• YAKHAK HOEJI
• /
• v.58 no.3
• /
• pp.190-199
• /
• 2014

The Korean Pharmaceutical Codex (KPC) analytical method of ambroxol hydrochloride and clenbuterol hydrochloride formulation is complicated and needed to carry out multiple processes during the test. To improve the low efficiency of analytical procedure that makes pharmaceutical laboratory consume much time and high cost to conduct the test of this formulation, this study was performed for simplifying the pretreatment process and optimizing conditions of the HPLC assay. The analytical procedure using HPLC was developed to establish analytical specification for ambroxol hydrochloride and clenbuterol hydrochloride formulations. The newly developed analytical method has good linearity ($R^2$ >0.999), specificity, precision (RSD<1.0%) and the recovery ranges of 98.50~101.84% for ambroxol, 98.29~101.35% for clenbuterol syrup and 98.66~101.71% for clenbuterol tablets. The LOQs were 0.204 ${\mu}g/ml$ for ambroxol, 0.021 ${\mu}g/ml$ for clenbuterol syrup and 0.073 ${\mu}g/ml$ for clenbuterol tablets. The new method was performed with commercially available samples to confirm analytical conditions and validated to be suitable for saving time and cost to control the quality of routine manufactured products. This analytical method will be used for revising the monograph of ambroxol hydrochloride and clenbuterol hydrochloride formulation in next supplement of KPC.

• The Korean Journal of Health Service Management
• /
• v.12 no.2
• /
• pp.63-73
• /
• 2018

Objectives : This study aimed investigate general characteristics, vaccination status and health beliefs related to vaccination for herpes zoster and to identify variables. Methods : The structured questionnaire was conducted from March 31, 2016 to April 20, 2016 with 312 outpatients who visited a university hospital. The data were analyzed by frequency analysis, t-test, $x^2-test$, correlation analysis and logistic regression analysis via SPSS statistics 22.0. Results : The vaccination rate of the herpes zoster was 16.0% and the vaccination cost was the most common reason for rejecting inoculation. More highly educated people with more than a university degree(OR=4.28, p=.002), those with higher susceptibility to herpes zoster(OR=1.56, p=.000), those more aware of the benefits of vaccination(OR=1.51, p=.009) and those with lower disability for vaccination(OR=0.74, p=.003) were more likely to be vaccinated. Conclusions : Therefore, to increase the vaccination rate of herpes zoster in adults over 50 years old, continuous publicity and education are needed to emphasize the susceptibility of herpes zoster and the benefit of vaccination. In addition, it is necessary to develop policies at the national level for the expensive vaccination cost that obstructs vaccination.

• Journal of the Korea Fashion and Costume Design Association
• /
• v.24 no.3
• /
• pp.33-48
• /
• 2022

This study aimed to investigate bag purchase behaviors according to materialism value. The subjects were 443 male and female adult consumers in their 20s to 50s. The research method was a survey, and the questionnaire consisted of questions on materialism value, bag purchase behaviors, and demographic characteristics. For data analysis, descriptive statistics, Cronbach's α, χ² test, factor analysis, cluster analysis, ANOVA, and Duncan's multiple range test were performed. The results of this study were as follows. First, materialism value was derived from three factors (happiness pursuit, possession-oriented, and success judgment). Second, subjects could be divided into three groups (happiness pursuit group, success judgment pursuit group, and immaterialism group) based on the materialism value variable. Third, the derived groups showed many differences in bag purchase behaviors. The happiness pursuit group considered all bag evaluation criteria factors (practicality, aesthetics, economy, symbolism) and bag purchasing information sources factors (mass media and personal sources) more than other groups, and showed a tendency to prefer select shops and complex shopping malls as bag purchasing places. In addition, the average annual cost and frequency of purchasing bags of this group were higher than those of other groups. The success judgment pursuit group considered symbolism as a bag evaluation criteria more than other groups, and considered personal sources as bag purchasing information sources more than mass media sources, and preferred luxury stores and department stores as bag purchasing places. On the other hand, the immaterialism group considered practicality and aesthetics as bag evaluation criteria and placed less importance on all information sources than other groups, and preferred Internet shopping malls as purchasing places. This group had the lowest average annual purchase cost and frequency among the three consumer groups. This study suggested that materialism value is a useful variable to segment male and female adult consumer markets effectively, and to understand the bag purchase behaviors of consumer groups divided by materialism value.

• Journal of Hospice and Palliative Care
• /
• v.26 no.2
• /
• pp.51-59
• /
• 2023

Purpose: We evaluated the status of patients enrolled in South Korea's pediatric palliative care pilot project based on the experience of a single center. This study examined factors related to end-of-life services and differences in medical costs. Methods: The medical records of 120 patients referred by a pediatric palliative care team were analyzed retrospectively. Data from July 1 to February 28, 2022 were collected and analyzed using the chi-square test and the Mann-Whitney U test. Results: Volunteer programs and psychological support (100%), family support and education (99.2%), and financial support through institutional linkage (62.5%) were provided to the participants. In the deceased group, there were no significant differences in general characteristics, which included age, gender, primary disease, religion, duration of hospitalization in an intensive care unit (ICU) and non-intensive care unit (non-ICU). However, the ICU group had fewer opportunities to access individual pain and physical symptom management than the non-ICU group and there were limitations in linking with external resources. Medical expenses were significantly different for the ICU group, with a 3-times higher average cost than the non-ICU group. Conclusion: Although an individualized approach is needed for each patient in pediatric palliative care, psychosocial care is essential. In addition, if early intervention for end-of-life pediatric patients is available from a palliative care team, the cost burden of medical care for patients and their families should be minimal.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
• /
• v.6 no.6
• /
• pp.469-477
• /
• 2016

This study develops an approach to assign numbers of facilities (rectangular shape) in a given plant and compares the test results by proposed approach with those by approaches in the literature. An improvement approach is proposed to minimize material handling cost given initial layout. Like popular heuristic approaches, the developed heuristic approach employs interchange routine to improve material handling cost in current layout. Horizontal interchange and vertical interchange procedures are applied to obtain better solution. Also, it is possible to rotate facility layout when the sizes of both facilities are same. However, the proposed approach generates good solutions without shape distortion. That means the shape of facilities remains rectangle in the final solution. In addition, the improve approach can find global optimal solution from local optimal solution by applying Tabu search technique. Based on 25 test problems in the literature, we obtained better solutions than other facility layout approaches in the literature when there are many facilities.

