• Journal of Pharmaceutical Investigation
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• 제31권2호
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• pp.73-80
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• 2001

Lung perfusion scanning, invariably combined with ventilation studies provides a reliable and non-invasive mean to diagnose lung related pathologies despite the availability of modern techniques such as angiography, magnetic resonance imaging, magnetic resonance angiography, and helical (spiral) computed tomography. The technique involves the generation of images by radiations emitted from radioisotopes introduced in to the lungs. Various radiopharmaceuticals have been proposed and designed to incorporate $Tc^{99m}$ in to macroparticulate form for lung perfusion imaging. However, most of these have associated difficulties such as reproducibility of the product with regards to particle size distribution and poor elimination from the lung capillary bed. $Tc^{99m}$ macroaggregated albumin $(Tc^{99m}-MAA)$ is used extensively for clinical lung perfusion imaging and is considered as the radiopharmaceutical of choice. It is non-toxic, safe, and being biodegradable, is easily eliminated from the lung capillary bed by proteolytic enzyme metabolism and by mechanical forces due to lung movement.

• Tuberculosis and Respiratory Diseases
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• 제50권1호
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• pp.117-121
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• 2001

간성수흉증은 폐나 심장에 일차적인 질환 없이 간경변증 환자에서 흉수가 동반된 경우로 대부분의 경우에서 복수를 동반하며 복수가 없는 간성수흉증은 매우 드물다. 저자 등은 호흡곤란을 주소로 내원한 75세 여자 환자에서 동위 원소로 증명된 복수를 동반하지 않은 간성수흉증 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한방사성의약품학회지
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• 제7권1호
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• pp.50-55
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• 2021

Low-dose radiotherapy has been known to have anti-inflammatory activity and been used for treatment of pneumonia together with anti-serum and sulfanilamide. However, it rapidly discontinued after the development of various antibiotics showing outstanding effect. Recently, it was re-considered to treat COVID-19 which has very limited treatment such as remdesivir and dexamethasone. So, several studies of COVID-19 therapy using low-dose radiation were reported very recently. They showed that low-dose radiation of 0.5~1.5 Gy were useful for decreasing the oxygen consumption and hospitalization period of COVID-19 patients without adverse reaction. Radiopharmaceuticals such as [⁹⁹mTc]Tc-macroaggregated albumin (MAA) also might be used for low-dose radiotherapy. Administration of vitamin D having anti-inflammatory effect would also be helpful for therapy with synergistic effect.