• BMB Reports
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• v.35 no.2
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• pp.172-177
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• 2002

We previously reported that cholesteryl ester transfer protein (CETP) inhibitory peptides (designated $P_{28}$ and $P_{10})$ have anti-atherogenic effects in hypercholesterolemic rabbits (Biochim. Biophys. Acta (1998) 1391, 133-144). To further investigate those effects, we studied rabbit plasma that was collected after 30 h of a $P_{28}$ or $P_{10}$ injection. We found that there is a strong correlation between the in vivo CETP inhibition effects and alterations of lipoprotein particle size distribution in rabbit plasma, as determined on an agarose gel electrophoresis and gel filtration column chromatography. In vivo effects of the peptide were observed again in C57BL/6 mice that expressed simian CETP. The $P_{28}$ or $P_{10}$ peptide ($7\;{\mu}g/g$ of body weight) that was dissolved in saline was injected subcutaneously into the mice. The $P_{28}$ injection caused the partial inhibition of plasma CETP activity up to 50%, decreasing the total plasma cholesterol concentration by 30%, and increasing the ratio of HD/total-cholesterol concentration by 150% in the CETP-transgenic (tg) mice. The CETP inhibition by the $P_{28}$ or $P_{10}$ made alterations that modulated the size re-distribution of the lipoproteins in the blood stream. Particle size of the very low (VLDL) and low density lipoproteins (LDL) from the peptide-injected group was highly decreased compared to the saline-injected group (determined on the gel filtration column chromatography). In contrast, The HDL particle size of the $P_{28}$-injected group increased compared to the control group (saline-injected). The expression level of the CETP mRNA of the $P_{28}$-injected CETP-tg mouse appeared lower than the saline-injected CETP-tg mouse. These results suggest that the injection of the CETP inhibitory peptide could affect the CETP expression level in the liver by influencing lipoprotein metabolism.

• Journal of the Korea Fashion and Costume Design Association
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• v.16 no.4
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• pp.217-228
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• 2014

The purpose of this study is to grasp inconveniences and improvements by examining wearing condition and satisfaction of protective clothing targeting 114 Korean farmers and to suggest basic data for enhancement of pattern and wearing satisfaction of protective clothing by understanding problems of pesticide-proof clothing through comparative analysis on the size of its commercial products. Most of male subjects were in charge of spraying pesticide, whereas female were most likely to play an assistant role to hold the hose of pesticide applicator. Both of female and male subjects were very aware of the harmful effect of pesticide on human body and tried to take off the clothes immediately after spraying it to reduce possible damage caused by pesticide. As a result of examining wearing condition, the farmers avoided wearing protective clothing because that it feels hot, stuffy, and uncomfortable to move. This hesitant response of wearing the clothing was not shown significantly in case of female subjects who play an assistant role for spraying. Although the farmers wore protective equipments such as mask or gloves in a proper way as compared to protective clothing, they seemed to choose alternative way rather than best way to block pesticide completely. The satisfaction regarding to the fitting of protective clothing which the subjects showed low in all items of upper-lower clothes except waistline. It is necessary to improve the functionality such as relief from heat stress and convenience for movement rather than design or economic in protective clothing development. As a result of comparing the size of five kinds of commercial protective clothing, the farmers got confused to choose the product since designation method of size across companies showed a significant difference in an identical clothing size. In addition, the sizing system developed on a basis of a well-built man has become a hindering factor in wearing satisfaction of female farmers.

• Journal of the Korean Society of Radiology
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• v.16 no.7
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• pp.1007-1014
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• 2022

Targeted radionuclide therapy (TRT) is a method of treating tumor cells using radiopharmaceuticals. Cells and nuclei constituting tissues of the human body are composed of spherical and oval shapes, but cancer cells are composed of various cell types. Therefore, this study analyzed the absorbed dose for each organelle according to the change in the size of the cell nucleus for beta-emitting nuclides during targeted radionuclide therapy through the Monte Carlo method. Cells were set in two sphere shapes, 5 ㎛ and 10 ㎛, and the internal structure was divided into cell nucleus, cytoplasm, and cell surface. Next, the absorbed dose according to the increase in the size of the cell nucleus was evaluated. As a result, ¹⁷⁷Lu among the target radionuclides showed the highest dose in all cell compartments. As the ratio of the nucleus in the cell increased, the absorbed dose on the cell surface increased, but the absorbed dose in the cytoplasm and nucleus tended to decrease. Accordingly, it is judged that it is important to select a radionuclide considering the size of cancer cells and determine an appropriate amount of radioactivity during targeted radionuclide treatment.

