• Title/Summary/Keyword: The side-effects

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대상포진후 신경통에서 Gabapentin의 효과 (Gabapentin for the Treatment of Postherpetic Neuralgia)

  • 이두익;김동옥;김건식;권무일;신광일;강화자
    • The Korean Journal of Pain
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    • 제12권2호
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    • pp.188-190
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    • 1999
  • Background: The goal of this study was to evaluate the effects of gabapentin on postherpetic neuralgia. Gabapentin is a known anti-seizure medication, whose cellular mechanism of action is not well understood. Unlike other anticonvulsant, gabapentin has the advantage of a low toxicity and favorable side effect profile. If has been recently recommended for use in treatment of neuropathic pain. Methods: Twelve patients with a diagnosis of postherpetic neuralgia were prescribed gabapentin after failure of routine therapeutic regimens. The dose of gabapentin ranged 300~1800 mg per day, in three divided doses. If initial dose was ineffective and no side effects were noted, the dosages was increased by 300 mg a day in divided doses, to the maximum level for 2 weeks. Patients were evaluated for analgesia using visual analogue scale (VAS) pain score (0; no pain, 10; worst possible pain) and possible side effects. Results: A significant decrease in pain scores with gabapentin were noted. There were several mild side effects such as dizziness, somnolence, dry mouth, constipation and facial edema, without need of special treatment. Conclusions: Gabapentin may be a useful adjunct for treating intractable postherpetic neuralgia with a minimal side effects.

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Morphine과 Naloxone의 경막외 동반 투여가 Morphine의 제통효과와 부작용에 미치는 효과 (Does Epidural Naloxone Reduce Side Effects of Epidural Morphine without Reversing Analgesia?)

  • 최종호;이재민;김태현
    • The Korean Journal of Pain
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    • 제11권1호
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    • pp.47-53
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    • 1998
  • Background: Epidural coadministration of opioids and local anesthetics has provided excellent analgesia during postoperative period. However, it is usually associated with the occurance of many side effects which were induced by epidural morphine. Low dose of intravenous naloxone has been known to reduce morphine-induced side effects without reversing analgesia, but the effect of epidural naloxone has not been defined in human study. Therefore we evaluated side effects and analgesia when naloxone was administered via epidural route. Methods: Eighty patients having epiduro-general anesthesia for hysterectomy were randomly assigned to one of four study groups. As a mean of postoperative pain control, all received 2 mg of epidural morphine bolusly at 1 hr before the end of surgery and continuous epidural infusion was started by Two-day Infusor containing morphine 4 mg in 0.125% bupivacaine 100 ml with either none of naloxone(Group 1, n=20), 2 ug/kg/day of naloxone(Group 2, n=20), 3 ug/kg/day of naloxone(Group 3, n=20) or 4 ug/kg/day of naloxone(Group 4, n=20). Study endpoints included visual analog scales(VAS) for pain, severity of nausea, itching, somnolence and respiratory depression. They were assessed at 2, 4, 8, 16, 32, and 48 hr postoperatively. Results: VAS for pain showed significant difference in Group 4 compared with Group 1 at all of the evaluation time. Itching score decreased significantly in Group 3 and 4 after 8 hr postoperatively and nausea score decreased significantly in Group 3 after 4 hr postoperatively. Alertness score decreased significantly in Group 3 and 4 especially in early postoperative period. Conclusion: This study suggests that epidural naloxone reduce morphine-induced side effects in dose-dependent fashion without reversal of the analgesic effect of epidural morphine.

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진동을 동반한 옆교각 운동이 요통 성인의 통증, 기능장애, 근력, 균형에 미치는 영향 (The Effects of Vibration and Side-lying Hip Abduction on Pain, Disability, Strength and Balance in Individuals with Low Back Pain)

  • 권애정;김선엽
    • 대한물리의학회지
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    • 제11권4호
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    • pp.127-137
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    • 2016
  • PURPOSE: This study aimed to compare the effects of side-lying hip abduction exercise with and without vibration on pain, disability, strength and balance in individuals with low back pain. METHODS: 30 participants enrolled in this study were randomly assigned to an experimental group (EG, n=15) for side-lying hip abduction with vibration and a control group (CG, n=15) for side-lying hip abduction without vibration. Both groups were treated 3 times per week for 4 weeks. Pain (Numeric Rating Scale), disability (Korean Oswestry Disability Index), hip abductor muscle strength, and static balance were measured in both groups before and after the program. Results were analyzed using paired t-test for comparing the difference within the group and independent t-test for comparing the difference between two groups. RESULTS: Compared to the CG, the EG showed significantly greater reductions in pain and disability (p<.05). There was a significant difference in all balance categories of both the painful and non-painful sides within the EG (p<.05). Balance showed a significant decrease except the envelope area (ENV) on the non-painful side within the CG (p<.05). There was a significant increase in all balance categories except ENV of non-painful side between the two groups (p<.05). Balance increased on both the painful and non-painful sides in the EG. Balance improved on the painful side in the CG, but significantly decreased on the non-painful side (p<.05). CONCLUSION: Side-lying hip abduction exercise with vibration is considered an effective treatment for pain, disability and balance in individuals with low back pain.

