• 한국전자파학회논문지
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• 제16권7호
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• pp.753-759
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• 2005

본 논문에서는 표면 MEMS 기술을 이용하여 제작된 $180^{\circ}$ 하이브리드 결합기가 집적된 60 GHz 대역의 단일평형 혼합기를 설계$\cdot$제작하였다. 혼합기에 사용된 $180^{\circ}$ 하이브리드 결합기는 substrate에 의한 dielectric loss를 최소화하기 위하여 polyimide dielectric을 지지대로 사용하여 신호선이 공기 중에 떠 있는 형태의 마이크로스트립 라인을 이용하여 설계하였으며, 이때 지지대의 높이는 $10{\mu}m$이고 면적은 $20{\mu}m{\times}20{\mu}m$을 사용하였다. 제작된 혼합기 의 측정 결과, LO 주파수가 58 GHz에서 LO power가 7.2 dBm 57 GHz에서 RF power가 -15 dBm 일 때, 15.5 dB의 변환 손실과 -40 dB의 RF-LO isolation 특성을 얻었다. 본 논문에서 제안된 혼합기는 RF MEMS 수동 소자를 MMIC와 집적화 함으로써 칩 성능의 감소 없이 크기를 줄일 수 있다는 장점을 가지고 있다.

• Journal of Animal Science and Technology
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• 제63권4호
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• pp.934-953
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• 2021

Ciglitazone is a member of the thiazolidinedione family, and specifically binds to peroxisome proliferator-activated receptor-γ (PPARγ), thereby promoting adipocyte differentiation. We hypothesized that ciglitazone as a PPARγ ligand in the absence of an adipocyte differentiation cocktail would increase adiponectin and adipogenic gene expression in bovine satellite cells (BSC). Muscle-derived BSCs were isolated from six, 18-month-old Yanbian Yellow Cattle. The BSC were cultured for 96 h in differentiation medium containing 5 µM ciglitazone (CL), 10 µM ciglitazone (CM), or 20 µM ciglitazone (CH). Control (CON) BSC were cultured only in a differentiation medium (containing 2% horse serum). The presence of myogenin, desmin, and paired box 7 (Pax7) proteins was confirmed in the BSC by immunofluorescence staining. The CL, CM, and CH treatments produced higher concentrations of triacylglycerol and lipid droplet accumulation in myotubes than those of the CON treatment. Ciglitazone treatments significantly increased the relative expression of PPARγ, CCAAT/enhancer-binding protein alpha (C/EBPα), C/EBPβ, fatty acid synthase, stearoyl-CoA desaturase, and perilipin 2. Ciglitazone treatments increased gene expression of Pax3 and Pax7 and decreased expression of myogenic differentiation-1, myogenin, myogenic regulatory factor-5, and myogenin-4 (p < 0.01). Adiponectin concentration caused by ciglitazone treatments was significantly greater than CON (p < 0.01). RNA sequencing showed that 281 differentially expressed genes (DEGs) were found in the treatments of ciglitazone. DEGs gene ontology (GO) analysis showed that the top 10 GO enrichment significantly changed the biological processes such as protein trimerization, negative regulation of cell proliferation, adipocytes differentiation, and cellular response to external stimulus. Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that DEGs were involved in the p53 signaling pathway, PPAR signaling pathway, biosynthesis of amino acids, tumor necrosis factor signaling pathway, non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, and Wnt signaling pathway. These results indicate that ciglitazone acts as PPARγ agonist, effectively increases the adiponectin concentration and adipogenic gene expression, and stimulates the conversion of BSC to adipocyte-like cells in the absence of adipocyte differentiation cocktail.

• 한국기술혁신학회:학술대회논문집
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• 한국기술혁신학회 2014년도 추계 학술대회 논문집
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• pp.238-256
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• 2014

• 한국기술혁신학회:학술대회논문집
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• 한국기술혁신학회 2004년도 정기총회 및 추계학술대회 논문집
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• pp.608-616
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• 2004

• 기술혁신연구
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• 제14권2호
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• pp.167-181
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• 2006

This paper reviews regional innovation policy in Japan. 'Technopolis' policy, the first technology-based regional development policy in the world, was implemented in Japan. Nonetheless, technology-based regional endogenous development did not occur. Then, regional technology transfer was pursued. In order to make use of universities and public research institutes in a region for development, university-industry collaboration and cross-over, such as university spin-offs, were promoted. Within this background, new technology-based regional development policies have been introduced based on a cluster approach. These policies are the knowledge cluster Initiative and the industrial cluster program. However, existing companies have difficulty in carrying out innovation. This paper argues that a cluster to create new start-ups that carry out innovation is also needed and explains a new concept of venturing cluster. Based on this new cluster concept, this paper analyzes the situation of Sapporo in Japan, where many university spin-offs are being created in the biotechnology field.

