• Archives of Plastic Surgery
• /
• v.42 no.5
• /
• pp.658-660
• /
• 2015

• Archives of Pharmacal Research
• /
• v.22 no.4
• /
• pp.398-400
• /
• 1999

Sufentanil, a potent anilidopiperidine analgesic, was synthesized from a simple thiophenylethylamine via six sequence. The key parts of this synthesis involved an efficient construction of thiophenylethylpiperidone by aminomethano desilylation-cyclization followed by Swern oxidation and a direct regioselective N-nucleophilic spiral epoxide cleavage with aniline promoted by Lewis acids.

• Journal of Korean Society of Archives and Records Management
• /
• v.14 no.4
• /
• pp.153-175
• /
• 2014

This paper tries to survey the problems of the archival appraisal system and practice through the appraisal agent, timing, and criteria in Korea. There are two sorts of appraisal criteria that contradict each other. This requires an urgent need for an appraisal policy statement. On this survey result, it suggests the trend to shift from passive and neutral appraisal to participatory appraisal by the active and conscious archivists and records managers.

• Archives of Pharmacal Research
• /
• v.12 no.2
• /
• pp.138-142
• /
• 1989

The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.

• Archives of Pharmacal Research
• /
• v.16 no.2
• /
• pp.168-174
• /
• 1993

The michael adducts 2a, b were obtained from the reaction of the phenylacelyl derivative 1 with benzadehyde and p-anisaldehyde and p-anisaldehyde respectively. 2a and 2b were subjected to react with cyanoethanoic acid hydrazide, malononitrile, cyanothioacetamide, cyanoacetamide and 1, 1, 3-tricyano-2-amino propene to yield 4a-h and 5a, b respecitively. Hydrogen peroxide oxidation of 2a, b gave the aurone derivative 6a, b. The pyone derivatives 8a, b were obtained from 2a, b by addition of chioroacetyl chioride followed by dehydrochlorination.

• Archives of Pharmacal Research
• /
• v.15 no.4
• /
• pp.376-378
• /
• 1992

A chemical tool was developed for the analysis of complex mixtures such as crude drugs by the method of pattern recognition. Pattern recognition was accomplished by a multiple reference peak identification method and three kinds of outlier statistics. This tool was tested on the analysis of synthetic mixtures.

• Archives of Pharmacal Research
• /
• v.6 no.1
• /
• pp.45-53
• /
• 1983

Novel halactolactonizations using NBS (2), NIS(3), and NSP(4) in dry DMF were found to be the most reasonable and efficient procedures. The participation of X as the cylization initiator could be clarly rationalized by experimental results and the regioselectivities of formed halolactones were reasonably elucidated by weakly bridged carbonium ion intermediate.

• Archives of Pharmacal Research
• /
• v.9 no.4
• /
• pp.233-236
• /
• 1986

The flavonoids isolated form the leaves of rhododendron brachycarpum were identified as quercetin, avicularin, quercitrin and hyperin.

• Archives of Pharmacal Research
• /
• v.24 no.5
• /
• pp.412-415
• /
• 2001

Along with five known triterpene glycosides, a new triterpene glucosyl ester, named crataegioside, was isolated from the roots of Rubus crataesifolius Bunge. The structure was established as ilexosapogenin A 28-O-$\beta$-D-glucopyranosyl ester by chemical and spectroscopic methods.

• Archives of Pharmacal Research
• /
• v.14 no.2
• /
• pp.114-117
• /
• 1991

From the leaves of Eucommia ulmoides, quercetin, astragalin, isoquercitrin, quercetin 3-O-$\beta$-D-sambubioside and chlorogenic acid were isolated and characterized by spectral data.