• 대한본초학회지
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• 제31권6호
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• pp.63-71
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• 2016

Objective : To suggest a scientific evidence of Aconitum carmichaeli Debx. (Aconiti Lateralis Radix Preparata: ALRP) as one of cooling and heating medicines on the regulation of body temperature, we investigated the effects of ALRP water extract on hypothyroidism. Methods : Hypothyroidism was induced by intradermal injection with PTU for 4 weeks in SD rats. ALRP extract or L-thyroxine as a control drug was orally administrated for 2 weeks with PTU injection in rats. The physiological and serological parameters were measured in rats. The histological change of thyroid tissues was observed by H&E staining, and also the expression of thermo-regulating proteins was determined by Western blot in dorsal root ganglia and brain tissues of rats. Results : The administration of ALRP extract in PTU-induced hypothyroidism rats was significantly increased body temperature, but did not changes on body weight, food and water intake. ALRP extract did not effect on the levels of TSH and T4 in the hypothyroidism rats. ALRP extract significantly decreased the levels of GPT, glucose, HDL-cholesterol, LDL-cholesterol, and total cholesterol in the hypothyroidism rats. In histological observation, the enlarged epithelium and atrophic follicles with higher concentration of follicular cells on hypothyroidism were improved by ALRP extract. In addition, ALRP extract increased the expression of TRPV1 and TRPM8 ion channel proteins in hypothyroidism rats. Conclusion : These results indicate that ALRP extract can improve PTU-induced hypothyroidism through regulation of body temperature and lipid accumulation. The action mechanism of ALRP extract is related with body temperature control by thermoregulation with TRP ion channels.

• 한국염색가공학회:학술대회논문집
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• 한국염색가공학회 2008년도 제39차 학술발표회
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• pp.135-136
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• 2008

EU-Reach Regulation 대비 유해물질 대체약품 개발 프로그램인 SVHC(Substance of very high concern)로부터 환경친화적인 방염제의 스크리닝으로 LOI 30이상의 Halogen-free 유기계 Organo-Phosphonate 화합물들이 유력한 후보로 선별되었으며 여기에 반응형 저에너지 타입 아(메타)크릴계 광기능성기를 도입하여 에너지 절감형이면서 친환경적인 가공약제를 개발 하였다. 먼저 열경화형 타입중에서도 면섬유에 취급이 용이한 DMP(dimethylphosphite)를 출발물질로한 N-Methylol type의 열경화형 인/질소 타입 알코올 함유 면섬유용 방염제를 제조한후 -OH기에 광반응형 아크릴 기능성기를 도입하여 개시제와 함께 광경화 방염가공 후 물성에 관한 특성를 관찰 하였다.

• 한국화재소방학회논문지
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• 제24권1호
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• pp.15-23
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• 2010

현재의 화재안전기준에서 규정하는 화재감지기의 배치방법은 면적에 따라 규정된 숫자를 적정하게 배치하는 수준이다. 이 기준은 과학적인 근거는 가지고 있지 못하다. 외국의 기준을 도입하여 그에 따라서 설치하고 있을 뿐이다. 소방시설을 설계하는 방법에는 화재안전기준과 같이 명문화 된 규정에 따르는 규범위주설계(Prescriptive-based)와 화재역학, 구조역학, 재료역학, 유체역학, 열역학 등 공학적 지식을 바탕으로 하는 성능위주설계(Performance-based design)가 있다. 현재로서는 성능위주설계가 활성화 되지 않았지만, 최근 소방시설공사업법은 성능위주설계방법을 이용하여 소방시설을 설계 할 수 있도록 개정('05. 8. 4)되었으며 그 시행령('07, 1. 24)에서 성능위주설계를 적용할 특정소방대상물의 범위를 정하고 있다. 이러한 시점에서 자동화재탐지설비의 화재감지기를 최적의 위치 및 거리에 설치하기 위하여 그에 대한 공식의 도입과 공식을 Software로 계산할 수 있도록 시뮬레이터를 제작하여 계산하고 규범위주설계에 따라 배치한 화재감지기의 상태와 비교 분석하며 향후 성능위주설계 방법으로서 정착시키기 위하여 연구를 시도하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권3호
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• pp.975-978
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• 2012

