• Asian-Australasian Journal of Animal Sciences
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• v.30 no.10
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• pp.1382-1387
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• 2017

Objective: During the last decade, genetic evaluation of dairy cows using longitudinal data (test day milk yield or 305-day milk yield) using random regression method has been officially adopted in several countries. The objectives of this study were to estimate covariance functions for genetic and permanent environmental effects and to obtain genetic parameters of 305-day milk yield over seven parities. Methods: Data including 60,279 total 305-day milk yield of 17,309 Iranian Holstein dairy cows in 7 parities calved between 20 to 140 months between 2004 and 2011. Residual variances were modeled by homogeneous and step functions with 7 and 10 classes. Results: The results showed that a third order polynomial for additive genetic and permanent environmental effects plus a step function with 10 classes for the residual variance was the most adequate and parsimonious model to describe the covariance structure of the data. Heritability estimates obtained by this model varied from 0.17 to 0.28. The performance of this model was better than repeatability model. Moreover, 10 classes of residual variance produce the more accurate result than 7 classes or homogeneous residual effect. Conclusion: A quadratic Legendre polynomial for additive genetic and permanent environmental effects with 10 step function residual classes are sufficient to produce a parsimonious model that explained the change in 305-day milk yield over consecutive parities of Iranian Holstein cows.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.6
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• pp.1034-1041
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• 2010

The oriental medicine Jangwonhwan, which is a boiled extract of 12 medicinal herbs/mushroom, has been prescribed for patients with cognitive dysfunction and it is originally from the Korean medical text, DonguiBogam(amnesia chapter). Recently, a modified recipe of Jangwonhwan (LMK02-Jangwonhwan) consisting of seven medicinal plants/mushroom, was shown to reduce ${\beta}$-amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model of Alzheimer disease. The toxicity of LMK02 was investigated in SD rats by oral repeated adminstration for 4 weeks and we tried to determine test does for 13 weeks repeated study. Quality control of tablet form of LMK02 was established by estimating indicative components, Ginsenoside Rg3 of Red Ginseng and Decursin of Angelicagigas Nakai. The toxicity of LMK02 was investigated in 6 weeks old specific pathogen free (SPF) Sprageu-Dawley rats by oral administration. Each test group were consist of 5 male and 5 female and they received doses of 500, 1,000 and 2,000 mg/kg/day of test substance for 4 weeks. The clinical signs, death rate, body weight, food consumption, ophthalmic examination, urinalysis, hematological and serum biochemistry, organ weight and pathological changes were examined and compared with those of control group. Urinalysis : We observed increase of PRO(p<0.01), SG(p<0.01) in female rats of 1,000 mg/kg/day and 2,000 mg/kg/day(p<0.01). Also, we observed increase of pH and KET in female rats of 1,000 mg/kg/day(p<0.05) and of 2,000 mg/kg/day(p<0.01). WBC in female rats in 1,000 mg/kg/day and 2,000 mg/kg/day were on increase. Hematological test : We observed increase of MCV in male rats of 250 mg/kg/day. (p<0.05) Serum biochemistry test : We found increase of CHO in female rats of 2,000 mg/kg/day(p<0.05). During the experimental period, there were no animals dead or moribund. There were no treatment related changes of general symptom, food and water consumption, organ weight and autopsy According to the results of 4-week repeated dose range finding study, the highest dose was established as 1000 mg/kg for 13-week repeated dose toxicity study and we determined to put 2 more groups by common ratio two.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.9
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• pp.1231-1236
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• 2005

Genetic parameters for first lactation milk production based on test day (TD) records of 56319 Iranian Holstein cows from 655 herds that first calved between 1991 and 2001 were estimated with restricted maximum likelihood method under an Animal model. Traits analyzed were milk yield and milk fat percentage. Heritability for TD records were highest in second half of the lactation, ranging from 0.11 to 0.19 for milk yield and 0.038 to 0.094 for milk fat percentage respectively. Estimates for lactation records for these traits were 0.24 and 0.26 respectively. Genetic correlations between individual TD records were high for consecutive TD records (>0.9) and decreased as the interval between tests increased. Estimates of genetic correlations of TD yield with corresponding lactation yield were highest (0.78 to 0.86) for mid-lactation (TD3 to TD8). Phenotypic correlations were lower than corresponding genetic correlations, but both followed the same pattern. For milk fat percentage no clear pattern was found. Results of this study suggested that TD yields especially in mid-lactation may be used for genetic evaluation instead of 305-day yield.

