• Parasites, Hosts and Diseases
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• 제27권4호
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• pp.249-252
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• 1989

Fibricola cratera is a strigeoid trematode indigenous to North America that, heretofore, was known only to infect wild mammals. Herein, it is reported that an experimental inoculation of a human volunteer produced a patellt infection that lasted 40 months. Symptoms of epigastric discomfort, loose stools and flatulence occurred over the first year of infection and ameliorated thereafter. Eggs per gram of stool were low (${\leq}2$) throughout the course of infection and were not detected by the standard technique of formalin-ether concentration. To monitor infection, the entire stool sample was examined each month after sieving through No. 10 (pore size 2 mm) and 100 (pore size $145{\;}{\mu\textrm{m}}$) sieves and collecting eggs on a No. 325 (pore size $45{\;}{\mu\textrm{m}}$) sieve. This is the first report of a North American strigeoid trematode capable of maturing in a human and is only the second species of strigeoid known to do so. The other species is F. seoulensis which has been implicated in 26 human infections in Korea.

• Journal of Pharmaceutical Investigation
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• 제40권spc호
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• pp.103-112
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• 2010

Pellets, which are multiple-unit dosage systems, have the several therapeutic advantages over single-unit dosage systems in oral drug delivery. This review focuses on the current status and explores extrusion-spheronization technique with special attention to controlled-release application of pellets including coated pellets for delayed release formulations, coated pellets for colon delivery, coated pellets for sustained drug delivery, sustained-release matrix pellets, pellets compressed into tablets, bioadhesive pellets, floating pellets, and pelletization with solubilization techniques.

• The Korean Journal of Pain
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• 제12권2호
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• pp.235-237
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• 1999

Meniere's disease is a disorder of the membranous labyrinth that is characterized by vertigo, hearing loss, tinnitus and ear fullness. The etiology of Meniere's disease is yet to be described and the management is also very difficult. Fifty-one years old female patient had paroxysm of severe tinnitus and dizziness after medical therapy and surgical intervention during several years. Patient received stellate ganglion block (SGB) and her symptoms were completely relieved. Therefore, SGB could be considered another therapeutic modality for Meniere's disease.

• 기술사
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• 제36권6호
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• pp.78-81
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• 2003

Physiologically functional food is a type of the processed foods showing bioactivities in a living body. Physiologically functional food is a healthy food reinforcing biofunctional abilities of the precaution and recovering of the illness, immunity reinforcement. bio - rhythm control, aging repression and cancer precaution, etc. The consumers are taking to expect the improvement of national health and extention of life span. etc., Physiologically functional food must be able to be ingested briefly and taken in the surroundings easily and the reasonable price. To achieve this goals, it is necessary to positive support of the authorities concerned, technique development of an educational - Industrial cooperation. establishment of reasonable standard and right understanding of the consumers on physiologically functinal food.

• Journal of Korean Neurosurgical Society
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• 제45권2호
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• pp.122-126
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• 2009

Single-balloon kyphoplasty via an extrapedicular approach has been reported to be effective because it requires less time than conventional two-balloon kyphoplasty and has comparable therapeutic efficacy. However, single-balloon kyphoplasty is not popular because the extrapedicular approach is believed to be complicated and unsuitable for the thoracolumbar and lumbar spine. The authors describe a standardized surgical technique that utilizes a far-lateral extrapedicular approach for single-balloon kyphoplasty, which can be performed in any part of the spine by physicians without substantial difficulty.

• 한국의학물리학회지:의학물리
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• 제6권1호
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• pp.19-37
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• 1995

레이저를 의료에 응용하는데 있어서 그 근본원리는 일반적인 레이저 응용기술과 차이가 없다고 할 수 있으나 응용대상이 인체라는 점에서 특수한 연구분야라 할 수 있다. 레이저를 의료에 응용하는 경우 종래의 의료기술과는 근본원리에 있어서 다른 경우가 보통이므로 새로운 의학기술로서의 연구개발이 수행되어야 할 것이다. 본 논문은 레이저 기초물리학을 비롯하여 레이저광과 생체조직의 상호작용, 치료 및 진단기술, 의료용 레이저와 광파이버 기술, 레이저 안전등에 관해 기술하고 있으며 레이저의 의학에의 전망에 대해 논의하고 있다.

