• Journal of Advanced Navigation Technology
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• v.24 no.2
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• pp.128-133
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• 2020

In this study, an 1-dimensional positioning method using iterative linear regression for path loss expression is proposed. In the proposed method, received signal strengths (RSS) measured in several locations and distances between the measuring locat ions obtained by dead reckoning are used to derive a linear regression for the path loss from the transmitting beacon. In the proposed method, for the distance between the transmitting beacon and a target measuring location, several tentative values are assumed. For each tentative value, a linear regression is obtained. Among the linear regression expressions, the one closest to the known reference RSS value is selected and used to derive the distance to the target location. Test results show that the proposed method is more accurate than path loss model.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.25 no.7
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• pp.563-568
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• 2012

Indium tin oxide (ITO) films were prepared using radio frequency (RF) magnetron sputtering method, magnets were equipped near the target in the sputter to bring the plasma near the target. The effect of magnetic field that brings the plasma near the substrate was compared with that of substrate heating. The effect of substrate heating on the grain size of the ITO thin film was larger than that of the magnetic field. However, the grain size of the ITO thin film was larger when the magnetic field was applied near the substrate during the sputtering process than when the substrate was not heated and the magnetic field was not applied. If stronger magnetic field is applied near the substrate during sputtering, it can be expected that the ITO thin film with good electrical conductivity and high transparency is obtained at low substrate temperature. When magnetic field of 90 Gauss was applied near the substrate during sputtering, the mobility of the ITO thin film increased from 15.2 $cm^2/V.s$ to 23.3 $cm^2/V.s$, whereas the sheet resistivity decreased from 7.68 ${\Omega}{\cdot}cm$ to 5.11 ${\Omega}{\cdot}cm$.

• Journal of Astronomy and Space Sciences
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• v.30 no.1
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• pp.49-58
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• 2013

ARGO-M is a satellite laser ranging (SLR) system developed by the Korea Astronomy and Space Science Institute with the consideration of mobility and daytime and nighttime satellite observation. The ARGO-M optical system consists of 40 cm receiving telescope, 10 cm transmitting telescope, and detecting optics. For the development of ARGO-M optical system, the structural analysis was performed with regard to the optics and optomechanics design and the optical components. To ensure the optical performance, the quality was tested at the level of parts using the laser interferometer and ultra-high-precision measuring instruments. The assembly and alignment of ARGO-M optical system were conducted at an auto-collimation facility. As the transmission and reception are separated in the ARGO-M optical system, the pointing alignment between the transmitting telescope and receiving telescope is critical for precise target pointing. Thus, the alignment using the ground target and the radiant point observation of transmitting laser beam was carried out, and the lines of sight for the two telescopes were aligned within the required pointing precision. This paper describes the design, structural analysis, manufacture and assembly of parts, and entire process related with the alignment for the ARGO-M optical system.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.7C
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• pp.527-537
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• 2012

In this paper, we propose unmanned vehicle based tracking network (UVTN) architecture and algorithms which employ multiple autonomous unmanned ground vehicles (AUGV) to efficiently follow targets in a group. The goal of UVTN is to maximize the service coverage while tracking target nodes for monitoring or providing the network access. In order to achieve this goal, UVTN performs periodic expansion and contraction which results in optimized redistribution of AUGV's in the network. Also, enhanced algorithms such as fast contraction and longest first are also discussed to improve the performance of UVTN in terms of the average coverage ratio and traveled distance. Simulation results show that the proposed UVTN and enhanced algorithms can effectively track the moving target and provide the consistent coverage.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.6C
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• pp.512-522
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• 2005

In this paper, an optimal determination method of the subband-frame size and mode-switching level is proposed for adaptive OFDM-TDD systems in frequency-selective time-varying channels. The optimization problem considering frequency selectivity. user's mobility, and the signaling overhead caused by the mode change information is formulated in the maximum spectral efficiency sense satisfying the target BER. Assuming that subband-frame size is given, the mode-switching level is first optimized so that the spectral efficiency can be maximized satisfying the target BER. The subband-frame size among candidates is then determined, which maximizes the spectral efficiency. Simulation results show that the proposed scheme outperforms conventional schemes, in terms of the spectral efficiency and the BER.

• Journal of Ginseng Research
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• v.47 no.2
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• pp.228-236
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• 2023

Background: QiShen YiQi pills (QSYQ) is a Traditional Chinese Medicine (TCM) formula, which has a significant effect on the treatment of patients with myocardial infarction (MI) in clinical practice. However, the molecular mechanism of QSYQ regulation pyroptosis after MI is still not fully known. Hence, this study was designed to reveal the mechanism of the active ingredient in QSYQ. Methods: Integrated approach of network pharmacology and molecular docking, were conducted to screen active components and corresponding common target genes of QSYQ in intervening pyroptosis after MI. Subsequently, STRING and Cytoscape were applied to construct a PPI network, and obtain candidate active compounds. Molecular docking was performed to verify the binding ability of candidate components to pyroptosis proteins and oxygen-glucose deprivation (OGD) induced cardiomyocytes injuries were applied to explore the protective effect and mechanism of the candidate drug. Results: Two drug-likeness compounds were preliminarily selected, and the binding capacity between Ginsenoside Rh2 (Rh2) and key target High Mobility Group Box 1 (HMGB1)was validated in the form of hydrogen bonding. 2 μM Rh2 prevented OGD-induced H9c2 death and reduced IL-18 and IL-1β levels, possibly by decreasing the activation of the NLRP3 inflammasome, inhibiting the expression of p12-caspase1, and attenuating the level of pyroptosis executive protein GSDMD-N. Conclusions: We propose that Rh2 of QSYQ can protect myocardial cells partially by ameliorating pyroptosis, which seems to have a new insight regarding the therapeutic potential for MI.

