• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.3D
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• pp.373-379
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• 2009

Cost estimation in the early phase enables government to plan public budgeting more efficiently by providing information about construction cost. However, cost estimation in the early phase is difficult to predict because only a little information can be utilized. The cost estimation method now being used by the government is calculated by length of the road multiplied by unit cost per length and shows high error rate because it cannot reflect the unique characteristics of each project. As the project is being proceeded, level of available information also changed. So, reflecting available information of a project is important. This paper divided early phase into two parts : planning phase and early design phase, and developed cost estimation model considering level of available information of each phase. Total 143 cases are utilized to find influencing variables and develop cost estimation model and model validation is done by adopting required accuracy level. This cost estimation model reflecting level of available information can be applied to public budgeting, feasibility test, and comparison between routes.

• Bioinformatics and Biosystems
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• v.1 no.2
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• pp.115-122
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• 2006

A three-dimensional pharmacophore model was developed based on 24 currently available inhibitors, which were rationally selected from 472 compounds with diverse molecular structure and bioactivity, for generating pharmacophore of uPA (Urokinase Plasminogen Activator) inhibitors. The best hypothesis (Hypo1) comprised of five features, namely, one positive ionizable group, one hydrogen-bond acceptor group and three hydrophobic aromatic groups. The correlation coefficient, root mean square deviation and cost difference were 0.973, 0.695, and 94.291 respectively, suggesting that a highly predictive pharmacophore model was successfully obtained. The application of the model showed great success in predicting the activities of 251 known uPA inhibitors (test set) with a correlation coefficient of 0.837, and there was also none of the outcome hypotheses that had similar cost difference and RMS deviation (RMSD) with that of the initial hypothesis generated by Cat-Scramble validation test with 95% confidence level. Accordingly, our model should be reliable in identifying structurally diverse compounds with desired biological activity.

• Structural Engineering and Mechanics
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• v.48 no.4
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• pp.479-500
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• 2013

This paper presents the experimental as well as analytical study conducted on layer-bonded scrap tire rubber pad (STRP) isolators to develop low-cost seismic isolators applicable to structures in developing countries. The STRP specimen samples were produced by stacking the STRP layers one on top of another with the application of adhesive. In unbonded application, the STRP bearings were placed between the substructure and superstructure without fastening between the contact surfaces which allows roll-off of the contact supports. The vertical compression and horizontal shear tests were conducted with varying axial loads. These results were used to compute the different mechanical properties of the STRP isolators including vertical stiffness, horizontal effective stiffness, average horizontal stiffness and effective damping ratios. The load-displacement relationships of STRP isolators obtained by experimental and finite element analysis results were found to be in close agreement. The tested STRP samples show energy dissipation capacity considerably greater than the natural rubber bearings. The layer-bonded STRP isolators serve positive incremental force resisting capacity up to the shear strain level of 150%.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.116-119
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• 2004

The existing monitoring and control systems of utility-pipe conduit (power tunnel, cable tunnel etc) have established communication lines using optical fiber, leaky coaxial cable (LCX), and several kinds of control cable. Due to the properties of the used media, the cost of equipment is considerably high and the maintenance of the system is difficult. Also, the term of carrying out is long so that the extension of the system is in difficulty. Now it is desirable to adopt Power Line Communication (hereinafter, PLC) technology in the monitoring and control systems and use the existing low-voltage power-line for lamplight as communication line. This will lead the reduction of the construction cost and the easy maintenance of the system. In this paper, we research the characteristics of PLC in conduit, design and manufacture the field test system, and analyze the performance of the system by field test. Then, we introduce the reliable monitoring and control system of utility-pipe conduit using PLC.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.10 no.4
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• pp.76-81
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• 2011

UV imprinting process can manufacture high-functional optical components with low cost. If hard polymers can be used as transparent molds at this process, the cost will be much lower. However, there are limited researches to predict the machinability and the burr of hard polymers. Therefore, a new method to predict them by analyzing load-depth curves which can be obtained by the instrumented indentation test was developed in this study. The load-depth curve contains elastic deformation and plastic deformation simultaneously. The ratio of the plastic deformation over the sum of the two deformation is proportional to the ductility of materials which is one of the parameters of the machinability and the burr. The instrumented indentation tests were performed on the transparent molds of the hard polymers and the values of ratio were calculated. The machinability and the burr of three kinds of hard polymers were predicted by the ratio, and the prediction was in agreement with the experimental results from the machined surfaces of the three kinds of hard polymers.

