• Food Science of Animal Resources
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• v.30 no.6
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• pp.957-965
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• 2010

To develop a new starter culture for fermented milk, Streptococcus macedonicus LC743 was isolated from raw milk and its physiological characteristics were investigated. S. macedonicus LC743 showed good immunomodulating activity compared to the index LAB starters tested. The optimum growth temperature of S. macedonicus LC743 was $40^{\circ}C$, and it took 18 h to reach pH 4.34 under these conditions. S. macedonicus LC743 showed higher sensitivity to novobiocin in a comparison of 15 different antibiotics and showed the highest resistance to gentamycin. It also showed higher activities of leucine arylamidase and acid phosphatase. Moreover, it was comparatively tolerant to bile juice and acid and displayed high resistance to Escherichia coli, Salmonella Typhimurium, Staphylococcus aureus with rates of 80.0%, 68.42%, and 81.54% respectively. These results demonstrate that S. macedonicus LC743 could be an excellent starter culture for fermented milk with a high level of immunomodulating activity.

• Microbiology and Biotechnology Letters
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• v.48 no.4
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• pp.429-438
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• 2020

The emergence of multi-drug resistant, pathogenic methicillin-resistant Staphylococcus aureus (MRSA) is a threat to global health and has created a need for novel functional therapeutic agents. In this study, we evaluated the underlying mechanisms of the anti-MRSA effect of an azaphilone pigment, sclerotiorin (SCL) from Penicillium sclerotiorum. The antimicrobial activity of SCL was evaluated using agar disc diffusion, broth microdilution, time-kill assays and biophysical studies. SCL exhibits selective activity against Gram positive bacteria including MRSA (range, MIC = 128-1028 ㎍/ml) and exhibited rapid bactericidal action against MRSA with a > 4 log reduction in colony forming units within three hours of administration. Biophysical studies, using fluorescent probes and laser or electron microscopy, demonstrated a SCL dose-dependent alternation in membrane potential (62.6 ± 5.0.4% inhibition) and integrity (> 95 ± 2.3%), and the release of UV260 absorbing materials within 60 min (up to 3.2 fold increase, p < 0.01) of exposure. Further, SCL localized to the cytoplasm and hydrolyzed plasmid DNA. While in vitro checkerboard studies revealed that SCL potentiated the antimicrobial activity of topical antimicrobials such as polymixin, neomycin, and bacitracin (Fractional Inhibitory Concentration Index range, 0.26-0.37). Taken together these results suggest that SCL targets the membrane and DNA of MRSA to facilitate its anti-MRSA antimicrobial effect.

• Animal cells and systems
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• v.16 no.4
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• pp.329-336
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• 2012

This study evaluated ecological health, using various biomarkers and bioindicators, of pale chub (Zacco platypus) as a sentinel species, in Daejeon Stream, South Korea, during AprilMay 2011. The biomarkers and bioindicators were compared among three sites of control: Reference ($C_z$), transition ($T_z$), and the urban zones ($U_z$); and the 7-Ethoxyresorufin-O-deethylase (EROD) activity, DNA damage, acetylcholinesterase (AChE) activity, and vitellogenin (VTG) concentrations were more significantly increased in the $U_z$ than in the $C_z$. Also, physiological markers such as condition factor, liver somatic index, visceral somatic index, and gonad somatic index were significantly increased in the $U_z$ than in the $C_z$. For the health assessments, three categorized parameters of blood chemistry, molecular biomarkers, and physiological bioindicators were standardized and calculated as a star-plot, representing values of Integrated Health Response (IHR). Values of IHR had more significant (P<0.05) increases in the $U_z$ than any other zones, indicating an impairment of ecological health by organic matter, nutrients (N, P), and toxic chemicals. This study is based on low levels of biological organization approach of molecular and physiological biomarkers and bioindicators, so further study of high-levels of biological organization approach such as community and population is required for overall range of health assessments. The approach of IHR values, however, may be useful in providing early warning of future impacts on ecological health.

• Journal of the Korean Geographical Society
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• v.49 no.5
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• pp.779-793
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• 2014

This study was aimed at examining the recent and the future changes of tourism climatic conditions for Chiaksan national park using TCI(Tourism Climate Index). The distribution type of daily mean of TCI showed the bimodal-shoulder peaks for all periods of the past and the future. Therefore, Chiaksan national park showed affordable climate of touring in spring and autumn due to temperature and relative humidity constituting Cid and Cia. Summer tourism climatic conditions of Chiaksan national park has become worse recently. In the future, these trends are projected more stronger. Also, the lowest TCI in the year is projected to shift from winter to summer due to a decrease of Cid.

