• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.04a
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• pp.139-149
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• 2006

Amyloid beta (A$\beta$) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of A$\beta$ is considered a primary therapeutic target. Immunization with A$\beta$ can reduce A$\beta$ burden and pathological features in transgenic AD model mouse. This means anti-A$\beta$ autoantibodies may have a role in AD pathology. Recent findings suggest anti-A$\beta$ autoantibodies level decrease in AD patients. The early detection of AD is important for treatment of this disease. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. To investigate whether it was possible to detect the presence and different levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma of patients with AD and age-matched controls. An advanced ELISA was performed to detect levels of naturally occurring anti-A$\beta$ autoantibodies in the plasma. The level of anti-A$\beta$ auto-antibodies from patients with idiopathic Parkinson's disease or stroke and from normal controls were compared to that of AD patients. Our results showed a significantly lower anti-A$\beta$ autoantibodies level in AD compared to those with other neurological diseases or control. The level of anti-A$\beta$ autoantibodies in the serum may be used to diagnose the presence of AD.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.47 no.1
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• pp.27-36
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• 2011

Squid by-product like viscera has just been recognized as one of the serious pollutants on the surrounding marine environment in Ulleung island of Korea. The effect as a marine pollutant, however, has not been examined and evaluated properly. It was carried out the comprehensive examination of the marine pollution by disposing squid by-products. The sediments and water qualities were investigated in several positions, including the dumping position around Ulleung island. It is also estimated a spreading of by-product in terms of estimating the sinking speed and evaluating the attracting characteristics as a feed. As a result, There were no significant pollutions of the sediment and water quality. The spreading of by-product by the local current was 2-2.5 times of the depth, and it will become longer in spring tide. It was confirmed that the squid by-product has attracting ability for local fish by acoustical survey. Furthermore, it can be useful for the local fish species as feeds.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.12
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• pp.8-14
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• 2008

A fully CMOS-integrated carbon nanotube (CNT) sensor array is proposed. After the sensor chip is fabricated in commercial CMOS process, the CNTs network is formed on the top of the fabricated sensor chip through the room-temperature post-CMOS processes. When the resistance of the CNT is changed by the chemical reaction, the read-out circuit in the chip measures the charging time of the $R_{CNT}$-Capacitor. finally the information of measured frequency is converted to a digital code. The CMOS sensor chip was fabricated by standard 0.18um technology and the size of the $8{\times}8$ sensor array is $2mm{\times}2mn$. We have carried out an experiment detecting the biochemical material, glutamate, using this sensor chip. From the experiment the CMOS sensor chip shows the feasibility of sensor for the simultaneous detection of the various target materials.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.45 no.2
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• pp.29-36
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• 2008

In this paper we propose a real-time method to estimate a pointing region from two camera images. In general, a pointing target exists in the face direction when a human points to something. Therefore, we regard the direction of pointing as the straight line that connects the face position with the fingertip position. First, the method extracts two points in the face and the fingertips region by using detecting the skin color of human being. And we used the 3D geometric information to obtain a pointing detection and its region. In order to evaluate the performance, we have build up an ICIGS(Interactive Cinema Information Guiding System) with two camera and a beam project.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.26 no.11
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• pp.999-1011
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• 2015

In modern electronic warfare, RADAR is under constant threat of ECM(Electronic Counter Measures) signals from nearby jammers. The conventional linear frequency modulated(Linear-FM) waveform is easy to be intercepted to estimate its signal parameters due to its periodical phase transition. Recently, APCN(Advanced Pulse Compression Noise) waveform using random amplitude and phase transition was proposed for LPI(Low probability of Intercept). But random phase code signals such as APCN waveform tend to be sensitive to Doppler frequency shift and result in performance degradation during moving target detection. In this paper, random phase and code rate transition based radar waveform(RPCR) is proposed for Doppler tolerance improvement. Time frequency analysis is carried out through ambiguity analysis to validate the improved Doppler tolerance of RPCR waveform. As a means to measure the vulnerability of the proposed RPCR waveform against LPI, WHT(Wigner-Hough Transform) is adopted to analyze and estimate signal parameters for ECCM(Electronic Counter Counter Measures) application.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.29 no.4
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• pp.308-315
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• 2018