• Journal of Applied Biological Chemistry
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• v.63 no.2
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• pp.161-168
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• 2020

It is known that different plant species have ability to deposit different amounts of particulate matter (PM) on their leaves and plants can absorb heavy metals in PM through their leaves. Heavy metals in PM can have toxic effect on human body and plants. Therefore, PM on different roadside trees at Chungbuk national University including box tree (Buxus koreana), yew (Taxus cuspidate), royal azalea (Rhododendron yedoense), and retusa fringetree (Chionanthus retusa) was quantified based on particle size (PM_>10 and PM_2.5-10). The metal concentration in PM accumulated on leaves was analyzed using inductively coupled plasma-mass spectroscopy. In this study, the mass of PM_>10 deposited on the surface of the tree leaves ranged from 6.11 to 32.7 ㎍/㎠, while the mass of PM_2.5-10 ranged from 0 to 14.8 ㎍/㎠. The royal azaleas with grooves and hair on the leaf surface retained PM particles for longer time, while the yews and box trees with wax on leaf surfaces accumulated more PM. The PM contained elements in crustal material such as Al, Ca, Mg, and Fe and heavy metals including Cu, Pb and Zn. The concentration of elements in crustal material was higher in the coarser size, while heavy metal concentration was relatively higher in the finer size fraction. The Mn, Cd, Cu, Ni, Pb, and Zn concentrations of leaves and PM_2.5-10 were significantly correlated indicating that PM was taken up through tree leaves.

• Journal of the Korean housing association
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• v.20 no.1
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• pp.59-70
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• 2009

The purpose of the study is to suggest the amount of space for each behavior according to the classification of behavior in the housing to plan the optimal floor space of the elderly housing. The method for calculating space for behavior begins with classifying behaviors, identifying them and then taking pictures of the model of elderly people who reproduce each behavior. Based on the pictures, body parts which are necessary for each behavior are assembled and the formula for behavioral space is created. The space for behavior is produced considering the body dimensions of Korean elderly in their sixty's as well as the furniture size and the psychological distance between people. 3D modeling is used to verify the result. Human behaviors can be classified into individual-related, housework-related, family-related, reception-related and other behaviors. These five behaviors are subdivided into more specific behaviors. The area for each specific behavior is calculated with the anthropometric data of the elderly, preferred furniture dimension and psychological area. As a result the required area for specific behaviors is as follows: the behavior of sleeping in a bed needs $4.3m^2$; the behavior of changing clothes on a chair, $1.7m^2$; the behavior of watching TV on the floor $1.3m^2$, the behavior of working and reading using a desk, $2.1m^2$, the behavior of exercise, $2.5m^2$; the behavior of showering on a chair, $1.3m^2$ and showering using a wheelchair, $1.9m^2$; the behavior of toileting using a wheelchair, $2.3m^2$; the behavior of washing up using a wheelchair, $1.9m^2$; the behavior of eating using a table for four persons, $4.4m^2$; the behavior of cooking and washing dishes, $0.9m^2$ per counter-top; the behavior of washing clothes using a washing machine, $0.9m^2$; the behavior of ironing on the floor $1.4m^2$; the behavior of reception(three persons) on the floor considering personal space, $4.0m^2$; the behavior of taking on and off shoes on a chair, $1.3m^2$. The result of the study is utilized as quantitative data to calculate optimal floor space for elderly housing. In addition, qualitative data such as characteristics of housing preference, spacial usage and storage capacity are necessary to produce the floor space which can provide convenient and safe living environment.

