• Asian Pacific Journal of Cancer Prevention
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• v.15 no.5
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• pp.2359-2362
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• 2014

Background: To investigate the effects of double radiofrequency hyperthermia on Th1/Th2 cells in esophageal cancer patients treated with radiotherapy. Materials and Methods: 22 patients with esophageal cancer were divided into a radiotherapy group (10 cases) and a combined group (double radiofrequency hyperthermia combined with radiotherapy group, 12 cases). Both groups received conventional radiotherapy using a cobalt-60 therapy apparatus (TD60-66Gy/30-33F). Patients in the combined group also underwent double radiofrequency hyperthermia (2F/W, 8-10F). Before and after treatment, Th1, Th2, Tc1 and Tc2 cells in peripheral blood were determined with flow cytometry. Results: In the radiotherapy group, Th1 cell contents before and after radiotherapy were $17.5{\pm}5.26%$ and $9.69{\pm}4.86%$, respectively, with a significant difference (p<0.01). The Th1/Th2 ratio was significantly decreased from $28.2{\pm}14.3$ to $16.5{\pm}10.4 $(p<0.01). In the combined group, Th1 cell content before radiotherapy was $15.9{\pm}8.18%$, and it increased to $18.6{\pm}8.84$ after radiotherapy (p>0.05), the Th1/Th2 ratio decreasing from $38.4{\pm}36.3$ to $28.1{\pm}24.0$ (p>0.05). Changes in Th2, Tc1 and Tc2 cell levels were not significant in the two groups before and after therapy (p>0.05). Conclusions: Double radiofrequency hyperthermia can promote the conversion from Th2 to Th1 cells, and regulate the balance of Th1/Th2 cells.

• Korean Journal of Veterinary Research
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• v.43 no.1
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• pp.1-3
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• 2003

The fused lumbar vertebrae (L) of the female Cheju native horse were observed macroscopically. The 5th L and 6th L were partially fused. They were composed of four parts between the spinous process of the 5th L and 6th L, left and right transverse process of the 5th L and 6th L, caudal articular process of the 5th L and cranial articular process of the 6th L, and fossa of vertebra of the 5th L and head of vertebra of the 6th L. The dorsal lumbar foramen and ventral lumbar foramen were formed each at left and right of medial parts in the fused transverse processes of the 5th and 6th lumbar vertebrae.

• English Language & Literature Teaching
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• v.7 no.2
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• pp.1-15
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• 2002

The English education policy of Korea has focused on cultivating communicative competence in Korean students. Especially the 6th national curriculum adopted a notional-functional syllabus instead of a grammatical-structural syllabus. The syllabus design of the 7th curriculum is different from that of the 6th curriculum in that the 6th curriculum adopted just one syllabus design-the Notional-Functional syllabus, but the 7th curriculum includes various syllabus types. The present study has two purposes. The first purpose is to historically survey syllabus design development in Korea : grammatical-structural syllabus(the 1st-5th curriculum), notional-functional syllabus(the 6th curriculum) and a new syllabus model(the 7th curriculum). The second purpose is to analyze the syllabus design of the 7th national curriculum according to the following criteria : a) communicative functional categories, b) sample sentences. The data was collected by analyzing the 7th grade English textbooks adopted on the basis of the 7th national curriculum.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.13 no.1
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• pp.19-35
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• 2009