Effects of Functional Electrical Stimulation (FES) on the Temporal-spatial Gait Parameters and Activities of Daily Living in Hemiplegic Stroke Patients

  • Oh, Dong-Gun;Yoo, Kyung-Tae
    • 대한물리의학회지
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    • 제16권3호
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    • pp.37-44
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    • 2021
  • PURPOSE: This study examined the effects of functional electrical stimulation (FES) on temporal-spatial gait and the activities of daily living in hemiplegic stroke patients. METHODS: The subjects were 29 hemiplegic stroke patients (57.7 ± 10.3). The patients walked at a self-controlled speed in four states: (1) walking without FES (non-FES), (2) walking with FES on the gluteus medius in the stance phase (GM), (3) walking with FES on the common peroneal nerve and tibialis anterior in the swing phase (PT), (4) walking with both GM and PT. A GAITRite system, Timed-Functional Movements battery, and Timed UP and Go test were used to measure the variables. RESULTS: Significant improvements were observed in all variables of the GM+PT, GM, and PT states compared to the non-FES state (p < .05). There were significant improvements in the GM+PT state compared to GM and PT states (p < .05). Moreover, significant improvements were noted in the single support time on the affected side, backward walking 10ft, and side stepping 10ft on the affected side of the GM state compared to the PT state (p < .05). There were significant improvements in the stride length on the affected side and side stepping 10ft on the unaffected side of the PT state compared to the GM state (p < .05). CONCLUSION: FES is effective in improving the temporal-spatial gait and activities of daily living in hemiplegic stroke patients.

압력면익단소익이 터빈 동익 압력면스퀼러팁 하류의 팁누설유동 및 압력손실에 미치는 영향 (Effects of Pressure-Side Winglet at an Elevation of Tip Surface on the Tip-Leakage Flow and Aerodynamic Loss Downstream of a Turbine Blade Equipped with Pressure-Side Squealer Tip)

  • 천주홍;이상우
    • 대한기계학회논문집B
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    • 제40권10호
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    • pp.645-651
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    • 2016
  • 본 연구에서는 압력면익단소익의 폭이 터빈 동익 압력면스퀼러팁 하류의 팁누설유동 및 압력손실에 미치는 영향에 대하여 연구하였다. 팁간극비 h/s = 1.36%에 대하여, 흡입면스퀼러의 높이는 $h_p/s=3.75%$로 일정하게 유지하고, 압력면익단소익의 폭은 w/p = 2.64%, 5.28%, 7.92%, 10.55% 등으로 변화시키면서 실험을 수행하였다. 일반적으로 압력면익단소익의 폭이 증가할수록, 통로와류 영역에서의 압력손실은 감소하였지만 팁누설유동 영역에서는 압력손실이 오히려 증가하였다. 그 결과 익단소익의 폭이 증가할수록, 질량평균 압력손실은 매우 소폭 감소하는 경향을 보였다. 본 연구 결과, 압력면스퀼러팁에 설치된 압력면익단소익은 압력손실 저감에 거의 기여를 하지 못함을 확인할 수 있었다.

동축류 확산화염에서 질소첨가가 Soot발생에 미치는 영향 (Dilution and Thermal Effects of N2 Addition on Soot Formation in Co-flow Diffusion Flame)

  • 엄재호;이종호;전충환;장영준
    • 한국연소학회:학술대회논문집
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    • 한국연소학회 2002년도 제24회 KOSCO SYMPOSIUM 논문집
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    • pp.185-191
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    • 2002
  • The influence of N2 addition on soot formation, flame temperature and NOx emissions is investigated experimentally with methane fuel co-flow diffusion flames. The motivation of the present investigation is the differences in NOx reduction reported between fuel-side and oxidizer-side introduction of N2. To determine the influence of dilution alone, fuel was diluted with nitrogen while keeping the adiabatic flame temperature fixed by changing the temperature of the reactants. And to see the thermal effect only, air was supplied at different temperature without N2 addition. N2 addition into fuel side suppressed the soot formation than the case of oxidizer-side, while flame temperature enhanced the soot formation almost linearly. These results reveals the relative influences of the thermal, concentration effects of N2 additives on soot formation In accordance with experimental study, numerical simulation using CHEMKIN code was carried out to compare the temperature results with those acquired by CARS measurement, and we could find that there is good agreement between those results. Emission test revealed that NOx emissions were affected by not only flame temperature but also N2 addition.

