• Journal of Life Science
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• v.25 no.3
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• pp.357-367
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• 2015

With the ongoing development of next-generation sequencing (NGS) platforms and advancements in the latest bioinformatics tools at an unprecedented pace, the ultimate goal of sequencing the human genome for less than $1,000 can be feasible in the near future. The rapid technological advances in NGS have brought about increasing demands for statistical methods and bioinformatics tools for the analysis and management of NGS data. Even in the early stages of the commercial availability of NGS platforms, a large number of applications or tools already existed for analyzing, interpreting, and visualizing NGS data. However, the availability of this plethora of NGS data presents a significant challenge for storage, analyses, and data management. Intrinsically, the analysis of NGS data includes the alignment of sequence reads to a reference, base-calling, and/or polymorphism detection, de novo assembly from paired or unpaired reads, structural variant detection, and genome browsing. While the NGS technologies have allowed a massive increase in available raw sequence data, a number of new informatics challenges and difficulties must be addressed to improve the current state and fulfill the promise of genome research. This review aims to provide an overview of major NGS technologies and bioinformatics tools for NGS data analyses.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.44 no.3
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• pp.34-38
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• 2007

There has been skeptical aspects for the robot to be effective in combat fields even though consensus of operational needs and some technological advancements. One of fundamental problems is difficulties in the autonomous technology applicable. This technology is not sufficient to be applied for heavy combat operation, therefore, developer first make open architecture, then, application is implemented on the condition that new functions or technologies will be developed later. It is also required to partition all the functions with common segments which are general to all platforms in order to operate together in the fields and to reduce the load of development to each platform respectively. In addition, common middleware based on the reference architecture is also developed to accommodate new technology evolution. This paper introduces the architecture and middleware applied in XAV(eXperimental Autonomous Vehicle) developed in ADD. In addition, the performance of autonomous navigation and system design characteristics are introduced briefly.

• Genomics & Informatics
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• v.14 no.3
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• pp.78-84
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• 2016

Extranodal natural killer (NK)/T-cell lymphoma, nasal type (NKTCL), is a malignant disorder of cytotoxic lymphocytes of NK or T cells. It is an aggressive neoplasm with a very poor prognosis. Although extranodal NKTCL reportedly has a strong association with Epstein-Barr virus, the molecular pathogenesis of NKTCL has been unexplored. The recent technological advancements in next-generation sequencing (NGS) have made DNA sequencing cost- and time-effective, with more reliable results. Using the Ion Proton Comprehensive Cancer Panel, we sequenced 409 cancer-related genes to identify somatic mutations in five NKTCL tissue samples. The sequencing analysis detected 25 mutations in 21 genes. Among them, KMT2D, a histone modification-related gene, was the most frequently mutated gene (four of the five cases). This result was consistent with recent NGS studies that have suggested KMT2D as a novel driver gene in NKTCL. Mutations were also found in ARID1A, a chromatin remodeling gene, and TP53, which also recurred in recent NGS studies. We also found mutations in 18 novel candidate genes, with molecular functions that were potentially implicated in cancer development. We suggest that these genes may result in multiple oncogenic events and may be used as potential bio-markers of NKTCL in the future.

• Journal of Digital Contents Society
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• v.16 no.5
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• pp.757-766
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• 2015

Recent technological advancements, along with an increase in mobile Internet access, have spurred on significant developments in the production of e-textbooks. This case study explored the affordances of an iPad e-textbook through teacher and student experiences in English lessons using observation and interviews. The results showed that English learners and teacher benefited from handy and quick web access and the all-in-one features of the e-textbook (dictionary, hyperlinks, and note-taking functions). However, information oversupply by the e-textbook confused students' learning and both students and teacher pointed out technical difficulties in using the e-textbook. In order to implement English pedagogy with technologies such as iPad e-textbooks, teachers should be equipped with the relevant technical skills and content knowledge in order to assist them in becoming autonomous learners in the digital classroom.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.4
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• pp.299-305
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• 2017

Re-engineering is gaining attention due to severe environmental pollution and economic crisis. Although re-engineering in shipbuilding has been carried out steadily, technological advancements, domestic ship repair and maintenance industries are not as prevalent as shipbuilding industries. In order to solve this problems, laser cladding can significantly aid with technical development. Laser cladding produces an outstanding clad layer with minimal dilution and little porosity. In this study, prior to applying laser cladding to an exhaust valve face, the effects of various parameters that affect the characteristics of the 1 pass clad layer were investigated. When laser power was increased, the clad layer width became broader and the height was decreased. In addition, it was identified that the hardness of the clad layer was inversely proportional to the power, and the entire clad layer was diluted through an EDS chemical composition analysis.

