• 한국임상약학회지
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• 제23권3호
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• pp.232-238
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• 2013

Background: Although thromboembolism is common and one of the major causes of mortality in cancer patients, maintaining therapeutic anticoagulation effect with warfarin is challenging. This study aimed to determine the prevalence and the causes of non-therapeutic INR (International Normalized Ratio) in cancer patients. Methods: Medical and pharmacy records for cancer patients managed by the pharmacist-run anticoagulation service (ACS) between May, 2010 and April, 2011 at Seoul National University Hospital were retrospectively reviewed. The causes of non-therapeutic INR were identified and compared with the results from a former study with mechanical heart valve patients. Results: A total of 335 cancer patients and 6,737 patient-visits were analyzed producing 68% (n=4,590) of non-therapeutic INR readings. Eighty-five percent of the non-therapeutic INR readings were categorized as sub-therapeutic. Frequent causes linked to non-therapeutic INR included inadequate dosage adjustment (21.8%), changes in health status (11.8%), dietary changes (8.1%), and drug interactions (4.2%). More than half of the non-therapeutic INR values had no known etiology. As causes for non-therapeutic INR, changes in health status (p<0.0001), adverse reactions (p<0.0001), and dietary changes (p=0.017) were statistically more frequent in cancer patients than in patients with mechanical heart valves. Furthermore, exposure to sub-therapeutic INR were more prevalent in cancer patients than in patients with mechanical heart valve (p<0.0001). Conclusions: This study shows that there is a tendency to keep the level of INR low and that health status change, dietary change, and drug interactions are found to be frequent causes for non-therapeutic INR in cancer patients.

• 대한통합의학회지
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• 제9권4호
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• pp.271-281
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• 2021

Purpose : This study aimed to apply muscle relaxation exercise and ultrasound therapy as an effective treatment method for tension headache patients by comparatively analyzing the muscle mechanical properties, neck disorder index, and headache impact test. Method : The subjects were classified into three groups based on the intervention received: the therapeutic ultrasound (n=15, group I), placebo therapeutic ultrasound combined with the suboccipital release (n=15, group II), and therapeutic ultrasound combined with suboccipital release (n=15, group III) groups. The intragroup and intergroup differences in muscle mechanical properties, neck disability index, and headache impact test were compared and analyzed. Result : The comparison and analyses of the changes in muscle tone and post hoc analysis revealed statistically significant intragroup decreases in the suboccipitalis and upper trapezius in groups I and III. Furthermore, statistically significant intergroup differences in the upper trapezius with a greater change in group III than in group II and suboccipitalis with greater changes in group III than in groups I and II were observed. The comparison and analyses of the changes in muscle stiffness and post hoc analysis revealed statistically significant intragroup decreases in the upper trapezius in group I and suboccipitalis in group III. Moreover, statistically significant intergroup differences in both muscles with greater changes in group III than in group II for both cases were observed. The comparison and analyses of the changes in the neck disability index and post hoc analysis revealed statistically significant intragroup decreases in all three groups and statistically significant intergroup differences with greater changes in group III than in groups I and II. The comparison and analyses of the changes in the headache impact test and post hoc analysis revealed statistically significant intragroup decreases in all three groups and a statistically significant intergroup difference with greater changes in group III than in groups I and II. Conclusion : The therapeutic ultrasound and suboccipital muscle release exercise effectively increased the flexibility of the muscles around the cervical vertebrae and reduced muscle tension and stiffness in tension-type headache patients.

• Journal of Animal Science and Technology
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• 제55권6호
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• pp.559-565
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• 2013

This study examined the effect of therapeutic horseback riding in children with spastic cerebral palsy. Participants were placed in a therapeutic riding (TR) group (n=7) or physical therapy (PT) group (n=7). This study was then conducted for 30 minutes, twice a week, for 8 weeks. The gross motor function measure (GMFM), range of motion (ROM), and spasticity test (ST) were analyzed pre-test (TR0 and PT0), mid-test (TR1 and PT1), and post-test (TR2 and PT2). We used the SPSS 12.0 statistical software for data analysis. We observed significant changes in GMFM Dimension C (crawling and kneeling), D (standing), and E (walking, running, and jumping) between TR2 and TR0 (P < 0.05). In the control group, GMFM Dimension B (sitting) and E showed significant changes between PT2 compared to PT0 (P < 0.05). In future studies we will consider using a therapeutic riding program for the treatment of children with disorders.

