• The Journal of Internal Korean Medicine
• /
• v.41 no.3
• /
• pp.542-551
• /
• 2020

Objectives: The purpose of this study was to retrospectively assess the effectiveness of Chunggan plus extract (CGX) in improving liver function in a Korean medical clinic. Methods: We collected the data of inpatients who received CGX to improve abnormal liver function test (LFT) results from March 2016 to February 2020. We analyzed the changes in LFT and adverse events based on subjective symptom changes and creatinine results. Results: The data of eight patients, three male and five female, were selected by inclusion criteria (patients who did LFT before and after the prescription of CGX and who prescribed CGX more than 6 days) and exclusion criteria (patients who administered other herbal medicine for improving liver function except CGX and who are diagnosed with terminal stage of hepatobiliary cancer). As a cause of abnormal LFT, one case was diagnosed with alcoholic liver disease, two cases with non-alcoholic fatty hepatitis, and one case with cholecystitis. Three of the other four were suspected to have drug-induced hepatitis, and one case was determined to have an unknown cause. Most patients showed a decrease in LFT results (Aspartate transaminase 87.5%, Alanine transaminase 87.5%, and Alkaline Phosphatase 100%) without any critical adverse events. Conclusions: CGX may be an efficient and convenient herbal medicine for improving liver function regardless of the chief impression. Further study should be conducted to evaluate the effectiveness of CGX.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.7 no.5
• /
• pp.147-158
• /
• 2008

Recently, Intelligent Transportation System (ITS) has been actively developed and built since the Transportation System Efficiency Promotion Act was enacted. However, since mutual connection among transportation information systems was not considered, the integration of transportation information services did not occur. Accordingly, the Ministry of Land Transport and Maritime Affairs established and announced the technical standard on ITS. In this study, the conformance testing of the transportation information and communication system interface standard on data exchange between the Transportation Information Center and terminals was researched The test items were categorized as data request tests and data providing tests by analyzing the communication procedures specified in the standard. A detail testing scenario was created for each item. The test assessment was established based on the conformance of data exchange procedures and the accuracy of data packet messages. Under the established technical standard, the number of times that tests should be performed was thought set to 30 and the success rate was set to 95%. The purpose of this study is to help the ITS of Korea perform the integrated management of transportation information by researching methods for conformance testing on the technical standard on ITS.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.23 no.1
• /
• pp.23-43
• /
• 2010

Objective : This study was performed to assess the effects of Aloe and Violae herba extracts on skin disease and skin beauty. Methods : Anti-oxidant effects were measured by the scavenging for DPPH radical, xanthine oxidase activity. Anti-inflammatory effects were examined by relations in NO synthesis, IL-$1{\beta}$, IL-6, TNF-$\alpha$, NF-kB, COX-2, MAP kinase. The skin wrinkle formation effects were measured by collagenase and elastase activities. The whitening effects were examined by tyrosinase activities, melanin synthesis in MNT-1 cell. Results : 1. In an anti-oxidant test, Aloe and Violae herba extracts showed high radical scavenging activity. 2. In an anti-inflammatory test, Aloe and Violae herba extracts strongly inhibited the lipopolysaccharide(LPS)-induced nitric oxide(NO) release from the RAW 246.7 macrophage cells. Aloe and Violae herba extracts also inhibited the LPS-induced IL-$1{\beta}$ and COX-2 expressions. The inhibitory effects of Aloe and Violae herba extracts on macrophage activation were via the inhibition of NF-kB, evidenced by transient transfection assay. Furthermore, Aloe and Violae herba extracts weakly inhibited the activation of Jun-N-terminal kinase(JNK) but they did not have any effects on p38 MAP kinase in RAW 264.7 cells. 3. In the skin wrinkle formation assay, Aloe extract strongly inhibited collagenase and elastase, whose activity are tightly related with the wrinkle formation. 4. In the skin whitening assay, Aloe and Viloae herba extracts weakly inhibited tyrosinase activity, however, it was not statistically significant. Besides they did not have any effects on melanin synthesis, indicating that they could not be applicable for skin whitening. Conclusion : This study show that Aloe and Violae herba extracts may play a significant role in skin disease and skin beauty.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 2016.10a
• /
• pp.638-641
• /
• 2016