• IMMUNE NETWORK
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• v.22 no.3
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• pp.21.1-21.21
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• 2022

As far the current severe coronavirus disease 2019 (COVID-19), respiratory disease is still the biggest threat to human health. In addition, infectious respiratory diseases are particularly prominent. In addition to killing and clearing the infection pathogen directly, regulating the immune responses against the pathogens is also an important therapeutic modality. Sirtuins belong to NAD+-dependent class III histone deacetylases. Among 7 types of sirtuins, silent information regulator type-1 (SIRT1) played a multitasking role in modulating a wide range of physiological processes, including oxidative stress, inflammation, cell apoptosis, autophagy, antibacterial and antiviral functions. It showed a critical effect in regulating immune responses by deacetylation modification, especially through high-mobility group box 1 (HMGB1), a core molecule regulating the immune system. SIRT1 was associated with many respiratory diseases, including COVID-19 infection, bacterial pneumonia, tuberculosis, and so on. Here, we reviewed the latest research progress regarding the effects of SIRT1 on immune system in respiratory diseases. First, the structure and catalytic characteristics of SIRT1 were introduced. Next, the roles of SIRT1, and the mechanisms underlying the immune regulatory effect through HMGB1, as well as the specific activators/inhibitors of SIRT1, were elaborated. Finally, the multitasking roles of SIRT1 in several respiratory diseases were discussed separately. Taken together, this review implied that SIRT1 could serve as a promising specific therapeutic target for the treatment of respiratory diseases.

• Molecules and Cells
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• v.28 no.3
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• pp.189-194
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• 2009

The modulating effect of IGF-I on the regulation of AR gene expression and activation in skeletal muscle cells remains poorly understood. In this study, the effects of IGF-I treatment on AR induction and activation in the absence of AR ligands were examined. Differentiating C2C12 cells were treated with different concentrations (0-250 ng/ml) of IGF-I or for various periods of time (0-60 min) of 250 ng/ml IGF-I. Treatment of C2C12 cells with IGF-I resulted in a dose- and time-dependent increase in total AR and phosphorylated AR (Ser 213). IGF-I treatment also led to significantly increased AR mRNA expression when compared with the control. The levels of skeletal ${\alpha}-actin$ and myogenin mRNA, known target genes of AR, were also significantly upregulated after 5 or 10 min of treatment with IGF-I. Confocal images revealed that IGF-I stimulated nuclear localization of AR in the absence of ligands. In addition, an electrophoretic mobility shift assay indicated that IGF-I stimulated the AR DNA binding activity in a time-dependent manner. The present results suggest that IGF-I stimulates the expression and activation of AR by ligand-independent mechanism in differentiating C2C12 mouse skeletal muscle cells.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.32 no.4
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• pp.340-346
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• 2008

An unmanned surveillance robot consists of a machine gun, a laser receiver, a thermal imager, a color CCD camera, and a laser illuminator. It has two axis control systems for elevation and azimuth. Because the current robot system is mounded at a fixed post to take care of surveillance tasks, it is necessary to modify such a surveillance robot to be installed on an UGV (Unmanned Ground Vehicle) system in order to watch blind areas. Thus, it is required to have a stabilization system to compensate the disturbance from the UGV. In this paper, a simulation based design scheme has been adopted to develop a mobile surveillance robot. The 3D CAD geometry model has first been produced by using Pro-Engineer. The required pan and tilt motor capacities have been analyzed using ADAMS inverse dynamics analysis. A target tracking and stabilization control algorithm of the mobile surveillance robot has been developed in order to compensate the motion of the vehicle which will experience the rough terrain. To test the performance of the stabilization control system of the robot, ADAMS/simulink co-simulations has been carried out.

• International Journal of Internet, Broadcasting and Communication
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• v.12 no.3
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• pp.156-162
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• 2020

Wireless Sensor Network (WSN) field is mainly studied to monitor and characterize large-scale physical environments to track various environmental or physical conditions, such as temperature, pressure, wind speed and humidity. WSN can be used in various applications such as wild surveillance, military target tracking and monitoring, dangerous environmental exploration and natural disaster relief. We design probabilistic mobile models that apply to mobile ad hoc network mobile environments. A probabilistic shift model proposed by dividing the number of moving nodes and the distance of travel into two categories to express node movement characteristics. The proposed model of movement through simulation was compared with the existing random movement model, ensuring that the width and variation rate of the first node node node node (FND) was stable regardless of the node movement rate. In addition, when the proposed mobile model is applied to the routing protocol, the superiority of network life can be verified from measured FND values. We overcame the limitations of the existing random movement model, showing excellent characteristics in terms of energy efficiency and stable in terms of changes in node movement.