• 기술혁신연구
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• 제14권2호
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• pp.49-65
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• 2006

In this paper, innovation policies for systems reform in China since the middle 80's are surveyed and its impacts on science industry linkage activities are investigated by looking into (1) technology market, (2) S&T outsourcing activities of firms and (3) co-invention patents by applicants in firms, universities and public research institutions. All of these findings suggest that the role of science sector in China's economic development process has become larger, and double skin problem (separation of science and industry sector) in China's innovation system has been gradually solved by a number of policy actions to facilitate science industry linkages.

• Journal of Information Technology Applications and Management
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• 제20권3_spc호
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• pp.279-293
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• 2013

In general, researchers, policymakers, and practitioners consider innovation by producers as a primary mode in a market economy. However, the recent research has shown that some of the most important, novel products and processes have been developed by users-both user firms and individual end-users. According to von Hippel [1988], he found that they were the developers who made about 80 percent of the most important scientific instrument innovations as well as the major innovations in semiconductor processing. In this research, we conducted grounded research on user-led innovation at the corporate-level. Also, we analyzed the train development project (SR000) of Seoul Metropolitan Rapid Transit Corporation (SMRT). We focused on identifying the success factors of user-led innovation, and development process.

• 기술혁신연구
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• 제16권2호
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• pp.17-40
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• 2008

The collaboration among academia, industry, and public research sector gains importance in these days. This is essential for implement competent regional and national innovation systems. There have been many governmental programs for activating collaboration among innovation actors. Most policy programs for collaboration have aimed at increasing S&T and innovation potential and constructing S&T infrastructure. However, Korea has not produced a sufficient level of collaboration, especially on regional level. Most policy programs could not reach regions and many regions have no enough innovation actors. In order to activate R&D collaboration, therefore, we suggest that Korean S&T community should build and implement "collaborative research centers" all over the regions. This concept is very new approach, especially because it focuses on collaboration among regional innovation actors. In this paper, we discuss a concept, type, and execution strategy of collaboration research centers. We expect that these centers will play an important role in implementing successful regional innovation systems, as they will link regional innovation actors very closely.

• 지식경영연구
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• 제7권1호
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• pp.49-63
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• 2006

The objective of the study is to verify the discriminatory power of technology innovation in predicting Early Stage Ventures' success or failure. To accomplish this objective, we test early stage ventures'(Firm's period is below 3 years)technology innovation and performance. The result of the study is expected to be useful in loan evaluation, investment decision, internal management decision making and business improvement. The results of study is as follows. First, Early Stage Ventures' technology innovation power is composed of 4 major indexes(technology, marketability, manufacturing infra and economic feasibility). Second, we find that thirty-seven minor indexes are significant ex-ante variable which are discriminating between firms' success and failure in Early Stage Ventures. Also thirty-seven minor indexes explain 57.2% of the total variance. This explainable power of these indexes is similar to that of the existing 58 index elements. Finally, we find that the most important technology innovation power of Early Stage Ventures' is economic feasibility.

• 항공우주시스템공학회지
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• 제10권4호
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• pp.41-49
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• 2016

본 연구는 산업별 혁신체제의 관점에서, 한국의 우주개발에서의 산업부문 혁신체제 모델을 창출하고자 하는 것이다. 주요 내용은, 우주개발 혁신체제의 3가지 하위 구성요소들을 도출하여, 그것들의 특성을 분석하는 것이다. 3가지 하위 구성요소들이란, 개발 체제 (정부출연연구소를 중심으로 한 주체 및 협력관계), 자원 (재원 및 인력) 및 연구 성과의 확산을 말한다. 산업부문의 기술혁신을 낳게 한 요인들을 파악하는 것은 기술혁신정책에서 중요하다. 기술혁신정책이 전 산업수준에서가 아니라 좀 더 구체적인 개별 산업차원에서 형성되어야 한다는 것이다.