• Journal of Sasang Constitutional Medicine
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• v.10 no.2
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• pp.181-220
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• 1998

1. PURPOSE This is a quantitative analysis of Sasang Constitution by measuring human body except face. This study is carried out for the purpose of searching out the theory of Sa-cho and the morphologic theory of Sasang Constitution. 2. METHOD (1) SUBJECTS Subjects are 338 person came to Dept. of Sasang Constitutional Medicine (KyungHee Oriental Medical Center) and Oriental Medicine and Western Medicine Cooperative Health Examination Center (KyungHee Medical Center) from October 1997 to Jauary 1998. The mean age is $41.7{\pm}12.39$. (2) CLASSIFICATION OF SASANG CONSTITUTION QSCCII(Questionnaire for the Sasang Constitution Classification) is used for the Classification of Sasang Constitution. The distributions of Sasang Constitution Classification are Soeumin 83, Soyangin 98, and Taeumin 157. (3) MEASURING INSTRUMENT & ITEMS Length, Breadth, Circomferece, and Skinfold thickness of each body segment are measured by Martin's measuring instrument and Skinfold Caliper. Measured items of this study is based on Lohman's methods and is added new items. (4) DATA ANALYSIS The Volume, Weight, Rate, and Index of each group are calculated by using measuring items. The difference of each group is analyzed by SPSS 7.0 for Win. 3. RESULT (1) THE MORPHOLOGIC CHARACTERISTIC of TAEUMIN First of all, the Taeumin has a emormous morphology. His trunk is huge but head-neck and limbs is small. The volume and weight of head-neck is smaller than other body segments but the volume and weight of upper-abdomen is bigger than ones. (2) THE MORPHOLOGIC CHARACTERISTIC of SOEUMIN The Soeumin has a small morphology. His head-neck rate is bigger than Taeumin's but his trunk rate is smaller than Taeumin's. And his lower limbs rate is bigger than other constitution but it's not a significant difference. His neck is thinest and longgest than others. His chest is thin and narrow. His lower-abdomen rate is bigger than other constitution but it's difference is not significant. (3) THE MORPHOLOGIC CHARACTERISTIC of SOYANGIN Soyangin has a middle size at head-neck and chest part. But the rate of upper limb is higer than other constitution. And the rate of lower-abdomen part is lower than other constitution. but that's not significant.

• Journal of radiological science and technology
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• v.23 no.1
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• pp.49-54
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• 2000

It is important to identify modifiable risk factors for breast cancer, because the breast cancer is one of the major causs of mortality among women. Some reported that obesity is a risk factor for breast cancer, but the results are not constant. Many risk factors are related to the duration of estrogenic stimulation of the breast. In general, early menarche and late menopause are positive risk factors. Human breast cancer has different characteristics according to the status of menopause(premenopause and postmenopause). In premenopausal women, about 60% of circulating estrogen is from the ovaries in the form of estradiol, and the remaining 40% is estrogen formed primarily in the adipose(fat) tissue via aromatization of androstenedion from the adrenal glands. After menopause this adipose cell production of estrone is the main source of estrogens and the level of estrone is maintained approximately at premenopausal levels. This study was undertaken to determine the role of body size and body mass index by status of menopause in development of breast cancer using retrospective case/control study. From March 1991 to February 1997 at the Wonkwang University Hospital, the breast cancer cases(n=72) and controls(n=86) were selected. By statistical analysis method, regression analysis, paired T-test and multiple logistic regression were done to estimate the influenced factors same as height, weight, BMI, age at menarche and age at menopause. The following results were obtained : 1. In premenopausal women, age at menarche was showed comparatively high correlation coefficients and BMI was described prominently highly in postmenopause. 2. At the results of multiple regression analysis, age at monarch, BMI and weight were showed as significant variables. In this method, critical factor ($R^2$) was 0.054. 3. Paired samples T-test was undertaken to test mean difference between two groups of cases and controls. The result of test performance showed a significant difference. 4. In comparison with women whose weight less than 50 kg, the ORs for the upper 5th group was 1.82(95% confidence interval). The heaviest women had a higher risk(OR=1.14, 95% confidence interval $1.12{\sim}1.31$, p=0.005). Higher body mass index was significantly associated with increased risk of premenopausal breast cancer (OR=1.01, 95% confidence interval $1.08{\sim}l.18$, p=0.05).

