• 재활간호학회지
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• 제7권1호
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• pp.7-14
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• 2004

To examine the cognitive function of elderly, the study examined the performance of Korean normal elderly population whose age over 65 using neuropsychological instruments. It was predicted that the performance of the Korean population would be different from the U, S. mainly due to their difference in language, culture, and education. Korean elderly people from the Chungchung and Daejeon Metropolitan city(n=97) participated. Two age scores were developed: below 74 years and over 75 years. The effect of age, gender and education was examined, which yield significant age, gender and education effect. The score of DSF, DSB, TMTA, and TMTB are expected to be utilized for research purposes, such as basic, clinical, epidemiological studies, as well as practice purposes such as diagnosis and assessment of the progression of cognitive decline and dementia with MMSE-K.

• Physical Therapy Rehabilitation Science
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• 제4권1호
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• pp.38-43
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• 2015

Objective: To investigate and compare the size of the rectus femoris (RF), tibialis anterior (TA), and medial gastrocnemius (GMM) using ultrasound (US) imaging in young, elderly, and very elderly groups. Design: Cross sectional study. Methods: This study consisted of 25 young (age 20 years), 24 elderly (age 65-74 years), and 25 very elderly (age 75-90 years) people with no physical dysfunctions. The cross sectional area (CSAs) of the RF and muscle thickness of the TA and GMM were measured at rest and during contraction using an US system. Results: The CSA of the RF and thickness of the TA and GMM were significantly smaller in the elderly and very elderly groups than in the young group (p<0.05). There was a significant difference of the CSA of the RF at rest and during contraction between elderly and very elderly group (p<0.05). In the comparison of the TA and GMM thickness between elderly and very elderly groups, there were no significant differences except for the TA thickness during contraction. There was a significant difference in the percentage change in RF CSA among the three groups (p<0.05). Conclusions: Our results revealed loss of muscle mass in the RF, TA, and GMM in elderly and very elderly people (${\geq}65$ years old). In particular, the greatest age-related decline in muscle mass was observed for the RF. Furthermore, the CSA of the RF declined with aging in the very elderly groups (${\geq}75$ years old).

• International Journal of Oral Biology
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• 제33권2호
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• pp.59-64
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• 2008

This study was designed to investigate the changes in the properties of the neuronal setm cells or progenitor cells associated with age-related decline in neurogenesis of the hippocampal dentate gyrus (DG). Active whole cells cycle marker Ki67 (a marker of whole cell cycle)-positive and S phase marker bromodeoxyuridine (BrdU)-positive. Neural stem cells gradually were reduced in the hippocampal subgranular zone (SGZ) in an age-dependant manner after birth (from P1 month to P1 year). The ratio of BrdUpositivecells/Ki67-positive cells was gradually enhanced in an age-dependent manner. The ratio of Ki67-positive cells/accu-mulating BrdU-positive cells at 3 hrs after BrdU injection was injected once a day for consecutive 5 days gradually decreased during ageing. TUNEL- and caspase 3 (apoptotic terminal caspase)-positive cells gradually decreased in the dentate SGZ during ageing and immunohistochemical findings of glial fibrillary acid protein (GFAP) were not changed during ageing. NeuN, a marker of mature neural cells, and BrdU-double positive cells gradually decreased in an age-dependent manner but differentiating ratio and survival rate of cells were not changed at 4 wks after BrdU injection once a day for consecutive 5 days. The number of BrdU-positive cells migrated from the hippocampal SGZ into granular layer and its migration speed was gradually declined during ageing. These results suggest that the adult neurogenesis in the mouse hippocampal DG gradually decrease through reducing proliferation of neural stem cells accompanying with cells cycle change and reduced cells migration rather than changes of differentiation.