UHD(Ultra High Definition) broadcasting is an attractive next-generation service of realistic broadcasting that enables you to feels like listening on the spot in ultra-high definition resolution. In addition, the test broadcasting run by UHD broadcasting agencies and UHDTV terminal launch could herald the full-scale UHD broadcasting era. However, in order that UHD broadcasting will be activated, the function of conditional access control and information protection through which we can on pay per view watch the programs of subscriber preference from the channels of various and subdivided genres is essential. To provide a technical foundation for these features and to achieve the UHD TV transition early, determining technology development & standardization strategy through the analysis of the key protection technologies is required In this paper, we propose standardization technologies which our country can lead and present a long-term driving directions by analyzing UHD broadcasting technology & test broadcasting trends and content protection technology & standardization trends.

• Clinical and Experimental Reproductive Medicine
• /
• v.48 no.1
• /
• pp.27-33
• /
• 2021

Objective: The chief outcome of testicular torsion in clinical and experimental contexts is testicular ischemia. Curcumin, a compound with anti-inflammatory and antioxidant properties, has fascinated researchers and clinicians for its promise in the treatment of fertility diseases. Methods: Thirty-five fully grown male mice were randomly classified into five groups: control, sham, testicular torsion, treatment group 1 (testicular torsion+short-term curcumin), and treatment group 2 (testicular torsion+long-term curcumin). Thirty-five days later, spermatozoa from the right cauda epididymis were analyzed with regard to count and motility. Toluidine blue (TB), aniline blue (AB), and chromomycin A3 (CMA3) staining assays were used to evaluate the sperm chromatin integrity. In addition, the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) test was used to assess apoptosis. Results: Treatment group 1 exhibited a remarkably elevated sperm count compared to the testicular torsion group. Additionally, notably lower sperm motility was found in the testicular torsion group compared to the control, treatment 1, and treatment 2 groups. Staining (CMA3, AB, and TB) and the TUNEL test indicated significantly greater testicular torsion in the torsion group compared to the control group (p<0.05). The data also revealed notably lower results of all sperm chromatin assays and lower apoptosis in both treatment groups relative to the testicular torsion group (p<0.05). Significantly elevated (p<0.05) AB and TB results were noted in treatment group 1 compared to treatment group 2. Conclusion: Curcumin can compensate for the harmful effects of testicular ischemia and improve sperm chromatin quality in mice.

• Journal of Hospice and Palliative Care
• /
• v.26 no.2
• /
• pp.69-79
• /
• 2023

Purpose: This study aimed to investigate the involvement of patients who died from hematologic neoplasms in the decision-making process surrounding the withdrawal of life-sustaining treatment (LST). Methods: A total of 255 patients diagnosed with hematologic neoplasms who ultimately died following decisions related to LST during their end-of-life period at a university hospital were included in the study. Data were retrospectively obtained from electronic medical records and analyzed utilizing the chi-square test, independent t-test, and logistic regression. Results: In total, 42.0% of patients participated in the decision-making process regarding LST for their hematologic neoplasms, while 58.0% of decisions were made with family involvement. Among these patients, 65.1% died in general wards and 34.9% in intensive care units (ICUs) as a result of decisions such as the suspension of LST. The period from the LST decision to death was longer when the decision was made by the patient (average, 27.15 days) than when it was made by the family (average, 7.48 days). Most decisions were made by doctors and family members in the ICU, where only 20.6% of patients exercised their right to make decisions regarding LST, a rate considerably lower than 79.4% observed in general wards. Decisions to withhold or withdraw LST were more commonly made by patients themselves than by their families. Conclusion: The key to discussing the decision to suspend hospice care and LST is respecting the patient's self-determination. If a patient is lucid prior to admission to the ICU, considerations about suspending LST should involve the patient input.

