• Journal of Preventive Medicine and Public Health
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• v.31 no.3 s.62
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• pp.471-480
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• 1998

This study was undertaken in order to estimate the accuracy of disease code of the Korean National Medical Insurance Data and disease the characteristics related to the accuracy. To accomplish these objectives, 2,431 cases coded as notifiable acute communicable diseases (NACD) were randomly selected from 1994 National Medical Insurance data file and family medicine specialists reviewed the medical records to confirm the diagnostic accuracy and investigate the related factors. Major findings obtained from this study are as follows : 1. The accuracy rate of disease code of NACD in National Medical Insurance data was very low, 10.1% (95% C.I. : 8.8-11.4). 2. The reasons of inaccuracy in disease code were 1) claiming process related administrative error by physician and non-physician personnel in medical institutions (41.0%), 2) input error of claims data by key punchers of National Medical Insurer (31.3%) and 3) diagnostic error by physicians (21.7%). 3. Characteristics significantly related with lowering the accuracy of disease code were location and level of the medical institutions in multiple logistic regression analysis. Medical institutions in Seoul showed lower accuracy than those in Kyonngi, and so did general hospitals, hospitals and clinics than tertiary hospitals. Physician related characteristics significantly lowering disease code accuracy of insurance data were sex, age group and specialty. Male physicians showed significantly lower accuracy than female physicians; thirties and fortieg age group also showed significantly lower accuracy than twenties, and so did general physicians and other specialists than internal medicine/pediatric specialists. This study strongly suggests that a series of policies like 1) establishment of peer review organization of National Medical Insurance data, 2) prompt nation-wide expansion of computerized claiming network of National Medical Insurance and 3) establishment and distribution of objective diagnostic criteria to physicians are necessary to set up a national disease surveillance system utilizing National Medical Insurance claims data.

• The Korean Journal of Petroleum Geology
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• v.11 no.1 s.12
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• pp.27-41
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• 2005

The hydrocarbon source rock potential of the Eocene units in the southern Oregon Coast Range was evaluated by using the Rock-Eval pyrolysis. Most Eocene units in southern Oregon Coast Range are thermally immature and contain lean, gas-prone Type III kerogen. However, some beds(coals) are sufficiently organic-rich to be sources of biogenic and thermogenic methane discovered in numerous seeps. The overall hydrocarbon source rock potential of the southern Oregon Coast Range is moderately low. Several requirements for commercial accumulations of hydrocarbon, however, probably exist locally within and adjacent areas. Three speculative petroleum systems are identified. The first includes the southern part of the Oregon Coast Range near the border with the Mesozoic Klamath Mountains and is related to a proposed subduction zone maturation mechanism along thrust faults. The second is centered in the northern part of the range and may be associated with basin-centered gas in an over-pressured zone. The third occurs near the eastern border of the range where maturation is related heating by sills and migration of hydrothermal fluids associated with mid-Tertiary volcanism in the Western cascade arc.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.759-765
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• 2016

Background: Breast cancer is the most frequent cancer of women in Pakistan with the majority presenting with stage III or IV lesionsat initial diagnosis. Patient and health system related factors are well known determinants of delay in presentation and diagnosis. Additionally, breast cancer being a heterogeneous disease, the various molecular subtypes featuring different aggressiveness also need to be considered. The present study evaluated the association of stage at initial diagnosis of breast cancer with these two factors in local women at a tertiary level health care facility in Lahore, Pakistan. Materials and Methods: Patient and tumor features were recorded separately during diagnostic workup in Breast Clinics at INMOL and at Services Hospital, Lahore. Data were entered in MS Excel and analyzed by descriptive statistics and Chi-Square test. Results: Among the 261 patients, 64% were staged as late breast cancer (LBC), the mean age was 46.8 with standard deviation of 13 years. Some 92% had invasive ductal carcinoma (IDC), 61% had luminal types (LT) of non-aggressive tumor while 39% had the non-luminal types (NLT) of of HER2-enriched or basal aggressive tumors. While 70% of patients presented within one year of symptomatic disease (early report group "ERG"), 30% reported after a mean delay of 4 years with a standard deviation of 3.75 years. The stage distribution among ERG patients was not statistically different from those reporting late (P=0.123). Statistically larger proportion of patients with NLT presented as LBC as compared to the LT (P =0.034). Among the ERG, statistically different stage distribution of disease was observed for the NLT versus LT (P=0.047). Among those presenting late, this difference was insignificant (P=0.416). Conclusions: Breast cancer is a distinct disease in Pakistan with a high frequency of aggressive molecular types affecting younger women, with the majority presenting as LBC. Association of NLT with higher stage at diagnosis is statistically significant whereas time delay in diagnosis is not. Further research is required to define the risk profile and features in local patients. The burden of LBC can be reduced by promoting breast health awareness and by establishing easily accessible dedicated breast care set ups in the hospitals.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.3
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• pp.286-292
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• 2005