In this paper, we present the basic design results for high-resolution radar development at S-band frequency that can precisely measure the miss distance between two targets. The basic system requirement is proposed for the design of a 3.5 GHz linear frequency-modulated (LFM) radar with maximum detection distance and distance resolution of 2 km and 1 m, respectively, and the specifications of each module are determined using the radar equation. Our calculations revealed a signal-to-noise ratio ${\geq}30dB$ with a bandwidth of 150 MHz, transmission power of 43 dBm for the power amplifier, gain of 26 dBi for the antenna, noise figure of 8 dB, and radar cross-section of $1m^2$ at a target distance of 2 km from the radar. Based on the calculation results and the theory and method of LFM radar design, the hardware was designed using software defined radar technology. The results of the subsequent field test are presented that prove that the designed radar system satisfies the requirements.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.9
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• pp.1400-1410
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• 2020

Objective: Genome-wide association study and two meta-analysis based on GWAS performed to explore the genetic mechanism underlying variation in pig number born alive (NBA) and total number born (TNB). Methods: Single trait GWAS and two meta-analysis (single-trait meta analysis and multi-trait meta analysis) were used in our study for NBA and TNB on 3,121 Yorkshires from 4 populations, including three different American Yorkshire populations (n = 2,247) and one British Yorkshire populations (n = 874). Results: The result of single trait GWAS showed that no significant associated single nucleotide polymorphisms (SNPs) were identified. Using single-trait meta analysis and multi-trait meta analysis within populations, 11 significant loci were identified associated with target traits. Spindlin 1, vascular endothelial growth factor A, forkhead box Q1, msh homeobox 1, and LHFPL tetraspan submily member 3 are five functionally plausible candidate genes for NBA and TNB. Compared to the single population GWAS, single-trait Meta analysis can improve the detection power to identify SNPs by integrating information of multiple populations. The multiple-trait analysis reduced the power to detect trait-specific loci but enhanced the power to identify the common loci across traits. Conclusion: In total, our findings identified novel genes to be validated as candidates for NBA and TNB in pigs. Also, it enabled us to enlarge population size by including multiple populations with different genetic backgrounds and increase the power of GWAS by using meta analysis.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.5
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• pp.2945-2948
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• 2013

Background: Mouse mammary tumor virus (MMTV) is the major cause of mammary tumors in mice. There is limited controversial evidence about the probable etiologic role of MMTV- like virus in human breast cancer. Materials and Methods: A total of 40 Formalin fixed paraffin embedded samples with diagnosis of breast cancer were collected in a period of 3 years from cancer institute of Iran. We selected both pre-menopausal and post-menopausal patients with different histologic grades and different ethnic groups. We evaluated presence of MMTV-like virus env gene through real time PCR method. Results: Forty patients (20 pre and 20 postmenopausal women) were evaluated with the mean age of 49.67. The average tumor size was 39 mm. None of the studied samples were positive for MMTV-like virus env gene target sequences. Conclusions: We found no evidence on the potential role of MMTV-like virus in the carcinogenicity of breast cancer among Iranian women.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.35 no.11
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• pp.1036-1042
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• 2007

It is rather difficult to improve flight control computer(FLCC) hardware(H/W) development schedule due to lack of commercial off-the-self(COTS) tools or target specific tools. Thus, it is suggested to develop an enhanced process utilizing modeling, simulation and virtual reality tools. This paper presents H/W design process enhancement tool(PET) for FLCC design requirements such as FLCC input/output(I/O) signal flow, I/O fault detection, failure management algorithm, circuit logic, PCB assembly configuration and installation utilizing simulation and visualization in virtual space. New tool will provide simulation capability of various FLCC design configuration including shop replaceable unit(SRU) level assembly/dis-assembly utilizing open flight format 3-D modeling data.

• 한국약용작물학회:학술대회논문집
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• 2006.04a
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• pp.137-149
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• 2006

Amyloid beta ($A{\beta}$) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of $A{\beta}$ is considered a primary therapeutic target. Immunization with $A{\beta}$ can reduce $A{\beta}$ burden and pathological features in transgenic AD model mouse. This means $anti-A{\beta}$ autoantibodies may have a role in AD pathology. Recent findings suggest $anti-A{\beta}$ autoantibodies level decrease in AD patients. The early detection of AD is important for treatment of this disease. However, diagnosis on AD has only been possible through limited methods such as neuropsychological examination or MRI. To investigate whether it was possible to detect the presence and different levels of naturally occurring $anti-A{\beta}$ autoantibodies in the plasma of patients with AD and age-matched controls. An advanced ELISA was performed to detect levels of naturally occurring $anti-A{\beta}$ autoantibodies in the plasma. The level of $anti-A{\beta}$ auto-antibodies from patients with idiopathic Parkinson's disease or stroke and from normal controls were compared to that of AD patients. Our results showed a significantly lower $anti-A{\beta}$ autoantibodies level in AD compared to those with other neurological diseases or control. The level of $anti-A{\beta}$ autoantibodies in the serum may be used to diagnose the presence of AD.