P63 is a gene product required in cell cycle regulation which plays vital roles in tumor differentiation. Aims of the present study were to assess the frequency, pattern, sensitivity and specificity of two p63 protein clones P63 4A4 and P63 4A4+Y4A3 in squamous cell carcinomas (SCCs). Thirty cases of head and neck region SCC diagnosed on the basis of H&E staining were examined along with 60 cases of head and neck region biopsies other than squamous cell carcinoma, negative on H&E staining, were taken as control. Immunostaining was performed on slides according to the Thermo Scientific UltraVision LP detection System. P63 4A4+Y4A3 clone is more sensitive 96.6% in comparison to 86% in P63 4A4 with having greater NPV of 98.3%. The results signify the importance of P63 4A4+Y4A3 marker over the old markers and may be used as a confirmatory marker of squamous cell carcinoma.

• 한국전산구조공학회논문집
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• 제21권1호
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• pp.35-42
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• 2008

원자력발전소에서는 열교환 파이프에서 발생하는 열피로 균열을 비파괴 탐상장비를 이용하여 조기에 발견하는 것이 안전을 위해 매우 필요하며, 따라서 이를 모사한 인공균열시편 제작에 많은 노력을 기울이고 있다. 그러나 이러한 균열은 일반 기계가공으로 제작하는 것이 불가능하여 실제 조건과 유사한 열 반복하중 하에서 제작될 수밖에 없는데, 이를 위해 많은 시간이 소요된다. 본 연구에서는 크랙성장 시뮬레이션 기법을 이용하여 이러한 균열 제작시간을 단축하기 위한 최적의 열하중 조건을 찾고자 하였다. 이를 위해 임의조건에서 시뮬레이션 및 열피로균열 발생 기초실험을 수행하여 균열 초기수명과 진전수명을 검증하였고, 이를 바탕으로 다양한 가열 및 냉각시간을 시뮬레이션 함으로써 제작시간을 최소화하는 열하중 조건을 구하였다. 시뮬레이션에서는 응력해석을 위해 상용 소프트웨어 ANSYS를 초기균열수명 계산을 위해 수치계산용 소프트웨어 ZENCRACK을 이용하여 코딩을 균열진전수명 평가를 위해 ZENCRACK 소프트웨어를 이용하였다. 그 결과 1mm 균열 제작에 소요되는 시간은 초기의 418시간에서 319시간으로 24% 단축되는 것으로 예측되었다.

• 한국의류학회지
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• 제36권3호
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• pp.259-268
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• 2012

This study suggests quantitative guidelines for inside clothing temperatures to improve the heat tolerance of 20's females in summer. First, the inside clothing temperatures ($T_{cl}$) of each subject was measured in daily use. The subjects were asked to record subjective thermal sensations, clothing items worn, clothing weight, and activities during an experiment designed to determine the comfort zone of $T_{cl}$. In a thermally neutral state, the comfort zone of $T_{cl}$ was decided on a mean value $T_{cl}{\pm}1{\sigma}$. Second, the subjects were asked to wear clothing that would enable them to feel 'slightly warm but still comfortable'. The rest of the processes were the same as previous steps that were designed to understand the way and degree of clothing control. The comfort zone of $T_{cl}$ was decided in the same manner as the previous step. The two comfort zones were combined and named the combined comfort zone of the definitive comfort zone. The results were as follows: 1. Thermally comfortable $T_{cl}$, Hcl were $34.0{\pm}1.1^{\circ}C$, $40{\pm}9%%RH$ and the thermally comfortable ambient climate was $25.0{\pm}1.6^{\circ}C$, $53{\pm}7%$RH. 2. When subjects were asked to wear 'slightly warm but still comfortable', there were difference in thermally comfortable $T_{cl}$, clothing weight and clothing layer by subject. 3. In this study, the optimal $T_{cl}$ was decided on the mid-point of the definitive comfort zone of $T_{cl}$.

