• Korean Journal of Environmental Agriculture
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• v.35 no.4
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• pp.278-285
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• 2016

BACKGROUND: Uptake patterns of ${\alpha}$-, ${\beta}$-isomers and sulfate metabolite of endosulfan (ED) by radishes grown in treated soils with ED concentrations of 2 and 10 mg/kg were investigated to establish soil management guidelines for ensuring the safety of radishes from ED residues. METHODS AND RESULTS: All samples of soils and radish plants separated into shoot and root parts were analyzed for ED residues using a gas-chromatography mass spectrophotometer, and the results were used to calculate the bioconcentration factor (BCF), indicating the ratio of ED concentrations between radishes and soils. During the experimental period, uptake and distribution rates of ED-sulfate in radishes were the highest, followed by ${\alpha}$- and ${\beta}$-ED. The BCF values to initial ED concentrations in soils were greater for root parts (0.0077 to 0.2345) than for shoot parts (0.0002 to 0.0429) and used to obtain regression equations by time. Long-term BCFs estimated by the obtained equations ($R^2$ of 0.86 to 1.00) were evaluated with the maximum residue limit (0.1 mg/kg) of ED for radishes, in order to suggest safe management guidelines of ED for radish-cultivating soils. CONCLUSION: Suggested guidelines showed the significant dependency on duration for radish cultivation and exposed concentration of ED in soil.

• Journal of Applied Biological Chemistry
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• v.55 no.1
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• pp.41-46
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• 2012

Arabinoxylan (Ara) rice bran has been shown to be a potent biological response modifier as manifested by stimulation of different arms of the immune system. We examined the effects of Ara rice bran and exercise on the immune function and cytokines in lipopolysaccharide (LPS)-stimulated rats. As the results, tumor necrosis factor-${\alpha}$ as representative inflammatory cytokines showed a significantly lower in Ara supplement group, thus the Ara rice bran had a higher inhibitory activity than the both exercise and control group. However, 4 weeks of exercise training significantly increased inflammatory reactions rather than treatment with Ara in LPS-treated rats. The Ara rice bran acted to decrease the inflammatory reaction. These results suggest that the supplement of Ara rice bran is likely contribute to inflammation response and the Ara rice bran can be used as a possible safe alternative to the immunotherapeutic modalities.

• Journal of Korean Society of Transportation
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• v.34 no.5
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• pp.409-420
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• 2016

Korea is expected to enter 'Super Aged Society' in 2026. However, as walking is the very basic human right of mobility, securing safe and convenient moving of elderly people comprising the majority of transportation vulnerable is thought to be the most basic welfare, which can be easily neglected. From this perspectives, this study provides the walking characteristics of elderly people to be used in design of pedestrian facilities. The analysis of the measurements using Motion Analysis Systems shows that all walking factors of elderly people is 75% level of the younger group. Elderly group shows slower movement, reduced shoulder movement and increased ankle movement compared to the others. Also, foots are risen less and ground repulsive force is increased. Cluster analysis shows that the group of the elderly shows high variability inside the group, and 2 or 3 clusters can be formed with factors of Walking, Balance and Muscles. These walking characteristics can be used in designing pedestrian road, slope and step height of roadway facilities.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.298-305
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• 2023

Burkitt's lymphoma is a distinct subtype of non-Hodgkin's lymphoma originating from B-cells that is notorious for its aggressive growth and association with immune system impairments, potentially resulting in rapid and fatal outcomes if not addressed promptly. Optimizing the use of Food and Drug Administration-approved medications, such as combining known safe drugs, can lead to time and cost savings. This method holds promise in accelerating the progress of novel treatments, ultimately facilitating swifter access for patients. This study explores the potential of a dual-targeted therapeutic strategy, combining the bruton tyrosine kinase-targeting drug Ibrutinib and the epidermal growth factor receptor/human epidermal growth factor receptor-2-targeting drug Lapatinib. Ramos and Daudi cell lines, well-established models of Burkitt's lymphoma, were used to examine the impact of this combination therapy. The combination of Ibrutinib and Lapatinib inhibited cell proliferation more than using each drug individually. A combination treatment induced apoptosis and caused cell cycle arrest at the S and G2/M phases. This approach is multifaceted in its benefits. It enhances the efficiency of the drug development timeline and maximizes the utility of currently available resources, ensuring a more streamlined and resource-effective research process.

