was decided to be "Saenggichan" bokbunja liquid and the slogan went with "guchondon-native thorn bokbunja from jar maturing."

• Proceedings of the Korean DIstribution Association Conference
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• 2001.02a
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• pp.49-63
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• 2001

Digital revolution is switching existing paradigms such as analogue to digital, off-line to on-line. Electronic commerce is the single most significant element to change the economic and social environments. After the middle of 1990's, electronic commerce have introduced two scenes; dramatic change of the existing distribution surroundings ad noticeable achievement of the economic advance and social efficiency. But, in the same scene, electronic commerce can be a threat to business condition, especially logistics management. In this study, we've done an empirical study to the experts who are in the real field; B2C and TPL(third party logistics). By the result of the study, we found five factors which means logistics bottlenecks to electronic commerce between business to consumer(B2C) as like; specialization and information, service quality and service variety, benefit-cost, reliability, and legal and policy factor.

• Journal of Environmental Science International
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• v.28 no.12
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• pp.1133-1145
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• 2019

Successful launch requires state-of-the-art launch vehicle technology and constant test operations, However, the meteorological threat to the launch vehicle flight trajectory is also an important factor for launch success. Atmospheric stability above the Naro Space Center at the this time is very important, especially because the initial flight operation can determine the success of the launch. Moreover, during the flight of launch vehicle with rapid pressure and thrust into the atmosphere, convection activity in the atmosphere may create environmental conditions that cause severe weather threats such as thunderstorms. Hence, studies of atmospheric instability characteristics over the Naro Space Center are a necessary part of successful launch missions. Therefore, the main aims of this study were to (1) verify the atmospheric stability index and convection activity characteristics over the Naro Space Center using radiosonde data observed from 2007 to 2018 by the Naro Space Center, (2) analyze changes in the atmospheric stability index according to monthly and seasonal changes, and (3) assess how the calculated atmospheric stability index is related to actual thunderstorm occurrence using statistical analysis. Additionally, we aimed to investigate the atmospheric characteristics above the Naro Space Center through the distribution chart of the atmospheric stability index during summer, when convection activity is highest. Finally, we assessed the relationship between lightning occurrence and unstable atmospheric conditions, through predictability analysis performed using the lightning observation data of the Korea Meteorological Administration.

• The Plant Pathology Journal
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• v.36 no.1
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• pp.76-86
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• 2020

Cucumber mosaic virus (CMV) is damaging to the growth and quality of lettuce crops in Lanzhou, China. Recently, however, for the first time an isolate of lettuce necrotic yellows virus (LNYV) has been detected in lettuce crops in China, and there is concern that this virus may also pose a threat to lettuce production in China. Consequently, there is a need to develop a rapid and efficient detection method to accurately identify LNYV and CMV infections and help limit their spread. Reverse transcription loop-mediated isothermal amplification (RT-LAMP) assays were developed to detect the nucleoprotein (N) and coat protein (CP) genes of LNYV and CMV, respectively. RT-LAMP amplification products were visually assessed in reaction tubes separately using green fluorescence and gel electrophoresis. The assays successfully detected both viruses in infected plants without cross reactivity recorded from either CMV or LNYV or four other related plant viruses. Optimum LAMP reactions were conducted in betaine-free media with 6 mM Mg²⁺ at 65℃ for LNYV and 60℃ for 60 min for CMV, respectively. The detection limit was 3.5 pg/ml and 20 fg/ml using RT-LAMP for LNYV and CMV plasmids, respectively. Detection sensitivity for both RT-LAMP assays was greater by a factor of 100 compared to the conventional reverse transcription polymerase chain reaction assays. This rapid, specific, and sensitive technique should be more widely applied due to its low cost and minimal equipment requirements.

• Journal of Communications and Networks
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• v.12 no.1
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• pp.52-66
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• 2010

Since large objects consume substantial resources, web proxy caching incurs a fundamental trade-off between performance (i.e., hit-ratio and latency) and overhead (i.e., resource usage), in terms of caching and relaying large objects to users. This paper investigates how and to what extent the current dedicated-server based web proxy caching scheme is affected by large file transfers in a high bandwidth campus network environment. We use a series of trace-based performance analyses and profiling of various resource components in our experimental squid proxy cache server. Large file transfers often overwhelm our cache server. This causes a bottleneck in a web network, by saturating the network bandwidth of the cache server. Due to the requests for large objects, response times required for delivery of concurrently requested small objects increase, by a factor as high as a few million, in the worst cases. We argue that this cache bandwidth bottleneck problem is due to the fundamental limitations of the current centralized web proxy caching model that scales poorly when there are a limited amount of dedicated resources. This is a serious threat to the viability of the current web proxy caching model, particularly in a high bandwidth access network, since it leads to sporadic disconnections of the downstream access network from the global web network. We propose a peer-to-peer cooperative web caching scheme to address the cache bandwidth bottleneck problem. We show that it performs the task of caching and delivery of large objects in an efficient and cost-effective manner, without generating significant overheads for participating peers.

• Management & Information Systems Review
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• v.10
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• pp.1-31
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• 2002

As the modern society is called the narcissistic society, the narcissism is widespread in the personality of individuals and the society at large. In consideration of this side, this study explored for several characteristics of the narcissistic personality and the job stress, and explored for the relationships between the two things theoretically. The narcissism is an attempt to repair self-esteem weakened by the splitting anxiety, the lack and the pathological fusion of self-structure. The job stress is a factor that a characteristic of the job influenced on the behavioral and affective response of the person on the job directly or indirectly. This study selected organizational justices, organizational constraints, role conflict, role ambiguity, role overload, organizational climate, interpersonal relations and career development as factors of the job stress. This study viewed that the stress is made from an interaction between environmental stimulus and personal particular reaction by defining the stress as an interaction model of stimulus-response and personal reaction is caused by psychological adjustment process, personal differences. On this occasion, this study discussed that the narcissistic personality is easy to get stress and weak in the job stress with regarding the personality as a mediation variation of psychological process. As a result, the narcissists estimated themselves positively and their self-esteem is high, but they excessively showed a self biased cognitive and affective response about the negative feedback to protect themselves. Moreover, this positive estimate on themselves and high self-esteem was vulnerable and weak in the self threat. In this view, the narcissistic personality is easy to get more job stress such as organizational justices, organizational constraints, role conflict, role ambiguity, role overload, organizational climate, interpersonal relations and career development.