• Biomolecules & Therapeutics
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• 제23권4호
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• pp.357-366
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• 2015

Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced intracellular reactive oxygen species (ROS) and attenuated the oxidative modification of DNA, lipids, and proteins in response to UVB radiation. Moreover, isorhamnetin repressed UVB-facilitated programmed cell death in the keratinocytes, as evidenced by a reduction in apoptotic body formation, and nuclear fragmentation. Additionally, isorhamnetin suppressed the ability of UVB light to trigger mitochondrial dysfunction. Taken together, these results indicate that isorhamnetin has the potential to protect human keratinocytes against UVB-induced cell damage and death.

• Nuclear Engineering and Technology
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• 제54권6호
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• pp.1947-1953
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• 2022

As the plasma facing material in the nuclear fusion reactor, tungsten has to bear the irradiation impact of high energy particles. The surface quality of tungsten may affect its irradiation resistance, and even affect the service life of fusion reactor. In this paper, tungsten samples with different surface quality were polished by mechanical processing, subsequently conducted by D₂⁺ implantation and thermal desorption. D₂⁺ implantation was performed at room temperature (RT) with the irradiation dose of 1 × 10²¹ D₂⁺/m² by 5 keV D₂⁺ ions, and thermal desorption spectroscopy measurements were done from RT to 900 K. In addition, He irradiation was also performed by 50 eV He⁺ ions energy with the fluxes of 5.5 × 10²¹ m^-2s^-1 and 1.5 × 10²² m^-2s^-1, respectively. Results reveal that the hydrogen/helium irradiation behavior are both related to surface quality. Samples with high surface quality has superior D₂⁺ retention behavior with less D₂ retained after implantation. However, such samples are more likely to generate fuzzes on the surface after helium irradiation. Different morphologies (smooth, wavy, pyramids) after helium irradiation also demonstrates that the surface morphology is related to tungsten crystallographic orientation.

• 폴리머
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• 제39권1호
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• pp.144-150
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• 2015

젤란검은 천연재료로써 내열성, 내산성, 내효소성 등이 우수하여 용도가 광범위하나 기계적 강도가 약하다는 단점이 있다. 따라서 본 연구에서는 기계적 성질을 개선하고자 젤란검 스폰지에 PLGA 미립구를 혼합하였다. PLGA 미립구의 다양한 함량의 젤란검 스폰지는 기계적 강도를 알아보고자 압축강도를 측정하였고, MTT 분석, SEM, 생체활성조직학적 평가 및 RT-PCR을 통해 세포의 증식 및 ECM 분비 효과를 확인하였다. 그 결과, PLGA 미립구가 50% 함유된 젤란검 지지체에서 섬유륜세포의 꾸준한 증식과 세포외기질 분비가 우수한 것을 확인할 수 있었다. 이 연구를 통하여 PLGA 미립구가 함유된 젤란검이 디스크조직 재건을 위한 지지체로서 적합함을 알 수 있었으며, 젤란검의 다양한 응용가능성을 제시하였다.

• 한국재료학회지
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• 제22권4호
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• pp.211-214
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• 2012

Optimal conditions for HA plasma spray-coating on Ti6Al4V alloy were investigated in order to obtain enhanced bone-bonding ability with Ti6Al4V alloy. The properties of plasma spray coated film were analyzed by SEM, XRD, surface roughness measurement, and adhesion strength test because the film's transformed phase and crystallinity were known to be influential to bone-bonding ability withTi6Al4V alloy. The films were formed by a plasma spray coating technique with various combinations of plasma power, spray distance, and auxiliary He gas pressure. The film properties were analyzed in order to determine the optimal spray coating parameters with which we will able to achieve enhanced bone-bonding ability with Ti6Al4V alloy. The most influential coating parameter was found to be the plasma spray distance to the specimen from the spray gun nozzle. Additionally, it was observed that a relatively higher film crystallinity can be obtained with lower auxiliary gas pressure. Moderate adhesion strength can be achievable at minimal plasma power. That is, adhesion strength is minimally dependent on the plasma power. The combination of shorter spray distance, lower auxiliary gas pressure, and moderate spray power can be recommended as the optimal spray conditions. In this study, optimal plasma spray coated films were formed with spray distance of 70 mm, plasma current of 800 A, and auxiliary gas pressure of 60 psi.

