• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제4권1호
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• pp.142-163
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• 1993

정서적인 문제로 갑자기 산만하고 공격적인 문제를 보였던 8세된 국민학교 남아의 놀이치료 내용과 이에 대한 집단 지도 ${\cdot} 감독(supervision)을 자세히 기술함으로써 놀이치료 초심자가 초기 놀이치료에서 경험할 수 있는 여러 가지 문제점과 과제에 대해 살펴보았다. 놀이치료 초기에 초심치료자가 흔히 범하는 잘못은 치료자 자신의 불안이나 성격적 특성 때문에 놀이를 환아가 선택하는 방향으로 보다는 자신에게 의미있는 내용으로 이끌려하고, 너무 적극적이거나 무반응, 과잉간섭, 과잉 및 부적절한 해석, 현실과의 직접적 인계시도이다. 놀이치료 초기의 가장 중요한 과제는 치료자가 환아의 긍정적이고 신뢰할 수 있는 관계를 형성하는 것임으로 그리기 위해서는 환아를 있는 그대로 수용하며, 환아가 이끄는 방향으로 놀이가 일어날 수 있도록 허용하며, 치료자와의 관계를 통해 수정된 발달경험을 함으로써 문제와 갈등이 해결될 수 있다는 확신을 전해주어야 한다. 치료자는 놀이치료의 초기에는 모든 노력을 관계형성을 이루는데 촛점을 맞추어야 한다.

• 한국보육지원학회지
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• 제14권6호
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• pp.35-51
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• 2018

Objective: The purpose of this study was to examine the effect of early childhood teacher-led child-centered group play therapy on young children's sociability. The changes of sociability in the therapeutic process were also examined. Methods: The subjects of this study were 12 young children who were five years old and attended a child care center in Gangwon-do. Subjects were divided into an experimental group and a control group. The experimental group received 15 early childhood teacher-led child-centered group play therapy sessions twice a week. The sociability scale was used for pre-post tests and the data were analyzed using SPSS 23.0. Every session was video-taped and recorded verbatim. Qualitative data were analyzed to examine changes in sociability. Results: Children who participated in the early childhood teacher-led child-centered group play therapy demonstrated significant improvement in sociability. During the therapy sessions, children's expressions and behaviors associated with sociability gradually increased. Conclusion/Implications: This study supports the use of early childhood teacher-led child-centered group play therapy as an effective intervention strategy for young children to improve their sociability.

• Archives of Pharmacal Research
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• 제21권1호
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• pp.1-5
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• 1998

Rebamipide, 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinone-4-yl]-propionic acid, a novel antipeptic ulcer agent, has been reported to prevent various acute experimental gastric mucosal lesions and to accelerate the healing of chronic ulcers. Therapeutic effect of rebamipide was investigated with regard to the inhibitory effect on xanthine oxidase activity and type conversion of the enzyme which play a profound role in oxygen radicals generation system. Intraperitoneal administration of rebamipide at 60 mg/kg body weight reduced the xanthine oxidase activity, lipid peroxide content in ammonia induced hemorrhagic lesion. These results suggest that the therapeutic effect of rebamipide on gastric mucosal lesion may be in part due to the inhibitory activity of xanthine oxidase and type conversion rate of the enzyme.

• BMB Reports
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• 제44권6호
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• pp.359-368
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• 2011

Polycystic kidney disease (PKD) is a common genetic disorder in which extensive epithelial-lined cysts develop in the kidneys. In previous studies, abnormalities of polycystin protein and its interacting proteins, as well as primary cilia, have been suggested to play critical roles in the development of renal cysts. However, although several therapeutic targets for PKD have been suggested, no early diagnosis or effective treatments are currently available. Current developments are active for treatment of PKD including inhibitors or antagonists of PPAR-${\gamma}$, TNF-${\alpha}$, CDK and VEGF. These drugs are potential therapeutic targets in PKD, and need to be determined about pathological functions in human PKD. It has recently been reported that the alteration of epigenetic regulation, as well as gene mutations, may affect the pathogenesis of PKD. In this review, we will discuss recent approaches to PKD therapy. It provides important information regarding potential targets for PKD.

• 한국놀이치료학회지
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• 제21권4호
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• pp.449-471
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• 2018

본 연구는 도구적 사례연구로 만 4세 여아의 놀이치료 과정에 나타난 놀이를 분석하였다. 내담 아동은 어린이집에서 집단 활동에 참여하는 것을 어려워하고 낯선 사람이 말을 걸면 울어버리는 것을 주 호소로 하여 놀이치료에 의뢰되었다. 치료적 개입으로 아동에 대한 개별 놀이치료와 회기 후 10분 모(母) 상담이 제공되었고, 모 상담은 촉진적인 양육 기술과 양육 환경을 조성하는 방향으로 진행되었다. 또한 매주 담임 교사가 아동의 어린이집 생활 모습을 관찰하고 매주 관찰척도를 작성하였다. 총 12회기(주 2회, 6주)가 실시되었으며 종료 후 한 달이 지난 시점에 추수 회기가 진행되었다. 이에 따라 유아의 놀이치료 과정에 나타난 매 회기 치료 장면을 제시하고 Erikson의 발달 이론에 기초하여 놀이를 분석하였다. 이를 통하여 유아의 놀이치료 과정을 이해하고자 할 때 기초 자료를 제공하였다는데 의의가 있다.

