• 한국식품영양학회지
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• 제16권3호
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• pp.180-186
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• 2003

가열살균 처리시의 온도값을 이용하여 다양한 미생물들의 가열살균 효과를 D값, z값 등의 미생물 내열성 특성치와 kinetic 모델 및 수식을 이용하여 살균치 계산을 컴퓨터를 이용하여 수행함으로써 target 미생물의 살균정도를 예측하고자, Excel과 Visual Basic을 연동하여 작성된 시스템으로 Excel을 기본으로 사용한 프로그램을 개발하였다. 가열살균 target 미생물을 선택하고자 야채식품을 기반으로 하는 식품에서의 미생물을 검토하여, 내열성인 가장 큰 호기성 포자형성균인 Bacillus spp. 계통이 산을 형성하여 맛 등의 품질을 저하시켜 변패를 유발하며, 위생적인 면에서 포자수를 줄이거나 사멸할 필요가 있어서 선택하였다. 병원성 균 중에서 $D_{121.1}$이 0.0065분, z값이 7.8$^{\circ}C$인 Bacillus cereus와 부패현상 관련 균 중에서 $D_{121.1}$이 0.5분, z값이 12$^{\circ}C$인 Bacillus subtilis를 대상으로 해서 개발되었으며, 필요시에는 D값과 z값을 직접 대입하므로서, 여러 가지 미생물에 대해서도 적용이 가능하게 하였다.

• Journal of Communications and Networks
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• 제15권2호
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• pp.164-172
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• 2013

We consider the problem of secure and robust clustering for quantized target tracking in wireless sensor networks (WSN) where the observed system is assumed to evolve according to a probabilistic state space model. We propose a new method for jointly activating the best group of candidate sensors that participate in data aggregation, detecting the malicious sensors and estimating the target position. Firstly, we select the appropriate group in order to balance the energy dissipation and to provide the required data of the target in the WSN. This selection is also based on the transmission power between a sensor node and a cluster head. Secondly, we detect the malicious sensor nodes based on the information relevance of their measurements. Then, we estimate the target position using quantized variational filtering (QVF) algorithm. The selection of the candidate sensors group is based on multi-criteria function, which is computed by using the predicted target position provided by the QVF algorithm, while the malicious sensor nodes detection is based on Kullback-Leibler distance between the current target position distribution and the predicted sensor observation. The performance of the proposed method is validated by simulation results in target tracking for WSN.

• 한국터널지하공간학회 논문집
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• 제21권3호
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• pp.397-418
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• 2019

터널 굴착으로 인한 지반 및 인접 구조물의 거동을 이해하고 분석하는 것은 매우 중요하며, 이는 현대사회에서의 과학기술의 발전과 함께 토목공학 분야에서 폭넓게 활용되고 있다. 근거리 사진계측기법은 지반공학 분야에서 주로 쓰이고 있으며, 최근 GeoPIV 등을 이용한 계측기법의 연구가 증가하고 있는 추세이다. 본래에는 지반의 거동을 계측하여 시각화하는 방법으로 알루미늄 봉과 타겟 포인트를 이용한 VMS 프로그램이 주로 사용되어 왔다. 하지만 이러한 방법을 적용할 경우, 타겟 포인트가 손에 의해 인위적으로 설치되기 때문에 외부적인 오차가 발생할 수 있다. 또한 포인트 사이의 그리드가 넓거나 좁을 경우 희박한 데이터가 도출될 수 있는 문제점을 안고 있다. 따라서 본 연구에서는 타겟의 사용 없이 변위를 분석할 수 있는 MATLAB 기반의 No-target 프로그램을 개발하였고 수치해석과 실내 모형시험을 통해 기존의 프로그램과의 비교 및 검증에 초점을 맞추었다. 연구 내용으로는 greenfield condition, strip foundation, pile foundation 3가지 Case에 대하여 실내 모형시험을 실시하였으며, VMS 프로그램과 No-target 프로그램의 결과로부터 total displacement와 vertical displacement의 오차율을 분석하였다. 또한 유한요소 수치해석 프로그램인 PLAXIS를 통하여 실내 모형시험과의 결과와 비교 및 검증하였다.