• Annals of Clinical Neurophysiology
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• v.16 no.2
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• pp.62-69
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• 2014

Background: Neuromodulation therapy has been used to an adjunctive treatment promoting motor recovery in stroke patients. The objective of the study was to determine the effect of repetitive transcranial magnetic stimulation (rTMS) on neurobehavioral recovery and evoked potentials in rats with middle cerebral artery occlusion. Methods: Seventy Sprague-Daley rats were induced permanent middle cerebral artery occlusion (MCAO) stroke model and successful stroke rats (n=56) assigned to the rTMS (n=28) and sham (n=28) group. The 10 Hz, high frequency rTMS gave on ipsilesional forepaw motor cortex during 2 weeks in rTMS group. The somatosensory evoked potential (SSEP) and motor evoked potential (MEP) were used to evaluate the electrophysiological changes. Behavioral function of the stroke rat was evaluated by the Rota rod and Garcia test. Results: Forty rats ($N_{rTMS}=20;\;N_{sham}=20$) completed all experimental course. The rTMS group showed better performance than sham group in Rota rod test and Garcia test at day 11 (p<0.05) but not day 18 (p>0.05). The amplitude of MEP and SSEP in rTMS group was larger than sham group at day 18 (p<0.05). Conclusions: These data confirm that the high frequency rTMS on ipsilesional cerebral motor cortex can help the early recovery of motor performance in permanent middle cerebral artery stroke model and it may simultaneously associate with changes in neurophysiological activity in brain.

• Asian-Australasian Journal of Animal Sciences
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• v.13 no.10
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• pp.1347-1352
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• 2000

The objectives of the study were to examine non-genetic factors that influence somatic cell counts in dairy cattle and to estimate the genetic parameters of somatic cell counts. A total of 34, 097-test day somatic cell count records were obtained from the Zimbabwe Dairy Services Association (ZDSA). The data were from 5, 615 Holstein daughters of 390 sires and 2, 541 dams tested between May 1994 and December 1998. First lactation cows contributed 22, 147 records to the data set, while 11, 950 records were from second and later parity cows. The model for analysis included fixed effects of month of calving, year of calving, stage of lactation, calving interval and test date. Milk yield and age on test day were fitted in the model as covariates. The additive genetic effects pertaining to cows, sires and dams and the residual error were the random effects. The Average Information Restricted Maximum Likelihood algorithm was used for analysis. The heritability of somatic cell scores was low at $0.027{\pm}0.013$ for parity one cows and $0.087{\pm}0.031$ for parity two and above. Repeatability estimates were $0.22{\pm}0.01$ and $0.30{\pm}0.01$ for the two lactation groups, respectively. Genetic and phenotypic correlations between the somatic cell scores and test day milk production were small and negative. It seems that there is no genetic link between somatic cell counts and milk yield in Holstein cattle in Zimbabwe. The results also seem to indicate that somatic cell count is a trait that is mainly governed by environmental factors.

• International Journal of Concrete Structures and Materials
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• v.18 no.3E
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• pp.191-198
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• 2006

The objective of this study is to examine fracture characteristics of concrete at early ages, i.g. critical stress intensity factor, critical crack-tip opening displacement, fracture energy, and bilinear softening curve based on the concepts of effective-elastic crack model and cohesive crack model. A wedge splitting test for Mode I was performed on cubic wedge specimens with a notch at the edge. By experimenting with various strengths and ages, load-crack mouth opening curves were obtained, and the results were analyzed by linear elastic fracture mechanics and FEM(finite element method). The results from the test and analysis showed that critical stress intensity factor and facture energy increased while critical crack-tip opening displacement decreased with concrete aging from 1 day to 28 days. Four parameters of bilinear softening curve from 1 day to 28 days were obtained from a numerical analysis. The obtained fracture parameters and bilinear softening curves at early ages from this study are to be used as a fracture criterion and an input data for the finite element analysis of concrete at early ages.

