• Journal of Computing Science and Engineering
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• v.6 no.1
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• pp.51-59
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• 2012

We describe the framework of a data-fuelled, interdisciplinary team-led learning system. The idea is to build models using patients from one's own institution whose features are similar to an index patient as regards an outcome of interest, in order to predict the utility of diagnostic tests and interventions, as well as inform prognosis. The Laboratory of Computational Physiology at the Massachusetts Institute of Technology developed and maintains MIMIC-II, a public deidentified high- resolution database of patients admitted to Beth Israel Deaconess Medical Center. It hosts teams of clinicians (nurses, doctors, pharmacists) and scientists (database engineers, modelers, epidemiologists) who translate the day-to-day questions during rounds that have no clear answers in the current medical literature into study designs, perform the modeling and the analysis and publish their findings. The studies fall into the following broad categories: identification and interrogation of practice variation, predictive modeling of clinical outcomes within patient subsets and comparative effectiveness research on diagnostic tests and therapeutic interventions. Clinical databases such as MIMIC-II, where recorded health care transactions - clinical decisions linked with patient outcomes - are constantly uploaded, become the centerpiece of a learning system.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.1 no.1
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• pp.18-22
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• 2008

A ganglion cyst contains clear high viscous fluid within dense fibrous connective tissue wall communicating with joint or tendon sheath, but is not frequent around the knee joint. A hard mass at the medial side of the knee joint of the 73 years old woman, mimic to hard tumor mass was diagnosed as the ganglion using ultrasonography. Ultrasonography was a useful diagnostic tool of the cystic lesion although the consistency of the mass was hard enough to be suspected as a tumor mass.

• Proceedings of the IEEK Conference
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• 2002.07b
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• pp.1137-1140
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• 2002

A V-band low-noise amplifiers (LNA) based on the Millimeter-wave monolithic integrated circuit (MIMIC) technology were fabricated using high performance 0.1 $\mu\textrm{m}$ $\Gamma$-shaped pseudomorphic high electron mobility transistors (PHEMT＇s), coplanar waveguide (CPW) structures and the integrated process for passive and active devices. The low-noise designs resulted in a two-stage MIMIC LNA with a high S$\sub$21/ gain of 14.9 dB and a good matching at 60 ㎓. 20 dBm of IP3 and 3.9 dB of minimum noise figure were also obtained from the LNA. The 2-stage LNA was designed in a chip size of 2.3 ${\times}$1.4 mm$^2$by using 70 $\mu\textrm{m}$ ${\times}$2 PHEMT’s. These results demonstrate that a good low-noise performance and simultaneously with a high gain performance is achievable with GaAs PHEMT's in the 60 ㎓ band.

• Macromolecular Research
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• v.14 no.4
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• pp.449-455
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• 2006

Ionic cluster mimic, polymer electrolyte membranes were prepared using polymer composites of crosslinked poly(vinyl alcohol) (PVA) with sulfated-${\beta}$-cyclodextrins (${\beta}-CDSO_3H$) or phosphated-${\beta}$-cyclodextrins (${\beta}-CDPO(OH)_2$). When Nafion, developed for a fuel cell using low temperature, polymer electrolyte membranes, is used in a direct methanol fuel cell, it has a methanol crossover problem. The ionic inverted micellar structure formed by micro-segregation in Nafion, known as ionic cluster, is distorted in methanol aqueous solution, resulting in the significant transport of methanol through the membrane. While the ionic structure formed by the ionic sites in either ${\beta}-CDSO_3H$ or ${\beta}-CDPO(OH)_2$ in this composite membrane is maintained in methanol solution, it is expected to reduce methanol transport. Proton conductivity was found to increase in PVA membranes upon addition of ionized cyclodextrins. Methanol permeability through the PVA composite membrane containing cyclodextrins was lower than that of Nafion. It is thus concluded that the structure and fixation of ionic clusters are significant barriers to methanol crossover in direct methanol fuel cells.