This study is to investigate the industrial boiler which can be significantly affected by the restriction of NOx. Note that the application of SNCR method to industrial boiler is usually blown as not feasible due to the insufficient residence time for proper mixing. The purpose of this study is to investigate the applicability of the SNCR system application to the industrial boiler, which produces 40 tons of steam per hour using heavy oil. For the industrial boiler with 3-D rectangular coordinate, the general coding are made fur various turbulence modeling such as turbulent flow, turbulent fuel combustion, thermal NO formation and destruction together with the NO reaction with reducing agents. Further, the incorporation of drop trajectory model is successfully made in 3-D rectangular coordinate with Lagrangian frame and the main swirl burner effect on the characteristics of flame is considered. As expected a short flame was created and thereby NOx is removed more efficiently by increasing the proper region of temperature for NO reduction reaction. The validation of program was made successfully by the comparison of experimental data. Based on the reliable calculation results, the SNCR method in a industrial boiler shows the possibility as one of viable NO reduction method by the use of well designed mixing air of reducing agent.

• Journal of the Korean Chemical Society
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• v.26 no.5
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• pp.333-339
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• 1982

Substituent effects of substrate and leaving group for the reaction of substituted ${\beta}$-phenylethyl arenesulfonates with pyridine were determined conductometrically in acetonitrile at 50∼70$^{\circ}$C. The substituent effect in substrate is not so significant than expected, but still the electron donating substituent shows the slight acceleration to give a small negative ${\rho}$ value and Hammett plots show slight curvature on the acting substituents, even though it is not so remarkable than that of benzyl system. These results represent a little bit the favorable bond breaking at the transition state by the electron donating substituents. The effects of leaving group in the arenesulfonates in which the rate constants are decreased by electron donating substituents, while electron withdrawing groups presented the reverse effects. Hammett ${\rho}$ value is significantly smaller than that of p-nitrobenzyl arenesulfonates and thus, the mechanism should be closer to tight $S_N2$ one. Especially 2,5-dichlorobenzenesulfonate was more accelerated than expected at the additivity of substituents. This facts showed that dichlorobenzenesulfonate anion is more stabilized by the great electron withdrawing substituents at transition state.

• Korea Journal of Hospital Management
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• v.7 no.3
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• pp.44-62
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• 2002