• 한국컴퓨터정보학회논문지
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• 제24권11호
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• pp.235-243
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• 2019

대학들이 기업체가 요구하는 문제해결 능력을 갖춘 인재를 양성하기 위하여 관련 전공 및 교과목을 개설하고 있다. 빠른 기술발전이 융복합인 인재를 요구되는 시대가 도래 한 것이다. 본 연구에서는 여자대학생들의 4차 산업혁명과 지능정보화 기술 인식 변화를 파악하고 대처하기 위해 3년간(2017년~2019년) 설문조사 결과를 분석하였다. 첫째, 4차 산업혁명에 대한 관심도는 2017년 59%에서 2019년에는 80%로 증가. 둘째, 기술 전략의 우선순위로 사물인터넷(IoT)과 정보통신, 인공지능, 교육연구 시스템 혁신. 셋째, 핵심 키워드는 인공지능(A.I), ROBOT, JOB, 넷째, 과학기술분야의 기회와 일자리 증가에 대한 예측으로는 50%. 다섯째, 대학 역할의 중요성은 50%, 기업의 역할은 80%로 기업의 역할이 더 높다. 여섯째, 과학기술에 필요한 정보로는 교육훈련정보, 미래사회변화, 유망미래정보, 일곱째, 가장 필요한 교육으로는 창의력교육, 코딩교육, 융합교육, 공학 순이었다. 4차 산업혁명 시대는 다방면에 걸쳐 SW 인력 기반을 확충하는 것이 필수적이다. 초융합을 위한 연결성을 제공해야 하는 대학교육은 융합과 연계교육, 창의적인 사고, 자기 주도적 문제해결 등 산업 수요에 최적화된 커리큘럼을 제공해야 한다.

• 융합정보논문지
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• 제9권11호
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• pp.110-117
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• 2019

본 연구는 오규일이 새긴 인장 완당예고의 융합적 요소를 분석하여 조선 시대 전각예술의 우수성을 널리 알리고자 했다. 완당예고의 외형을 다른 인장들과 비교했다. 완당예고에 담긴 서법 철학, 인문 완(阮), 당(堂), 예(隷), 고(古)의 구성, 오규일의 도법이 집중적으로 분석되었다. 연구 결과, 완당예고는 세계 최대급 방형 인장이었고, 그의 스승 김정희의 서법 철학이 담겨 있었다. 오규일은 전각예술가였고 인장의 손잡이 제작전문가였다. 그는 '충도'와 '절도'를 적절하게 섞어 사용했고, 절묘한 동양의 황금비가 적용된 구성으로 동양예술의 사의적 감성을 자극했다. 실재 인장의 중요성이 제시되었고, 인장 완당예고가 세계적으로 걸출한 작품인 것도 방증했다. 본 연구 결과가 회화, 조각, 디자인에 담긴 융합 요소를 분석하는 데 새로운 연구 방법론이 될 것으로 기대한다.

• 실천공학교육논문지
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• 제16권2호
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• pp.121-128
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• 2024

이 연구는 특성화고 학생들에게 인벤터 소프트웨어를 사용하여 로봇 팔을 디자인하고 3D 프린터를 통해 제작하여 아두이노 마이컴으로 제어하는 융합 교육 방법을 소개하며, 학생들에게 실무 경험을 제공하고 다양한 학문 분야의 지식과 기술을 융합할 수 있는 기회를 제공할 수 있다. 학생들은 CAD 소프트웨어로 디자인을 시작하고, 3D 프린팅 기술을 통해 실제로 로봇 팔의 부품을 제작하며, 마지막으로 부품을 조립한 로봇 팔을 프로그래밍하여 제어하게 하였다. 이 융합교육에서 학생들의 문제 해결능력과 창의성을 키우고, 학습 동기를 높이는 데 도움이 되었고 이런 교육적시도가 실제 교육과정에 적용하기 위해서는 적절한 자원과 교사의 지속적인 관심과 지원이 필요하며, 이러한 연구는 향후 교육에서 적용 가능성을 탐색하기 위한 기초적인 연구로 간주된다.