• Human Ecology Research
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• 제61권3호
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• pp.335-348
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• 2023

The purpose of this study was to identify: (a) the latent profiles of the difficulties associated with the schoolto-work transition (decline in confidence, mood swings, family disagreements, the burdens of familial expectations, economic hardship, and a lack of support) made by university students, (b) predictors (gender, age, grade, university location, co-residence with parents on weekdays, monthly household income, and parental educational attainment) of these profiles, and (c) how the profiles were associated with mental wellbeing. The participants of this study were 311 senior or above students (164 males and 147 females) under the age of 29, who were unmarried and preparing for employment. The findings of this study were as follows. First, the latent profile analysis revealed three distinct profiles: the "low overall difficulties" type (25.4%), the "moderate overall difficulties" type (49.9%), and the "high overall difficulties" type (24.7%). Second, the factors that predicted each profile included gender, age, co-residence with parents on weekdays, monthly household income, and parental educational attainment. Third, the "low overall difficulties" type demonstrated the highest level of mental well-being (emotional, social, and psychological well-being). This study was significant for examining the latent profiles of the difficulties associated with the school-to-work transition made by university students preparing for employment, while also exploring their mental well-being. Based on the results of this study, practical implications, limitations, and suggestions for further study were discussed.

• Journal of Preventive Medicine and Public Health
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• 제45권5호
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• pp.323-328
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• 2012

Objectives: Economic growth and development of medical technology help to improve the average life expectancy, but the western diet and rapid conversions to poor lifestyles lead an increasing risk of major chronic diseases. Coronary heart disease mortality in Korea has been on the increase, while showing a steady decline in the other industrialized countries. An age-period-cohort analysis can help understand the trends in mortality and predict the near future. Methods: We analyzed the time trends of ischemic heart disease mortality, which is on the increase, from 1985 to 2009 using an age-period-cohort model to characterize the effects of ischemic heart disease on changes in the mortality rate over time. Results: All three effects on total ischemic heart disease mortality were statistically significant. Regarding the period effect, the mortality rate was decreased slightly in 2000 to 2004, after it had continuously increased since the late 1980s that trend was similar in both sexes. The expected age effect was noticeable, starting from the mid-60's. In addition, the age effect in women was more remarkable than that in men. Women born from the early 1900s to 1925 observed an increase in ischemic heart mortality. That cohort effect showed significance only in women. Conclusions: The future cohort effect might have a lasting impact on the risk of ischemic heart disease in women with the increasing elderly population, and a national prevention policy is need to establish management of high risk by considering the age-period-cohort effect.

• BMB Reports
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• 제52권1호
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• pp.5-12
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• 2019

Organismal aging is accompanied by a host of progressive metabolic alterations and an accumulation of senescent cells, along with functional decline and the appearance of multiple diseases. This implies that the metabolic features of cell senescence may contribute to the organism's metabolic changes and be closely linked to age-associated diseases, especially metabolic syndromes. However, there is no clear understanding of senescent metabolic characteristics. Here, we review key metabolic features and regulators of cellular senescence, focusing on mitochondrial dysfunction and anabolic deregulation, and their link to other senescence phenotypes and aging. We further discuss the mechanistic involvement of the metabolic regulators mTOR, AMPK, and GSK3, proposing them as key metabolic switches for modulating senescence.

• 대한핵의학회지
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• 제35권4호
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• pp.231-240
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• 2001

Purpose: Normal aging results in detectable changes in the brain structure and function. We evaluated the changes of regional cerebral glucose metabolism in the normal aging process with FDG PET. Materials and Methods: Brain PET images were obtained in 44 healthy volunteers (age range 20-69 'y'; M:F = 29:15) who had no history of neuropsychiatric disorders. On 6 representative transaxial images, ROIs were drawn in the cortical and subcortical areas. Regional FDG uptake was normalized using whole brain uptake to adjust for the injection dose and correct for nonspecific declines of glucose metabolism affecting all brain areas equally. Results: In the prefrontal, temporoparietal and primary sensorimotor cortex, the normalized FDG uptake (NFU) reached a peak in subjects in their 30s. The NFU in the prefrontal and primary sensorimotor cortex declined with age after 30s at a rate of 3.15%/decade and 1.93%/decade, respectively. However, the NFU in the temporoparietal cortex did not change significantly with age after 30s. The anterior (prefrontal) posterior (temporoparietal) gradient peaked in subjects in their 30s and declined with age thereafter at a rate of 2.35%/decade. The NFU in the caudate nucleus was decreased with age after 20s at a rate of 2.39%/decade. On the primary visual cortex, putamen, and thalamus, the NFU values did not change significantly throughout the ages covered. These patterns were not significantly different between right and left cerebral hemispheres. Of interest was that the NFU in the left cerebellar cortex was increased with age after 20s at a rate of 2.86%/decade. Conclusion: These data demonstrate regional variation of the age-related changes in the cerebral glucose metabolism, with the most prominent age-related decline of metabolism in the prefrontal cortex. The increase in the cerebellar metabolism with age might reflect a process of neuronal plasticity associated with aging.