Advanced surgical technology demands more precise, meticulous, and time-consuming procedures. In addition, the patient's preference of tertiary health providers makes over crowding of the University Hospitals. Therefore, it has been necessary to maximize utilization of the operating room of such hospitals to accommodate these requirements. This study, targeting 1,302 surgical cases performed in 22 operating rooms at a university hospital in Seoul from October 8 to November 1, 2001, analyzed reasons for delay, and factors that caused delayed use of operating rooms. This study also assessed that the rate of operating room use would increase if the sources for possible reform were improved. 1. Among total of 1,302 cases of surgery, the incidence of surgeries in which there were no time delays and no factors for delay were discovered is 71.4% or 930 cases: the incidence in which surgeries were delayed was 28.6% or 372 cases. 2. As results of logistic regression for delay, procedures involving women were delayed 1.4 times more frequently than those of men. Compared to Department A, Department B was 1.8 times more likely to be delayed, and Department H was 0.4 times less likely to be delayed. Regional anesthesia was 2.4 times more likely to be delayed than general anesthesia, and surgeries that PCA was applied were 0.6 times less likely to be delayed than those when it was not. Surgeries performed on the Thursday were 1.7 times more likely to be delayed than those performed on the Monday. Compared to surgeries performed between 07:00-07:59, those performed between 08:00-08:29 were 4.3 times higher. 3. The reasons for delay were related to surgeon, surgical department, patient, anesthesia, administrative system, sick ward, and support services. Among these, 5,755 minutes for 276 delayed cases could be resolved easily, and resolving delays of 3,320 minutes for 131 cases would be more difficult. Among the causes for delay that could be improved, delays due to patient's transfer and surgeon's factor were the most common, 21.6% and 17.4% respectively. 4. If resolvable delays are improved, pre-anesthesia room is administered, and regional anesthesia and PCA are done ahead of time, use of emergency operating rooms will increase, we can increase overall utilization by 4.09%, we will save 744 minutes a day, we can reduce the time the operation room is used after 4 PM by 35%, and we can resolve the operation cancellations due to insufficient operating rooms. For the increase in the use of operating rooms, we need to maximally decrease the delays that could be improved, by allocating block time based on used totals hours of elective cases, giving accurate information on surgery schedule, voluntary cooperation by staff participating in surgeries in reducing delay time, and the hospital management's will to improve delay.

• Journal of agricultural medicine and community health
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• v.30 no.3
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• pp.255-262
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• 2005

Purpose: In Ulleung island, emergency medical transport by helicopter is very important. So, we analysized our experience with emergency medical transport by helicopter for 4 years and we were compared our data with other data for 1997-2001. Therefore we need to research public health development direction. Method: We analysized patient's medical record for 4 years. Result: During 4 years, 104 transports were done and 130 patients were trasported to tertiary hospital center, there was more increased than that from 1997 to 2001. Helicopters from Pohang coast guard, Donghae coast guard, Navy, and 119 rescue etc. were used, but 119 rescue transport was decreased more and more. The 60's patients was most, 22.3% and teenager's and 80's patients was lowest. The male was 65% but the female was increased more and more annually. In addition, the older patients was the more portion of female patient. The transport was concentrated in daytime. The traumatic patient was much in winter period. The cerebrovascular accident was 1st cause of patient and fracture was many also. Conclusioon: Except Fire service's helicopter, the other helicopter was not apt to emergency medical tansport. But Fire service's helicopter was not used commonly because Fire service's helicopter was in Daegu, so distant and time consumed. As a result, emergency medical transport helicopter is needed in east coast like Fire service's helicopter. In addition, trauma prevention education and public health education for hypertension and diabetes will be essential and public health system in Ulleung island will be prepared for aging society.

• 한국지구물리탐사학회:학술대회논문집
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• 2009.05a
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• pp.57-65
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• 2009

Selection of good mineralized area is a combination of the integration of all the available geo-scientific (i.e., geological, geochemical, and geophysical) information, extrapolation of likely features from known mineralized terrenes and the ability to be predictive. The time-space relationships of the hydrothermal deposits in the East Asia are closely related to the changing plate motions. Also, two distinctive hydrothermal systems during Mesozoic occurred in Korea: the Jurassic/Early Cretaceous deep-level ones during the Daebo orogeny and the Late Cretaceous/Tertiary shallow geothermal ones during the Bulguksa event. Both the Mesozoic geothermal system and the mineralization document a close spatial and temporal relationship with syn- to post-tectonic magmatism. The Jurassic mineral deposits were formed at the relatively high temperature and deep-crustal level from the mineralizing fluids characterized by the relatively homogeneous and similar ranges of ${\delta}^{18}O$ values, suggesting that ore-forming fluids were principally derived from spatially associated Jurassic granitoid and related pegmatite. Most of the Jurassic auriferous deposits (ca. 165-145 Ma) show fluid characteristics typical of an orogenic-type gold deposits, and were probably generated in a compressional to transpressional regime caused by an orthogonal to oblique convergence of the Izanagi Plate into the East Asian continental margin. On the other hand, Late Cretaceous ferroalloy, base-metal and precious-metal deposits in the Taebaeksan, Okcheon and Gyeongsang basins occurred as vein, replacement, breccia-pipe, porphyry-style and skarn deposits. Diverse mineralization styles represent a spatial and temporal distinction between the proximal environment of sub-volcanic activity and the distal to transitional condition derived from volcanic environments. However, Cu (-Au) or Fe-Mo-W deposits are proximal to a magmatic source, whereas polymetallic or precious-metal deposits are more distal to transitional. Strike-slip faults and caldera-related fractures together with sub-volcanic activity are associated with major faults reactivated by a northward (oblique) to northwestward (orthogonal) convergence, and have played an important role in the formation of the Cretaceous Au-Ag lode deposits (ca. 110-45 Ma) under a continental arc setting. The temporal and spatial distinctions between the two typical Mesozoic deposit styles in Korea reflect a different thermal episodes (i.e., late orogenic and post-orogenic) and ore-forming fluids related to different depths of emplacement of magma (i.e., plutonic and sub-volcanic) due to regional changes in tectonic settings.

