• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.32 no.3
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• pp.85-92
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• 2021

Attention-deficit/hyperactivity disorder (ADHD) leads to functional decline in academic performance, interpersonal relationships, and development in school-aged children. Early diagnosis and appropriate intervention can significantly reduce the functional decline caused by ADHD. Currently, there is no established biological marker for ADHD. Some studies have suggested that various indicators from the quantitative electroencephalogram (QEEG) may be useful biological markers for the diagnosis of ADHD. Until the 2010s, theta/beta ratio (TBR) was a biomarker candidate for ADHD that consistently showed high diagnostic value. However, limitations of TBR have recently been reported. Studies have demonstrated that phase-amplitude coupling, especially theta phase-gamma amplitude coupling, are related to cognitive dysfunction and may assist in the diagnosis of ADHD. As yet, the underlying mechanism is not clearly established, and the clinical efficacy of these biomarkers needs to be proven through well-controlled studies. Based on the heterogeneous characteristics of ADHD, subgrouping through QEEG plays a key role in diagnosis and treatment planning. Sophisticated, well-designed studies and meta-analyses are necessary to confirm these findings.

• Journal of Biomedical Engineering Research
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• v.40 no.1
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• pp.15-19
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• 2019

In this study, Theta Gamma Coupling (TGC) analysis was carried out after performing simple and repeated upper limb exercise and comparative experiment to observe changes in the motor cortex of the brain through TGC and to see if mobile rehabilitation therapy is actually effective. As a result, exercise using mobile devices showed higher TGC values in motor cortex as compared with simple repeat upper limb exercise. In addition, paired t-test using SPSS showed statistically significant difference between exercise using mobile devices and simple repeat exercise at P3(t=3.390, df(degree of freedom)=12, p value=0.005). Exercise using mobile devices is effective for rehabilitation because it increases the Theta-Gamma Coupling and activates the motor cortex. Also, since the mobile game contents required the subject to detailed athletic ability adjustment with immersion in the task, it may be thought that brain activation is stronger than simple rehabilitation.