• Title/Summary/Keyword: The Quaternary

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PREPARATION OF CHITO-OLIGOSACCHARIDE AS AN ANTIMICROBIAL AGENT AND ITS EFFECT ON COTTON FABRICS

  • Seong, Ha-Soo;Kim, Jae-Pil;Ko, Sohk-Won
    • Proceedings of the Korean Fiber Society Conference
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    • 1998.04a
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    • pp.329-333
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    • 1998
  • The major classes of antimicrobial agents for textiles include organo-metallics, phenols, quaternary ammonium salts, and organo-silicones. These finishes should be durable, have selective activity towards undesirable organisms, be compatible with other finishes and dyes, and be nontoxic to man [1]. Chitosan, as a deacetylated derivative of chitin, is a natural, non-toxic and biodegradable polymer. Chitosan is also known as an antimicrobial polysaccharide due to antimicrobial action of the amino group at the C-2 position of the glucosamine residue.(omitted)

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Synthesis and Anti-HIV-1 Activity of Carbocyclic Versions of Stavudine Analogues Using a Ring-closing Metathesis

  • Liu, Lian-Jin;Ko, Ok Hyun;Hong, Joon-Hee
    • Bulletin of the Korean Chemical Society
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    • v.29 no.9
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    • pp.1723-1728
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    • 2008
  • An efficient synthetic route for carbocyclic versions of stavudine analogues and their evaluation on antiviral activity are described. The construction of an ethynylated quaternary carbon at the 4'-position of carbocyclic nucleosides was accomplished using Claisen rearrangement of 11 and ring-closing metathesis (RCM) of dienyne 14 as key transformations. An antiviral evaluation of the synthesized compounds, 20, 21, 22, and 25 against HIV-1, HSV-1, HSV-2, and HCMV showed that only the guanine analogue 25 is moderately active against HIV-1 in the MT-4 cell line ($EC_{50}$ = 11.91 $\mu$mol).

Surface Chemical Properties of Surface Active Aminocyclitol Derivatives (계면활성(界面活性) 아미노싸이클리톨 유도체(誘導體)의 계면화학적(界面化學的) 성질(性質))

  • Sohn, Joo-Hwan;Lee, Chang-Sup
    • Journal of the Korean Applied Science and Technology
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    • v.4 no.1
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    • pp.45-52
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    • 1987
  • Surface chemical properties including surface tension, Ross-Miles foaming power, foam stabilities, emulsifying properties, emulsion stabilities, effectiveness of dispersion, dispersion stabilites of the quaternary ammonium salt type deoxyaminoimositol derivatives such as sixteen kinds of dimethylafkyl-deoxyscyllo-inosityl- dimethylalkyl-2-deoxy-2-myo-inosityl-, dimethylakyl-2-deoxy-2-epi-inosityl- and dimethylalkyl-4-deoxy-4-myo-inosityl ammonium chlorides are tested. And critical micelle concentration of these compounds are estimated from the curves of surface tension and concentration. The experimental results show that the members of this class of compounds have necessary surface active properties to make them effective surfactants.

NMR Characterization of Oxidized Form of Human 8-kDa Dynein Light Chain

  • Shin, Jae-Sun;Jeong, Woo-Jin;Chi, Seung-Wook
    • Journal of the Korean Magnetic Resonance Society
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    • v.14 no.2
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    • pp.127-133
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    • 2010
  • Redox-dependent conformational change of human 8-kDa Dynein light chain (LC8) plays important role in regulating NF-${\kappa}B$ signaling pathway. In this study we characterized the structural states of the oxidized and reduced forms of LC8 by using NMR spectroscopy. The $^1H-^{15}N$ 2D HSQC spectra of oxidized LC8 indicated that no significant change in tertiary structure of LC8 occurred upon oxidation. The chemical shift perturbations of LC8 upon oxidation suggest a redox-dependent quaternary structural change.

The Practical Use of the Productive Aquifer Systems as a Source of a Renewable Thermal Energy and Local Water Works (지방상수도의 신규 수원과 재생에너지원으로서 고산출성 대수층의 활용)

  • Hahn, Jeongsang
    • Journal of Soil and Groundwater Environment
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    • v.23 no.4
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    • pp.16-25
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    • 2018
  • The Quaternary volcanic rocks, clastic sedimentary rocks of Kyongsang System, and carbonate rocks of Joseon and Pyongan System are known as good productive and potential aquifer systems in South Korea. National Groundwater Informaton Mangement and Service System (GIMS) indicates that the exploitable, sustainable, and current use of groundwater are about 18.8, 12.9, and $3.73billion\;m^3/a$, respectively. The rest amount ($9.1billion\;m^3/a$) can still be used for an additional water supply source. Therefore. comprehensive groundwater survey work comprising hydrogeological mapping, subsurface investigation and quantitative aquifer test etc. are highly required to establish rational groundwater management strategy.