• 대한후두음성언어의학회지
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• 제29권1호
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• pp.19-23
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• 2018

Ultrasonography has increasingly moved from being a modality confined to the radiology department to an active diagnostic and therapeutic aid available to the head and neck at the point of patient care. However, the application of ultrasonography to the laryngeal disorder is very rare due to progressive age-related ossification of laryngeal cartilage and the presence of air in the lumen, which contribute to difficult conditions for transmission of the ultrasonic waves. The observation about the movements of larynx or surrounding structures is important to understand the physiology of phonation or swallowing and to diagnose the disease. Ultrasonography is a noninvasive and safe imaging technique that can be used to investigate the anatomic structures of the head and neck. Recently, the development of high-frequency ultrasonography makes it possible to apply the ultrasound in the evaluation of larynx.

• Clinical and Experimental Reproductive Medicine
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• 제10권1호
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• pp.1-6
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• 1983

Women were used as their own controls in the comparison of presterilization and poststerilization menstrual patterns. Five parameters were studied: regularity of cycle length, duration and amount of flow and incidence of dysmenorrhea and intermenstrual bleeding. Three parameters in the electrocoagulation group (regularity of cycle length and duration and amount of flow) and one parameter in the tubal ring group (duration of flow) showed significant changes after sterilization. However, by controlling for the effect of previous contraceptive methods used, no significant menstrual pattern changes following sterilization were discerned in either technique group.

• Bulletin of the Korean Chemical Society
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• 제32권7호
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• pp.2274-2278
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• 2011

Verapamil is a calcium channel blocker and is classified as a class IV anti-arrhythmic agent. It is used in the control of supra ventricular tachyarrhythmias, and in the management of classical and variant angina pectoris. It is also used in the treatment of hypertension and used as an important therapeutic agent for angina pectoris, ischemic heart disease, hypertension and hypertrophic cardiomyopathy. Verapamil commonly co-administered with NSAIDs (non-steroidal anti-inflammatory drugs) i.e. diclofenac sodium, flurbiprofen, Ibuprofen, mefanamic acid and meloxicam. A simple and rapid RP-HPLC method for simultaneous determination and quantification of verapamil and NSAIDs was developed and validated. The mobile phase constituted of acetonitrile: water (55:45) whose pH was adjusted at 2.7 and pumped at a flow rate of 2.0 mL $min^{-1}$ at 230 nm. The proposed method is simple, precise, accurate, low cost and least time consuming for the simultaneous determination of verapamil and NSAIDs which can be effectively applied for the analysis of human serum.

• Reproductive and Developmental Biology
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• 제35권4호
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• pp.503-510
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• 2011

Cellular uptake of nanoparticles for stem cell labeling and tracking is a critical technique for biomedical therapeutic applications. However, current techniques suffer from low intracellular labeling efficiency and cytotoxic effects, which has led to great interest in the development of a new labeling strategy. Using silica-coated nanoparticles conjugated with rhodamine B isothiocyanate (RITC) (SR), we tested the cellular uptake efficiency, biocompatibility, proliferation or differentiation ability with murine bone marrow derived hematopoietic stem/progenitor cells. The bone marrow hematopoietic cells showed efficient uptake with SR with dose or time dependent manner and also provided a higher uptake on hematopoietic stem/progenitor cells. Biocompatibility tests revealed that the SR had no deleterious effects on cell cytotoxicity, proliferation, or multi-differentiation capacities in vitro and in vivo. SR nanoparticles are advantageous over traditional labeling techniques as they possess a high level of cellular internalization without limiting the biofunctionality of the cells. Therefore, SR provides a useful alternative for gene or drug delivery into hematopoietic stem/progenitor cells for basic research and clinical applications.