• Journal of Sensor Science and Technology
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• v.32 no.3
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• pp.180-186
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• 2023

Test devices can perform various functions, such as research on detection targets, sensors that detect detection targets, combined products containing sensors, and certification for the launch of combined products. However, the scope of use of test devices is limited because they perform only a single role or could only serve a particular purpose in the past. Therefore, studies on test devices that can perform various functions, such as research on detection targets, sensors that detect detection targets, combined products containing sensors, and certification for the release of combined products are necessary. Accordingly, this study proposes a test device that can increase the scope of use in the technical field of electric fires. In addition, we examine various outcomes of the proposed test device.

• Proceedings of the Materials Research Society of Korea Conference
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• 1994.11a
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• pp.29-29
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• 1994

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.13 no.2
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• pp.155-161
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• 2015

Technetium-99m (^99mTc) is an important, short-lived decay product of molybdenum-99 (⁹⁹Mo), and it is considered the backbone of the modern nuclear diagnostic procedures. Since fission of ²³⁵U is the main source of production of ⁹⁹Mo, either highly-enriched uranium (HEU) targets or low-enriched uranium (LEU) targets are irradiated in the research reactors. The use of LEU targets is being promoted by the international community to avoid the proliferation issues linked with the use of HEU. In order to define the waste management strategy at the planning stage of establishment of an LEU based ⁹⁹Mo production facility, the impact of the use of LEU targets on the radioactive waste stream of the ⁹⁹Mo production facility was analyzed. Because the volume of uranium waste is estimated to increase six times, the use of high uranium density targets and the utilization of hot isostatic pressing were recommended to reduce the increased waste volume from the use of LEU based targets.

• Journal of Microbiology and Biotechnology
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• v.15 no.5
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• pp.965-970
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• 2005

In our previous study [14], we found that heat-shock exposure did not stimulate the neutral trehalase activity in Sacchromyces cerevisiae KNU5377, but did in ATCC24858. Consequently, the trehalose content in KNU5377 became 2.6 times higher than that in ATCC24858. Because trehalose has been shown to stabilize the structure and function of some macromolecules, the present work was focused to elucidate the relationship between trehalose content of these strains and thermal stabilities of whole cells, through differential scanning calorimetry (DSC), and to predict critical targets calculated from the hyperthermic cell killing rates. These analyses showed that the prominent DSC transition of both strains gave identical $T_m$ (transition temperature) values in exponentially growing cells, and that the $T_m$ values of critical targets was about $3^{\circ}C$ higher in KNU5377 than in ATCC24858. Both heat-shocked KNU5377 and ATCC24858 cells displayed similar shifts in their DSC transition profiles. On the other hand, the $T_m$ value of the critical target of KNU5377 was decreased by $2.1^{\circ}C$, which was still higher than ATCC24858 showing no changes. In view of these results, the intrinsic thermotolerance of KNU5377 did not appear to result from the stability of entire cellular components, but rather possibly from that of particular macromolecules, including critical targets, even though it should be investigated in more details. Although the trehalose levels in heat-shocked cells are significantly different, as described in our previous study [14], the overall pattern of thermal stabilities and their predicted critical targets in two heat-shocked strains seemed to be identical. These data suggest that the trehalose levels examined before and after heat shock of exponentially growing cells are not closely correlated with the stabilities of whole cells and/or critical targets in both yeast strains.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10345-10350
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• 2015

Background: Punica granatum (family: Lythraceae) is mainly found in Iran, which is considered to be its primary centre of origin. Studies on pomegranate peel have revealed antioxidant, anti-inflammatory, anti-angiogenesis activities, with prevention of premature aging and reducing inflammation. In addition to this it is also useful in treating various diseases like diabetes, maintaining blood pressure and treatment of neoplasms such as prostate and breast cancer. Objectives: In this study we identified anti-cancer targets of active compounds like corilagin (tannins), quercetin (flavonoids) and pseudopelletierine (alkaloids) present in pomegranate peel by employing dual reverse screening and binding analysis. Materials and Methods: The potent targets of the pomegranate peel were annotated by the PharmMapper and ReverseScreen 3D, then compared with targets identified from different Bioassay databases (NPACT and HIT's). Docking was then further employed using AutoDock pyrx and validated through discovery studio for studying molecular interactions. Results: A number of potent anti-cancerous targets were attained from the PharmMapper server according to their fit score and from ReverseScreen 3D server according to decreasing 3D scores. Conclusion: The identified targets now need to be further validated through in vitro and in vivo studies.

• BMB Reports
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• v.37 no.4
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• pp.439-444
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• 2004

Double stranded targets on the cDNA microarray contain representatives of both the coding and noncoding strands, which will introduce hybridization competition with probes. Here, the effect of double and single strands of targets on the signal intensity and the ratios of Cy5/Cy3 within the same slide were compared. The results show that single stranded targets can increase the hybridization efficiency without changing the Cy5/Cy3 ratio. Based on these results, a new strategy was established by generating cDNA targets with asymmetric PCR, instead of conventional PCR, to increase the sensitivity of the cDNA microarray. Furthermore, the feasibility of this approach was validated. The results indicate that the cDNA microarray system based on asymmetric PCR is more sensitive, with no decrease in the reliability and reproducibility as compared with that based on conventional symmetric PCR.