• The Journal of Korean Physical Therapy
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• 제18권3호
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• pp.9-21
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• 2006

Purpose: This study was intended to examine the effects of electroacupuncture and therapeutic exercise on muscle atrophy and exercise function in an ischemic stroke model induced by middle cerebral artery occlusion. Methods: This study selected 120 Sprangue-Dawley rats, 8-week of age, divided them into six groups, and assigned 5 rats to each group. Experiments were conducted for 1, 3 days, 1, and 8 weeks, respectively. Group I was a group of electroacupuncture and therapeutic exercise after inducing ischemic stroke; Group II was a group of therapeutic exercise after inducing ischemic stroke; Group III was a group of electroacupuncture after inducing ischemic stroke; Group IV was a sham group of electroacupuncture after inducing ischemic stroke; Group V was a control group and Group VI was a sham group without ischemic stroke. In each group, changes in weight of muscle and relative muscle of TA muscle, neurologic motor behavior test, histologic observations were observed and analyzed. Results: For the changes in muscle weight of unaffected and affected sides of TA muscle, muscle atrophy was seen in an affected side 3 days after ischemic stroke was induced. There was statistically significant difference in Group I 1 week and 8 weeks after ischemic stroke was induced, compared to Group V (p<0.05). For the changes in relative muscle weight of unaffected and affected sides of tibial anterior muscle, there was significant decrease in each group 3 days after ischemic stroke was induced, compared to Group IV, while there was statistically significant increase in Group I 1 week after ischemic stroke was induced, compared to Group V (p<0.05). For neuologic exercise behavior test, Group I generally had the highest score, compared to other groups. Conclusion: electroacupuncture and therapeutic exercise may improve muscle atrophy and change in histologic observations expression of ischemic stroke rats and contribute to the improvement of exercise function.

• 한국콘텐츠학회논문지
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• 제22권7호
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• pp.332-344
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• 2022

본 연구는 실제 상담에서 내담자들이 상담자의 진정성을 어떻게 인식하는지 그 구성요인들을 확인하고, 상담자 진정성과 관련된 치료적 변화와 그 과정에 대해 살펴보고자 수행되었다. 이를 위해 대학원에서 상담을 전공하고 있는 내담자 12명을 대상으로 심층면접을 실시하였고, 질적 연구 방법 중 근거이론 접근법을 사용하여 분석한 결과, 57개의 개념과 40개의 하위범주, 그리고 14개의 범주가 도출되었다. 주요 연구결과로는, 첫째 내담자가 인식하는 상담자 진정성의 구성 요인은 '진솔성,' '진심어린 태도,' '정성스런 돌봄'으로 확인되었다. 둘째 상담자 진정성은 내담자에 대한 깊은 수준의 수용과 공감이 동반될 때 더 깊고 일반화된 치료적 변화를 가져오는 것으로 나타났다. 마지막으로 상담자 진정성의 치료적 변화로는 '자기이해와 수용의 증가', '진정성 모델링의 일반화', '문제 대처에 대한 적극성 증가'로 나타났다. 본 연구는 실제 상담에서 내담자가 경험한 상담자 진정성과 치료적 변화에 대해 면밀히 살핌으로써, 진정성이 가지는 치료적 가치와 관련 요인들을 확인하고 초심상담자의 훈련과 교육에 대한 시사점을 제공하였다는데 그 의의가 있다.

• 보건행정학회지
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• 제21권2호
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• pp.249-262
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• 2011

Since May 1st in 2008, the products of ginkgo biloba extract have had to be used with the patient's out-of-pocket payment due to reimbursement restriction guidelines. This study aims to analyze the policy effects of reimbursement restriction on pharmaceutical expenditures using interrupted time series(ITS) analysis. We retrieved monthly NHI claims data for the period between May, 2005 and December 2009. The ingredients identified as a substitute for ginkgo biloba have similar indications based on the similar pharmacological activities. The effects of changes in reimbursement scope were evaluated both for all relevant pharmaceuticals within the same therapeutic class and for 2 separate groups : ginkgo biloba's and its substitutes. According to the study results, restrictions on reimbursement scope resulted in savings of the drug expenditures in the targeted therapeutic class. Direct restriction on ginkgo biloba was associated with a decrease in expenditure level by 60.1% and changes in trend from an average increase rate of 1.4% to an average decrease rate of 1.5% for the therapeutic class, with a dramatic decrease in expenditure level(-191.5%) for ginkgo biloba itself, but with an increased expenditure level(+50.1%) and changes in trend from an average increase rate of 2.0% to an average decrease rate of 1.0% for the substitute group. Further policy to restrict nicergoline was associated with additional decrease in expenditure level for the therapeutic class. Additionally, we could identify the balloon effect - a new policy squeezing one part results in bulging out elsewhere. After the restriction of ginkgo biloba, the utilization of and expenditures on its substitutes increased significantly. In conclusion, we demonstrated that consecutively introduced policies effectively reduced overall expenditures on the therapeutic class of interest. Some ingredients played as a substitute while others did not. Further studies need to be conducted to identify which factors determine a substitute.

