• Journal of Pharmaceutical Investigation
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• 제23권3호
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• pp.179-186
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• 1993

In vitro dissolution test and pharmacokinetic study in human volunteers were conducted to evaluate the pharmacokinetic characteristics of 150 mg furbiprofen sustained-release capsule (FPSR-150). As a reference product, 50 mg flurbiprofen conventional-release capsule (FPCR-50) was used. Dissolution tests of two products were run using the paddle method in 450 : 540 (v/v %) mixture of simulated gastric and intestinal fluids (K.P. VI) by adjusting medium pH according to time. FPCR-50 was dissolved very rapidly, and it took about 1.5 hr for FPCR-50 to be dissolved over 90%, whereas 15 hr for FPSR-150. Also, in pharmacokinetic study, ten healthy male volunteers were administered one capsule of FPSR-150 or two capsules of FPCR-50 (FPCR-l00) with randomized two period cross-over study. Significant differences between FPCR-l00 and FPSR-150 were found in mean times to reach peak concentration, mean resident times and mean terminal phase halflives, while not in AUC/Dose (Student's t-test). In ANOVA for AUC/Dose to compare the bioavailabilities of two FP products, there was no significant difference. From the comparison of the simulated steady-state plasma concentration-time curves following multiple medications of FPCR-50 (3 capsules a day, dosing interval=8 hrs) and FPSR-150 (1 capsule a day) based on the above results obtained from single doses of two FP products, it was noted that the medication of FPSR-150 is more useful in clinical application rather than FPCR-50.

• Journal of Astronomy and Space Sciences
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• 제29권1호
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• pp.33-40
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• 2012

Triplet Ionospheric Observatory (TRIO) CubeSatforIon, Neutral, Electron MAgneticfields (CINEMA) is a CubeSat with the weight 3 kg that will be operated in the orbit conditions of about 800 km altitude and $90^{\circ}$ inclination angle, using the S-band and ultra-high frequency (UHF)-band communication frequencies. Regarding the communication antenna loaded on the satellite, the two patch antennas has the downlink function in the S-band, whereas the two whip antennas has the function to receive the command sent by the ground station to the satellite in the UHF-band. The uplink ground station that communicates through the UHF-band with the CINEMA satellite was established at Kyung Hee University. The system is mainly composed of a terminal node controller, a transceiver, and a helical antenna. The gain of the helical antenna established at the Kyung Hee University ground station was 9.8 dBi. The output of the transceiver was set to be 5 W (6.9 dB) for the communication test. Through the far-field test of the established system, it was verified that the Roman characters, figures and symbols were converted into packets and transmitted to the satellite receiver in the communication speed of 9,600 bps.

• Journal of Korean Neurosurgical Society
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• 제57권6호
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• pp.445-454
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• 2015

Objective : In the present study we analyzed neuroprotective and antiapoptotic effect of the difumarate salt S-15176, as an anti-ischemic, an antioxidant and a stabilizer of mitochondrial membrane in secondary damage following spinal cord injury (SCI) in a rat model. Methods : Three groups were performed with 30 Wistar rats; control (1), trauma (2), and a trauma+S-15176 (10 mg/kg i.p., dimethyl sulfoxide) treatment (3). SCI was performed at the thoracic level using the weight-drop technique. Spinal cord tissues were collected following intracardiac perfusion in 3rd and 7th days of posttrauma. Hematoxylin and eosin staining for histopatology, terminal deoxynucleotidyl transferase dUTP nick end labeling assay for apoptotic cells and immunohistochemistry for proapoptotic cytochrome-c, Bax and caspase 9 were performed to all groups. Functional recovery test were applied to each group in 3rd and 7th days following SCI. Results : In trauma group, edematous regions, diffuse hemorrhage, necrosis, leukocyte infiltration and severe degeneration in motor neurons were observed prominently in gray matter. The number of apoptotic cells was significantly higher (p<0.05) than control group. In the S-15176-treated groups, apoptotic cell number in 3rd and 7th days (p<0.001), also cytochrome-c (p<0.001), Bax (p<0.001) and caspase 9 immunoreactive cells (p<0.001) were significantly decreased in number compared to trauma groups. Hemorrhage and edema in the focal areas were also noticed in gray matter of treatment groups. Results of the locomotor test were significantly increased in treatment group (p<0.05) when compared to trauma groups. Conclusion : We suggest that difumarate salt S-15176 prevents mitochondrial pathways of apoptosis and protects spinal cord from secondary injury and helps to preserve motor function following SCI in rats.