• Journal of Korean Society for Quality Management
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• v.47 no.1
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• pp.33-46
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• 2019

Purpose: This study proposed a DEA (Data Envelopment Analysis)-based stepwise benchmarking target selection for inefficient DMU (Decision Making Unit) to improve its efficiency gradually to reach most efficient frontier considering resource (DEA inputs and outputs) improvement preferences. Methods: The proposed method proceeded in two steps. First step evaluates efficiency of DMUs by using DEA, and an evaluated DMU selects benchmarking targets of HCU (Hypothesis Composit Unit) or RU (Real Unit) considering resource improvement preferences. Second step selects stepwise benchmarking targets of the inefficient DMU. To achieve this, this study developed a new DEA model, which can select a benchmarking target of an inefficient DMU in considering inputs or outputs improvement preference, and suggested an algorithm, which can select stepwise benchmarking targets of the inefficient DMU. Results: The proposed method was applied to 34 international ports for validation. In efficiency evaluation, five ports was evaluated as most efficient port, and the remaining 29 ports was evaluated as relative inefficient port. When port 34 was supposed as evaluated DMU, its can select its four stepwise benchmarking targets in assigning the preference weight to inputs (berth length, total area of pier, CFS, number of loading machine) as (0.82, 1.00, 0.41, 0.00). Conclusion: For the validation of the proposed method, it applied to the 34 major ports around the world and selected stepwise benchmarking targets for an inefficient port to improve its efficiency gradually. We can say that the proposed method enables for inefficient DMU to establish more effective and practical benchmarking strategy than the conventional DEA because it considers the resource (inputs or outputs) improvement preference in selecting benchmarking targets gradually.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.4
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• pp.365-374
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• 2023

Crohn's disease (CD) is a chronic inflammatory illness of the digestive system with unknown etiology, and its incidence is increasing worldwide. However, there are currently no effective treatments or medications available for individuals with CD. Therefore, novel therapeutic strategies are urgently needed. The bioactive compounds and targets associated with compounds of Qinghua Xiaoyong Formula (QHXYF) were examined using The Traditional Chinese Medicine Systems Pharmacology database, and 5 disease target databases were also used to identify CD-related disease targets. A total of 166 overlapping targets were identified from QHXYF-related and CD-related disease targets and they were found to be enriched in oxidative stress-related pathways and the PI3K/AKT signaling pathway. Molecular docking was then used to predict how the bioactive compounds would bind to the hub targets. It was found that quercetin could be the core bioactive compound and had good binding affinity to the top 5 hub targets. Finally, animal experiments were performed to further validate the findings, and the results revealed that QHXYF or quercetin inhibited 2,4,6-trinitrobenzenesulfonic acid-induced inflammation and oxidative stress processes by inhibiting the PI3K/AKT pathway, thereby improving CD symptoms. These findings suggest that QHXYF and quercetin may be potential novel treatments for CD.

• Korean Journal of Remote Sensing
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• v.31 no.2
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• pp.111-125
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• 2015

In this study, the target detection using both high-resolution satellite SAR and Elecro-Optical (EO) images such as TerraSAR-X and WorldView-2 is performed, considering the characteristics of targets. The targets of our interest are featured by being stationary and appearing as cluster targets. After the target detection of SAR image by using Constant False Alarm Rate (CFAR) algorithm, a series of processes is performed in order to reduce false alarms, including pixel clustering, network clustering and coherence analysis. We extend further our algorithm by adopting the fast and effective ellipse detection in EO image using randomized hough transform, which is significantly reducing the number of false alarms. The performance of proposed algorithm has been tested and analyzed on TerraSAR-X SAR and WordView-2 EO images. As a result, the average false alarm for group of targets is 1.8 groups/$64km^2$ and the false alarms of single target range from 0.03 to 0.3 targets/$km^2$. The results show that groups of targets are successfully identified with very low false alarms.

• Korean Journal of Remote Sensing
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• v.24 no.2
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• pp.91-98
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• 2008

We present an efficient and robust technique to estimate the velocity of moving targets from a single SAR image. In SAR images, azimuth image shift is a well blown phenomenon, which is observed in moving targets having slant-range velocity. Most methods estimated the velocity of moving targets from the distance difference between the road and moving targets or between ship and the ship wake. However, the methods could not be always applied to moving targets because it is difficult to find the road and the ship wake. We propose a method for estimating the velocity of moving targets from azimuth differentials of range-compressed image. This method is based on a phenomenon that Doppler center frequency shift of moving target causes a phase difference in azimuth differential values. The phase difference is linearly distorted by Doppler rate due to the geometry of SAR image. The linear distortion is eliminated from phase removal procedure, and then the constant phase difference is estimated. Finally, range velocity estimates for moving targets are retrieved from the constant phase difference. This technique was tested using an ENVISAT ASAR image in which several unknown ships are presented. In the case of a isolated target, the result was nearly coincident with the result from conventional method. However, in the case of a target which is located near non-target material, the difference of the result between from our algorithm and from conventional method was more than 1m/s.