• 근관절건강학회지
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• 제29권1호
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• pp.11-17
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• 2022

Purpose: This study aimed to provide objective and basic data for an effective treatment method by examining changes in the mechanical properties of muscles and the degree of tenderness when a combination of stretching exercise and ultrasound therapy is applied to patients with tension headaches. Methods: The participants were classified into two groups based on the intervention received: the therapeutic ultrasound combined with suboccipital stretching (n=15, experimental group) and infrared combined with suboccipital stretching (n=15, control group) groups. The intragroup differences in mechanical muscle properties and modified total tenderness score were compared and analyzed. Results: The comparison and analyses of the changes in muscle tone and stiffness revealed statistically significant intragroup decreases in the upper trapezius and suboccipitalis in the experimental group. Similarly, the comparison and analyses of the changes in muscle stiffness revealed statistically significant intragroup decreases in the upper trapezius in the control group. Conclusion: Therapeutic ultrasound combined with suboccipitalis stretching effectively increased the flexibility of the muscles around the cervical vertebrae and reduced muscle tension and stiffness in tension-type headache patients

• 한방재활의학과학회지
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• 제26권3호
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• pp.183-189
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• 2016

A 84 year old male patient with amyotrophic lateral sclerosis (ALS) was treated by Jeungsonbaekchulsan and Gakbyeongyeonsu-tang for ten days. In the course of treatments, this patient was evaluated with Roussel Uclaf Casusality Assessment Method (RUCAM), showing results of drug induced liver injury. Herb medicine was immediately discontinued, followed by therapeutic laser treatments once a day for one week combined with 2 weeks of GODEX$^{(R)}$ administration. Transaminase results were lowered and changes in blood test results were time-effective changes. Therapeutic laser therapy could be considered effective on drug induced liver injury with further studies.

• 재활복지
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• 제22권3호
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• pp.189-208
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• 2018

본 연구는 세 명의 두경부암 환자들을 대상으로 말산출 관련 기능 개선을 목표로 치료적 노래부르기 중심의 음악중재를 시행하고, 각 사례 별로 변화를 관찰 기술한 사전-사후 개별 사례연구이다. 중재는 개별 세션의 형태로 매 회기 30분, 주 2회씩 총 12회기 동안 진행되었으며, 시행된 프로그램은 호흡근 이완을 위한 신체움직임, 조음기관의 운동범위 확장 및 성대이완을 위한 발성훈련과 치료적 노래부르기의 총 3단계로 구성되었다. 중재에 따른 대상자들의 말산출 관련 기능의 변화를 알아보기 위해 음성의 질, 길항반복운동속도(diadochokinesis, DDK), 모음공간면적(vowel space area, VSA) 변화 등의 음향학적 분석과 <산책>문단 읽기 과제 시의 청지각적 평가를 시행하였고, 프로그램 참여 시의 관찰 및 사전 사후 면담을 통해 대상자의 심리정서적 변화를 추가적으로 살펴보았다. 중재 과정에서 모든 대상자의 재활동기 및 음성 사용에 대한 긍정적 변화 양상이 관찰되었고, 중재 후에는 음성의 질, DDK에 변화가 있었으며, VSA의 확대가 나타났다. 본 연구를 통해 치료적 노래부르기 중심의 음악중재프로그램이 두경부암 환자들의 음성 기능 및 잔존하는 조음기관 운동성을 향상시키는데 긍정적인 영향을 미칠 수 있음을 알 수 있었다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.919-922
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• 2005

Generally, we take a bath to obtain a clean body as well as a good health. Human body generates various physical and emotional changes by stimulations of therapeutic effect of heat and hydraulic pressures. Accordingly, we can obtain not only relaxations but also effects of hydrotherapy. The survey of bathing/showering behaviors and therapeutic effect of heat reactions present elementary data for development of a bathing/showering system. However, there are few existing data for bathing/showering behaviors and effects. Consequently, surveys were performed to know patterns of bathing and showering, and relations between physiological changes and water temperature were examined by partial bathing on human body in this study.