• 한방안이비인후피부과학회지
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• 제23권3호
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• pp.11-32
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• 2010

Objective : The aim of this study is to determine the effects of Dendrobii herba extract and Punica granatum extract on skin disease and skin beauty. Methods : To investigate in vitro anti-oxidant activity assay, ethanol extracts of medicinal plants tested by DPPH radical, xanthine oxidase activity. In the next experiment, to investigate anti-inflammatory activity assay, examined by relations in NO synthesis, IL-$1{\beta}$, IL-6, TNF-${\alpha}$, NF-${\kappa}B$, COX-2, MAP kinase. To study Skin wrinkle formation effect, we were examined by tyrosinase activities, melanin synthesis in MNT-1 cell. Results : 1. In an anti-oxidant test, Dendrobii and Punica granatum extract showed high radical scavenging activity. 2. In an anti-inflammatory test, Dendrobii herba and Punica granatum extract weakly inhibited the lipopolysaccharide(LPS)-induced nitric oxide(NO) release from RAW 246.7 macrophage cells. Dendrobii herba and Punica granatum extract also inhibited LPS-induced IL-$1{\beta}$ and COX-2 expressions. The inhibitory effect of Dendrobii herba and Punica granatum extract on macrophage activation were via the inhibition of NF-${\kappa}B$, evidenced by transient transfection assay. however, Dendrobii herba and Punica granatum extract did not have any effects about activation of Jun-N-terminal kinase(JNK) and inhibition of p38 MAP kinase in RAW 264.7 cells. 3. In the skin wrinkle formation assay, Dendrobii herba and Punica granatum extract weakly inhibited collagenase and elastase, however it was not statistically significant. 4. In the skin whitening assay, Dendrobii herba and Punica granatum extract weakly inhibited tyrosinase activity, however, it was not statistically significant. They did not have any effect on melanin synthesis, indicating that they could not be applicable for skin whitening. Conclusion : Dendrobii herba extract and Punica granatum extract may play a significant role in skin disease and skin beauty.

• 대한치과보철학회지
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• 제28권1호
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• pp.43-61
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• 1990

The laser reflexion method is a new technique which permits precise contactless measurement and observation of tooth mobility as well as tooth movement. The purposes of this study were to clarify the reliability of the laser reflexion method in clinical application and to measure the abutment tooth movement according to clasp design. This study was designed to determine 1) How much a bending movement of the impression plate stand affects the position of the reflexion pattern and how precise the patient bites into plate 2) Which clasp design causes greater movement of the abutment tooth. Under medium and maximum bite forces, tests were performed on central loading position which was 13mm distal to terminal abutment tooth of distal extension removable partial denture. The movement in the mesiodistal and buccolingual directions was measured. The Duncan's New Multiple-Range test was used to compare the means for the four castings under each direction-load combination; and the paired sample t-test was for medium and maximum bite forces. From this experiment, the following results were obtained. 1. The Roach clasp, the combination clasp, the RPI clasp, and the Akers clasp did not significantly differ in their effects on buccolingual movement of the abutment tooth. 2. The direction of abutment tooth movement was not significantly altered by clasp design and all abutment tooth movements were oriented distobuccally. 3. Under medium bite force, the Akers clasp caused greater distal movement of the abutment tooth than did the combination clasp and the RPI clasp. Under maximum bite force, the Akers clasp caused greater distal movement of the abutment tooth than did the RPI clasp. 4. The testing apparatus and procedures used in this study(laser reflexion method) proved to be reliable in clinical application.

• 한국항해항만학회지
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• 제31권5호
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• pp.377-383
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• 2007

선사들의 자가 터미널 확보, 전략적 제휴 및 M&A, 선박의 대형화는 항만으로 하여금 기항지 축소와 항만간 경쟁을 초래하게 하였다. 이러한 해운 항만의 환경변화는 선사들이 항만평가 기준인 항만선호도, 성장가능성 항만경쟁력 등에 대한 평가도 변하게 하고 있다. 선사들의 항만평가 기준의 변화는 항만이 추구해야 하는 정책방향을 결정하기 때문에 중요한 연구의 주제라고 할 수 있다. 따라서 본 연구에서는 ANVOA 분석과 Duncan 검증을 통해 선사들의 항만 기항선호도, 성장가능성, 항만경쟁력의 평가변수들을 대상으로 전세계 8개 주요항만(싱가포르항, 홍콩항, 상하이항, 부산항, 로테르담항, 함부르크항, 카오슝항, 도쿄항)을 유사 항만군으로 그룹핑하여 평가하고자 한다. 이는 평균차이 검증을 통해 선사들이 전세계 주요 항만을 평가하는 객관적인 평가결과로 사용될 수 있을 것이다.