• Journal of Convergence for Information Technology
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• v.11 no.11
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• pp.23-30
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• 2021

Due to the recent advancements of mobile telecommunication technology and high mobile phone penetration rate, researches on emergency text alert service for enhancing the accessibility have been actively conducted. The worldwide spread of COVID-19 further accelerates the efforts for the alert services. Existing emergency text services are simple and efficient. However, unclear reception area may cause unintended alert messages frequently. In this paper, we analyze survey results regarding the 5G-based text-alert services to derive service requirements for technological advancement. Then we propose an emergency disaster text service scenario using Active Geo-Targeting that enables active disaster text reception of terminals. In addition, we newly define an interface protocol that is CIB(Control Information Block) to operate the proposed scenario.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2016.10a
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• pp.210-212
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• 2016

Today, video games created via 3D softwares become a core part of the essential the video game contents field because their properties that can produce more easier than 2D games and can save budget of contents makings. It is very important that reducing polygon counts of 3D characters and environments for Gaming optimization. We can formulate elaborate 3D game models with low polygon counting in virtue of technological advancements, and these technologies continue to evolve. In 2012, Pixar made public Open subdivision which is the new technology to make high quality 3D models with low polygons and distributed that via Open source verification. This paper will compare and analyze the characteristics, and merits and demerits of these various kinds of these skills(Mesh smooth, Turbo Smooth, Open subdivision) and will inquire which method is the most efficient one to make 3D video games.

• Journal of dental hygiene science
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• v.21 no.2
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• pp.104-110
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• 2021

Background: Regardless of countries, the myth that rain makes the body ache has been worded in various forms, and a number of studies have been reported to investigate this. However, these studies, which depended on the patient's experience or memory, had obvious limitations. Google Trends is a big data analysis service based on search terms and viewing videos provided by Google LLC, and attempts to use it in various fields are continuing. In this study, we endeavored to introduce the 'value as a research tool' of the Google Trends, that has emerged along with technological advancements, through research on 'whether toothaches really occur frequently on rainy days'. Methods: Keywords were selected as objectively as possible by applying web crawling and text mining techniques, and the keyword "bi" meaning rain in Korean was added to verify the reliability of Google Trends data. The correlation was statistically analyzed using precipitation and temperature data provided by the Korea Meteorological Agency and daily search volume data provided by Google Trends. Results: Keywords "chi-gwa", "chi-tong", and "chung-chi" were selected, which in Korean mean 'dental clinic', 'toothache', and 'tooth decay' respectively. A significant correlation was found between the amount of precipitation and the search volume of tooth decay. No correlation was found between precipitation and other keywords or other combinations. It was natural that a very significant correlation was found between the amount of precipitation, temperature, and the search volume of "bi". Conclusion: Rain seems to actually be a cause of toothache, and if objective keyword selection is premised, Google Trends is considered to be very useful as a research tool in the future.

• International Journal of Computer Science & Network Security
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• v.21 no.11
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• pp.301-311
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• 2021

The technological advancements of the last two decades directed the era of the Internet of Things (IoT). IoT enables billions of devices to connect through the internet and share their information and resources on a global level. These devices can be anything, from smartphones to embedded sensors. The main purpose of IoT is to make devices capable of achieving the desired goal with minimal to no human intervention. Although it hascome as a social and economic blessing, it still brought forward many security risks. This paper focuses on providing a survey of the most commonly used application layer protocols in the IoT domain, namely, Constrained Application Protocol (CoAP), Message Queuing Telemetry Transport (MQTT), Advanced Message Queuing Protocol (AMQP), and Extensible Messaging and Presence Protocol (XMPP). MQTT, AMQP, and XMPP use TCP for device-to-device communication, while CoAP utilizes UDP to achieve this purpose. MQTT and AMQP are based on a publish/subscribe model, CoAP uses the request/reply model for its structuring. In addition to this, the quality of service provision of MQTT, AMQP, and CoAP is not very high, especially when the deliverance of messages is concerned. The selection of protocols for each application is very a tedious task.This survey discusses the architectures, advantages, disadvantages, and applications of each of these protocols. The main contribution of this work is to describe each of the aforementioned application protocols in detail as well as providing their thorough comparative analysis. This survey will be helpful to the developers in selecting the protocol ideal for their system and/or application.

• Journal of Dental Anesthesia and Pain Medicine
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• v.23 no.1
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• pp.1-8
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• 2023

Backgrounds: Pain management is one of the most important factors affecting the success of pediatric dentistry. Therefore, new needle- and pain-free local anesthesia techniques have been developed in parallel with technological advancements. The purpose of this study is to compare the pain perception and dental anxiety levels associated with a needle-free injection system (Comfort-in^TM) and the classic needle method during treatment-required infiltration anesthesia in children. Methods: This randomized controlled crossover split-mouth clinical study included 94 children who required dental treatment with local anesthesia using a dental needle or needle-free injection system for the bilateral primary molars. The Wong-Baker Scale (WBS) was used to measure pain perception at different times, and the Modified Child Dental Anxiety Scale (MCDAS) was used to measure the anxiety level of the child. A statistical software package was used to process the data. Statistical significance was set at P < 0.05. Results: There was no significant difference between the needle-free injection system and dental needle method during the induction stage for filling and pulpotomy (P > 0.05). "Pain on postoperative 1st day" was similar in both types of anesthesia (P = 0.750). Conclusions: The needle-free injection system was as effective as the dental needle method. The Comfort-in^TM system was an acceptable alternative for patients during the postoperative period. Understanding how pain management may be provided during local anesthesia administration and a child's fear and anxiety regarding the dentist may lead to better dental compliance.