• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2002.06a
• /
• pp.63-63
• /
• 2002

RNA pseudoknots are not only important structural elements for forming the tertiary structure, but also responsible for several functions of RNA molecules such as frameshifting, read-through, and the initiation of translation. There exists no automatic method for drawing RNA pseudoknot structures, and thus representing RNA pseudoknots currently relies on significant amount of manual work. In this talk, I will introduce the first algorithm for automatically generating a drawing of RNA pseudoknot structures. Two basic criteria were adopted when designing the algorithm: (1) Overlapping of structural elements should be minimized to increase the readability of the drawing, and (2) The whole RNA structure as well as the pseudoknots themselves should be recognized quickly and clearly. The algorithm has been implemented in a JAVA program, which can be executed on any computing systems. Experimental results show that this program generates a clear and compact drawing of RNA pseudoknots and allows a biologist to gain insights into RNA pseudoknot structures. The program can also be used as useful aids in designing biochemical experiments to elucidate more precise mechanism of RNA functions associated with pseudoknots.

• Journal of Species Research
• /
• v.6 no.2
• /
• pp.190-194
• /
• 2017

Two new species of the genus Luffariella (Dictyoceratida: Thorectidae), L. tubula n. sp. and L. koreana n. sp. were collected from Jeju-do, Korea. These species differ significantly from the previously reported five species in terms of shape and skeletal structure. L. tubula n. sp. has two categories in thickness of secondary fibres which were different from other species. L. koreana n. sp. is very similar to L. variabilis from Tahiti in skeletal structure, but differs in sponge shape with irregular branching and indistinct surface conules. Primary fibres of the two new species are separated from secondary and tertiary fibres.

• BMB Reports
• /
• v.35 no.6
• /
• pp.590-594
• /
• 2002

To elucidate the effect of gamma-irradiation on the molecular properties of myoglobin, the secondary and tertiary structures, as well as the molecular weight size of the protein, were examined after irradiation at various irradiation doses. Gamma-irradiation of myoglobin solutions caused the disruption of the ordered structure of the protein molecules, as well as degradation, cross-linking, and aggregation of the polypeptide chains. A SDS-PAGE study indicated that irradiation caused initial fragmentation of the proteins and subsequent aggregation, due to cross-linking of the protein molecules. The effect of irradiation on the protein was more significant at lower protein concentrations. Ascorbic acid protected against the degradation and aggregation of proteins by scavenging oxygen radicals that are produced by irradiation. A circular dichroism study showed that an increase of the irradiation decreased the a-helical content of myoglobin with a concurrent increase of the aperiodic structure content. Fluorescence spectroscopy indicated that irradiation increased the emission intensity that was excited at 280 nm.

• Korean Journal of Pharmacognosy
• /
• v.17 no.1
• /
• pp.49-54
• /
• 1986

To explore the biological activities of Thalictrum alkaloids, a study was initiated to investigate the alkaloidal constituents from T. fauriei, a species indigenous to Taiwan. Extensive fractionation of the ethanolic extract provided three known aporphines, (+)-oconovine (Ia), (+)-isocorydine (Ib), and (+)-corydine (Ic) from nonphenolic tertiary base fraction. From quaternary base fraction two new protoberberinium salts, thalifaurine (IIa), dehydrodiscretine (IIb), in addition to magnoflorine (III), were isolated. The structure of both new compounds were confirmed by total syntheses. Fractionation of phenolic bases yielded a dihydromorphinandienone, (-)-ocobotrine (IV), as well as a novel aporphine-pavine dimer, tentatively named EP-10. The structure of EP-10 was established by means of 2D NMR studies. Preliminary study indicated a weak activity of lyzing Hela cells, in vitro, for EP-10.

• Journal of Photoscience
• /
• v.3 no.2
• /
• pp.71-76
• /
• 1996

Anil K. Singh, Mrunalini M. Kapil, Department of Chemistry, Indian Institute of Technology Bombay - 400076, INDIA Purple membrane (PM, $\lambda$$_{max}$ 570 nm) of H. halobium on treatment with sulphuric acid changes its colour to blue ($\lambda$$_{max}$ 608 nm). The purple chromophore can be regenerated from the blue chromophore by exogeneous addition of anions such as CI$^-$ and HPO$_4^{2-}$. Chloride ion is found to be more effective than the dibasic phosphate ion in regenerating the purple chromophore. Nevertheless, one thing common to the anion regeneration is that both CI$^-$ and HPO$_4^{2-}$ show marked pH effect. At pH 1.0 the efficiency of regeneration of the purple chromophore is greater than at pH 2.0, for the same anion concentration. Fluorescence and circular dichroic studies indicate that the proteins do not undergo drastic changes at the secondary' or tertiary structure level and the native structure is preserved during this transition. However, chromophoric-site interactions between retinal and the apoprotein are affected during this colour transition. A molecular mechanism is advanced for this transition.