• Journal of The Korean Society of Agricultural Engineers
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• v.57 no.2
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• pp.47-56
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• 2015

At the present, the mechanized form roads pavement was constructed with plain concrete. Mostly, it was used by welded wire mesh for preventing crack. Cellulose fibers for the reinforcement of concrete offer relatively high levels of elastic modulus, fiber count (per unit weight), specific surface, and bond strength to cement-based materials. The construction of concrete pavement confirmed that cellulose fiber reinforced concrete was applicable to mechanized form roads pavement. In the study, cellulose fibers were used here at 0.08 % volume fraction, which is equivalent to a fiber content of $1.2kg/m^3$. Cellulose fiber reinforced concrete were compared with plain concrete. Field test results indicated that cellulose fiber reinforced concrete showed slightly to increase of 28 days compressive strength and improved the initial strength. it tended to increase of splitting tensile strength. Test results showed that the slump and air content tend to decreased. but, the variation of air contends is very little. Also, construction cost of cellulose fiber reinforced concrete is less than about 25.7 % the case of welded wire mesh previously used. Therefore, The cost reduction is expected to be possible in construction site by mechanized form roads pavement.

• Transactions of the Korean Society of Automotive Engineers
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• v.10 no.5
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• pp.199-205
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• 2002

The scale of repair parts market reached 0.1 billion won. Above all, it is remarkable that the automotive insurance business world is paying f3r 40 ~5o% of the whole repair cost. The repair parts consist of a genuine parts, non-genuine parts, recycling used parts. It is the recent trend that recycled parts are more popular than the genuine parts f3r repairing crashed cars due to the cost. Performance of recycled continuous velocity(CV) joints and power steering(PS) gear box as replacement parts was tested and analysed in this study. To examine the durability of the recycled parts, the replaced CV joints and PS gear box after repair were tested and analysed periodically. The results were showed that basic performance of the recycled parts was normal. However the ball cage of CV joints was more frequently damaged than genuine parts. We concluded that a test standard and amendment of related laws for recycled parts is required to get a safe and durable parts.

• Journal of the Korean Geotechnical Society
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• v.16 no.1
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• pp.235-241
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• 2000

The existing methods for installation of long steel pipe pile have some uneconomical problems such as increase of installation cost and period due to the welding of two piles and removal of soil plug, and decrease of driving efficiency due to the increase of driving resistance resulting from time effect during the welding of piles and removal of soil plug, etc. Thus, in this study, new installation method for long steel pipe pile is suggested to solve the existing problems, and calibration chamber tests were performed to investigate both driving and economical efficiency for the suggested method. The test results showed that the new method increased bearing capacity, and decreased the installation cost and period for long steel pipe piles compared with existing methods.

• Journal of Genetic Medicine
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• v.12 no.2
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• pp.72-78
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• 2015

Recently, noninvasive prenatal test (NIPT) has been adopted as a primary screening tool for fetal chromosomal aneuploidy. The principle of NIPT lies in isolating the fetal fraction of cell-free DNA in maternal plasma and analyzing it with bioinformatic tools to measure the amount of gene from the target chromosome, such as chromosomes 21, 18, and 13. NIPT will contribute to decreasing the need for unnecessary invasive procedures, including amniocentesis and chorionic villi sampling, for confirming fetal aneuploidy because of its higher positive predictive value than that of the conventional prenatal screening method. However, its greater cost than that of the current antenatal screening protocol may be an obstacle to the adoption of this innovative technique in clinical practice. Digital polymerase chain reaction (dPCR) is a novel approach for detecting and quantifying nucleic acid. dPCR provides real-time diagnostic advantages with higher sensitivity, accuracy, and absolute quantification than conventional quantitative PCR. Since the groundbreaking discovery that fetal cell-free nucleic acid exists in maternal plasma was reported, dPCR has been used for the quantification of fetal DNA and for screening for fetal aneuploidy. It has been suggested that dPCR will decrease the cost by targeting specific sequences in the target chromosome, and dPCR-based noninvasive testing will facilitate progress toward the implementation of a noninvasive approach for screening for trisomy 21, 18, and 13. In this review, we highlight the principle of dPCR and discuss its future implications in clinical practice.

• Bulletin of the Korean Chemical Society
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• v.35 no.7
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• pp.2097-2108
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• 2014

Chemical feature based quantitative pharmacophore models were generated using the HypoGen module implemented in DS2.5. The best hypothesis, Hypo1, which was characterized by the highest correlation coefficient (0.96), the highest cost difference (61.60) and the lowest RMSD (0.74), consisted of one hydrogen bond acceptor, one hydrogen bond donor, one hydrophobic and one ring aromatic. The reliability of Hypo1 was validated on the basis of cost analysis, test set, Fischer's randomization method and GH test method. The validated Hypo1 was used as a 3D search query to identify novel inhibitors. The screened molecules were further refined by employing ADMET, docking studies and visual inspection. Three compounds with novel scaffolds were selected as the most promising candidates for the designing of Mcl-1 antagonists. Finally, a 10 ns molecular dynamics simulation was carried out on the complex of receptor and the retrieved ligand to demonstrate that the binding mode was stable during the MD simulation.