• Journal of KIISE:Software and Applications
• /
• v.37 no.12
• /
• pp.882-891
• /
• 2010

Many automated dynamic test data generation technique have been proposed. The techniques evaluate fitness of test data through executing instrumented Software Under Test (SUT) and then generate new test data based on evaluated fitness values and optimization algorithms. Previous researches and experiments have been showed that these techniques generate effective test data. However, optimization algorithms in these techniques incur much time to generate test data, which results in huge test case generation cost. In this paper, we propose a technique for reducing the time of evaluating a fitness of test data among steps of dynamic test data generation methods. We introduce the concept of Fitness Evaluation Program (FEP), derived from a path constraint of SUT. We suggest a test data generation method based on FEP and implement a test generation tool, named ConGA. We also apply ConGA to generate test cases for C programs, and evaluate efficiency of the FEP-based test case generation technique. The experiments show that the proposed technique reduces 20% of test data generation time on average.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.9
• /
• pp.4665-4667
• /
• 2012

Cervical cancer is the most common cancer in Laos women and a screening programme, even with the PAP smear test (PAP test), has yet to be established for routine use. The Pap test is accepted as the most appropriate for cervical cancer screening in some settings but it is not commonly available in Laos hospitals, because there are few cytopathologists and gynecologists have little experience. As a pilot program, seminars for the PAP test were given in 2007 and 2008, and then PAP tests were carried out using self-sampling instrument (Kato's device) with 200 healthy volunteers in Setthathirath hospital, Laos, in 2008. The actual examination number was 196, divided into class I 104 (53.1%), class II 85 (43.3%), class IIIa 4 (2.0%), class IIIb 1 (0.5%), and class V 1 (0.5%) by modified Papanicolau classification. Four cases had menstruation. There were 6 cases with epithelial cell abnormalities including malignancy. There were 7 cases with fungus and 2 cases with trichomonas in Class II. More than 70% volunteers felt comfortable with the Kato's device and wanted to use it next time, because of the avoidance of the embarrassment and a low cost as compared with pelvic examination by gynecologists. This first trial for PAP test for healthy Laos women related to a hospital found three percent to have abnormal cervical epithelial cells. Therefore, this appraoch using a self-sampling device suggests that it should be planned for cervical cancer prevention in Laos.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.34 no.12
• /
• pp.90-95
• /
• 2006

The wall of thermal vacuum chamber which is used for the satellite thermal balance test doesn't absorb satellite's IR emission perfectly and reflects some part of that. It is estimated that small thermal vacuum chamber has relatively larger wall effect than the big one. The small thermal vacuum chamber is required for the small satellite test to reduce the test cost. A quantitative analysis was carried out to investigate the chamber wall effect. As a result, temperature errors caused by chamber wall effect was calculated, and the temperature data acquired in the thermal balance test have been compensated. By defining the optimized area ratio between chamber surface and satellite surface area, the baseline to be able to determine the minimum size of thermal vacuum chamber was established to minimize the wall effect. Also, theoretical analysis about transparent material coating which can reduce the chamber wall effect is conducted.

• Proceedings of the KIEE Conference
• /
• 2009.07a
• /
• pp.294_295
• /
• 2009

Superconducting fault current limiter (SFCL) is an power device of a novel concept. While SFCLs generate no ohmic loss during the operation carrying normal currents, they can limit fault currents very fast making large impedance by their quench characteristics. In 2006, KEPCO has developed a distribution class hybrid type SFCL by a collaborative research project with LS industrial systems. The SFCL has merits in practical and economical points of view. In the SFCL, the superconductor just plays a role of a fault detector and the current limiting is completed by the other current limiting element made of normal metals throu호 the line commutation. As a result, the required amounts of superconductors can be reduced considerably. Consequently, the hybrid SFCL can be fabricated with small size and cost, maintaining perfect current limiting performance. Currently, KEPCO is carrying out a research project at Gochang power test center for the purpose of the verification test of the 22.9 kV/ 630 A class SFCL for the practical application in real grid. Through the project, a long term operational test and fault current test will be done. In this paper, the back ground of development and installation of the SFCL will be explained and the operation plan of the SFCL for the verification test is also introduced.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.11 no.1 s.53
• /
• pp.21-27
• /
• 2007

In this study, an approach that installs seismic isolation bearings was proposed for the seismic retrofit of the existing bridges. The method that replaces all existing bearings with seismic isolators was proposed already. However, in this study, we recommend to utilize the existing bearings for the benefit of safety and cost. According to our proposal, the seismic isolators do not support vertical loads but they Just function as the period shifter and the horizontal damper. To verify this approach experimentally, the real scale bearings and lead rubber bearings far the real highway bridges were designed and fabricated. And the responses of this isolated bridges to the assumed earthquakes were determined by the pseudo dynamic test scheme. The test results were also compared to the responses computed by the well known structural analysis software to check the reliability of the test. From the test results, we found that the retrofitted bridges using the proposed method showed stable performances under earthquakes.