• Journal for History of Mathematics
• /
• v.28 no.4
• /
• pp.167-179
• /
• 2015

We study the solution of truncated series of Lee Sang-hyeog with the aspect of visualization. Lee Sang-hyeog solved a problem of truncated series by 4 ways: Shen Kuo' series method, splitting method, difference sequence method, and Ban Chu Cha method. As the structure and solution of truncated series in tertiary number is already clarified with algebraic symbols in some previous research, we express and explain it by visual representation. The explanation and proof of algebraic symbols about truncated series is clear in mathematical aspects; however, it has a lot of difficulties in the aspects of understanding. In other words, it is more effective in the educational situations to provide algebraic symbols after the intuitive understanding of structure and solution of truncated series with visual representation.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.3
• /
• pp.1037-1040
• /
• 2011

The dinuclear complex 1 with cooperative hydrogen bonds can be prepared by the metal-directed reaction of Eq. (2). This work shows that the coordinated hydroxyl group trans to the secondary amino group is deprotonated more readily than that trans to the tertiary amino group and acts as the hydrogen-bond accepter. The lattice water molecules in 1 act as bridges between the two mononuclear units through hydrogen bonds. The complex is quite stable as the dimeric form even in various polar solvents. The complex exhibits a weak antiferromagnetic interaction between the metal ions in spite of relatively long Cu$\cdots$Cu distance. This strongly supports the suggestion that the antiferromagnetic behavior is closely related to the cooperative hydrogen bonds.

• Korea Journal of Hospital Management
• /
• v.20 no.1
• /
• pp.13-24
• /
• 2015

The purpose of this study is to examine the preparation of medical institutions for Russian medical tourists. The data for this study include 44 cases which were selected from Korea Health Industry Development Institute list. Data were collected through the e-mail survey from Feb. 24 to Jul. 1 in 2014. The results of the study are as follows. Overall, tertiary hospitals were well prepared in hardware resources and structure(e.g. the number of coordinators and marketers, accreditation)compared to hospitals and clinics. On the other hand, hospitals were well prepared in service process protocol.

• Bulletin of the Korean Chemical Society
• /
• v.30 no.7
• /
• pp.1567-1572
• /
• 2009

Conformational change of ubiquitin variant with valine to alanine mutation at sequence position 26 was studied by varying solvent pH. Fluorescence emission spectra indicated that this variant ubiquitin has some residual structures in acidic and basic solution as compared to denaturant-induced unfolded state. Far-UV circular dichroic spectra indicated that the base-denatured state had more secondary structure than the acid-denatured state. Near-UV circular dichroic spectra indicated that the aromatic side-chains were in the relatively more rigid environment in the base-denatured state than those in the acid-denatured state. Although it appears that the more tertiary structure present in the base-denatured state, refolding reactions measured by stopped-flow fluorescence device suggest that both the acid- and base-denatured states occur before the major folding transition state. The acid- and base-denatured states are considered to reflect the early event of protein folding process.

• Textile Coloration and Finishing
• /
• v.16 no.5
• /
• pp.35-41
• /
• 2004

Poly(ethylene terephthalate), polyimide(Kapton), and polypropylene surfaces were modified with argon low temperature plasma by RF glow discharge at 240m Torr, 40W to investigate the surface morphological changes due to the plasma treatment using atomic force microscopy(AFM). Analysis of the AFM images and Ra(average roughness) revealed that the plasma treatment resulted in significant ablation on the surfaces. The morphological changes and surface roughness, however, were different depending on material characteristics such as heat stability, presence of amorphous region, swelling phenomenon, and molecular structure of repeating unit. It was assumed that polypropylene due to its tertiary hydrogen was ablated easily compared to poly(ethylene terephthalate), and that polyimide was more resistant to the ablation than PET due to rigid skeleton of imide and stable phenyl ring structure.