• Asia Marketing Journal
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• 제16권2호
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• pp.39-57
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• 2014

There has been recognition of the increasing importance of cooperation as an element of marketing strategy. Such cooperation is confined to four levels based on product development, sales promotion, pricing arrangements, and place (or distribution) mechanisms as the usual marketing 4Ps mixed (Varadarajan 1986). At present, however, little is known about the nature of tie-in promotion as a cooperative sales promotion comparing three other levels. The primary goal of this study is to examine the effect of consumer - tie-in promotion relationship on loyalty. The construct of consumer - tie-in promotion relationship is based on the previous research on consumer-brand relationship. In addition, this study divides the concept of loyalty into host brand loyalty and partner brand loyalty to reflect the characteristics of tie-in promotion including program in order to determine the effect of the consumer - tie-in promotion relationship on loyalty. The results showed that the three dimensions of the consumer - tie-in promotion relationship (i.e., commitment, intimacy, and interdependence) had significantly positive effect on program loyalty. The effect of program loyalty is significantly on both host and partner brand loyalty. This study empirically tested the relationships among consumer - tie-in promotion relationship, program loyalty, host brand loyalty, and partner brand loyalty, and then compared with the difference in the suggested model for the target customers and non-target customers. As a result, for target customers, intimacy and interdependence among dimensions of consumer - tie-in promotion relationship had significantly positive influence on program loyalty. In case of non-target customers, however, commitment and interdependence among dimensions of consumer - tie-in promotion relationship had significantly positive influence on program loyalty. Also, program loyalty had significantly positive impact on host brand loyalty and partner brand loyalty in both target and non-target customers. This study has significance in that it addresses the need to identify research and academic implications by analyzing the consumer - tie-in promotion relationship to determine the relationship between tie-in promotion and loyalty, which has not been clearly described by previous studies. Furthermore, this study builds a foundation for firms and managers actively using tie-in promotion to establish tie-in promotion strategies that can maximize loyalty for both host and partner brands from the consumers' point of view.

• 대한물리치료과학회지
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• 제17권1_2호
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• pp.33-39
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• 2010

Purpose: The purpose of this study was to analyze the effects of a balance training program using the TARGET Balance Trainer(TBT), which utilizes a visual target, on the balancing ability of normal, healthy individuals. Methods: Twelve healthy female students with an average of 20.7 years(SD=0.25), were participated in this study. They were randomly divided into two groups(6 subjects in each group); experimental group, control group. The experimental group underwent a 3-week training program using the TBT, while the control group trained using only a dynamic air cushion(DAC). Results: Compared to those who trained using only the DAC, participants who trained with the TBT had a smaller difference between the weights distributed(N) to their left and right foot while normal standing with their eyes open. The TBT group also showed a smaller discrepancy between the weights distributed(N) to their left and right sides while standing on one leg with their eyes open, and also with their eyes closed by eye band. Conclusions: TBT is effective to reduce the degree of weight shifting between left and right side in each group. This study is expected to provide a model for future clinical studies.

• Genomics & Informatics
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• 제3권3호
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• pp.53-62
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• 2005

MicroRNAs play an important role in regulating gene expression, but their target identification is a difficult task due to their short length and imperfect complementarity. Burge and coworkers developed a program called TargetScan that allowed imperfect complementarity and established a procedure favoring targets with multiple binding sites conserved in multiple organisms. We improved their algorithm in two major aspects - (i) using well-defined UTR (untranslated region) database, (ii) examining the extent of conservation inside the 3' UTR specifically. Average length in our UTR database, based on the ECgene annotation, is more than twice longer than the Ensembl. Then, TargetScan was used to identify putative binding sites. The extent of conservation varies significantly inside the 3' UTR. We used the 'tight' tracks in the UCSC genome browser to select the conserved binding sites in multiple species. By combining the longer 3' UTR data, TargetScan, and tightly conserved blocks of genomic DNA, we identified 107 putative target genes with multiple binding sites conserved in multiple species, of which 85 putative targets are novel.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2004년도 The 3rd Annual Conference for The Korean Society for Bioinformatics Association of Asian Societies for Bioinformatics 2004 Symposium
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• pp.150-157
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• 2004