• BMB Reports
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• 제54권5호
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• pp.253-259
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• 2021

Aging is characterized by a functional decline in most physiological processes, including alterations in cellular metabolism and defense mechanisms. Increasing evidence suggests that caloric restriction extends longevity and retards age-related diseases at least in part by reducing metabolic rate and oxidative stress in a variety of species, including yeast, worms, flies, and mice. Moreover, recent studies in invertebrates - worms and flies, highlight the intricate interrelation between reproductive longevity and somatic aging (known as disposable soma theory of aging), which appears to be conserved in vertebrates. This review is specifically focused on how the reproductive system modulates somatic aging and vice versa in genetic model systems. Since many signaling pathways governing the aging process are evolutionarily conserved, similar mechanisms may be involved in controlling soma and reproductive aging in vertebrates.

• 재활치료과학
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• 제8권2호
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• pp.43-53
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• 2019

목적 : 본 연구의 목적은 Upper extremity performance test for elderly (TEMPA)의 한국 노인 표준치를 제시하고, 수집된 자료를 바탕으로 한국 노인의 연령별, 성별 손 기능의 특성과 근력의 차이를 알아보는 것이다. 연구방법 : 연구에 참여한 대상자는 60세 이상의 손 기능에 장애가 없는 노인 103명이었다. 손 기능의 특성을 알아보기 위하여 모든 대상자에게 TEMPA 평가를 시행하였고, Jarmar dynamometer, pinch gauge를 사용하여 손과 손가락 근력을 평가하였다. 결과 : 나이가 증가함에 따라 수행 속도와 소 근육의 움직임의 질이 유의미하게 감소하였다. 남성 노인의 수행 속도와 소 근육 움직임의 질이 여성 노인보다 더 높게 유지 되었다. 노인의 손과 손가락의 근력 또한 연령이 증가함에 따라 유의미하게 감소하였다. 결론 : 작업치료사는 노인의 손 기능과 근력 감소에 대한 관심을 가지고 그 기능 수준을 유지하기 위한 중재를 제공하는 것이 필요할 것이다. 본 연구를 통해 TEMPA의 한국 노인 표준치가 확립되었다. 이 자료가 임상적 평가 및 근거 기반의 연구에 있어 유용하게 쓰이기를 기대한다.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권4호
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• pp.261-268
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• 2013

Purpose: To investigate the clinical characteristics and outcomes among infants and toddlers with failure to thrive (FTT). Methods: This retrospective study was done with 123 patients who had visited Pusan National University Children's Hospital during their first two years of life and had received an FTT diagnosis. We compared the clinical characteristics of the patients based on the causes of their FTT and their ages at the time of first hospital visit. We investigated triggering factors, feeding practices, and outcomes in 25 patients with nonorganic FTT (NOFTT). Results: Eighty cases (65.0%) were NOFTT. The gestational ages, birth weights, and weights at the first visits were significantly lower in patients with organic FTT (OFTT) (p<0.05). Infants who had first visited the clinic at age <6 months had the least z-score. The percentage of patients with severe weight decline was higher in OFTT than in NOFTT (60.0% vs. 17.3%). The z-scores at the follow-up visits were improved after treatment in both of the groups. Preceding infection was the most common triggering factor of NOFTT and persecutory feeding as abnormal behavior of caregiver was observed in 22 cases (88.0%). After treatment with feeding method modification, all patients with NOFTT showed normal growth. Conclusion: Weight decline is more severe in OFTT patients and in younger patients at the first visit. Infants with FTT can attain normal weight gain growth by treating organic diseases and supplying proper nutrition in OFTT, and by correcting abnormal dietary behavior of caregiver in NOFTT.