• Tribology and Lubricants
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• 제32권1호
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• pp.1-8
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• 2016

This paper focuses on the thermal deformation induced preload change in the tilting pad journal bearing, using a three-dimensional (3D) thermo-hydro-dynamic (THD) approach. Preload is considered as a critical factor in designing the tilting pad journal bearing. The initial preload measured under nil external load and nil thermal gradient is influenced by two factors, namely, the thermal deformation and elastic deformation. Thermal deformation is due to a temperature distribution in the bearing pads, whereas the elastic deformation is due to fluid forces acting on the pads. This study focuses on the changes induced in preload and film clearance due to thermal deformation. The generalized Reynolds equation is used to evaluate the force of the fluid and the 3D energy equation is used to calculate the temperature of the lubricant. The abovementioned equations are combined by establishing a relationship between viscosity and temperature. The heat transfer within the bearing pads, the lubricant, and the spinning journal is calculated using the heat flux boundary condition. The 3D Finite Element Method (FEM) is used in modeling the (1) heat conduction in the spinning journal and bearing pads, (2) thermal gradient induced thermal distortion of the spinning journal and pads, and (3) viscous shearing, and heat conduction and convection in a thin film. This evaluation method has an increased fidelity, and it can prove to be a cost-effective tool that can be used by designers to predict the dynamic behavior of a bearing.

• 대한한방종양학회지
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• 제4권1호
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• pp.1-16
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• 1998

In order to investigate the effect of Bujaleejungtang, by means of oral medication to rats and mice, to isolated intestine and stomach, and the effect to pyloric ulcer, indomethacin-induced ulcer, secretion of gastric juice, and to transport ability of intestine content were studied as the action to G-I tract. The effect to normal rats and resperpine-treated rats were studied as the action to thermo-regulation. The results were as follows: 1. Bujaleejungtang showed the inhibitory effect on the smooth muscle contraction induced by acethylcholine chloride and barium chloride in the isolated mice ileum. 2. Bujaleejungtang showed inhibitory effect on the contraction induced by acetylcholine chloride and barium chloride in the rat fundus-strip. 3. Inhibitory effect of Bujaleejungtang on pyloric ulcer, indomethacin-induced gastric ulcer in rats was statistical recognized(p<0.05). 4. No inhibitory effect of Bujaleejungtang on gastric juice secretion in Shay rats was recognized. 5. Inhibitory effect of Bujaleejungtang on gastric free acidity and total acidity in Shay rats was recognized only when Bujaleejungtang was medicated in high thickness(2000mg/kg) (p<0.001). 6. Inhibitory effect of Bujaleejungtang on pepsin output in Shay rats was recognized only when Bujaleejungtang was medicated in high thickness(2000mg/kg)(p<0.001). 7. Inhibitory effect of Bujaleejungtang on barium sulfate transport in the small intestine of mice was recognized only when Bujaleejungtang was medicated in high thickness(2000mg/kg)(p<0.05). 8. Inhibitory effect of Bujaleejungtang on barium sulfate transport in the large intestine of mice was recognized(p<0.05). 9. Inhibitory effect of Bujaleejungtang on rectal temperature in normal rats was recognized. 10. Inhibitory effect of Bujaleejungtang on rectal temperature in reserpine-treated rats was recognized only when Bujaleejungtang was medicated in high thickness(2000mg/kg)(p<0.05).

• Asian-Australasian Journal of Animal Sciences
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• 제12권6호
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• pp.886-890
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• 1999

From previous studies, there is a strong possibility in buffaloes that the marked increase in blood volume (BV) under hot conditions contributes to heat transportation from the rectum to the skin. The present study was done to clarify changes with environmental temperature on water-shift between blood and extracellular fluid (ECF), heat distribution between the rectum and the skin, and blood flow rates (BFR) at the hind legs (reflecting the skin surface). Four buffaloes and four Friesian cows were successively exposed to three different temperatures of $20^{\circ}C$, $30^{\circ}C$ and $35^{\circ}C$. BV and ECF volume were measured with Evans' blue and sodium-thiocyanate dilution methods, respectively. Rectal and subcutaneous (as the skin) temperatures were measured by copper-constantan thermocouples. BFR were measured by a supersonic blood flow meter. With an increase in environmental temperature, skin temperature in buffaloes increased significantly than cows, but rectal temperature was not significantly different between two species. BV, especially plasma compartment, increased significantly in only buffaloes, while ECF volume did not change in both species. BFR increased significantly in buffaloes, but not in cows. From these results, the increased of BV may be caused by water flowing from ECF compartment. The water-shift may induce the increase of BFR and skin temperature. It is suggested in the present study that internal changes of blood compartment in buffaloes contribute to transfer of heat to the skin surface.