microRNA (miRNA)는 21-25 nucleotide (nt)의 single-stranded RNA 분자로서 mRNA의 3' untranslated region (3' UTR)에 상보적으로 결합하여 유전자 발현을 제어하는 새로운 조절물질이다. 지금까지 실험을 통해 수백 개의 miRNA가 알려져 있으나, miRNA에 의해 조절되는 target 유전자는 실험상의 어려움으로 아직까지 거의 알려지지 않았다. miRNA는 서열의 길이가 짧고 target과 느슨한 상보적 결합을 하기 때문에 기존의 서열 비교 방법으로 miRNA의 target을 찾는 것은 쉬운 일이 아니다. 본 논문은 신경망을 이용하여 Caenorhabditis elegans mRNA의 3' UTR에서 miRNA가 결합하는 영역을 예측하였다. 신경망은 복잡한 비선형 데이터를 잘 분리해내고 불완전하고 잡음이 많은 입력에 강하기 때문에 miRNA target 예측에 적합하다. miRNA와 mRNA의 결합 영역을 다양하게 분석하였고 민감도 0.59, 특수도 0.99의 성능을 갖는 신경망을 구현하였다. 신경망 입력 값을 달리하여 각각의 특성이 결과에 미치는 영향을 분석하였고 기존 예측 방법에 의한 결과와 비교하여 성능을 평가하였다.

• 한국인구학
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• 제5권1호
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• pp.117-132
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• 1982

During the period of 1962 through 1981, a total of 11. 7 million cummulative acceptors have received contraceptive services under the national family planning program. The number of annual acceptors have steadly increased from 151, 200 in 1963 to 842, 200 in 1975, and since then it has maintained the range of 600, 000 to 800, 000 acceptors per year. From the beginning of the program, the IUD had been the principal method of contraception provided by the government program until 1976, at which time the government made female sterilization services available thorough the introduction of the laparoscopy method. The popularity of female sterilization has increased very rapidly during the last few years. Out of 614, 200 program acceptors in 1981, the proportion of female sterilization and IUD acceptors were virtually the same(26.8% and 27.2% respectively). Considering various anticipated problems such as a large proportion of contraceptive users for the fertility termination and the high discontinuation rates of IUD and other traditional method, the government has emphasized the distribution of female sterilization and deemphasized condom and pill contraceptives since 1978. However, the recent service statistics has revealed that the acceptance rate of female sterilization has steadly declined since 1979. Thus, the purpose of this analysis is to review the current government policy on contraceptive distribution with emphasis of female sterilization by estimating the prospect of sterilization acceptablilty. According to the Fifth Five-Year Plan for Family Planning Program(1982-1986) the annual average target of sterilization was set up to secure 230, 000 acceptors by the government sector during the period. If the sterilization target is to be met as planned, about 80 percent of exposed women aged 30-44 will be remained as sterilized women in 1985. This means the the high acceptance rate of sterilization shown in the past years can not be expected, unless the acceptors' age of sterilization is drastically lowered below 30 years. Accordingly, the current policy on contraceptive distribution with emphasis on sterilization should be gradually changed to encourage target population to use contraceptives for birth spacing by increasing access to such contraceptives as IUDs, pills, and condoms, and to improve continuation rates through better program management system including target setting, acceptors' follow-up, supervision, and evaluation system.

• Interdisciplinary Bio Central
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• 제3권1호
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• pp.3.1-3.16
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• 2011

Investigation of the genetic functions in complex biological systems is a challenging step in recent year. Hence, several valuable and interesting research projects have been developed with novel ideas to find out the unknown functions of genes or proteins. To validate the applicability of their novel ideas, various approaches are built up. To date, the most promising and commonly used approach for discovering the target proteins from biological system using small molecule is well known a forward chemical genetics which is considered to be more convenient than the classical genetics. Although, the forward chemical genetics consists of the three basic components, the target identification is the most challenging step to chemical biology researchers. Hence, the diverse target identification methods have been developed and adopted to disclose the small molecule bound protein. Herein, in this review, we briefly described the first two parts chemical toolbox and screening, and then the target identifications in forward chemical genetics are thoroughly described along with the illustrative real example case study. In the tabular form, the different biological active small molecules which are the successful examples of target identifications are accounted in this research review.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.439-441
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• 2002

The aim of this study is to reconstruct the 3D target volume from multiple projection images. It was assumed that we were already aware of the target position exactly, and all processes were performed in Target Coordinates whose origin was the center of the target. We used six projections: two projections were used to make a Reconstruction Box and four projections were for image acquisition. Reconstruction Box was made up of voxels of 3D matrix. Projection images were transformed into 3D volume in this virtual box using geometrical based back-projection method. Algorithm was applied to an ellipsoid model and horse-shoe shaped model. Projection images were created using C program language by geometrical method and reconstruction was also accomplished using C program language and Matlab(The Mathwork Inc., USA). For ellipsoid model, reconstructed volume was slightly overestimated but target shape and position was proved to be correct. For horse-shoe shaped model, reconstructed volume was somewhat different from original target model but there was a considerable improvement in target volume determination.