• 한국정보통신학회논문지
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• 제17권3호
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• pp.730-739
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• 2013

국내 에너지의 30%이상이 조명부문에서 소비되고 있어서 그 소비량과 $CO_2$ 배출량은 점차적으로 늘어날 수밖에 없다. 이와 같은 상황에서 스마트그리드 기반의 전등 제어시스템 구축에는 중요한 의미가 있다. 결과적으로 오늘날 산업현장에서 사용되는 전력선망 통신모뎀과 응용 단말기들을 활용, 본 논문은 PC기반의 전력선망 통신 제어시스템을 구현해봄과 동시에 다양한 통신 테스트 장치 및 도구로 활용하는데 유용할 것이다. 실험을 위해서 사용되는 모뎀은 ZIC 프로토콜 기반의 플래넷 제품을 활용하고 응용프로그램은 랩뷰(LabView)를 사용한다. 그 결과는 주로 저속 전력선 통신에 의한 장치 제어에 초점이 맞추어져 있으며, 전력선 통신 실험을 위한 전력선 통신 테스트 장치로 각종 실험을 수행할 수 있다.

• Journal of Biosystems Engineering
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• 제14권4호
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• pp.272-281
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• 1989

It is desirable for the vertical wind tunnel which can build uniform air flow across the vertical duct to be used for the purpose of the investigation of the aerodynamic properties of grains. This study was conducted to examine how the air velocity profile in the vertical duct is influenced by the various alternations of the elements of the wind tunnel, and to prepare design guidance of the vertical wind tunnel which can be used for investigating aerodynamic properties of grains. In addition, several tests were conducted to locate the test section which can be applicable for determining the terminal velocity of grain. The following conclusions were obtained from the study: 1. The size and the location of the outlet of the plenum chamber should be determined such that the outlet air flow is less affected by the air flow and the back pressure by the side wall of the chamber. 2. The honeycomb was not helpful for attaining uniform air flow in case that the air flow profile at the bottom of the vertical duct is serverely different from the ideal one. 3. Even though considerable pressure drop was resulted from the screens installed within the vertical duct, the screens were helpful for attaining uniform air flow in the duct. 4. It is desirable for the test section to be located at the position that not only the air flow of the duct is not disturbed by the distorted back pressure in the plenum chamber, but also less boundary layer is developed.

• 한국추진공학회지
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• 제18권6호
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• pp.82-87
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• 2014

이중펄스 로켓모타는 두 개의 펄스모타 사이에 격벽 또는 격막을 통하여 1단 펄스모타 연소 후 2단 펄스모타가 연소하는 방식으로 일회성 추력 방식이 아닌 효율적으로 이중추력을 조절한다. 이러한 추력 배분을 통하여 사거리와 종말속도를 증가시켜 미사일의 기동성 및 사거리를 향상시킨다. 본 연구에서는 격막 펄스분리장치를 갖는 소형 이중펄스모타에 설계하였고 지상연소시험을 통하여 특성을 분석하였다. 결과적으로 얻어진 데이터 값들은 향후 F-type 이중펄스모타의 설계에 적용가능할 것으로 판단된다.

• 전기전자학회논문지
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• 제21권4호
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• pp.338-347
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• 2017

본 논문은 TDL(전술 데이터 링크)의 항공용 단말의 구성품인 고출력증폭기의 설계 및 제작에 관해 기술하였다. 동일한 주파수 대역을 사용하는 레이다 및 다른 통신장비와 한정된 주파수 자원을 효율적 사용이 가능하도록 고속주파수도약기술, 인지무선기술, 수신필터뱅크 기술을 적용하였다. 고출력증폭기는 물리적으로 송신부, 수신부, 기구부, 케이블조립체로 구성되며, 최대 전송 거리, 수신감도 등의 전기적 특성과 온도 특성을 충족하도록 설계되었다. 고출력증폭기의 요구 규격을 만족하기 위해 모델링 및 시뮬레이터를 이용하였다. 송신 출력과 잡음 지수는 각각 50.02dBm 및 2.682dB로 측정되었다. 전기적 특성 시험 및 환경 특성 시험으로 요구 규격을 모두 만족함을 확인하였다.