• Biomolecules & Therapeutics
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• v.17 no.4
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• pp.388-394
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• 2009

The cytokines which is produced by allergen-specific T helper (Th) cells play a pivotal role in the pathogenesis of asthma. Asthma is caused by exaggerated T-helper 2 (Th2)-based immune responses. It is suggested that controlling such Th2-based response is necessary for asthma therapy. The current therapies for asthma focus primarily on control of symptoms and suppression of inflammation, without affecting the underlying cause. So, we examined that anti-asthmatic drugs might have play a certain role in Th2/Th1 balance. Splenocytes isolated from ovalbumin (OVA)-sensitized mice cultured with anti-asthmatic drugs. It is well known that Th2 and Th1 immune responses can balance one another, as Th2 mediators suppress Th1 responses and Th1 mediators similarly inhibit Th2 responses. But salmeterol inhibits both of Th1 and Th2 mediators, which salmeterol is a suppressor of immune responses not only a suppressor of Th2-based immune responses. Aminophylline is a weak suppressor of immune responses. But ipratropium and cromoglycate don't have any suppressor effect to Th2-driven responses. They only have suppressor effect to Th1 immune responses. Salmeterol, ipratropium, aminophylline, and cromoglycate augmented mRNA levels of CRTH2, EP2, and IP2 receptors in OVA-sensitized splenocytes. It is well known that the up-regulation of CRTH2 - $PGD_2$ receptor - results in restraint of eosinophil recruitment and that the increment of IP and EP2 - $PGI_2$ and $PGE_2$ receptor, respectively - may induce the accumulation of cAMP that decrease the effector function of T cells. Moreover salmeterol and cromoglycate increase the mRNA expression of $PGD_2$ synthase. These findings indicate that anti-asthma agents may alleviate the immunological responses that cause the asthmatic diseases.

• The Research Journal of the Costume Culture
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• v.16 no.4
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• pp.748-761
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• 2008

This study was initiated out of necessity to inquire into the trend of costume regulation between the mid-15th century and mid-17th century, and what influence the change of dress and its ornaments had on the people at the time. As for the resources this study was based on, the True Record of Joseon Dynasty, which was the historical record of official compilation, was used as basic material, and the excavated relics at the time were referred to. The forbidden dress and ornaments mentioned in the records from the time of King Seonjong to the time of King Hyeonjong were classified into textiles, clothes, ornaments and dresses, according to the objects. It was designed to identify the laws and ordinances or regulations enacted by the state and the contents of discussions, which were caused by the extensive consumption of silk gauze and fabrics and the luxury in dress and ornaments, and the phenomenon induced by the consumption desire of the social class with economic power, and to help understand the cause. So to speak, the law and ordinance or regulations were established to solve the social problems caused by the failure in controlling dress and ornaments wearing based on social position, during the process in which the king and court officials were making effort to intensify their political power in each regime.

• Herbal Formula Science
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• v.17 no.1
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• pp.141-151
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• 2009

We investigated the inhibitory effect of an oral administration of a Sophora flavescens Aiton ethanol extract (SFE) on the development of atopic dermatitis (AD) by using NC/Nga model mice. The induction of atopic dermatitis-like lesion was conducted by the removal of the back hairs and topical application of a mite antigen (Dermatophagoides farinae, Df) on to the back skin twice a week for 8 weeks. SFE was orally administered at a different doses (100-400 mg/kg). Atopic dermatitis-like skin lesions were evaluated by dermatitis scores, skin histology and immunological parameters (serum levels of IgE, TARC/CCL17, MDC/CCL22, and CTACK/CCL27). Oral administration of SFE significantly inhibited the clinical sign of Df-induced atopic dermatitis, including dermatitis score and leukocyte infiltration. Moreover, SFE suppressed significantly the serum IgE and Th2 chemokine (TARC/CCL17, MDC/CCL22, and CTACK/CCL27) levels in a concentration dependent manner. These results suggest that oral administration of SFE could reduce significantly the clinical signs and Th2 chemokines in Df-induced atopic dermatitis model mice. Therefore, SFE may be effective substances for the management of AD in human.

