• Journal of Biomedical Engineering Research
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• 제23권5호
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• pp.341-349
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• 2002

The target controlled infusion(TCI) pump system is a logical approach to the development of improved administration techniques of an intravenous anaesthetic agent. The principle of TCI system is based on an understanding of the pharmacokinetic properties, three or four compartment model. The TCI system is optimal and flexible control of the plasma drug concentration. But the clinical goal is always to achieve a therapeutic drug effect, not a therapeutic concentration. So we developed the algorithm to target the concentration at the site of drug effect rather than the concentration in the plasma. If impulse drug is inputted into body, the decline of plasma concentration with time is shown, resulting in the expression of the differential equation. Therefore, we must reformulate our three-compartment model as four-compartment model with the effect compartment. And we tested plasma targeting and effect targeting algorithm by computer simulation using four-compartment model. So we developed the TCI capable of applying all intravenous drugs by adjusting individual pharmacokinetic parameters independently.

• BMB Reports
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• 제50권11호
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• pp.554-559
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• 2017

MicroRNAs (miRNAs) are ~22nt-long single-stranded RNA molecules that form a RNA-induced silencing complex with Argonaute (AGO) protein to post-transcriptionally downregulate their target messenger RNAs (mRNAs). To understand the regulatory mechanisms of miRNA, discovering the underlying functional rules for how miRNAs recognize and repress their target mRNAs is of utmost importance. To determine functional miRNA targeting rules, previous studies extensively utilized various methods including high-throughput biochemical assays and bioinformatics analyses. However, targeting rules reported in one study often fail to be reproduced in other studies and therefore the general rules for functional miRNA targeting remain elusive. In this review, we evaluate previously-reported miRNA targeting rules and discuss the biological impact of the functional miRNAs on gene-regulatory networks as well as the future direction of miRNA targeting research.

• Journal of the Korean Society of Safety
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• 제25권5호
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• pp.62-68
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• 2010

The main purpose of this study was to examine relative effects on safety behaviors between global feedback and specific feedback at a construction site. Participants were 30 full-time workers at a construction site. Five safety related behaviors were identified as critical behaviors. An ABCB within-group design was adopted. After baseline (A), participants received global feedback on their average percentage of all five target safety behaviors (B). In the next phase, participants received specific feedback on the percentages of individual target behaviors (C). In the final phase, the global feedback condition was reintroduced (B). Results showed that both global feedback and specific feedback were effective in increasing the frequencies of safety behaviors and there were no differences in the effectiveness between the two types of feedbacks.

• Journal of Integrative Natural Science
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• 제10권1호
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• pp.20-26
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• 2017

Chemerin receptor, which predominantly expressed in immune cells as well as adipose tissue, was found to stimulate chemotaxis of dendritic cells and macrophages to the site of inflammation. Chemerin is a widely distributed multifunctional secreted protein implicated in immune cell migration, adipogenesis, osteoblastogenesis, angiogenesis, myogenesis, and glucose homeostasis. Recent studies suggest chemerin may play an important role in the pathogenesis of obesity and insulin resistance and it becomes a potential therapeutic target for treating type II diabetes. The crystal structure of chemerin receptor has not yet been resolved. Therefore, in the present study, homology modelling of CMKLR1 was done utilizing the crystal structure of human angiotension receptor in complex with inverse agonist olmesartan as the template. Since the template has low sequence identity, we have incorporated both threading and comparative modelling approach to generate the three dimensional structure. 3D models were generated and validated. The reported models can be used to characterize the critical amino acid residues in the binding site of CMKLR1.

• Journal of the Korean Society of Safety
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• 제11권1호
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• pp.60-66
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• 1996

As the recently proposed JTC has been proven to be effective for implementation of real-time target tracking system, the interest on the electronic support system for the real-time JTC tracker has been increased. Accordingly, we proposed a tracking system which is based on BPEJTC and adaptive the fixed site. But because the EOTS is generally needed in the moving site such as aircraft and vehicles, and there are many different tracking algorithm to adopt the BPEJTC, we present an advanced version of BPEJTC dniver which has synchronization input so as to be used for the target pointer. In addition to the designed system architecture, some experimental results conducted by this system are illustrated.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 한국지하수토양환경학회 2004년도 임시총회 및 추계학술발표회
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• pp.286-289
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• 2004

On site, In situ soil remediation technologies are very important among the remediation technologies and in general efficiency of these technologies are turned to site characterization and environmental condition. specially using of only one technology has so many limitation factors. for example, existing state of tailing and channeling and so on. actually, filled land have high concentration cation exchange capacity because of existence in abundance soil organic matter. Therefore we used various on site in Situ technologies by phase for overcome the limitation factors. Target site is petroleum (diesel) impacted filled land and using technologies are SVE(Soil Vapor Extraction), BV(Bioventing), Bioremediation, Soil flushing, Chemical oxidation.

• Journal of the Korea Institute of Information Security & Cryptology
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• 제29권1호
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• pp.93-103
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• 2019

Recently, malicious code distribution of ransomware through a web site based on a drive-by-download attack has resulted in service disruptions to the web site and damage to PC files for end users. Therefore, analyzing the characteristics of the target web site industry, distribution time, application type, and type of malicious code that is being exploited can predict and respond to the attacker's attack activities by analyzing the status and trend of malicious code sites. In this paper, we will examine the distribution of malicious codes to 3.43 million websites in Korea to draw out the characteristics of each detected landing site, exploit site, and distribution site, and discuss countermeasures.

• Journal of the Korean Solar Energy Society
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• 제33권5호
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• pp.1-8
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• 2013

Wind resource data of short-term period has to be corrected a long-term period by using MCP method that Is a statistical method to predict the long-term wind resource at target site data with a reference site data. Because the field measurement for wind assessment is limited to a short period by various constraints. In this study, 2 different MCP methods such as Linear regression and Matrix method were chosen to compare the predictive accuracy between the methods. Finally long-term wind speed, wind power density and capacity factor at the target site for 20 years were estimated for the variability of wind and wind energy. As a result, for 20 years annual average wind speed, Yellow sea off shore wind farm was estimated to have 4.29% for coefficient of variation, CV, and -9.57%~9.53% for range of variation, RV. It was predicted that the annual wind speed at Yellow sea offshore wind farm varied within ${\pm}10%$.

• Journal of Environmental Impact Assessment
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• 제20권1호
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• pp.13-24
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• 2011

This study was carried out to analyze ecological characteristics and select target species for effective restoration plans of wildlife corridors at Galmachi of Sungnam City. The actual vegetation in study area was physiognomically mixed with deciduous broad leaved forests dominated by oaks and artificially planted species. And it is a secondary forest formatted by sprout originated stand and being on early succession stage as a young stand. So study site was regarded as not suitable for the habitats for wildlife. The number of mammal species at study site was total 22 species, but most of these species were found as not so many in individual numbers. The individual number of hare was approximately 4 to 8, while the raccoon dog and water deer with 2 to 3 and 1 to 2, respectively. As such, it was estimated as a low population density due to discontinuation of ecosystem and the man-made impacts. In this study, raccoon dog and water deer were selected as the target species because of their migration patterns and ecological value in local ecosystem. It was suggested to establish a wildlife corridors of an over-bridge type at the peak area of Galmachi, known to be the mostly-used migratory route for 2 target species.

• Proceedings of the Korean Society of Plant Pathology Conference
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• 한국식물병리학회 1999년도 정기총회 및 춘계 학술발표회
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• pp.38-38
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• 1999