• 한국기술혁신학회:학술대회논문집
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• 한국기술혁신학회 2003년도 춘계학술대회
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• pp.413-425
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• 2003

Information Technology is the kernel technology deciding the industrial standard of one nation, and biotechnology will be the main technology of next generation. Based on this fact, a lot of efforts were made to industrialize them. Nano Technology is beginning to position itself as the kernel fusion technology, and its usage and popularity is expanding. Environmental and Energy Technology is a must-have strategic technology considering the increase demand of new energy development, the international environment correspondence, the environment-friendly production, and so forth. Space Technology is the field, which will contribute to raise the domestic component and system technology to the next level. In 2001, new technology research development costs total of 1 trillion 32 billion won in the following fields; 437.82 billion won in IT, 88.457 billion won in BT, 46.799 billion won in NT, 315.682 billion won in ET, and 112 billion won in ST. from component ratio, IT forms 42% which is the most, 31% for ET and in order of BT, ST and NT. ETRI and KISTI are concentrating on IT, KIBB is on BT, KAERI, KIER, KERI and KBSI are focusing on ET, and KIMM, KRISS, KRICT and KORDI is participating together in 4∼5 new technology such as IT, BT, NT and ET. Funds for research development costs in 5 new technology fields of 13 contribution (year) are consisted as follows; The Office for Government Policy Coordination has contributed 131 billion won (13%), 387 billion won (37%) by MOST, 256 billion won (25%) by Ministry of Information and Communication, 67 billion won (6%) by Ministry of Commerce, Industry and Energy, 19% by others and the industrial world. < Strategy for Technology Advancing > o Promotion of comprehensive contributing (year) new technology development research plan project o Increase research efficiency by promoting new technology development project connected with peculiar projects of organization by contribution (year) o Formation of superior research group by technology and introduction of operation system for research accumulation are needed. o Technology demand-oriented assignment deduction and promotion of research development project connected with intermediate long term objective o National will and investment extension of research development costs, training and popularization of professionals, commercialization promotion with efficient control for research plan and result.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8685-8688
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• 2014

The objective of the present study was to investigate cloning, expression, and functions of the recombinant protein, Siva1. Siva1 gene was synthesized by RT-PCR from HCT116 cells. Plasmids were cleaved with the restriction endonuclease, BamH1/Sal1 and products were connected to pQE30, which underwent cleavage by BamH1/Sal1. The recombinant plasmid, pQE30-Siva1, was identified after digestion with restriction endonucleases followed by transformation into E. coli M15. Expression of Siva1 was induced by IPTG and identified by SDS-PAGE following purification with affinity chromatography. The results showed that size of Siva1 was 12 kDa, consistent with the molecular weight of the His-Siva1 fusion protein. Functional test demonstrated that Siva1 significantly inhibited the invasion and migration of HCT116 cells. It may thus find clinical application for control of cancers.

• Environmental Engineering Research
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• 제15권4호
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• pp.225-230
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• 2010

In order to treat soil contaminated with high percentages of water and petroleum, the combined microwave and thermal desorption process was studied, which was composed of the consecutive connection of two pre-treatment processes. For the thickness of the contaminated soil layer on the transfer conveyor belt, the optimal total petroleum hydrocarbon (TPH) removal rate was studied with respect to the duration of microwave exposure in the consecutive process combined with thermal desorption. The TPH removal rate when the contaminated soil layer thickness was 1 cm at 6 kW of microwave power was 80%. The removals rates for 2 and 3 cm soil layer thicknesses were both 70%. Under identical experimental conditions, the TPH removal rate for the microwave pre-treatment, when considering the soil particle size, was over 70%. The lowest TPH removal rate was achieved with a particle diameter of 2.35 mm. For contaminated soil with 30% water content, 6 kW and a thermal desorption temperature of $600^{\circ}C$ were the optimal operational conditions for the removal of THP. However, considering the fuel consumption cost, 4 kW and a thermal desorption temperature of $300^{\circ}C$ would be the most economic conditions.