• Korean Journal of Clinical Pharmacy
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• v.22 no.3
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• pp.211-219
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• 2012

Nonsteroidal antiinflammatory drugs (NSAIDs) are used in the treatment of extensive diseases related to various symptoms; inflammation, pain and fever. NSAIDs work by blocking prostaglandin synthesis, but adverse drug events (ADEs) have been increasing dramatically such as gastrointestinal bleeding, perforation and stenosis, a kind of serious ADEs. Therefore, NSAID-related ulcer complication guidelines have been announced containing various risk factors and symptoms. Thus, this study aims to evaluate of NSAID usage and appropriateness for prevention of NSAID-related ulcer complication based on American journal of gastroenterology (AJG) guideline 2009. Further, the study suggests Korean guideline for prevention of NSAID-related ulcer compared to AJG guideline. For this study, data was collected through electronic medical record (EMR) at Seoul national university of Bundang hospital. The primary end point was a composite of NSAID-related ulcer risk factor, types of NSAIDs, co-prescribed NSAID ulcer prevention drugs and NSAID-related ulcer after taking NSAID. The risk factors include over 65 years, high dose NSAID, previous ulcer history and taking drugs (e.g. aspirin, anticoagulant and steroid) causing ulcer. If a patient has 3 or 4 factors, that patient was classified high risk group. And if 1 or 2 factors that patient was classified moderate risk group. The patient who has no risk factor was in low risk group. I studied 8,120 patients who received NSAID from 1 January 2009 to 31 December 2009. High risk group was 16(0.2%), moderate risk group was 4,364(53.7%), and low risk group was 3,740(46.1%). The results show that high risk group should be prescribed COX-2 inhibitors with ulcer prevention drugs, and moderate or low risk group need traditional NSAIDs with ulcer prevention drugs. This may be different with 2009 AJG guideline because AJG guideline suggested taking COX-2 inhibitor alone in moderate group or taking traditional NSAID alone in low risk group could get higher ulcer complication. The results indicated that choosing preventive drug is important in case that how many risk factors the patients have. The proper drugs would be helpful for safe and effective NSAID usage in each patient group.

• Culinary science and hospitality research
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• v.19 no.5
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• pp.249-263
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• 2013

This study was performed to analyze the perception, preference and intake frequency of Jangachi(Korean Pickle) in order to develop low salt healthy Jangachi(Korean pickle). The findings are summarized as follows: The reason for eating Jangachi was 'Stimulation of appetite(47.8%).' The problem of commercial Jangachi was 'having high Na and sodium contents(59.1%).' The most influential improvement points for development of low-sodium Jangachi was 'Sanitarily distributed,' followed by 'not too salty,' 'low price,' and 'safe to store.' The important items of manufacture factor for making low-sodium Jangachi were safety(4.36 points), sanity, safekeeping and storage, and quality of ingredients. The important items of quality factor were taste(4.30 points), salinity, nutrition and temperature. The most preferred and frequently intake Jangachi was 'garlic Jangachi', followed by 'perillar leaf Jangachi', 'dried radish Jangachi', 'onion Jangachi', 'pepper Jangachi', 'garlic stem Jangachi', 'cucumber Jangachi', 'radish Jangachi', and 'soy leaf Jangachi'.

• Land and Housing Review
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• v.2 no.2
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• pp.195-204
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• 2011

During mechanical demolition of RC structures, weights of dismantling equipment and demolition waste of building are applied to unexpected load which did not be considered during the design of structural member. Nevertheless, the loading of dismantling equipment and dismantling process are mainly dependent on field managers' field workers' or experiences without considering safety of structural member by a structural engineer. It is urgently required that reflecting actual circumstance of mechanical demolition, safety evaluation method to evaluate the safety and the guideline for appropriate capacity of structural member to support dismantling equipment weight, be provided. Through site investigation and questionnaire on field workers, this paper proposed demolition waste load, load factor, strength reduction factor, and so on. These are essential to safe evaluation of a building, ready to demolition. Considering actual circumstance of mechanical demolition, safety evaluation method of building and design method of slab and beam was suggested to a dilapidated building. An capability to loading of dismantling equipment was proposed, applied to RC slab and RC beam. Therefore, the suggested safety evaluation method and the guideline for an capability to loading of dismantling equipment weight can reasonably evaluate the capacity of structural member in demolition and use effectively as increasing efficiency and improving safety of demolition through proper management of dismantling equipments.

