• Journal of the Earthquake Engineering Society of Korea
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• v.18 no.2
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• pp.73-78
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• 2014

In this paper, the stochastic 1D site response analysis method using Monte Carlo simulation and considering thespatial variation of shear wave velocity profile isproposed. To consider thespatial variation of shear wave velocity profile for 1D site response analysis, the proposed method generates random shear wave velocity profiles representing the target site, and Monte Carlo simulation is used to calculate theprobability distribution of the site response analysis results such as thepeak ground acceleration. Through the field application, The applicability of the proposed method is verified through field application.

• Molecules and Cells
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• v.42 no.5
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• pp.386-396
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• 2019

Labeling of a protein with a specific dye or tag at defined positions is a critical step in tracing the subtle behavior of the protein and assessing its cellular function. Over the last decade, many strategies have been developed to achieve selective labeling of proteins in living cells. In particular, the site-specific unnatural amino acid (UAA) incorporation technique has gained increasing attention since it enables attachment of various organic probes to a specific position of a protein in a more precise way. In this review, we describe how the UAA incorporation technique has expanded our ability to achieve site-specific labeling and visualization of target proteins for functional analyses in live cells.

• Journal of Korean Society of Water and Wastewater
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• v.23 no.1
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• pp.15-22
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• 2009

This study reports the serial use of a 3-D hydrodynamic model, EFDC-Hydro and a dynamic water quality model WASP7.2 that are maintained by USEPA. The 48 km section of the Geum River downstream between Daechung Dam and Gongju was selected as a sample study site. Topographical information was used to accurately represent morphology of the study site and boundary conditions were derived from governmental databases including WAMIS by Ministry of Land and Ocean and WEIS by Ministry of Environment. EFDC-Hydro was successfully calibrated for observed water level and WASP was calibrated using monthly observed water quality data obtained from the above sources. It was found that the current water quality target of BOD for the Geum River-H point could not be met on monthly basis though every other tributary of the area would meet its own water quality target as assigned in Korean TMDL. This study proposed the new target BOD water quality for the Gabcheon and Mihocheon as 4.3 and 3.6 mg/l, respectively so that the Geum River-H point can meet the target. When Sejong City is constructed, it is estimated that effluent discharge limit of BOD must be less than 4.5 mg/l to meet water quality of the point. This study shows that it is possible to carry out more precise modeling considering both water movement and water kinetics by using EFDC and WASP simultaneously.

• Journal of The Korean Dental Society of Anesthesiology
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• v.14 no.3
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• pp.167-172
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• 2014

Background: Propofol is the most commonly used anesthetic for sedation and target-controlled infusion (TCI) is useful for dental treatment. However, it is important to assess and maintain an adequate depth of sedation in patients with severe intellectual disabilities Therefore, in this study we aimed to evaluate the adequate propofol target concentration for dental treatment in severely intellectually disabled patients. Methods: We undertook retrospective review of the sedation records of severely intellectually disabled patients who underwent dental treatment under TCI propofol sedation from September 2011 to April 2012. We evaluated the initial target concentration, stabilized concentration of propofol and monitored vital signs, including BIS score using sedation records. Results: Total 20 patients (10 male and 10 female patients) were included in the study. Every participant was severely intellectually disabled. The mean sedation duration was $70{\pm}16$ (45-100) minutes. The initial propofol target concentration infusion amount was $2.7{\pm}0.45$ (2.0-3.0) mcg/ml. The propofol effect site concentration (Ce) was $2.6{\pm}0.7$ (1.0-4.0) mcg/ml. The average value of BIS was $52.6{\pm}13$ (28-81). During the treatment period, there were no severe complications. Conclusions: The average propofol Ce for deep sedation without any complications in intellectually disabled patients was 2.6 mcg/ml.

• Korean Journal of Remote Sensing
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• v.32 no.5
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• pp.403-412
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• 2016

Compact Reconnaissance Imaging Spectrometer for Mars(CRISM) is 489-band hyperspectral camera of Mars Reconnaissance Orbiter(MRO) that provided data used on many mineral researches over Martian surface. For the detection of minerals in planet, mineral index using a few spectral bands have been used. In this study, we applied Matched Filter and Adaptive Cosine Estimator(ACE) target detection algorithm on CRISM data over Gusev Crater: landing site of Spirit(Mars Exploration Rover A) to investigate its mineral distribution. As a result, olivine, pyroxene, magnetite, etc. is detected at Gusev Crater's Columbia Hills. These results are corresponding to the Spirit rover's field survey result. It is expected that hyperspectral target detection algorithms can be used as effective and easy to use method for the detection and mapping of surface minerals in planet.

• Journal of The Korean Dental Society of Anesthesiology
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• v.13 no.3
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• pp.89-94
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• 2013

Background: Various strategies have been studied to reduce the propofol injection pain. This study was designed to find out effect-site target concentration (Ce) of remifentanil at which there was a 50% probability of preventing the propofol injection pain (EC50). Methods: Anesthesia was induced with a remifentanil TCI (Minto model). The Ce of remifentanil for the first patient started from 2.0 ng/ml. The Ce of remifentanil for each subsequent patient was determined by the response of the previous patient by Dixon up-and-down method with the interval of 0.5 ng/ml. After the remifentanil reached target concentrations, propofol was administered via a target-controlled infusion system based on a Marsh pharmacokinetic model using a TCI device (Orchestra$^{(R)}$; Fresenius-Vial, Brezins, France). The dose of propofol was effect site target-controlled infusion (TCI) of $3{\mu}g/ml$. Results: The EC50 of remifentanil to prevent the propofol injection pain was $1.80{\pm}0.35ng/ml$ by Dixon's up and down method. Conclusions: The EC50 of remifentanil to blunt the pain responses to propofol injection was $1.80{\pm}0.35ng/ml$ for propofol TCI anesthesia.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.13 no.5
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• pp.38-50
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• 2010