• 한국의사학회지
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• 제25권1호
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• pp.71-79
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• 2012

Present Saam acupuncture can be divided into two types of Therapeutic part that is composed of physiology, pathology, classification of the symptoms, treatment and Experiential part that is composed of clinical case. Therapeutic part is authored by Saam and experiential part is authored by Ji-san. Experiential part is based on therapeutic part, but it has been changed. So, Measuring "chapter10. Saam acupuncture(apply to therapeutic part)" against "chapter11. Clinical case of Ji-san(apply to experiential part)", Author get to know that experiential part of Saam acupuncture has been changed. "chapter10. Saam acupuncture(apply to therapeutic part)" and "chapter11. Clinical case of Ji-san(apply to experiential part)" belong to "TaeHanUiHakJeonJip Acupuncture part" that is similar to manuscript of Saam acupuncture. The following is changed situation of Saam acupuncture. First, While the theory of Jeong form is already established in therapeutic part, the theory of Seung form is established in experiential part. So, In experiential part, they are equal in their relations. Second, In experiential part, the term that is named 'prescription of ${\bigcirc}{\bigcirc}$' has been used since experiential part. Third, Some of spots on the body suitable for acupuncture mentioned in therapeutic part are omitted in experiential part. And to conclude, experiential part play a large role in the establishment and change of early Saam acupuncture.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3997-4000
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• 2012

MicroRNAs (miRNAs) play roles in the clinic, both as diagnostic and therapeutic tools. The identification of relevant microRNAs is critically required for ovarian cancer because of the prevalence of late diagnosis and poor treatment options currently. To identify miRNAs involved in the development or progression of ovarian cancer, we analyzed gene expression profiles downloaded from Gene Expression Omnibus. Comparison of expression patterns between carcinomas and the corresponding normal ovarian tissues enabled us to identify 508 genes that were commonly up-regulated and 1331 genes that were down-regulated in the cancer specimens. Function annotation of these genes showed that most of the up-regulated genes were related to cell cycling, and most of the down-regulated genes were associated with the immune response. When these differentially expressed genes were mapped to MiRTarBase, we obtained a total of 18 key miRNAs which may play important regulatory roles in ovarian cancer. Investigation of these genes and microRNAs should help to disclose the molecular mechanisms of ovarian carcinogenesis and facilitate development of new approaches to therapeutic intervention.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제3권1호
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• pp.138-146
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• 1992

선택적 함구증을 보인 6세 아동의 놀이치료 과정을 통해 나타난 정신역동 및 치료과정을 발달학적 관점에서 소개하였다. 비지시적 지지적 놀이치료를 실시하였고 치료자와의 관계속에서 환아는 놀이를 통하여 단계적으로 발달과정을 재경험하여 분리 불안 및 유기공포를 극복하고 자율성을 회복하므로써 증상의 소실과 함께 정상적 외디푸스시기의 발달을 이루게 되었다.

• Journal of Plant Biotechnology
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• 제37권3호
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• pp.262-268
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• 2010

Antibodies are powerful and versatile tools to play a critical role in the diagnosis and treatment of many diseases. Their application has been enhanced significantly with the advanced recombinant DNA and heterologonous expression technologies, allowing to produce immunotherapeutic proteins with improved biofunctional properties. However, with currently available technologies, mammalian cell-based therapeutic antibody production, as an alternative for production in humans and animals, is often not plentiful for passive immunotherapeutics in treatment of many diseases. Recently, plant expression systems for therapeutic antibodies have become well-established. Thus, plants have been considered to provide an attractive alternative production system for therapeutic antibodies, as plants have several advantages such as the lack of human pathogens, and low cost of upstream production and flexible scale-up of highly valuable recombinant glycoproteins. Recent advances in modification of posttranslational processing for human-like glycosylation in transgenic plants will make it possible that plant can become a suitable protein expression system over the animal cellbased current production system. This review will discuss recent advances in plant expression technology and issues for their application to therapeutic antibody production.

• 대한건축학회논문집:계획계
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• 제35권9호
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• pp.65-75
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• 2019

This study aims at analyzing the therapeutic design characteristics implemented in the indoor atriums of the outpatient areas in four children's hospitals in London and San Francisco. A mixed-method approach was used to examine the spatial configurations and design elements in the atriums, while a literature review was conducted to understand the therapeutic design characteristics relevant to atrium spaces and children's healthcare facilities. The spatial design and the pattern of use of the atrium in each hospital were studied during field visits and interviews with the hospital management staff. Based on the literature review and the observations from the field study, a Visibility Graphic Analysis was chosen to examine the visibility, accessibility, and intelligibility of the spatial configurations in the atriums of each hospital. In addition, the openness, restfulness, and vibrant ambience of the design elements in the atriums of each hospital were investigated by surveying fifty-two design professionals on the quality of the design elements in the atriums. A spatial configuration analysis, confirmed that all the atrium spaces had high visibility, accessibility, and intelligibility due to their high connectivity, integration, intelligibility, and because the atriums were laid out in the open lobby space, along the major circulation axis, or in the circulation intersection. In the survey of the design element evaluation, all atriums proved to be appropriate in terms of openness, while the adequacy of restfulness and vibrant ambience differed depending on the hospitals. Notably, location and orientation, access, natural light, outdoor view, and play facilities were found significant environmental design elements determining the successful implementation of the therapeutic design in the atriums. The observations from the aforementioned are further discussed to enhance the therapeutic design quality of atrium spaces in children's hospitals.