Structures of Fraxinellone Derivatives by Hydrogenation with $PtO_2$ in HOAc (백선피의 성분 Fraxinellone의 백금산 촉매에 의한 환원물질의 구조)

  • Kim, Ju Sun;Kang, Sam Sik
    • Korean Journal of Pharmacognosy
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    • v.44 no.1
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    • pp.6-9
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    • 2013
  • Two fraxinellone-based hydrogenated derivatives were prepared from fraxinellone, a well-known degraded limonin, via catalytic hydrogenation in the presence of $PtO_2$ in HOAc. Their structures were confirmed as (3S,3aR,3'R)-3a,7-dimethyl-3-(tetrahydrofuran-3-yl)-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one and (3S,3aR,2'R)-3-((R)-1-hydroxybutan-2-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one on the basis of 2D NMR assignments. The $^{13}C$ NMR assignments of two quaternary carbons in the ${\alpha}$,${\beta}$-unsaturated carbonyl moiety of ${\gamma}$-butyrolactone core of fraxinellone should be revised.

Manufacturing Polymer/clay Nanocomposites Using a Supercritical Fluid Process

  • Jung, Hyun-Taek;Yoon, Ho-Gyu;Lim, Soon-Ho
    • International Journal of Precision Engineering and Manufacturing
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    • v.9 no.4
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    • pp.63-65
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    • 2008
  • The increased interest in reducing the environmental effects caused by releasing organic compounds and aqueous waste has motivated the development of polymeric materials in supercritical fluids. Recently, supercritical fluids have been used in material synthesis and processing because of their special properties, such as high diffusivity, low viscosity, and low surface tension. Supercritical carbon dioxide is the most attractive because it is non-toxic, non-flammable, and has moderate critical temperature and critical pressure values. Supercritical carbon dioxide can also swell most polymers. In this study, we prepared polymer/clay nanocomposites using supercritical fluids. Cloisites 10A, 15A, 25A, and 30B used in this study are montmorillonites modified with a quaternary ammonium salt. The nanocomposites of polymer/clay were characterized by X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry.

Colorimetric Determination of Trace Mercury(II) in Water by Back Extraction and PAR (역추출과 PAR법에 의한 수질중 미량 수은의 비색정량에 관한 연구)

  • 정창웅
    • Journal of Environmental Health Sciences
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    • v.21 no.3
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    • pp.96-101
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    • 1995
  • A selective and highly sensitive spectrophotometric measurements have been developed for the determination of trace mercury(II) with thiosulfate and PAR. Hg(II)-thiosulfate complex was extracted into high molecular alkylamine such as quaternary ammonium salt and back extracted into 1 M-HCl solution. The Hg(II)-PAR complex has maximum absorbance at 499 nm and obeys Beer's law in the range of 0.04~1.0 $\mu g/mL$ of mercury(II). The molar absorptivity and Sandell's sensitivity are $6.27\times 10^4 L.mole^{-1} cm^{-1}$ and $3.2\times 10^{-3}g/cm^2$ respectively.

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Antimicrobial efficacies of alkaline disinfectant solution and commercial disinfectants against Brucella ovis

  • Yoo, Jong-Hyun
    • Korean Journal of Veterinary Service
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    • v.32 no.4
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    • pp.347-351
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    • 2009
  • Bruella spp. involves a considerable danger of public health and farm animal industry. In this study, we assessed the disinfection efficacy of alkaline disinfectant solution and three commercial farm disinfectants (quaternary ammonium compound, sodium dichloroisocyanurate, potassium monopersulphate/sodium dichloroisocyanurate) against Brucella ovis. A bactericidal efficacy test by broth dilution method was used to determine the lowest effective dilution of selected disinfectants following exposure to test bacteria for 30 minutes at $4^{\circ}C$. Disinfectants and test bacteria are diluted with distilled water (DW), hard water (HW) or organic matter suspension (OM) according to treatment condition. Three commercial disinfectant showed excellent antimicrobial activity (up to dilution of $\times200$ in OM treatment). Alkaline disinfectant solution demonstrated favorable bactericidal efficacy against B. abortus (at dilution of $\times20$ in OM treatment). Three commercial farm disinfectants possess excellent efficacy against B. ovis. Alkaline disinfectant solution has lower potency than commercial farm disinfectant but could help to limit the spread of brucellosis.

Antigenicity Study on IDC7181, a Quaternary Ammoniopropenyl Cephalosporin Possessing Two Vinyl Groups (Cephalosporin계 항생제 IDC7181에 대한 항원성시험)

  • 신지순;장호송;최은경;권운;채희열;조영민;김윤배;강종구
    • Toxicological Research
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    • v.19 no.4
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    • pp.321-324
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    • 2003
  • Antigenic potential of a novel cephalosporin, IDC7181 was examined a active systemic anaphylaxis (ASA) and passive cutaneous anaphylaxis (PCA) test, in guinea pig and mouse-rat models, respectively. In ASA test, IDC7181 induced the signs of restlessness in a few animals immunized with a high dose (100 mg/kg) of IDC7181 alone or in combination with Freund's complete adjuvant (FCA). In PCA test, only one of ten sera from the animals immunized with a high dose (100 mg/kg) of IDC7181 in the absence or presence of FCA showed positive reaction. The positive reaction, induced by IDC7181, which may be due to $\beta$-lactam ring, in ASA and PCA tests were negligible in comparison with those of traditional cephalosporins. Taken together, it is suggested that IDC7181 do not cause immunological problems in clinical dosage.