• Toxicological Research
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• v.17 no.3
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• pp.203-213
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• 2001

We investigated the toxic effects of propylthiouracil (PTU) In Sprague-Dawley (SD) rats to develop and validate an enhanced Protocol for Test Guideline 407 as OECD Project. Twenty male and female SD rats,7 weeks old, were treated with PTU in corn oil at levels of 0, 0.1, 1 and 10 mg/kg/day for 4 weeks orally. Clinical observation, body weight changes, food uptake, water consumption, urinalysis, estrus cycle and sperm analysis, serum chemist교, autopsy findings and histopathological findings were evaluated in this study. No clinical signs and mortality were observed in the study. The body weights and food uptakes in the group treated with 10 mg/kg/day were reduced from 3 weeks after the initiation of the treatment. The levels of 3,5,3'-triiodothyronine (T3) and thyroxine (T4, 3,5,3',5'-tetraiodothyrosine) were also significantly decreased in the group treated with 10 mg/kg/day. Also, the relative and absolute organ weights of thymuses were decreased. Thyroid glands of rats in the group treated with PTU 10 mg/kg/day were bigger than those of rats in the control group. In the histopathological examination, diffuse hyperplasia and hypertrophy of thyroid follicular cells were observed in all treatment groups, leading to the reduction of lumen size and papillary enfolding of lining epithelium. The degree of lesion was increased in a dose-dependent manner. The results suggested that PTU would cause toxicity in thyroid gland and decrease the levels of T3 and T4 in SD rats. However there were no effects on the other organ including testis and uterus especially in spermatogenesis and estrus cycle. On the basis of the results, enhanced protocol for Test Guideline (TG) 407 may be sensitive and reliable to detect endocrine-active substances like PTU.

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.128-128
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• 2002

In association with the international validation project to establish a test protocol for the "Enhanced OECD Test Guideline 407", we performed a 28-day repeated-dose toxicity study of vinclozolin (VCZ), an androgen antagonist, and ketoconazole (KCZ), a biosynthesis inhibitor of testosterone (T), and assessed the sensitivity of new parameters for detecting endocrine-related effects of endocrine-disrupting chemicals.(omitted)

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.05a
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• pp.128-128
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• 2002

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.3
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• pp.509-517
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• 2016

This study examined the influence of patient safety culture and safety care activities of general hospital nurses. The participants were 178 nurses working in a hospital in D and G cities. Data were collected from June to July, 2015 through Questionnaires that included the Measure of Patient Safety Culture by Kim et al.(2007), and the Measure of Safety Care Activities by Lee(2009). The collected data were analyzed by descriptive analysis, t-test, One-way ANOVA, Pearson correlation coefficients, and stepwise Multiple regression. A statistically significant positive relationship was observed between the nurses perception of the patient safety culture and their safety care activities (r=.407, p<.001). The findings show the patient safety culture accounted for 43.3% of the variance in the safety care activities for hospital nurses followed by the importance of hospital work environment among nurses to improve the safety care activities. These findings highlight the need to develop effective programs to improve the perception of patient safety culture and safety nursing guideline.