• Biomolecules & Therapeutics
• /
• v.5 no.2
• /
• pp.117-124
• /
• 1997

The analgesic effects of DA-5018, a new caosaucin derivative, were evaluated in various experimental pain models. Drugs were administered subcutaneously or topically. When drugs were administered subcutaneously, 1) the $ED_{50}$ of DA-5018, morphine . HCI, capsaicin and acetaminophen were 0.091-2.0, 0.3-4.3, 1.4-26.5 and 45.4-643 mg/kg, respectively in various pain or inflammatory models including acetic acid writhing, formalin, tail flick, Randall-Selitto, hot plate and crouton oil-induced ear edema test, 2) the AD2 values (the dose for doubling of pain threshold of vehicle control) of DA-5018, capsaicin and ketoprpgin were 1.07 $\pm$ 0. 18, 23.47$\pm$4.46 and 2.97$\pm$0.43 mg/kg in Freund's complete adjuvant (FCA)-induced arthritic pain model. And by topical application, 1) neither DA-5018 0.3% cream nor Zostrix-HP (capsaicin 0.075%) were effective in formalin test, 2) although DA-5018 0.3% cream significantly inhibited the croton oil-induced ear edema being better than Zostrix-HP and Kenofen (ketoprofen 3%). 3) In FCA model, DA-5018 0.3% cream reversed the decreased pain threshold of arthritic rat from 136.4 g (day 0) to 289.0 g (day 5) and 250.1 g (day 10), which was similar to Zostrix-HP. These results suggest that DA-5018 administered subcutaneously has a potent and broad analgesic spectrum than nonsteroidal antiinflammatory drugs against acute and chronic pain, and by topical application it exerts comparable analgesic and antiinglammaatory effects to capsaicin cream.

• Asian-Australasian Journal of Animal Sciences
• /
• v.31 no.5
• /
• pp.636-642
• /
• 2018

Objective: The objective of this study was to estimate genetic parameters of milk, fat, and protein yields within and across lactations in Tunisian Holsteins using a random regression test-day (TD) model. Methods: A random regression multiple trait multiple lactation TD model was used to estimate genetic parameters in the Tunisian dairy cattle population. Data were TD yields of milk, fat, and protein from the first three lactations. Random regressions were modeled with third-order Legendre polynomials for the additive genetic, and permanent environment effects. Heritabilities, and genetic correlations were estimated by Bayesian techniques using the Gibbs sampler. Results: All variance components tended to be high in the beginning and the end of lactations. Additive genetic variances for milk, fat, and protein yields were the lowest and were the least variable compared to permanent variances. Heritability values tended to increase with parity. Estimates of heritabilities for 305-d yield-traits were low to moderate, 0.14 to 0.2, 0.12 to 0.17, and 0.13 to 0.18 for milk, fat, and protein yields, respectively. Within-parity, genetic correlations among traits were up to 0.74. Genetic correlations among lactations for the yield traits were relatively high and ranged from $0.78{\pm}0.01$ to $0.82{\pm}0.03$, between the first and second parities, from $0.73{\pm}0.03$ to $0.8{\pm}0.04$ between the first and third parities, and from $0.82{\pm}0.02$ to $0.84{\pm}0.04$ between the second and third parities. Conclusion: These results are comparable to previously reported estimates on the same population, indicating that the adoption of a random regression TD model as the official genetic evaluation for production traits in Tunisia, as developed by most Interbull countries, is possible in the Tunisian Holsteins.

• Journal of Korea Multimedia Society
• /
• v.25 no.10
• /
• pp.1448-1456
• /
• 2022

This paper studies a model to diagnose efficiency reduction of inverter using Multilayer Perceptron(MLP). In this study, two inverter data which started operation at different day was used. A Multilayer Perceptron model was made to predict photovoltaic power data of the latest inverter. As a result of the model's performance test, the Mean Absolute Percentage Error(MAPE) was 4.1034. The verified model was applied to one-year-old and two-year-old data after old inverter starting operation. The predictive power of one-year-old inverter was larger than the observed power by 724.9243 on average. And two-year-old inverter's predictive value was larger than the observed power by 836.4616 on average. The prediction error of two-year-old inverter rose 111.5572 on a year. This error is 0.4% of the total capacity. It was proved that the error is meaningful difference by t-test. The error is predicted value minus actual value. Which means that PV system actually generated less than prediction. Therefore, increasing error is decreasing conversion efficiency of inverter. Finally, conversion efficiency of the inverter decreased by 0.4% over a year using this model.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.37 no.1
• /
• pp.37-48
• /
• 1995

The TIDE, nonlinear finite element model for the simulation of tidal analysis in a shal- low ooastal area was tested for its applicability at the Saemankeum day. Calibration of the TIDE model has been carried out using the six observed field data collected at five locations within the region for tidal velocity. Verification tests have been done using the six observed field data and four data o- tained from the hydraulic model test for the tidal velocity and elevation. Since the simula- tion results for the tidal elevation at Kunsan outer port by the TIDE model are well agreed with the results from the tidal table for one month, it is proved that the TIDE model may be used effectively to predict the tidal movement in the Saemankeum bay for a longer period.

