• Title/Summary/Keyword: The UK

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A Study on the EU-UK Agreement for New Relations and New Paradigm of International Law for the Korea-EU-UK Relations (EU-영국의 새로운 관계를 위한 협정과 한국-EU-영국의 관계를 위한 새로운 국제법 패러다임에 관한 연구)

  • Bong-Chul Kim;Ho Kim
    • Korea Trade Review
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    • v.46 no.1
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    • pp.155-168
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    • 2021
  • The EU and the UK apply a treaty to establish new relations from 2021. Brexit is making a big difference in relations among the EU, the UK, and third countries. A new paradigm of international law has begun to be applied to relations among Korea, the EU, and the UK. The UK was excluded from the application of the Korea-EU FTA, and the Korea-UK FTA was applied to trade relations between Korea and the UK. The signing of these new treaties and the changes in the subject to which they apply are impacting the existing international legal system. The countries are showing some response, but it cannot be evaluated as a complete level, and there are still tasks to be solved. Therefore, the legal basis for EU-UK relations, Korea-EU relations, and Korea-UK relations should continue to be laid down in the future. The Korea-UK FTA cannot govern all the problems arising from trade and economic cooperation. Many interests that the UK did not reflect in the course of previous Korea-EU FTA negotiations will be revealed, so a new legal framework for Korea-UK bilateral relations will be established according to the negotiations between the two sides. There should be more detailed research and suggestion of alternatives in the field of law.

Fusion Protein Cleavage by Urokinase Covalentley Immobilized to Activated Sepharose Gels (활성화된 Sepharose Gels에 공유결합으로 고정화된 Urokinase를 이용한 융합단백질 절단반응)

  • 서창우;강관엽;이효실;안상점;이은규
    • KSBB Journal
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    • v.15 no.1
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    • pp.42-48
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    • 2000
  • Urokinase (UK), a thrombolytic enzyme used to clear catheters obstructed by blood clots, can be also used industrially in the recombinant protein purification system to cleave a fusion protein linked with a certain fragment of GST. We have immobilized UK by covalent attachment to activated Sepharose 6B-Cl gels and evaluated its performance to cleave a fusion protein of hGH and GST. The Sepharose gels were activated by etherification with glycidol (2,3-epoxypropanol) and further oxidized with periodate resulting in glyceryl-Sepharose gels. After the activation treatment, surface density of the aldehyde groups was 7-30 $\mu$mol-aldehde/mL-gel. Immobilization yield was higher than 99% at high pH (10.5), and the immobilized UK maintained ca. 80% specific activity of the soluble UK. In a column reaction the cleavage yield heavily depended on the feed rate, and it was nearly 86% of that from soluble UK. And the immobilized UK was successfully regenerated by unfolding and refolding with 6M GuHCl. After cleavaging reaction, the monomeric hGH was purified by using expanded bed adsorption chromatography.

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A Collaborative Study to Establish a Korea National Biological Standard for Antithrombin Concentrate

  • Kang, Hye-Na;Lee, Sung-Han;Kim, Soon-Nam;Hong, Choong-Man;Lee, Ki-Hong;Oh, Ho-Jung;Yoo, Si-Hyung;Shin, In-Soo;Choi, Seung-Eun;Lee, Seok-Ho;Gray, Elaine;Okada, Yoshiaki;Hong, Seung-Hwa
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.272.1-272.1
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    • 2002
  • We have carried out collaborative study to evaluate a preparation of antithrombin concentrate whether or not it was suitable to serve as the candidate for a Korea National Biological Standard. Six laboratories. including three manufacturers and three National Control Laboratories. participated in this study. The potency of this candidate preparation was determined using the heparin cofactor chromogenic method. (omitted)

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RUNX1 Dosage in Development and Cancer

  • Lie-a-ling, Michael;Mevel, Renaud;Patel, Rahima;Blyth, Karen;Baena, Esther;Kouskoff, Valerie;Lacaud, Georges
    • Molecules and Cells
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    • v.43 no.2
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    • pp.126-138
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    • 2020
  • The transcription factor RUNX1 first came to prominence due to its involvement in the t(8;21) translocation in acute myeloid leukemia (AML). Since this discovery, RUNX1 has been shown to play important roles not only in leukemia but also in the ontogeny of the normal hematopoietic system. Although it is currently still challenging to fully assess the different parameters regulating RUNX1 dosage, it has become clear that the dose of RUNX1 can greatly affect both leukemia and normal hematopoietic development. It is also becoming evident that varying levels of RUNX1 expression can be used as markers of tumor progression not only in the hematopoietic system, but also in non-hematopoietic cancers. Here, we provide an overview of the current knowledge of the effects of RUNX1 dosage in normal development of both hematopoietic and epithelial tissues and their associated cancers.

The development of Britain after the European era (后脱欧时代英国的发展走向)

  • Chuan, Zhou
    • Industry Promotion Research
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    • v.2 no.1
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    • pp.113-115
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    • 2017
  • A brief analysis of the impact of the UK off Europe paper on both the positive and negative aspects. For example, in the UK after the EU referendum, out of the shackles of the UK's European Union in the short term, away from the impact of refugees. On the contrary, however, it can have a tremendous impact on the UK's foreign trade and financial industry, while the UK's International will be influenced by the West.

