• Biomolecules & Therapeutics
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• v.2 no.2
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• pp.185-189
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• 1994

The eight combined products composed of ranitidine.HCI, tripotassium dicitrato bismuthate and sucralfate were prepared with various ratios and studied in therapeutic effects of them on various gastrointestinal diseases. These were induced in rats with the porous ligation, ethanol-HCI, acetic acid and cysteamine method, etc. In all experimental setting, the effect of the combined treating was more pronounced than the effect of each drug alone. Specially, the combined treatment consisted of ranitidine : tripotassium dicitrato bismuthate sucralfate ratio of 1.5 : 2 : 6 showed the most powerful therapeutic effect on acute gastric ulcer model and revealed a significant acceleration of the healing on chronic gastroduodenal ulcer model. And that, therapeutic doses of ranitidine, tripotassium dicitrato bismuthate arid sucralfate given in combination had an additive or, in some case, synergistic effect. From the above results, this combined treatment may useful to heal the gastrointestinal diseases that aren't cured well by treatment of each them alone.

• Journal of the Society of Naval Architects of Korea
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• v.56 no.1
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• pp.82-93
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• 2019

In this paper, the ductile fracture criteria for a marine structural steel (EH36) are presented and validated. The theoretical background of the recently developed Hosford-Coulomb (HC) fracture strain model and the DSSE fracture strain model which was developed to apply to the shell elements is described. In order to accurately estimate the flow stress in the large strain range up to the fracture, the material constants for the combined Swift-Voce constitutive equation were derived by the numerical analyses of the smooth and notched specimens made from the EH36 steel. As a result of applying the Swift-Voce flow stress to the other notched specimen model, a very accurate load - displacement curve could be derived. The material constants of the HC fracture strain and DSSE fracture strain models were independently calibrated based on the numerical analyses for the smooth and notch specimen tests. The user subroutine (VUMAT of Abaqus) was developed to verify the accuracy of the combined HC-DSSE fracture strain model. An asymmetric notch specimen was used as verification model. It was confirmed that the fracture of the asymmetric specimen can be accurately predicted when a very small solid elements are used together with the HC fracture strain model. On the other hand, the combined HC-DSSE fracture strain model can predict accurately the fracture of shell element model while the shell element size effect becomes less sensitive.

• Wind and Structures
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• v.27 no.1
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• pp.29-40
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• 2018

To investigate the characteristics of the combined wind field produced by the natural wind field and the train-induced wind field on the bridge, the aerodynamic models of train and bridge are established and the overset mesh technology is applied to simulate the movement of high-speed train. Based on ten study cases with various crosswind velocities of 0~20 m/s and train speeds of 200~350 km/h, the distributions of combined wind velocities at monitoring points around the train and the pressure on the car-body surface are analyzed. Meanwhile, the difference between the train-induced wind fields calculated by static train model and moving train model is compared. The results show that under non-crosswind condition, the train-induced wind velocity increases with the train speed while decreases with the distance to the train. Under the crosswind, the combined wind velocity is mainly controlled by the crosswind, and slightly increases with the train speed. In the combined wind field, the peak pressure zone on the headstock surface moves from the nose area to the windward side with the increase of wind velocity. The moving train model ismore applicable in analyzing the train induced wind field.

• Health Policy and Management
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• v.10 no.2
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• pp.1-21
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• 2000

This study reviewde various parametic and nonparametic method for forexasting hospital closures in Korea. We compared multivariate discriminant analysis, multivartiate logistic regression, classfication and regression tree, and neural network method based on hit ratio of each model for forecasting hospital closure. Like other studies in the literture, neural metwork analysis showed highest average hit ratio. For policy and business purposes, we combined the four analytical method and constructed a foreasting model that can be easily used to predict the probabolity of hospital closure given financial information of a hospital.

• International Journal of Highway Engineering
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• v.15 no.4
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• pp.167-175
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• 2013

PURPOSES : The objective of this study is to investigate the capability of the combined model of traffic simulation, emission and air dispersion models on the impact analysis of air quality of mobile sources such as vehicles. METHODS : The improvement of the quality of life brings about the increasing interest of the public environment. Many endeavors including the travel demand management, the application of the state-of-the-art ITS technologies, the promotion of eco-friendly vehicles have been tried in transportation area to reduce the modal emissions. Especially, it is expected that the increasing number of eco-friendly vehicles in the road network would be able to reduce the pipe-tail emissions tremendously. From this perspective, we have performed a study on the impact analysis of the popularization of the eco-friendly vehicle in the place of the fossil fuel energy powered vehicles on the surrounding air quality using the combined framework of microscopic traffic simulation, emission and air dispersion model. RESULTS : The combined model successfully captured the effect of moving to the eco-friendly vehicles on the air quality, and the results showed that the increasing usage of eco-friendly vehicles can improve the surrounding air quality tremendously and that the air dispersion model plays a crucial role in the investigation of the air quality change around the main corridor. CONCLUSIONS : This study demonstrated the capability of the combined model showing the spatio-tempral change of emission concentration.