• Journal of the Korean Society of Food Science and Nutrition
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• v.40 no.2
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• pp.177-182
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• 2011

This study was designed to evaluate the effect of Yukwa prepared by addition of green tea powder on change of lipid composition and body weight in mouse model. Mice were fed with Yukwa containing the five different types of green tea powders such as Bucho-cha, Okro-cha, Yongjeong-cha, Oolong-cha and Hong-cha with a normal diet. Body weight changes of Yukwa fed mice were measured once in a week for seven weeks. After seven weeks, mice were sacrificed and serum and tissues were collected for the following: adipose tissue weight, liver morphology, adipose tissue size and cholesterol content. The Yukwa combination with green tea fed mice reduced all the parameters compared to Yukwa alone fed mice. In conclusion combination with green tea showed reducing effect of hypocholesterolemia, which suggests the possibility of application to green tea as a food ingredient.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.199-202
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• 1996

Artificial hearts are intended for use in patients with severe forms of heart disease for which no surgical repair is possible. The moving-actuator pump was developed to decrease the overall volume size of the electromechanical total artificial heart (TAH) by eliminating the occupied space of the fixed-actuator in the conventional pusher-plate type pump. In our pump, the actuator moves back and forth for alternative ejections of left and right ventricles. The problem of fitting the TAH to atrial remnants and arterial vessels could also be improved by circular or penduluous mot ion of the actuator instead of linear mot ion of the pusher-plate in the conventional pumps. We have evaluated two types of moving- actuator pump; one is a rolling cylinder type, and the other a pendulum type pump. In the rolling cylinder pump, frictional energy loss exists between the pump housing's guide bars and the actuator's end caps, while the bottom rack under the cylindrical actuator increases the height of the pump, the pump is therefor not implantable inside the small chest of human-sized animals with a body weight of less than 70kg. The new human type pump has a penduluous mot ion actuator to correct the above problems while maintaining the advantage of the moving- actuator's small total volume. The totally implantable TAH is composed of a blood pump, a control system and pheriperal equipments. The blood pump, which is constructed by a moving actuator, a right and left blood sac, and four artificial valves, is implanted in the thoracic. In 1988, the first implantation of the rolling cylinder TAH was performed into a female calf weighing 100kg, and the cal f recovered to the degree of voluntary standing and eat ing and survived to 100 hrs. We then survived two female sheep weighing about 63kg with the new human type TAH for three days.

• Korean Journal of Veterinary Research
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• v.21 no.2
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• pp.105-112
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• 1981

The morphological and structural studios of Anisakinae larva has been carried out since Sept. of 1980. The larva were collected from naturally infested eleven swine of 1,531 examined at Kwang-Ju abattoir and from marine fishes, Somber japonicus, bought at Kwang-Ju fish market. The results observed were as follow : 1. Anisakis larva found in the stomach wall and on the surface of the mucosa were more or less degenerated. According to the progress of degeneration, the cross sections showed varied structures (Fig. 6, 7). 2. Size of the larva both from swine and fishes were measured respectively in average(mm); 18.0 and 18.7 in body length, 0.30 and 0.41 in body width, 1.64 and 1.68 in esophagus(muscular-part), 0.56 and 0.67 in ventriculus (glandular part), and 0.13 and 0.12 in tail. It was notable that body length of the larva in this present data, 18.0mm and 1.87mm, were shorter than those in previous dada, 24.3mm from human cases and 28.4mm from, however, the present data were almost similar to the data, 1.75mm, from swine case. 3. The Boring tooth, Mucron, long ventriculus and short round tail were observed in the larva of this present study. These structures were differentiated from Anisakis type II larvae which was provided with short ventriculus, and conical and tapering tall without mucron. 4. The ventricular appendix and intestnal caecum were not present in the larva. These might be differentiated from other Anisakidae larva such as Terranova larvae, Contracaecum larvae, Raphidascaris larvae and Thynnascaris larvae. 5. The findings through the histological observation were a pair of Y-shaped or butterfly-shaped lateal chords, ventral and dorsal chords, excretory(Renette) cell, high columnar epithelial cells of digestive tract and muscle cells. These morphological characteristics revealed varied features in the structures in the degenerative degree of the larva in the stomach wall. 6. The above-mentioned characteristics of the larva observed could be indentified as Anisakis type I larvae. 7. The reports on natural infestation of domestic animal with Anisakis type I larvae were two swine cases in Korea and Japan respectively, On the other hand two human cases of the larva were reported in Korea and more than one thousand cases in Japan. In Twiwan no reports of human and domestic animal cases could be found.