• Journal of the Korean Institute of Gas
• /
• v.27 no.2
• /
• pp.49-56
• /
• 2023

As AI (Artificial Intelligence)-related technologies are highly developed due to the 4th industrial revolution, cases of applying AI in various fields are increasing. The main reason is that there are practical limits to direct processing and analysis of exponentially increasing data as information and communication technology develops, and the risk of human error can be reduced by applying new technologies. In this study, after collecting the data received from the 'remote potential measurement terminal (T/B, Test Box)' and the output of the 'remote rectifier' at that time, AI was trained. AI learning data was obtained through data augmentation through regression analysis of the initially collected data, and the learning model applied the value-based Q-Learning model among deep reinforcement learning (DRL) algorithms. did The AI that has completed data learning is put into the actual city gas supply area, and based on the received remote T/B data, it is verified that the AI responds appropriately, and through this, AI can be used as a suitable means for electricity management in the future. want to verify.

• Korean Journal of Microbiology
• /
• v.49 no.2
• /
• pp.105-111
• /
• 2013

The Erm family of adenine-$N^6$ methyltransferases (MTases) is responsible for the development of resistance to macrolide-lincosamide-streptogramin B antibiotics through the methylation of 23S ribosomal RNA. Recently, it has been proposed that well conserved amino acids in ErnC' located in concave cleft between N-terminal 'catalytic' domain and C-terminal 'RNA-binding' domain interacts with substrate RNA. We carried out the site-directed mutagenesis and studied the function of the ErmSF R237 mutant in vitro and in vivo. R237 amino acid residue is located in the concave cleft between two domains. Furthermore this residue is very highly conserved in almost all the Erm family. Purified mutant protein exhibited only 51% enzyme activity compared to wild-type. Escherichia coli with R237A mutant protein compared to the wild-type protein expressing E. coli did not show any difference in its MIC (minimal inhibitory concentration) suggesting that even with lowered enzyme activity, mutant protein was able to efficiently methylate 23S rRNA to confer the resistance on E. coli expressing this protein. But this observation strongly suggests that R237 of ErmSF probably interacts with substrate RNA affecting enzyme activity significantly.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.9 no.4
• /
• pp.102-112
• /
• 2010

The existing K-CASH system doesn't allow compatible between different regions, different public transportations and the technologies made by different operators. If a K-cash user wants to use public transportation charged not by K-CASH but other operator, then he or she would have to get other type of card available for that transportation. Also, the incompatibility of the existing K-CASH might cause unnecessary expense because similar systems would have to be doubly constructed if the K-CASH operator would like to install the K-CASH system on the same infra as the other operators already did. As a result, a system which allows people to use just one card for their convenience regardless of regions, types of transportation and operators has been strongly demanded. In this paper, we developed Nation-wide Interoperable K-Cash system, Nation-wide Interoperable K-CASH Card, Purchase terminal, Purchase SAM and Settlement system that were updated from the existing K-CASH system. And we performed a conformity test to confirm performance. Also Korea Financial Telecommunications & Clearings and the KORAIL NETWARKS and the HiPlusCard joined for the testbed in Gwangju for 6 months. This result of testbed finally proved that the Nation-wide Interoperable K-CASH system is completely compatible.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.47 no.1
• /
• pp.36-43
• /
• 2020

The aim of this study was to assess the occlusal relationships of primary dentition of Korean preschool children in Hwaseong city. Total 444 children of age group between 2 and 5 years were selected. One pediatric dentist took intraoral photos of children. Evaluation and categorization of the primary molar relationships were done by single examiner. Statistical analysis was performed with Pearson chi-squared test. Total 389 samples, which is consisted of 185 boys, 204 girls were satisfied with inclusion criteria. Bilateral mesial step was seen in 61.7%. Bilateral flush terminal plane was seen in 15.4%. When the primary molar relations of the right and left sides were not the same, the combination of the mesial step and flush terminal plane was 14.7%. The present study provides insight into occlusal relationships in the primary dentition of 2 - 5 years old of Korean children in Hwaseong city. Pediatric dentists should understand occlusal relationships of primary dentition for establishment of appropriate treatment strategies and occlusal guidance.