• 한국정보디스플레이학회:학술대회논문집
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• 2006.08a
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• pp.1402-1405
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• 2006

Using a indium zinc oxide (IZO) alloy target with a ratio of 90:10 in wt%, highly transparent conducting oxide (TCO) thin films are prepared on polyethersulfone (PES) substrates by lowfrequency (LF) magnetron sputtering system. These films have amorphous structures with excellent electrical stability, surface uniformity and high optical transmittance. Experiments were carried out as a function of applied voltage. At optimal deposition conditions, thin films of IZO with a sheet resistance of 29 ohm/sq. and an optical transmission of over 82 % in the visible spectrum range were achieved. The IZO thin films fabricated by this method do not require substrate heating during the film preparation or any additional post-deposition annealing treatment.

• Environmental Mutagens and Carcinogens
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• v.26 no.2
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• pp.35-40
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• 2006

Background: Inorganic arsenic is a human carcinogen that can target the liver, but its carcinogenic mechanisms are still unknown. Inorganic arsenic induces a spectrum of tumors including hepatocellular carcinoma in mice. Methods: Pregnant C3H mice were supplied with drinking water containing 50 ppm sodium arsenite during their pregnancy. The protein expression profile in the liver of 0.5-day-old. male offsprings exposed transplacentally to sodium arsenite was analyzed using protein 2D gel electrophoresis followed by mass spectrometry (MALDI-TOF). Results: Expression of proteins such as hydroxymethylglutaryl-CoA synthase mitochondrial precursor (HMG-CoA synthase), ${\beta}$-actin (cytoplasmic 1) and apolipoprotein A-IV precursor (Apo-AIV) were induced in mouse liver by sodium arsenite, while uricase (urate oxidase), guanine nucleotidebinding protein beta subunit 2-like 1 (RACK1) and fructose-bisphosphate aldolase B (Aldolase 2) were down-regulated. Summary: Expression of proteins that have been implicated in carcinogenesis, such as HMG-CoA, ${\beta}$-actin, and RACK1, was regulated in the liver of mice transplacentally exposed to inorganic arsenic.

• BMB Reports
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• v.32 no.1
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• pp.12-19
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• 1999

Gaegurin 4 (GGN4), a broad-spectrum antibiotic, is a 37-amino acid peptide isolated from the Korean frog, Rana rugosa. In this study, we have chemically synthesized and purified GGN4 analogues where the C-terminal portion is truncated and/or substituted with tryptophan. These peptides show significantly different biological activities depending on the location of tryptophan and the number of amino acids truncated from the C-terminal end. While deletion of 9 amino acids from the C-terminal seems to be marginally tolerable in maintaining the antimicrobial activity, further deletion of up to 14 amino acid residues decreases the potency by more than 60-fold towards Gram-positive, and 10-fold towards Gram-negative, bacteria. Surprisingly, the reduced activity of the shorter peptide can be completely restored by a single substitution of aspartic acid 16 to tryptophan 16 (D16W). Also, the truncation seems to decrease the specificity of antibiotic activity more towards Gram-positive than towards Gram-negative bacteria studied. These data suggest a partial role of the C-terminal region in determining the binding specificity and the activity of peptides upon binding to their target cell membranes.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2001.09a
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• pp.67-74
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• 2001

This paper presents the Safe Shutdown Earthquake(SSE) input motion for the seismic design of the Advanced Power Reactor 1400(APR1400). The Design Ground Response Spectra(DGRS) far the SSE is based on the design spectrum specified in regulatory Guide(RG) 1.60 of U.S. Nuclear Regulatory Commission(US NRC), anchored to a Peak Ground Acceleration(PGA) of 0.3g and enriched in the high frequency range. This SSE seismic input motion is to be applied to the seismic analysis as the free-field seismic motion at the ground surface of both the rock and generic soil sites fur APRI1400. The enrichment for APR1400 seismic input motion is performed considering the current US NRC regulations, the seismic hazard studies performed by the Lawrence Livermore National Laboratory (LINL) and Electric Power Research Institute(EPRI) for the Central and Eastern United States nuclear power plant sites, and the seismic input motions used in the design certifications of the three existing U.S. advanced standard plants. It is represented by a set of DGRS and the accompanying Target Power Spectral Density(PSD) Function in both the horizontal and vertical directions.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.1685-1689
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• 2016

Physical wedges still can be used as missing tissue compensators or filters to alter the shape of isodose curves in a target volume to reach an optimal radiotherapy plan without creating a hotspot. The aim of this study was to investigate the dosimetric properties of physical wedges filters such as off-axis photon fluence, photon spectrum, output factor and half value layer. The photon beam quality of a 6 MV Primus Siemens modified by 150 and 450 physical wedges was studied with BEAMnrc Monte Carlo (MC) code. The calculated present depth dose and dose profile curves for open and wedged photon beam were in good agreement with the measurements. Increase of wedge angle increased the beam hardening and this effect was more pronounced at the heal region. Using such an accurate MC model to determine of wedge factors and implementation of it as a calculation algorithm in the future treatment planning systems is recommended.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2014.10a
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• pp.48-53
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• 2014