• Journal of Microbiology and Biotechnology
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• v.28 no.4
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• pp.571-578
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• 2018

Biofuel production using lignocellulosic biomass is gaining attention because it can be substituted for fossil fuels without competing with edible resources. However, because Saccharomyces cerevisiae does not have a ${\text\tiny{D}}$-xylose metabolic pathway, oxidoreductase or isomerase pathways must be introduced to utilize ${\text\tiny{D}}$-xylose from lignocellulosic biomass in S. cerevisiae. To elucidate the biochemical properties of xylose isomerase (XI) from Piromyces sp. E2 (PsXI), we determine its crystal structure in complex with substrate mimic glycerol. An amino-acid sequence comparison with other reported XIs and relative activity measurements using five kinds of divalent metal ions confirmed that PsXI belongs to class II XIs. Moreover kinetic analysis of PsXI was also performed using $Mn^{2+}$, the preferred divalent metal ion for PsXI. In addition, the substrate-binding mode of PsXI could be predicted with the substrate mimic glycerol bound to the active site. These studies may provide structural information to enhance ${\text\tiny{D}}$-xylose utilization for biofuel production.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2013.10a
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• pp.442-444
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• 2013

In this paper, we may by gestures and voice, to know the effect of imitation on the life. Measuring how much about what is imitation unconsciously during conversation to collect data for measuring mimic such speak a short (1 sec) words. It can be used as a basis to predict the outcome of the interview further. Even used as a basis to predict future outcomes. We expect that our group and other researchers will continue to pursue this analysis with larger datasets and across different demographics.

• Journal of the Korean Data and Information Science Society
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• v.20 no.5
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• pp.933-939
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• 2009

The bivariate data in clinical research fields often has two types of failure times, which are mark variable for the first failure time and the final failure time. This paper showed how to generate bootstrap data to get Bayesian estimation for the joint distribution of bivariate survival times. The observed data was generated by Frank's family and the fake date is simulated with the Gamma prior of survival time. The bootstrap data was obtained by combining the mimic data with the observed data and the simulated fake data from the observed data.

• Proceedings of the KSR Conference
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• 2001.05a
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• pp.114-122
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• 2001

As of these, the exterior design of the public transportation systems, especially electric multiple, tends to mimic advanced country's design rather than design of car shape reflecting cultural and spiritual background. However, in the new transportation system, the design which satisfies the transportation demand must be changed into the design which creates transportation demand. In this respect, this research focuses on the factor's embodiment which is perceived by Korean passenger sympathetic to cultural and spiritual needs. The results of this research are Korean AGT design on rubber tire AGT, steel wheel AGT, LM AGT system and environmental design related to AGT systems.

• YAKHAK HOEJI
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• v.30 no.4
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• pp.198-201
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• 1986

The successful elucidation of the opiate receptor and its natural ligands has generated speculation that other drugs might interact with cellular sites designed to accommodate endogenous mediators. The properties of binding sites for the cardiac glycosides(CG), together wit the potency and specificity of the digitalis drugs suggest that CG mimic an endogenous digitalis-like factor. Recenthy, several laboratories have reported the potency in mammalian tissues and fluids of unidentified materials that share certain specific propeties of the CG. Identification of body's own digitalis might yield a natural co pound whose synthetic analogs may provide safer and more effective drugs than can be achieved by structural edification of the CG of plant origin.

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.88-88
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• 2003

The syntheses of different types of stilbenoid libraries have been studied recently. In these courses, the screening of the generated natural product-mimic focused libraries led to the identification of the novel lead compounds for human cytochrome P450 (CYP) lAs, melanin production, and sortase A. A library of trans-stilbene derivatives was prepared through a new efficient solution pahse synthetic pathway and their inhibitory activities were evaluated on human cytochrome P450s(CYP) 1A1, 1A2, and 1B1 to find a potent and selective CYP1 inhibitor. (omitted)