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Change in Pelvic Motion Caused by Visual Biofeedback Influences Trunk and Hip Muscle Activities During Side-Lying Hip Abduction in Asymptomatic Individuals

  • Yu, Ilyoung;Kang, Minhyeok
    • 국제물리치료학회지
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    • 제10권3호
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    • pp.1818-1822
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    • 2019
  • Background: Ipsilateral pelvic elevation has been reported as a common compensatory movement during side-lying hip abduction. It has been reported that pelvic elevation inhibits sufficient contraction of gluteus medius. However, few studies have identified the effects of controlled pelvic elevation on the trunk and hip muscles. Objective: To examine the effects of controlled pelvic elevation using visual biofeedback on the muscle activity of the trunk and hip muscles. Design: Crossover study. Methods: Twelve healthy males performed side-lying hip abduction exercises with and without visual biofeedback for pelvic elevation. Electromyography (EMG) activities of the gluteus medius, quadratus lumborum, and multifidus were analyzed using a wireless EMG system while the ipsilateral pelvic elevation angle was measured using a motion sensor during side-lying hip abduction exercises. Results: EMG activities of the gluteus medius (p = .002), quadratus lumborum (p = .022), and multifidus (p = .020) were significantly increased and ipsilateral pelvic elevation was significantly decreased (p = .001) during side-lying hip abduction with visual biofeedback compared to without visual biofeedback. Conclusions: The results of this study suggest that the application of biofeedback for pelvic motion could improve the trunk and hip muscle activation pattern and decrease compensatory pelvic motion during side-lying hip abduction exercise.

등가 드로오비드를 적용한 Front Side Member의 성형해석 및 충돌평가 (Forming Analysis of the Front Side Member using Equivalent Draw-bead for Crashworthness Assessment)

  • 송정한;김기풍;김승호;허훈;김현섭;홍석길
    • 소성∙가공
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    • 제12권4호
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    • pp.320-327
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    • 2003
  • This paper is concerned with forming analysis of Front Side Members and effects of the forming analysis on crash analysis of an auto-body. For efficient forming analysis, equivalent draw-bead restraining forces are calculated with ABAQUS/Standard and then used as the boundary condition in forming simulation. In order to demonstrate the validity of the forming analysis, the thickness variation in the numerical simulation result is compared quantitatively with the one in the real product. Forming histories obtained kom the forming analysis are utilized as the initial condition of the crash analysis for accurate assessment of the crashworthiness. Crashworthiness such as the load-carrying capacity, crash mode and the energy absorption is evaluated and investigated for the identification of forming effects.

측류유동을 고려한 실린더 주위의 캐비테이션 유동 현상 해석 (SIMULATION OF CAVITATING FLOW PAST CYLINDERS WITH STRONG SIDE-FLOW)

  • 이병우;박원규;이건철
    • 한국전산유체공학회지
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    • 제14권4호
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    • pp.78-85
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    • 2009
  • Cavitating flow simulation is of practical importance for many engineering systems, such as marine propellers, pump impellers, nozzles, injectors, torpedoes, etc. The present work has focused on the simulation of cavitating flow past cylinders with strong side flows. The governing equation is the Navier-Stokes equation based on the homogeneous mixture model. The momentum and energy equation is in the mixture phase while the continuity equation is solved liquid and vapor phase, separately. An implicit dual time and preconditioning method are employed for computational analysis. For the code validation, the results from the present solver have been compared with experiments and other numerical results. A fairly good agreement with the experimental data and other numerical results have been obtained. After the code validation, the strong side flow was applied to include the wake flow effects of the submarine or ocean tide.

Effects of Closed-Sling Exercise on Muscle Activity and Balance; Football Club Player with Chronic Ankle Instability

  • Hong, Seong bum
    • 국제물리치료학회지
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    • 제9권4호
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    • pp.1608-1613
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    • 2018
  • The purpose of this study was to investigate the effects of sling exercise on muscle activity and balance on football players with chronic ankle instability. Eight subjects performed Biodex and sling exercises for four weeks and compared the muscle activity and balance ability of the uninjured and injured feet. Stable and unstable foot % MVIC did not change significantly after treatment in all muscles. The total balance ability was not significantly different between the two groups, however, increased only in the unstable side. The anterior/posterior balance ability also represented no significant difference between the groups and was significantly improved only in the unstable side. The medial/lateral balance ability was not significantly different between the groups and was significantly improved only in the unstable side. This study suggests that sling exercise contributes to improving % MVIC, total balance ability, anterior/posterior balance ability, and medial/lateral balance ability of the unstable side.