• Food Science of Animal Resources
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• v.30 no.5
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• pp.703-716
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• 2010

It has recently been considered urgent to establish an accurate definition and scope of functional foods in the livestock industry in Korea. The tertiary function of food is gradually emphasized with various changes in conditions such as international competitive power enhancement of the whole world, including Korea. Therefore, the purpose of this study was carried out to gather basic information toward the establishment of standardization, management plans, and a system adapted to the Korean state through researching management systems of functional meat and meat products in the European Union (EU) and the Oceania Area (OA). A brief summary of this study is as follows. In the EU and OA, special management systems and laws about functional livestock and products were once nonexistent; only 'nutrition claims' and 'health claims' operated in the nutritional consolidation side of foods. Also, it was once thought that functional index materials and permissions established in the application of functional products sufficed, because management standards for enriched food were not established. Therefore, standardization of functional live stock products needs to be considered based on the case of developed countries in the EU and OA. It also seems that the above functional indicative substances can be applied, based on normal standards of indicative substances of functional products and the normal standards of indicators of functional substances added to livestock products presented in this study.

• BMB Reports
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• v.31 no.6
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• pp.595-599
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• 1998

To investigate conformational information of a low oxygen affinity recombinant hemoglobin (rHb) containing $96Val{\rightarrow}Trp$ mutation at the ${\alpha}96$ position, we ave produced rHb (${\alpha}96Val{\rightarrow}Phe$) and rHb (${\alpha}96Val{\rightarrow}Tyr$), using the Escherichia coli expression system and site-directed mutagenesis. The oxygen affinity of rHb (${\alpha}96Val{\rightarrow}Phe$) is similar to that of human normal adult hemoglobin (Hb A). However, the oxygen affinity of rHb (${\alpha}96Val{\rightarrow}Tyr$) showed much lower oxygen affinity than Hb A which is similar to that of rHb (${\alpha}96Val{\rightarrow}Tyr$), providing an opportunity as a potential candidate for a hemoglobin-based blood substitute. Both rHb (${\alpha}96Val{\rightarrow}Phe$) and rHb (${\alpha}96Val{\rightarrow}Tyr)$ showed high cooperativity in oxygen binding. IH-NMR spectroscopy shows that both rHb (${\alpha}96Val{\rightarrow}Phe$) and rHb (${\alpha}96Val{\rightarrow}Tyr$) have very similar tertiary structure around the heme pockets and uaternary structure in the ${\alpha}_1/{\beta}_2$ subunit interface ompared to Hb A. The low oxygen affinity of rHb (${\alpha}96Val{\rightarrow}Tyr$) has been suggested to be due to a hydrogen bond caused by an extra hydroxyl group not present in rHb (${\alpha}96Val{\rightarrow}Phe$). However, investigation of the carbonmonoxy form of rHb (${\alpha}96Val{\rightarrow}Phe$) and (${\alpha}96Val{\rightarrow}Try$) in the presence of inositol hexaphosphate at low temperature suggests that low oxygen affinity of (${\alpha}96Val{\rightarrow}Try$) may arise from a mechanism different to that of rHb (${\alpha}96Val{\rightarrow}Trp$).