• Journal of the Korean Society of Costume
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• v.52 no.1
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• pp.145-158
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• 2002

The so-called 'Bustle'which was a support put on waist to heave the side the buttocks means the grandiloquent style to express to ideal body. Bustle style. one of the outstanding and remarkable fashion trends in the late 20th century, has significant meaning in fashion history. This is because not only the style has the longest history, but also it has been periodically repeated every end of a century from the 17th to the 20th century. To analyse to cause the Bustle style was shown, I studied first the sign of forthcoming activity of the Bustle style, the change of the Bustle style shown In the times at the end of century and feature of the Bustle style. Based on the previous reasons of appearance of the Bustle style In the history. there are two similarities. First. reaction led to an occurrence of the reactionary tendency, the Bustle style as they were eager for the past because of a feeling of uneasiness about a coming century. Second, the principle of retrogression led to an occurrence of the Bustle style craving for new style. This Bustle style welch was reaction from being tired of the former fashion appeared to expression a desire for new style. In short, Bustle style was an intermediation between different histories and the basis for continuous development of new eras. rather than lust a part of classicism.

• Journal of the Korean Society of Costume
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• v.59 no.8
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• pp.49-65
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• 2009

As basic materials in this research, 874 pieces of engraving that recorded the garment produced by diverse authors in the 17-18th century were collected among the collections of male and female garment in the engraving kept by National Library of France and 216 pieces of engraving were classified among them to observe justaucorps as stated in the materials. Since type of justaucorps in the 18th century can be classified by difference in shape and change through the above engraving materials in large quantity and the shape and composition can be compared and analyzed with other materials such as picture, stored garment, written materials without difficulty, the chronology can be composed by single type of justaucorps. Intending to understand the change in composition caused by type classification and pattern making as per analysis of type property of justaucorps, the men's upper garment in France in the 18th century. Checking change in design per from and materials, justaucorps of 1680-1700s was in silhouette where waist in the length above knee was adhered and slightly spread to lower part. In the type of 1710-1750s, waist adhered remarkably and many pleats were made under waist to produce volume of form that spread to lower part like skirt. In the type of 1760-1780s, straight silhouette was attached to whole body and end of front adjustment in slant line turns to rear part. The developmental aspect of construction can be checked by making pattern. Changing the cutting line of body plate to smoothly connect section and to try to adhere to the body, the development of simpler and delicate pattern production technique was confirmed.

• Journal of Acupuncture Research
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• v.19 no.1
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• pp.24-38
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• 2002

This study was undertaken to examine the effects of acupuncture at LI4 on temperature changes of the facial surface randomly divided into 17 areas. The volunteers who participating in this study had taken rest for 20 - 30 min in room temperature ($23-25^{\circ}C$) before acupuncture and informed them what to prohibit smoking, drinking and drug for the previous one day. The Temperature of facial surface was measured by using Digital Thermography IR 2000 (Meridian Co., Korea) at 5 min before and immediately, 5, 10, and 15 min after acupuncture on LI4. The results of this study showed that there was no significancy in thermal changes of facial surface randomly divided into 17 areas, but different significantly in the aggregate changes at the difference of the thermal changes on facial surface (p < 0.001). The difference of aggregate change was increased time-dependent and the changes at 1st, 3rd, and 13th area were comparatively smaller than the other areas. However, the changes at 6th, 8th, 10th and 15th area were more increased than the others. This study suggests that acupuncture at LI 4 help human being increase the reaction to maintain thermal homeostasis in facial surface and the ability to treat at these area's disease.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.9
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• pp.129-140
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• 2018