Rocket, held using the CCA for the mission, a plurality of recording devices, and navigation equipment. In case of a projectile which is entered the water after fired into the air, after performing stages and fairing separated in flight to enter the underwater. It is caused by the explosion of gunpowder mainly, vibration phenomenon of a large transition is induced structurally very, also on entering the water, have a significant shock structurally separated. If shock is transmitted directly to the CCA through the body, it can be caused malfunction of payloads, resulting in failure of the mission of the projectile. In order to ensure the stability against shock, in this paper, Calculating a target resonacne frequency of the CCA, and verified through modal test and analysis. Maximum acceleration position of CCA is checked by SRS analysis. In addition, effectiveness of shock isolation system through shock analysis.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.135-135
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• 1998

To find an antagonist of Pythium ultimum, the causal agent of damping-off, numerous actinomycete strains were screened for in vitro inhibiting mycelial growth of the target fungus and producing bioactive metabolites. A strain identified as Streptomyces sp. G60655 was isolated and used for further antagonistic efficacy. The degree of antagonism between the fungus and G60655 was affected by the medium used. Furthermore, the preinoculation of the antagonist was found to be necessary to exhibit the maximum efficacy of antagonsim against the fungus. From the culture broth, a bioactive metabolite was detected and purified by solvent extraction, silica gel chromatography and preparative HPLC. The FAB-MS spectrum of the active compound showed a molecular ion peak at m/z 1101 (M + H)$\^$+/, suggesting the molecular weight of 1100. The UV absorptions at 242 and 323 nm indicated the presence of aromatic functions. The structure of this compound was identified as echinomycin, a depsipeptide antibiotic by spectroscopic studies including various NMR measurements. Echinomycin was inactive against several soil born fungi, but inhibited the mycelial growth of P. ultimum and its related oomycetous fungi.

• Biomaterials and Biomechanics in Bioengineering
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• v.5 no.1
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• pp.65-86
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• 2020

As conventional drug delivery system is being improved rapidly by target-based drug delivery system, finding suitable Drug Delivery System (DDS) for new drugs remains a challenge. Although there are many drug delivery vehicles in existence, a significant improvement is required to some DDS such as for local, implant-based treatments used for musculoskeletal infections. Many polymers have been considered for providing the improvement in DDS. Synthetic polymer, for example, has gained popularity for broad-spectrum physicochemical and mechanical properties. This article reviews the biomedical applications of Poly(TriMethylene Carbonate-co-Caprolactone) (PTMCC), which has attracted attention due to its biocompatibility, biodegradability and rubber-like properties. Its synthesis, physical properties, and degradation are also discussed here. Although it is relatively new in biomedical applications, it is readily usable for the fabrication of differing format of DDS of superior mechanical strength and degradation properties. The use of PTMCC is expected to increase in coming years as more is revealed about its potentials.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.10
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• pp.5095-5111
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• 2019

A multi-rotor Unmanned Aerial Vehicle (UAV) system is developed to solve the manhole cover detection problem for the infrastructure maintenance in the suburbs of big city. The visible light sensor is employed to collect the ground image data and a series of image processing and machine learning methods are used to detect the manhole cover. First, the image enhancement technique is employed to improve the imaging effect of visible light camera. An imaging environment perception method is used to increase the computation robustness: the blind Image Quality Evaluation Metrics (IQEMs) are used to percept the imaging environment and select the images which have a high imaging definition for the following computation. Because of its excellent processing effect the adaptive Multiple Scale Retinex (MSR) is used to enhance the imaging quality. Second, the Single Shot multi-box Detector (SSD) method is utilized to identify the manhole cover for its stable processing effect. Third, the spatial coordinate of manhole cover is also estimated from the ground image. The practical applications have verified the outdoor environment adaptability of proposed algorithm and the target detection correctness of proposed system. The detection accuracy can reach 99% and the positioning accuracy is about 0.7 meters.

• Earthquakes and Structures
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• v.14 no.6
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• pp.505-523
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• 2018

Static pushover analyses of typical existing reinforced concrete frames, designed according to the previous generations of design codes in Greece, have established these structures' inelastic characteristics, namely overstrength, global ductility capacity and available behaviour factor q, under planar response. These were compared with the corresponding demands at the collapse limit state target performance point. The building stock considered accounted for the typical variability, among different generations of constructed buildings in Greece, in the form, the seismic design code in effect and the material characteristics. These static pushover analyses are extended, in the present study, in the time history domain. Consequently, the static analysis predictions are compared with Incremental Dynamic Analysis results herein, using a large number of spectrum compatible recorded base excitations of recent destructive earthquakes in Greece and abroad, following, for comparison, similar conventional limiting failure criteria as before. It is shown that the buildings constructed in the 70s exhibit the least desirable behaviour, followed by the buildings constructed in the 60s. As the seismic codes evolved, there is a notable improvement for buildings of the 80s, when the seismic code introduced end member confinement and the requirement for a joint capacity criterion. Finally, buildings of the 90s, designed to modern codes exhibit an exceptionally good performance, as expected by the compliance of this code to currently enforced seismic provisions worldwide.