UK's Digital Policies: Focusing on Strategies of AI and International Provisions (영국의 디지털 정책: AI와 국제규범 전략을 중심으로)

  • J.Y., Lee
    • Electronics and Telecommunications Trends
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    • v.37 no.6
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    • pp.11-22
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    • 2022
  • The UK is a service superpower with solid and well-developed financial and insurance services, including FinTech. Much of the UK's service industry is digital and becoming increasingly so. Primary sources constituting the UK's comparative advantage in services could be factored in business conditions driving innovation in the digital age and world-leading digital competitiveness. Therefore, this study examined the UK's digital policies. This research's focal strands were the UK's digital strategy, national artificial intelligence strategy, and digital trade objectives. As an essential insight for policymakers and other stakeholders, this study proposes that government policies in response to the digital economy are inextricably linked, leading to a critical driver for the UK's digital competitiveness.

Survey of Status for Ageing Population, Charge Organizations and Polices in UK

  • Kee, Dohyung
    • Journal of the Ergonomics Society of Korea
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    • v.33 no.5
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    • pp.387-394
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    • 2014
  • Objective: The purpose of this study is to survey trend and the real state of ageing population in UK, and its charge organizations, relevant policies and studies. Background: As in other countries, UK population is ageing and people aged 65 or over account for about 17% of population in UK. Considering this ageing population, there are varying basic studies and policies for older people in UK. Method: First, the author consulted ageing and its policies in UK with some faculties in an UK university. Next, based on the results of consultation, wide literature survey was conducted, which includes papers in relevant academic journals, publications and website surfing. Results: A number of basic studies for surveying status and characteristics of older people as well as simple population trend for them have been conducted in UK. Healthcare services are free for all UK residents, and varying social care services including equipment, home and residential cares, financial support, etc., are provided by local governments. Cost of social cares is means-tested and is not free for everyone. There are a number of governmental or non-profit organizations dedicated to help older people access social care services or to financially fund research projects older people. Conclusion: There are more basic studies, and healthcare and social care services for older people in UK, compared to Korea. Application: It would be useful as basic data for establishing effective polices for old people in Korea.

Effects of UK 14,304, An ${\alpha}_2$-Adrenergic Agonist, on Renal Function in Dog (${\alpha}_2$-아드레날린 효능약인 UK 14,304의 신장기능에 미치는 영향)

  • Ko, Suk-Tai;Kim, Hai-Suk;Choi, Hong-Seok
    • YAKHAK HOEJI
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    • v.41 no.4
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    • pp.498-511
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    • 1997
  • The effects of UK 14,304, an ${\alpha}_2$-adrenergic agonist, on renal function were investigated in dogs. UK 14,304, when given intravenousely($15.0{\mu}g/kg,\;50{\mu}g/kg$), produced the increase of urine flow accompanied with the marked augmentation of free water clearance ($C_{H_2O}$) and reabsorption rates of sodium in renal tubules ($R_{Na}$), and the remarkable decrease of osmolar clearance ($C_{osm}$) and the amounts of sodium excreted in urine ($E_{Na}$). UK 14,304 given into a renal artery($1.5{\mu}g/kg,\;5.0{\mu}g/kg$) elicited the increase of urine flow with the augmentation of $C_{H_2O}$ in both kidney. UK 14,304, when administered into carotid artery($3.0{\mu}g/kg,\;10.0{\mu}g/kg$). exhibited the same aspect as shown in intravenous UK 14.304 at smaller dose than the intravenous dose. Diuretic action of intravenous UK 14,304 were produced together with increase of $C_{H_2O}$ in situation of water diuresis too, changes of renal function in this state were the increase of $C_{osm},\;E_{Na},\;and\;E_K$ (excreted amounts of potassium in urine), and the decrease of $R_{Na}\;and\;R_K$, these were different appearances from situation of saline diuresis. Diuretic action of intravenous UK 14,304 were blocked completely by post or pretreatment of yohim-bine, ${\alpha}_2$-adrenergic blocking agents, and inhibited by pretreatment of vasopressin, antidiuretic hormone. Above results suggest that UK 14,304 produces the diuretic action by the inhibition of vasopressin secretion and suppression of electrolytes reabsorption of electrolytes in renal tubules mediated with central ${\alpha}_2$-adrenoceptor in dog.

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Development of Chemical and Electric Propulsion Systems for Spacecraft in UK (영국의 우주비행체용 화학추진 및 전기추진시스템 개발)

  • HAN, Cho Young
    • Journal of Aerospace System Engineering
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    • v.2 no.1
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    • pp.37-45
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    • 2008
  • KARI has jointly developed COMS bipropellant propulsion system with EADS Astrium, UK. It is well known at the moment about American or even German efforts for space development and space propulsion activities. On the contrary UK's capability for space development hasn't been recognised well in Korea. The major space activities relevant to the development of chemical and electric propulsion systems in UK, in reference to our space propulsion programme are addressed in detail. In addition the collaboration in prospect between two countries is proposed.

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