• 제목/요약/키워드: The National Archives

검색결과 2,637건 처리시간 0.031초

Pharmacological Evaluation of the Glycosidated Phenylpropanoids Containing Fraction from Orobanche crenata

  • El-Shabrawy, O.A.;Melek, F.R.;Ibrahim, M.;Radwan, A.S.
    • Archives of Pharmacal Research
    • /
    • 제12권1호
    • /
    • pp.22-25
    • /
    • 1989
  • Ethylacetate fraction from Orobanche crenata, contained two phenylpropanoid glycosides, exhibited some pharmacological properties. It was found to be non-toxic to rats in oral doses up to 500mg/100gm body weight. In large doses, it lowered the arterial blood pressure of anaethetised rats, and produced significant analgesic effect in mice and diuretic effect in rats. It further showed smooth muscle relaxant and antispasmodic effects in the isolated rabbit intestine and guinea-pig ileum respectively.

  • PDF

Synthesis and Biological Effects of 2, 3-Diphenyl-5-Methoxyindole and Substituted Benzophenone Derivatives

  • Hishmat, O.H.;El-Sbabrawy, O.A.;Nakkady, S.S.;Mahmoud, S.S.
    • Archives of Pharmacal Research
    • /
    • 제12권3호
    • /
    • pp.149-153
    • /
    • 1989
  • Seven 2, 3-diphenyl-5-methoxyindole derivatives were synthesized. The effect of structural variation of these molecules on biological activities was examined. None of the tested compounds was found to be toxic up 5 gm/Kg body weight. Four compounds demonstrated smooth muscle relaxant effects and one showed a persistent hypotensive effect. Only the parent compound, 2, 3-diphenyl-5-methoxyindole, showed a significant analgesic effect.

  • PDF

Pharmacological Activities of Water Extracts of Umbelliferae Plants

  • Kim, Chang-Min;Heo, Moon-Young;Kim, Hyun-Pyo;Sin, Kwan-Seog;Pachaly, Peter
    • Archives of Pharmacal Research
    • /
    • 제14권1호
    • /
    • pp.87-92
    • /
    • 1991
  • In order to evaluate the pharmacological activities of Chinese medicine, nine Umbelliferae plants were selected and their restoring activity against dexamethasone-induced disorders, liver protective activity, antimicrobial activity, anti-inflammatory activity and antimutagenic activity were tested and compared. Angelica dahurica. Angelica acutiloba and Ostericum koreanum showed various activities in these tests at the dose used in this study.

  • PDF

Alkaloidal Components of panax ginseng

  • Han, Byung-Hoon;Park, Myung-Hwan;Han, Yong-Nam;Woo, Lin-Keun
    • Archives of Pharmacal Research
    • /
    • 제9권1호
    • /
    • pp.21-23
    • /
    • 1986
  • Over twelve alkaloids were delected in the roots of Panax ginseng C. A. Meyor. Among them three alkaloids were isolated and were identified as $N_{9}$-formylharman, ethyl $\beta$-carboline-1-carboxylate and perlolyrine on the basis of spectroscopic studies.

  • PDF

Lignans of Rosa multiflora Roots

  • Yeo, Hosup;Chin, Young-Won;Park, Shin-Young;Kim, Jin-Woong
    • Archives of Pharmacal Research
    • /
    • 제27권3호
    • /
    • pp.287-290
    • /
    • 2004
  • Five known lignans, (+)-pinoresinol (1), (+)-8-hydroxypinoresinol (2), (-)- dehydrodiconiferyl alcohol (3), (+)-trans-dehydrodiconiferyl alcohol (4), and (-)-olivil (5), were isolated from the roots of Rosa multiflora for the first time. Their structures were determined using spectroscopic data.

Acetophenones from the Roots of Cynanchum wilfordii HEMSLEY

  • Hwang, Bang-Yeon;Kim, Young-Ho;Ro, Jai-Seup;Lee, Kyong-Soon;Lee, Jung-Joon
    • Archives of Pharmacal Research
    • /
    • 제22권1호
    • /
    • pp.72-74
    • /
    • 1999
  • Two acetophenones, cynandione A (1) and cynanchone A (2), were isolated from the roots of Cynanchum wilfordii. Their structures were identified by comparison of their physicochemical and spectral data with reported values.

  • PDF

Isolation of a new sapogenin from alibizzia julibrissin

  • You, Yong-Hyo;Woo, Won-Sick;Park, Jae-Sue;Kang, Sam-Sik
    • Archives of Pharmacal Research
    • /
    • 제5권2호
    • /
    • pp.33-38
    • /
    • 1982
  • From the hydrosate of the strong uterotonic active saponin of Albizzia julibrissin a new sapogenin, mechaerinic acid mmethylester together with acacic acid lactone was isolated and characterized.

  • PDF

Studies on the Anti-inflammatory Activity of Aralia continentalis (II)

  • Han, Byung-Hoon;Park, Myung-Hwan;Han, Yong-Nam;Josefina B.Manalo
    • Archives of Pharmacal Research
    • /
    • 제6권1호
    • /
    • pp.75-77
    • /
    • 1983
  • Two phenolic acids were isolated from the hydrolyzed butanol fraction of Aralia continenetalis K. in crystalline form. They were identified by chemical tests and by analysis of spectra of UV, IR and NMR as ferulic acid and caffeic acid.

  • PDF

A Rubrofusarin Gentiobioside Isomer from Roasted Cassia tora

  • Lee, Hee-Jung;Jung, Jee-Hyung;Kang, Sam-Sick;Choi, Jae-Sue
    • Archives of Pharmacal Research
    • /
    • 제20권5호
    • /
    • pp.513-515
    • /
    • 1997
  • From the roasted seeds of Cassia tora L., a new naphthopyrone glycoside was isolated and characterized as 10-[${\beta}$-D-glucopyranosyl-$(1{\rightarrow}6)-O-{\beta}-D-$glucopyranosyl)oxy]-5-hydrox y-8-methoxy-2-methyl-4H-naphtho[1, 2-b]pyran-4-one(isorubrofusarin gentiobioside). Along with isorubrofusarin gentiobioside, alaternin and adenosine were isolated and identified.

  • PDF

The absolute configuration of ketoprofen

  • Kim, Jin-Woong;Jew, Sang-Sup;Cho, Youn-Sang;Cook, Chae-Ho
    • Archives of Pharmacal Research
    • /
    • 제10권1호
    • /
    • pp.25-28
    • /
    • 1987
  • (+)-Ketoprofen was obtained form resolution with (S) (+)-2-amino-1-butanol and its absolute configuration was determined to be (S) by chemical correlation with (S) (+)-ethyl hydratropate using Beckmann rearrangement as a key step.

  • PDF