Objectives : In the study on the waveform analysis of radial artery pulse diagnosis, we need to establish fundamentals of contemporary pulse diagnosis research. To achieve certain experimental basis on traditional pulse diagnosis, we have to research the differences of pulse waveform according to pressure (in 5 level) and position (Chon, Gwan, Cheok in radial artery). As a first step, in present thesis, we tried to find the differences of pulse waveform according to pressure. Methods and Results : In this research, we analyzed seven parameters of the waveform at five levels of pressure. The parameters are E(so called 'energy', a representative of pulse strength), h1(height of percussion wave) and h2(height of subincisura). The results were as follows. 1. When we analyzed the change of the waveform according to pressure in the left Gwan, E, hl, h2 and A differed between 1st and 2nd grade, between 1st and 3rd grade, between 1st and 4th grade, between 1st and 5th grade, between 2nd and 3rd grade, between 2nd and 5th grade, between 3rd and 5th grade and between 4th and 5th grade in 95% confidence interval. 2. And t2, t4 differed between 1st and 2nd grade, between 1st and 5th grade, between 2nd and 4th grade, between 2nd and 4th grade, between 2nd and 5th grade, between 3rd and 4th grade, between 3rd and 5th grade and between 4th and 5th grade in 95% confidence interval. 3. W differed between 1st and 3rd grade, between 1st and 4th grade, between 2nd and 3rd grade, between 2nd and 4th grade, between 2nd and 5th grade, between 3rd and 4th grade, between 3rd and 5th grade, and between 4th and 5th grade in 95% confidence interval. 4. And h2/h1 differed between 1st and 4th grade, between 1st and 5th grade, between 2nd and 4th grade, between 2nd and 5th grade, between 3rd and 4th grade & between 3rd and 5th grade in 95% confidence interval. 5. There were differences between 1st and 2nd grade & between 2nd and 5th grade in the case of t4/t2 in 95% confidence interval. And there were differences between 1st and 5th grade, between 3rd and 4th grade, between 3rd and 5th grade & between 4th and 5th grade in the case of W/A in 95% confidence interval. And were differences between 1st and 2nd grade, between 2nd and 3rd grade, between 2nd and 4th grade, between 3rd and 4th grade, between 3rd and 5th grade & between 4th and 5th grade in the case of A/E in 95% confidence interval. Conclusions : As mentioned above, we conclude that the waveform analysis according to five grade pressure in the left Gwan shows the difference of waveform in each grade pressure.

• Asian Journal of Turfgrass Science
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• v.1 no.1
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• pp.56-68
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• 1987

During the regrowth the process after mowing, NRA in the leaf was the highest activity from the 5th day to the 7th day. Before mowing, the NRA in the root was not almost detected. But, the NRA in root appeared a rapid increasing activity from the 3rd day to the 4th day after mowing ( Figs.27 ~ 32). During the regrowth process after mowing, a general tendency of AA in the aboveground parts appeared an increasing tendency from the 1st day to the 4th day, a rapid increasing tendency from the 7th day to the 8th day reaching its peak, and a decreasing rate on the 8th and 9th day reaching its peak, and a decreasing rate on the 8th and 9th day. But the AA in the root appeared rapid increasing rate from the 2nd day to the 7th day, the heginning of reagrowth, this tendency showed a similar figure in the case of Total Soluble Carbohydrate ( TSC) in the internode. Both AA and NRA were appeared recovery stage frorn the 8th day after mowing(Figs.15~20). During the regrowth process after mowing, changes of the maximum plant lengths were 18.27cm in the 6cm mowing plot on the 24th day after mowing, 18.83cm in the 3cm mowing plot on the 18th day after mowing, and 18.16cm in the 6cm mowing plot on the 14th day after mowing ( Fig.2). During the regrowth process after mowing. changes in Dry Matter (DM) contents in leaf and stem were a slow decreasing tendency from the 1st day to the 4th day. From the 5th day to the 8th day it appeared a rapid increasing tendency. And afterward until the 15th day. All treatments were reached at a steady state ( Figs.3 ~ 8). During the regrowth process after mowing, changes in the TSC contents of stem and crown were a slow decreasing tendency from the 1st day to the 5-6th day. Prom the 7th to the 8th day three was a rapid increasing tendency. And afterward until the 15th day there was a decreasing rate at a steadyv state. In root there was a similar tendency to that of leaf and stem organs. A general tendency in internode, the TSC content appeared a similar figure to increment of AA (Figs. 9 - 14). During the regrowth process after mowing, changes in te Crude Proem (CP) content of ahoveground parts appeared a slow increasing tendency from the 1st day to the 5-6th day, where it is peak. And afterward to the 15th day there was a decreasing rate at a steady state. But, in toot there were a contrary tendency to that of aboveground