• Journal of Korean Society on Water Environment
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• v.30 no.1
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• pp.16-24
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• 2014

A combined watershed and receiving waterbody model was developed for operational water flow forecasting of the Nakdong river. The Hydrological Simulation Program Fortran (HSPF) was used for simulating the flow rates at major tributaries. To simulate the flow dynamics in the main stream, a three-dimensional hydrodynamic model, EFDC was used with the inputs derived from the HSPF simulation. The combined models were calibrated and verified using the data measured under different hydrometeological and hydraulic conditions. The model results were generally in good agreement with the field measurements in both calibration and verification. The 7-days forecasting performance of water flows in the Nakdong river was satisfying compared with model calibration results. The forecasting results suggested that the water flow forecasting errors were primarily attributed to the uncertainties of the models, numerical weather prediction, and water release at the hydraulic structures such as upstream dams and weirs. From the results, it is concluded that the combined watershed-waterbody model could successfully simulate the water flows in the Nakdong river. Also, it is suggested that integrating real-time data and information of dam/weir operation plans into model simulation would be essential to improve forecasting reliability.

• Journal of the Earthquake Engineering Society of Korea
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• v.27 no.6
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• pp.275-281
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• 2023

The demand for high-strength steel is rising due to its economic efficiency. Low-cycle fatigue (LCF) tests have been conducted to investigate the nonlinear behaviors of high-strength steel. Accurate material models must be used to obtain reliable results on seismic performance evaluation using numerical analyses. This study uses the combined hardening model to simulate the LCF behavior of high-strength steel. However, it is challenging and complex to determine material model parameters for specific high-strength steel because a highly nonlinear equation is used in the model, and several parameters need to be resolved. This study used the particle swarm algorithm (PSO) to determine the model parameters based on the LCF test data of HSA 650 steel. It is shown that the model with parameter values selected from the PSO accurately simulates the measured LCF curves.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.15 no.2
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• pp.31-39
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• 2019

Cracked component analysis is needed for structural integrity analysis under seismic loading. Under large amplitude cyclic loading conditions, the change in material properties can be complex, depending on the magnitude of plastic strain. Therefore the cracked component analysis under cyclic loading should consider appropriate cyclic hardening model. This study introduces a procedure for determining an appropriate cyclic hardening model for cracked component analysis. The test material was nuclear-grade TP316 stainless steel. The material cyclic hardening was simulated using the Chaboche combined hardening model. The kinematic hardening model was determined from standard tensile test to cover the high and wide strain range. The isotropic hardening model was determined by simulating C(T) test under cyclic loading using ABAQUS debonding analysis. The suitability of the material hardening model was verified by comparing load-displacement curves of cyclic C(T) tests under different load ratios.

• Computers and Concrete
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• v.29 no.5
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• pp.285-301
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• 2022

This study aims at developing a torsional strength model based on a nonlinear analysis method presented in the previous studies. To this end, flexural neutral axis depth of a reinforced concrete section and effective thickness of an idealized thin-walled tube were formulated based on reasonable approximations. In addition, various sectional force components, such as shear, flexure, axial compression, and torsional moment, were considered in estimating torsional strength by addressing a simple and linear strain profile. Existing test results were collected from literature for verifications by comparing with those estimated from the proposed model. On this basis, it can be confirmed that the proposed model can evaluate the torsional strength of RC members subjected to combined loads with a good level of accuracy, and it also well captured inter-related mechanisms between shear, bending moment, axial compression, and torsion.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.32 no.4
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• pp.362-370
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• 2008

In this paper, we propose a 2D-FE model in single impact with combined physical factors to obtain a unique residual stress by shot peening. Applied physical parameters consist of elastic-plastic deformation of shot ball, material damping coefficients, strain rate, dynamic friction coefficients. As a kinematical parameter, there is impact velocity. Single impact FE model consists of 2D axisymmetric elements. The FE model with combined factors showed converged and unique distributions of surface stress, maximum compressive residual stress and deformation depth. Further, in contrast to the FE models with rigid shot and elastic deformable shot, FE model with plastic deformable shot produces residual stresses very close to experimental solutions by X-ray diffraction. We therefore validated the 2D FE model with combined peening factors and plastic deformable shot. This FE model will be a base of the 3D FE model for residual stresses by multi-impact shot peening.