The purpose of this study was to reconsider existing hypotheses on the orinination and changes of changbang-anchogongs and their types and suggest an alternative hypothesis. The earliest changbang-anchogongs in $17^{th}$ century is presumed to originate as imitations of chungbang ppaelmoks for ornamental and reinforcing parts for changbangs. They were framed whole sides of buildings equally, and were used in small numbers of extant royal buildings and Buddhist halls. From late $17^{th}$ century, enlarged dragon shape changbang-anchogongs applied to Buddhist halls maily to decorate and strengthen front side of buildings. As a result of exchange between changbang-anchogongs and Ikgong type brackets, combined changbang-anchogongs in Buddhist halls were invented for stronger connection with upper bracketing units and have been spread during $18^{th}$ century. Danpyeongbang anchogongs were originated by the connection between short pieces of pyeongbangs and early type of anchogongs similar to ppaelmoks. They belong to minority subtype, but were drawn in illustrations by mistake, as parts of main halls of royal palaces from $19^{th}$ century, because of painter's confusion about new techniques for changbang-anchogongs. Combined changbang-anchogongs for royal buildings were presumed to be invented in 1790s by stimulation from a Buddhist hall related to royal tomb. However, unlike Buddhist precedence, they were used to reinforce and decorate whole sides, even corners, of buildings, and their frameworks and shapes were imported from Daeryang-anchogongs at flanks of ritual halls in royal tombs and royal shrines from $17^{th}$ century.

• Journal of architectural history
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• v.30 no.4
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• pp.67-78
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• 2021

This is a study on the structural changes of the tumulus and causes setting up a Sabangseok at the front of the tumulus at the royal tomb in the JoSeon dynasty, during the 17th~18th centuries. The Sabangseok was first used in the tumulus of Mongnueng(穆陵) in 1630. It is a multipurpose stone for boundary, foundation of the tumulus and blocking the sliding down of the tumulus. It was set up, when constructing a Yeongneung(寧陵) in 1673. But the vast spill of tumulus soil made it improve structure of the Sabangseok. Consequently, when the Yeongneung was re-constructed, the structure of the tumulus was fundamentally improved. The soil layer on the lime of the subterranean chamber became eliminated. Also the lime of the tumulus and the lime of the subterranean chamber became a united structure. The Sabangseok was still used until 1757 on account of precedents, although it would become unnecessary after structural improvement of the tumulus in 1673. In 1757, Yeongjo(The 21th monarch of the Joseon Dynasty) commanded repeal on the use of the Sabangseok, when constructing the Hongneung(tomb of Queen Jeongseong). The decision and discussions about abolition on the use of the Sabangseok was recorded in Gukjosangryebopyeon.

• Molecules and Cells
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• v.44 no.5
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• pp.318-327
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• 2021

CD4+ T helper (Th) cells play a crucial role in the modulation of innate and adaptive immune responses through the differentiation of Th precursor cells into several subsets, including Th1, Th2, Th17, and regulatory T (Treg) cells. Effector Th and Treg cells are distinguished by the production of signature cytokines and are important for eliminating intracellular and extracellular pathogens and maintaining immune homeostasis. Stimulation of naive Th cells by T cell receptor and specific cytokines activates master transcription factors and induces lineage specification during the differentiation of Th cells. The master transcription factors directly activate the transcription of signature cytokine genes and also undergo post-translational modifications to fine-tune cytokine production and maintain immune balance through cross-regulation with each other. This review highlights the post-translational modifications of master transcription factors that control the differentiation of effector Th and Treg cells and provides additional insights on the immune regulation mediated by protein argininemodifying enzymes in effector Th cells.

• Journal of the Korea Institute of Military Science and Technology
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• v.17 no.6
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• pp.828-835
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• 2014

GC-TSQ CI technique was applied for analysis of samples for the $32^{nd}$ OPCW proficiency test. Eight chemical weapon convention(CWC) related chemicals were identified by product ion mode analysis with GC-TSQ in the samples. Choice of specific precursor ion made it possible to supply selective total ion chromatograms(TICs) of target molecule. GC-TSQ CI anaylsis technique was useful method for chemical warfare agent verification because analysis selectivity was improved by choice of mother molecule as precursor ion and gave mass spectra.