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1347-1355
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• 2004

In this study, the immunological effect of a traditional Korea herbal acupuncture, that has been widely used for the treatment of various immunological disorders including inflammation in Korea, was examined in vitro and in vivo. In our previous study demonstrated that BV increased the expression of IFN-γ mRNA, that plays pivotal role in T cell response. This study was designated to evaluate the effect of BV on helper T cell development by monitoring Th1/Th2 specific cytokine secretion patterns in artificially induced Th1/Th2 polarized condition and in vivo. The results demonstrated that BV didn't have mitogenic effects on the unstimulated CD4+ T cell, but increased the CD4+ T cell proliferation upon activation with anti-CD3/CD28 antibody. The Th1 cells were over-populated dramatically in Th1 driven condition with BV treatment, while the Th2 cells were increased slightly in Th2 skewed condition. Furthermore, under Th1-skewed conditions, the level of IFN-γ was considerably increased with BV treatment. Besides, the expression of T-bet, a transcription factor that plays pivotal role in Th1 lineage programming, was increased with BV treatment. The expressions of IFN-γ and T-bet were also significantly increased in vivo. The results that Th1 specific cytokine secretion were considerably increased and Th2 specific cytokine secretion were not significantly changed in vitro and in vivo indicated that BV enhances Th1 lineage development, Therefore, these results suggest that BV might be desirable agent for correction of Th1 dominant pathological disorders.

• Journal of Fisheries and Marine Sciences Education
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• v.25 no.1
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• pp.102-112
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• 2013

The purpose of this study was to investigate the influence of parent and peer attachment on school adjustment of 5th and 6th graders. In order to achieve this research purpose, following research questions were established. First, does attachment to parents influence on school adjustment of 5th and 6th graders? Second, does attachment to peers influence on school adjustment of 5th and 6th graders? Third, what are relative influences of parent and peer attachment on school adjustment of 5th and 6th graders? Three hundred eighty nine 5th and 6th graders in Busan participated in this study and completed Inventory of Parent and Peer Attachment and School Adjustment Scale. Collected data were analyzed using Two-way ANOVA and ${\eta}^2$. The major findings of this study were that parent attachment and peer attachment would significantly influence on school adjustment of 5th and 6th graders; Relative influence of Parent attachment and peer attachment would differ depending upon sub-factors of school adjustment. These results were discussed in terms of theoretical and practical implications. Finally, the limitations of this study were commented and suggestions for future research were made.

• Korean Journal of Plant Resources
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• v.27 no.5
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• pp.567-575
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• 2014

Resveratrol is a naturally occurring stilbene which is safe and well-described compound with a potent anti-inflammatory activity. Recent studies suggested that resveratrol suppressed various inflammation mediated diseases such as asthma, chronic colitis, rheumatoid arthritis, and type 1 diabetes. These studies indicated that resveratrol might directly modulate $CD4^+$ helper T cells (Th cells)-mediated immune responses. However, it is not fully elucidated whether resveratrol directly regulates $CD4^+$ Th cell activation and differentiation. In the present study, $CD4^+$ Th cells were purified from C57BL/6 and treated with various concentrations of resveratrol. We found that resveratrol directly suppressed $CD4^+$ Th cells activation, leading to a defect in T cell proliferation. When $CD4^+$ Th cells were treated with resveratrol, cytokine production was also significantly reduced in a dose dependent manner. In accordance with these results, resveratrol even inhibited $CD4^+$ Th cells differentiation into Th1, Th2 or Th17, which produces IFN-${\gamma}$, IL-4 or IL-17 respectively. We also found that resveratrol could induce apoptosis of $CD4^+$ T cells at a high concentration. Our data demonstrated that resveratrol inhibited directly $CD4^+$ Th cells activation and differentiation. It suggests that resveratrol could be an efficient therapeutic strategy for autoimmune diseases in which $CD4^+$ Th cells play a critical role.