• Korean Journal of Environmental Agriculture
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• v.40 no.3
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• pp.203-210
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• 2021

BACKGROUND: Pesticides can persist in soil due to multiannual uses. To decrease the concerns for potential carry-over of such residues from treated soil during preceding crop cultivation to non-target crops grown in rotation, an uptake study of procymidone was conducted under the actual cultivation conditions in Korea. METHODS AND RESULTS: Procymidone was sprayed twice by foliar application with recommended and double dose according to the safe use guidelines for Korean cabbage up to 14 days before harvest. Arable land was kept fallow for 4 days after harvesting Korean cabbage, and spinach was cultivated as a succeeding crop. Initial residues in soil were 5.670-14.175 mg/kg that were degraded to 3.098-4.555 mg/kg until harvest of Korean cabbage, and then persisted at 1.026-1.300 mg/kg by spinach harvest. Procymidone residues in edible part of succeeding crops from soil uptake were in range of 0.020-0.048 mg/kg for recommended dose and 0.055-0.116 mg/kg for double dose. Root concentration factor (RCF) values of procymidone at different concentration ranged from 0.053 to 0.123, and translocation factor (TF) ranged from 0.176 to 0.768 for spinach. The value of TF was higher than RCF, indicating that the capability of translocation to shoot was relatively higher than that of root uptake and accumulation. CONCLUSION: Procymidone applied on Korean cabbage can be carried-over to spinach and detected at a level similar to MRL (0.05^T mg/kg). Therefore, this study suggests a follow-up study for establishment of plant back interval (PBI) of succeeding crops reflecting the actual agricultural conditions as this study.

• Korean Security Journal
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• no.22
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• pp.231-258
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• 2010

A study apartment house inhabitants of to, crime prevention effort is done satisfaction analysis and that deduce design plan of CPTED that can overcome safe life space embodiment and criminal fear from crime in Juminin viewpoint through atomize group's interaction by background fantast. Is positive because factor analysis wave and satisfaction index of deduce universe (Total group) 8 factor are presented more than all 0, and quite was expose by level that is worth accommodating. Satisfaction index of The secondary design group (Group1) 8 factor is positive because is presented more than all 0, and mechanical access control, mechanical surveillance is level that is worth accommodating quite, and level that is proper in remainder 6 dimension appear. Can know that 1 The secondary design group(Group2) is expose by level that satisfaction characteristic of 8 factor can be presented more than all 0 and appeared positively, and accommodate quite in all dimensions. Result that analyze Two-way ANOVA satisfaction difference of environment design of group by satisfaction of the primary and the secondary design group is high in 8 all dimensions of CPTED, and satisfaction by appeared satisfaction high in group less than natural access control, 2 years of natural surveillance, and reciprocal action effect that go with group is high satisfaction in 2 years low in The secondary design group more than the primary and the secondary design group of systematic access control and natural access control, and the primary and the secondary design group appeared high in subgroup of 2 remainders. Satisfaction difference by group by crime prevention effort satisfaction of the primary and the secondary design group is high in 8 all dimensions of CPTED, and satisfaction difference by crime prevention effort appeared satisfaction high in 'A prize' group to The secondary design group, and reciprocal action efficiency is high in 'A prize' group in The secondary design group more than the primary and the secondary design group in mechanical access control, systematic access control, natural access control, territoriality reinforcement, and satisfaction of 'Between' and 'Very' group appeared high in the primary and the secondary design group.

• Korean Journal of Environmental Agriculture
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• v.32 no.3
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• pp.224-230
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• 2013

BACKGROUND: Perchlorate(${ClO_4}^-$) is an anion that is extremely water-soluble and environmentally stable. It mostly exists in the form of sodium perchlorate, ammonium perchlorate and potassium perchlorate which are used in rocket fuels, propellants, ignitable sources, air bag inflation systems and explosives. Perchlorate can be taken into the thyroid glands and interfere with iodide uptake. The determination of perchlorate in agricultural products is important due to its potential health impact on humans. The objective of this study was to determine the perchlorate concentrations in the samples of various agricultural products and soils. METHODS AND RESULTS: In this study, samples of cereal(Rice, Barley, Corn, Bean), vegetable(Spinach, Lettuce, Sesame, Chives, Chili, Pumpkin, Tomato), fruit(Apple, Pear, Tangerine, Grape) were analyzed for perchlorate contents. Perchlorate concentrations were analyzed by liquid chromatography-tandem mass spectrometry. The results showed that agricultural products respectively contained perchlorate concentrations in the range of : cereals N.D.~$7.46{\mu}g/kg$, vegetables $0.52{\sim}23.06{\mu}g/kg$, fruits $0.19{\sim}2.66{\mu}g/kg$. Bioconcentration factor was in the order of : vegetables > cereals > fruits. Bioconcentration factor was highest follwed by Sesame 37.88, Corn 21.51, Spinach 10.57, Tangerine 4.39, Chives 2.89 and Lettuce 1.90. The recoveries of perchlorate from spiked agricultural products and soils ranged from 87.72~111.26% and 102.09~111.23%. CONCLUSION(S): The health risk assessment results obtained in this study are lower than the RfD(Reference Dose, 0.0007 mg/kg/body weight/day) value as suggested by the Integrated Risk Information System(US IRIS). Our results indicate that, people currently exposed to perchlorate from agricultural products consumption are considered as safe.