Expressways are often upgraded by widening the lanes and/or by reshaping the roads to be more linear for faster travel time. However, during the process of improving the route of the expressways, the areas where the old expressways used to be are often unused and abandoned. When these neglected sites are left alone, they often become dump sites causing pollution and impacting the surrounding environment. Therefore, it is important to restore the abandoned expressway sites to its full natural beauty. In this study, the abandoned expressway at the Soksa interchange in Pyungchang county, located in Kangwon province was studied for establishing the model of ecological restoration project. Considering the characteristics of the site, the target flora species was chosen to be Quercus species and the target fauna species as amphibians. After the target species were carefully chosen, each species' habitat requirements were studied in order to figure out the appropriate methods toward habitat restoration specifically for these species. In addition, to determine the most efficient method toward restoration of abandoned expressways, the study utilized the planting hole techniques, the crack techniques, and the colonization techniques. In terms of the spatial organization, public education program is incorporated at the main entrance area and the programs for experimenting, and developing vegetation and habitat restoration techniques are placed in the vicinity. In the master plan-to provide natural ecosystem at the site-ASCON (asphalt concrete) was removed first, then plans for restoration including species' habitat restoration were established. Furthermore, the project included plans for improving water quality polluted through non-point source considering the surrounding nearby road and farm lands. Finally, the study established a planning process that will experimentally apply to the abandoned expressway restoration method. In the future, there will be a continuous monitoring of the methods applied to verify if the restoration methods are effective. Also, new restoration techniques should be available according to a variety of abandoned expressways' characteristics.

• International Journal of Aeronautical and Space Sciences
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• v.17 no.2
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• pp.253-259
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• 2016

The typical method for performing an absolute radiometric calibration of a Synthetic Aperture Radar (SAR) System is to analyze its response, without interference, to a target with a known Radar Cross Section (RCS). To minimize interference, an error-free calibration site for a Corner Reflector (CR) is required on a wide and flat plain or on an area without disturbance sources (such as ground objects). However, in reality, due to expense and lack of availability for long periods, it is difficult to identify such a site. An alternative solution is the use of a Triangular Trihedral Corner Reflector (TTCR) site, with a surrounding protection wall consisting of berms and a hollow. It is possible in this scenario, to create the minimum criteria for an effectively error-free site involving a conventional object-tip reflection applied to all beams. Sidelobe interference by the berm is considered to be the major disturbance factor. Total interference, including an object-tip reflection and a sidelobe interference, is analyzed experimentally with SAR images. The results provide a new guideline for the minimum criteria of TTCR site design that require, at least, the removal of all ground objects within the fifth sidelobe.

• The Korean Journal of Pesticide Science
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• v.9 no.3
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• pp.191-198
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• 2005

Hippuryl-L-histidyl-L-leucine (Hip-L-His-L-Leu, HHL) is the known substrate of ACE, which used often in inhibition kinetic study to design new inhibitor. Here we use HHL molecule as a template to predict pharmacophore which can interact with residues in active site of AnCE, new potential insecticide target protein. To explain physicochemical properties related to molecular geometry and conformational change in reaction field as well as electron density of atoms associated to pharmacophores, geometry optimization, NMR chemical shifts and natural population analysis were performed by ab initio and DFT method. Calculated NMR chemical shifts showed good agreement with the experimental ones and obtained electron densities were used for analyzing pharmacophores of corresponding atoms. Finally, we could extract aye pharmacophores related to hydrophobic aliphatic and aromatic site, hydrogen bonding donor and acceptor site and Zn binding site from the HHL molecule.

• Journal of the Korean Operations Research and Management Science Society
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• v.32 no.2
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• pp.17-40
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• 2007

Most research on web site design has focused on technological factors, while visual aesthetic factors have been considered less important. In contrast, this study focuses on visual aesthetic factors in web site design. Findings of this study can be summarized as follows : (1) The result of SPSS-factor analysis shows that there are 3 distinct factors, 'classical aesthetics', 'expressive aesthetics', and 'usability' 'Classical aesthetics' and 'expressive aesthetics' can be described by visual aesthetic design, 'Visual aesthetic design' can be distinguished from 'usability'. This conceptual confusion relating to 'usability' and 'visual aesthetic design' can be clarified by these findings. (2) As a result of multiple regression analyses, 'classical aesthetics', 'expressive aesthetics', and 'usability' have a positive influence on 'interactivity' and 'web site evaluation'. This research clarifies the concepts of 'expectations' of Grier [18] and 'engagement' of Rosen and Purinton [33] as the 'interactivity' between users and web sites. Furthermore, this research suggests a valid model with high $R^2$(interactivity, 48% : web site evaluation, 68%). (3) Empirical tests show that the differences among users in 'entry point' are related to the characteristics of web sites and the personal characteristics of users. The differences among users in terms of 'scanning time' are closely related to the attitudes and evaluation tendencies of users with respect to web sites. These findings could contribute to the 'search phase' of the Faraday model [16], enabling it to be more precise and extensible. The managerial implication of this study is that customers' preferences regarding web site designs are differences, as their preferences are based on their individual characteristics. Therefore, marketing managers should consider promotional tools on web sites that are relevant to the target market. An optimal strategy for web design could be a carefully-selected combination of factors that are relevant to the 'interactivity' and 'evaluation' of web sites. Additionally, if marketing managers want to attract more favorable attitudes and more affirmative evaluations from users, web sites should be designed so that they are understood more quickly by users. finally, this study suggests that 'good design' for web sites depends on understanding how to attain the appropriate balance between 'classical aesthetics' and 'expressive aesthetics', based on the target customer.