• Journal of Chest Surgery
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• v.25 no.11
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• pp.1169-1179
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• 1992

To determine the period and degree of full recovery of postoperative pulmonary function, the author performed seiral pulmonry function test with spirometry at preoperative period and 1st, 2nd, 3rd, 4th, 6th and 8th postoperative week in 64 patients who underwent chest surgery form 1990. 1. to 1990. 8. at Dep. of Thoracic & Cardiovascular surgery, Pusan National University Hospitcal, Pusan, Korea 28 patients underwent lung resection[Group A], 14 patients mediastinal and other thoracic surgery[Group B], and 22 patients heart surgery with cardiopulmonary bypass[Group C]. Al of them recovered normally and discharged without any complications. Their serial changes of pulmonary function test were compaired and its results was as follows; l. Over all mean recovery time of restrictive ventilatory function tests[ie, VC, ERV, IC, FEF1, FVC, FEF200-1200, MVV] were 4th & 6th postoperative week, and that of obstructive ventilatory function tests[ie., EFE25-75%, Vmax50] were 2nd postoperative week. 2. In patient who underwent lung resection surgery[Group A], FEF1 recovered in 4th~6th postoperative week and its ratio to preoperative value was 70% in pneumonectomy, and 75% in lobectomy. FVC recovered in 4th~6th postoperative week and its ratio to preoperative value was 65% in pneumonectomy, and 80% in lobectomy. MVV was recovered in 4th~8th postoperative week and recovery ratio was 80%, FEF200-1200 was recovered at 4th~6th postoperative week and its recovery ratio was 70%, FEF25-75% and Vmax50 was recovered in 2nd~4th postoperative week and recovered nearly to preoperative level. 3. In patient who underwent mediastinal and other thoracic surgery[Group B], FEV1 and FVC and recovered in 4th~6th postoperative week and the recovery ratio of FVC in blebectomy was 90%. MVV reached preoperative level in 4th~8th postoperative week. FEF200-1200, FEF25-75% and Vmax50 were recovered in 2nd~4th postoperative week and the recovery of FEF25-75% and Vmax50 in blebectomy was prominant. 4. In patient who underwent heart surgery[Group C], FEV1 and FVC were recovered in 4th~6th postoperative week. The recover ratio of FEF25-75% and Vmax50 was delaied to 6th~8th postoperative week From the above results we concluded that the recovery time of posoperative restrictive ventilatory disorder was 4th postoperative week and pulmonary complication would possibly occure during that period. So more intensive observations will be needed.

• The Korean Journal of Zoology
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• v.36 no.2
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• pp.209-222
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• 1993

The present study attempts to explore the first appearance 8nd subsequent development of %cosine hvdroxvlase (TH)-containing neurons in the rat brain from embryonic day (E) 10.5 to the neonate. To increase the senti노ivity and resolution power, a double bridge peroxidase-anti-peroxidase technique was employed for cellular localization of TH. In situ hybridization histochemistw with synthetic TH oligomer (30-mer) codinB TH was also used to detect TH mRNA. TH-containing neurons were first detected at E11.5 in the intermediate zone of prosencepha1on and mesencephalon. At this stage, TH-immunoreactive neurons were small, ovoid bee and emitted their fibres into their immediate surroundings. From this stage, TH-immunoreactive neurons increased in their number and underwent migration and cell differentiation. At E15.5, the distribution pattern of the maior groups of TH neurons was similar to that of adult catecholaminergic groups, and at E19.5 the external laver of median eminence showed TH-immunoreactive processes.