• Journal of the Korean Geotechnical Society
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• v.25 no.5
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• pp.17-28
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• 2009

When embankments are constructed on soft clay deposit, unsymmetrical surcharges due to embankments may generate the excessive vertical settlement and lateral deformation of soft clay foundation. The excessive deformations in soft grounds cause not only stability problem of the embankment itself but also that of the adjacent structures. The objectives of this research are to study the deformational behavior of soft ground due to the embankment load with different loading and soil conditions. Five model tests are carried out with different test conditions. From the results of the model tests, it is concluded that the lateral displacement induced by the embankment load occurs in the range of two times of the embankment width from a toe. In addition, the relationship between loading rate, v, and the vertical settlement of the soft ground, ${\Delta}s$, and the lateral displacement at the toe of embankment, ${\Delta}y_m$, is investigated based on the model test results.

• Journal of Environmental Science International
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• v.24 no.4
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• pp.461-470
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• 2015

As hydrogeologic parameters such as hydraulic conductivity and specific yield are estimated by aquifer test, these are dependent on specific points at which field test was conducted. To overcome these site-specific limitations, a method of estimating transmissivity of aquifer using distribution features for parameters in Water table fluctuation model is newly suggested. Distribution features in reaction factor, specific yield and transmissivity having the function of pore space in aquifer are used to derive empirical equation for estimating transmissivity. From the result for applying the equation for 10 groundwater stations in Northeast Jeju Island, this equation is available for estimating transmissivity compared to the value estimated by existing equations. The estimated transmissivity ranged from 14.2 to $3,716.9m^2/day$, and its average was $821.8m^2/day$.

• Proceedings of the Korea Water Resources Association Conference
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• 2010.05a
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• pp.77-81
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• 2010

This study carried out hydraulic model test for water circulation system in Cheongna district as part of Incheon Free Economic Zone. Canal way project of Cheongna was planned to establish for environment-friendly water circulation system, improve quality of life and diversification of traffic through using boat as a water-friendly international business city. The navigation canal, There are two intake facility in central park and it can purify water 15,000$m^3$ per day. After purify, water move to 8 facility of water culture area which supplies water in canal way. This process called water circulation system in cheongna. Also, there are several flow induction machine in canal way except south-north way. Therefore, this study will verify about validity of water circulation system's safety through hydraulic model test.

• Journal of Families and Better Life
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• v.19 no.6
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• pp.241-263
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• 2001

The objectives of this study were empirically to test the reformative model for Korean sacrificial rite and to investigate the effects of demographic variables. the survey was conducted by means of questionnaire with 600 persons located in Seoul. Major findings were as follows ; 1, Sacrificial day ; was displayed (1) dead day (2) holiday in back and forth of dead day 2. Sacrificial time ; was showed (1) 8-9 h. p.m (2) 6-7 h. p.m 3. Sacrificial extent ; was displayed (1) grandparents and parents (2) only parents 4. Participative extent ; was showed (1) Cousin (2) only sons and daughters 5. Sacrificial procedure ; was displayed twice deep bow and 1 minute\`s silent prayer. 6. New year's and Chusok's rite ; was showed (1) simple foods (2) joint leisure time 7. Sacrificial table ; was displayed (1) boiled rice . water . gustoish articles. (2) omission of food table 8. rite\`s socialization ; was showed (1) delivery and marketing sale\`s food (2) special sacrificial restaurant. 9. Womens'and mens'difference ; women were active 7ut men were passive 10. Age's difference ; excepting 30-40, the all generations were more reformative. 11. Number of brothers ; small number of brothers were more reformative than a many number. 12. Sacrificial manager or not , managers were conservative than persons were not managers.