• Journal of Biosystems Engineering
• /
• v.35 no.2
• /
• pp.91-99
• /
• 2010

A Model of small scale total mixed rations(TMR) plant which can be utilized round bales was developed, tested and analyzed in this study. This study consist of two parts. One is development of a small scale TMR plant model which was already reported at the previous paper. This is the second part of the study. For the study, a series of tests of the model plant were performed and its costs was analyzed. Also, the break-even point of the model plant by comparing with market price of commercial TMR feed was determined. Results of the research are summarized as follows ; As the results of mixing test, the average coefficient of variation(CV) value for mixing of the feed was 13.0 % at the gate of the mixer. The production cost was estimated as 8,298 won/head for dairy cattle farm and 2,495 won/head for beef cattle farm, when producing 8 batch a day. Also, it is recommended to utilize the model plant when farm size is over 79 heads for dairy cattle farm and 113 heads for beef cattle farm. As an overall conclusion, the model plant designed for farm size TMR feed mill will be very useful model for both beef cattle and dairy farms in Korea. Also it is expected that the capital investment for the model plant can be recovered with 8 months compare with purchasing commercial TMR feed if the model plant feeds 1,000 beef cattle approximately.

• Biomolecules & Therapeutics
• /
• v.25 no.3
• /
• pp.259-265
• /
• 2017

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey's test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4-L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.

• Natural Product Sciences
• /
• v.22 no.4
• /
• pp.246-251
• /
• 2016

This study investigated the effects of (-)-sesamin on memory deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD). MPTP lesion (30 mg/kg/day, 5 days) in mice showed memory deficits including habit learning memory and spatial memory. However, treatment with (-)-sesamin (25 and 50 mg/kg) for 21 days ameliorated memory deficits in MPTP-lesioned mouse model of PD: (-)-sesamin at both doses improved decreases in the retention latency time of the passive avoidance test and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid, improved the decreased transfer latency time of the elevated plus-maze test, reduced the increased expression of N-methyl-D-aspartate (NMDA) receptor, and increased the reduced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-response element binding protein (CREB). These results suggest that (-)-sesamin has protective effects on both habit learning memory and spatial memory deficits via the dopaminergic neurons and NMDA receptor-ERK1/2-CREB system in MPTP-lesioned mouse model of PD, respectively. Therefore, (-)-sesamin may serve as an adjuvant phytonutrient for memory deficits in PD patients.

• Asian-Australasian Journal of Animal Sciences
• /
• v.24 no.12
• /
• pp.1757-1762
• /
• 2011

Aflatoxins are natural contaminants of poultry feeds and feed ingredients and cause liver damage, immunosuppression, reduction in performance and mortality in broilers. A number of studies have been carried out to study the effects of aflatoxin on feed conversion ratio in broilers. The results on feed conversion ratio of 10 research articles in broilers fed with aflatoxin from first day of age to six weeks of age were compiled and were subjected to meta-analysis. Chi-square test and $Tau^2$ (heterogeneity co-efficient) were applied to test for significance of heterogeneity of studies. To integrate results, fixed effect model by Inverse Variance method (IV method) was used when heterogeneity was insignificant and otherwise random effect model by DerSimonian and Laird Method (DL method) was used. The results of meta-analysis showed that the adverse effect of aflatoxin on feed conversion ratio at the end of first week was negligible, second week was medium and third to six weeks was very large.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2001.05a
• /
• pp.215-220
• /
• 2001

The objective of this study is to examine the fracture characteristics of concrete at early ages such as critical stress intensity factor, critical crack-tip opening displacement, fracture energy based on the concepts of the effective-elastic crack model and the cohesive crack model. A wedge splitting test for Mode I was performed on cubic wedge specimens with a notch at the edge. By varying strength and age, load-crack mouth opening displacement curves were obtained and the results were analyzed by linear elastic fracture mechanics. The results from the test and analysis showed that critical stress intensity factor and fracture energy increased, and critical crack-tip opening displacement decreased with concrete age from 1 day to 28 days. The obtained fracture parameters at early ages may be used as a fracture criterion and an input data for finite element analysis of concrete at early ages.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.27 no.6
• /
• pp.17-22
• /
• 2013

Fuzzy linear regression method has been used for short-term load forecasting of the special day in the previous researches. However, considerable load forecasting errors would be occurring if a special day is located on Saturday or Monday. In this paper, a new load forecasting method for the consecutive holidays is proposed with the consideration of the power demand variation rate. In the proposed method, a exponential smoothing model reflecting temperature is used to short-term load forecasting for Sunday during the consecutive holidays and then the loads of the special day during the consecutive holidays is calculated using the hourly power demand variation rate between the previous similar consecutive holidays. The proposed method is tested with 10 cases of the consecutive holidays from 2009 to 2012. Test results show that the average accuracy of the proposed method is improved about 2.96% by comparison with the fuzzy linear regression method.