• Korean Journal of Food Science and Technology
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• v.25 no.3
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• pp.282-287
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• 1993

The effect of ethanol concentration for extraction of cinnamon on chemical and physical properties of the extracts was investigated. The cinnamon was extracted at $80^{\circ}C$ for 5 hours. High contents of cinnamic acid, aldehyde, eugenol and antioxidant activity were found in the extracts of $60{\sim}90%$ ethanol. Free sugar, tannin, degree of browning and total solids were measured relatively high in 70% ethanol extract while total amino acids and minerals were increased as the ethanol concentration decreased. The overall data suggested 70% ethanol as the most effective solvent for cinnamon extraction.

• Journal of radiological science and technology
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• v.43 no.1
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• pp.23-27
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• 2020

In South Korea, female individuals in their forties show a high rate of incidence, with approximately 13% of the patients being <40 years. This statistic is more than twice as high as that in Western countries. It is therefore necessary to identify the risk factors for breast cancer incidence by age and economic activity participation status. Women aged 30 to 59-whether breast cancer patients or those in the control group and having no breast cancer-were appraised from the sample cohort database. The data were analyzed using the statistical software R36.2. To identify the factors affecting breast cancer incidence, the degree of association was determined with HR and 95% CI by means of cox regression analysis. As for the socio-demographic variables, the older the individual, the higher the risk of breast cancer incidence becomes. As for the economic activity variables, those who were dependents (unemployed) and who had higher income (medium and high) were at higher risk of breast cancer incidence, which was statistically significant. The income-adjusted HR (model 1) for breast cancer development associated with the economic activity was 1.452 (95% CI, 1.19-1.77). The body mass index and alcohol intake-adjusted HR (model 2) was 1.431 (95% CI, 1.18-1.74). One needs to pay attention to policy plans regarding women's quality of life, as well as to the risk of breast cancer incidence by their economic activity. In other words, policies need to give post care, instead of focus on early detection and cancer treatment.

• ETRI Journal
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• v.35 no.6
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• pp.1134-1143
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• 2013

The rising pace of technological change in information and communications technology (ICT) has provoked technological convergence by providing a new mode of diversification. This paper investigates the nature of ICT-based converging technologies by examining comparative empirical evidence on converging versus nonconverging technologies in relation to the following issues: patent application trends, concentration across technologies, the concentration of patenting activity across firms, R&D efforts, and a technology impact index. For this study, a new operational definition of ICT-based converging technology is derived, and a massive quantity of patents, up to around 600,000, is analyzed. This study follows the International Patent Classification as well as the modified European Commission's industry classification system for the classification of technologies and industries, respectively.

• Journal of Hydrogen and New Energy
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• v.23 no.2
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• pp.191-197
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• 2012

The hydrogen storage is one of the key technologies to achieve the successful hydrogen economy and a chain to connect hydrogen production to its utilization. In this paper, characteristics and strong candidates of hydrogen storage technologies were analyzed from the objective information of patents. Also, the hydrogen storage technology trends and gaps were assessed using statistical or qualitative analysis. In this study the patents applied in Korea, Japan, US and EU from 10 or 20 years ago to 2011 were analyzed. The result of patent analysis could be used for developing or searching for promising technology of the hydrogen storage.

• Journal of Korea Technology Innovation Society
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• v.14 no.spc
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• pp.1187-1208
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• 2011

This research aims to propose a systematic approach to identify emerging technology-product portfolio for small and medium enterprises (SMEs). Firstly, operational definition of emerging technology for SMEs is presented. Secondly, research framework is suggested and case study to show usefulness of the newly proposed framwork is analyzed. In detail, reference patent set which represent company's capabilities and business area are constructed. The research constructs patent data set for bibliometric analysis using reference patent set and citing patents to 2nd level. Clustering (expert judgement) and keyword based bibliometric approach are used. Then, cluster activity index (AI) and relevance index (RI) comparing with reference patent set are estimated. With emerging technology-product portfolio using AI and RI, a firm can identify emerging technology-product area and monitoring area.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.14 no.3
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• pp.215-222
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• 2021

As the importance of human-computer interaction (Human Computer Interface) technology grows and research on HCI is progressing, it is inferred about the research emotion inference or the computer reaction according to the user's intention, not the computer reaction by the standard input of the user. Stress is an unavoidable result of modern human civilization, and it is a complex phenomenon, and depending on whether or not there is control, human activity ability can be seriously changed. In this paper, we propose an intelligent emotional recommendation system using music as a way to relieve stress after measuring heart rate variability (HRV) and acceleration photoplethymogram (APG) increased through stress as part of human-computer interaction. The differential evolution algorithm was used to extract reliable data by acquiring and recognizing the user's biometric information, that is, the stress index, and emotional inference was made through the semantic web based on the obtained stress index step by step. In addition, by searching and recommending a music list that matches the stress index and changes in emotion, an emotional recommendation system suitable for the user's biometric information was implemented as an application.