• Title/Summary/Keyword: Target Level of Safety

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New Fungicides: Opportunities and Challenges - A Case Study with Dimethomorph

  • Spadafora, V. J.;Sieverding, E.
    • Proceedings of the Korean Society of Plant Pathology Conference
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    • 1998.06a
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    • pp.50-69
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    • 1998
  • Dimethomorph is a novel fungicide with a high level of activity against diseases induced by certain Oomycetes, including fungal populations that are resistant to other products. In several ways, this fungicide illustrates the opportunities and challenges presented by many modern pesticides. The specific mode of action, which affects cell wall formation, is associated with a very high level of performance and low dose rates under field conditions. These low dose rates, combined with a low level of toxicity to non-target organisms present an outstanding safety profile. This same highly-specific mode of action, however, limits the spectrum of activity and suggests the need for a resistance management plan, both of which must be addressed in new product development. In addition, the biological and physiochemical properties of this, and other new products are not adequately described by the traditional classification of fungicides into“protectant”and“systemic”types. These unique profiles provide novel and useful products for disease control.

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Dietary Risk Assessment of Snf7 dsRNA for Coccinella septempunctata

  • Jung, Young Jun;Seol, Min-A;Choi, Wonkyun;Lee, Jung Ro
    • Proceedings of the National Institute of Ecology of the Republic of Korea
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    • v.2 no.3
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    • pp.210-218
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    • 2021
  • Recently, pest-resistant living modified (LM) crops developed using RNA interference (RNAi) technology have been imported into South Korea. However, the potential adverse effects of unintentionally released RNAi-based LM crops on non-target species have not yet been reported. Coccinella septempunctata, which feeds on aphids, is an important natural enemy insect which can be exposed to the double-stranded RNA (dsRNA) produced by RNAi-based LM plants. To assess the risk of ingestion of Snf7 dsRNA by C. septempunctata, we first identified the species through morphological analysis of collected insects. A method for species identification at the gene level was developed using a specific C. septempunctata 12S rRNA. Furthermore, an experimental model was devised to assess the risk of Snf7 dsRNA ingestion in C. septempunctata. Snf7 dsRNA was mass-purified using an effective dsRNA synthesis method and its presence in C. septempunctata was confirmed after treatment with purified Snf7 dsRNA. Finally, the survival rate, development time, and dry weight of Snf7 dsRNA-treated C. septempunctata were compared with those of GFP and vATPase A dsRNA control treatments, and no risk was found. This study illustrates an effective Snf7 dsRNA synthesis method, as well as a high-concentration domestic insect risk assessment method which uses dsRNA to assess the risk of unintentional released of LM organisms against non-target species.

An Investigation of Reliability and Safety Factors in RC Flexural Members Designed by Current WSD Standard Code (현행(現行) 허용응력설계법(許容應力設計法)으로 설계(設計)되는 RC 휨부재(部材)의 신뢰성(信賴性)과 안전율(安全率) 고찰(考察))

  • Shin, Hyun Mook;Cho, Hyo Nam;Chung, Hwan Ho
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.1 no.1
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    • pp.33-42
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    • 1981
  • Current standard code for R.C. design consists of two conventional design parts, so called WSD and USD, which are based on ACI 318-63 and 318-71 code provisions. The safety factors of our WSD and USD design criteria which are taken primarily from ACI 318-63 code are considered to be not appropriate compared to out country's design and construction practices. Furthermore, even the ACI safety factors are not determined from probabilistic study but merely from experiences and practices. This study investigates the safety level of R.C. flexural members designed by the current WSD safety provisions based on Second Moment Reliability theory, and proposes a rational but efficient way of determining the nominal safety factors and the associated flexural allowable stresses of steel bars and concretes in order to provide a consistent level of target reliability. Cornell's Mean First-Order Second Moment Method formulae by a log normal transformation of resistance and load output variables are adopted as the reliability analysis method for this study. The compressive allowable stress formulae are derived by a unique approach in which the balanced steel ratios of the resulting design are chosen to be the corresponding under-reinforced sections designed by strength design method with an optimum reinforcing ratio. The target reliability index for the safety provisions are considered to be ${\beta}=4$ that is well suited for our level of construction and design practices. From a series of numerical applications to investigate the safety and reliability of R.C. flexural members designed by current WSD code, it has been found that the design based on WSD provision results in uneconomical design because of unusual and inconsistent reliability. A rational set of reliability based safety factors and allowable stress of steel bars and concrete for flexural members is proposed by providing the appropriate target reliability ${\beta}=4$.

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Seismic Performance Evaluation of An Old School Building Through Linear Analysis (선형구조해석을 통한 노후된 학교시설 내진성능평가)

  • LEE, Do Hyung;Kim, Taewan;Kim, Seung Re;Chu, Yurim;Kim, Hyun Sik
    • Journal of Industrial Technology
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    • v.38 no.1
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    • pp.21-27
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    • 2018
  • In January 2018, the Ministry of Education published "Seismic design criteria for school buildings" and "Manual for seismic performance evaluation and retrofit of school buildings" to evaluate seismic performances through linear analysis. This paper evaluates the seismic performance of an old school building through the linear analysis. The target building was constructed in the late 1970s, and the seismic-force-resisting system was assumed to be a reinforced concrete moment frame with an un-reinforced masonry wall. As a result of the evaluation, the target building does not satisfy the 'life safety' level of 1.2 times the design spectrum. The average strength ratio of moment frames, an indicator of the level of seismic performance tends to be controlled by beams. However, through the Pohang earthquake, it was known that the short column effect caused by the partially infilled masonry wall caused shear failure of the columns in school buildings. Therefore, it is necessary to improve the linear analysis so that the column controls the average strength ratio of moment frames.

Quantitative Risk Analysis of a Pervaporation Process for Concentrating Hydrogen Peroxide (과산화수소 농축을 위한 투과증발공정의 정량적 위험성 분석)

  • Jung, Ho Jin;Yoon, Ik Keun;Choi, Soo Hyoung
    • Korean Chemical Engineering Research
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    • v.52 no.6
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    • pp.750-754
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    • 2014
  • Quantitative risk analysis has been performed for a pervaporation process for production of high test peroxide. Potential main accidents are explosion and fire caused by a decomposition reaction. As the target process has a laboratory scale, the consequence is considered to belong to Category 3. An event tree has been developed as a model for occurrence of a decomposition reaction in the target process. The probability functions of the accident causes have been established based on the frequency data of similar events. Using the constructed model, the failure rate has been calculated. The result indicates that additional safety devices are required in order to achieve an acceptable risk level, i.e. an accident frequency less than $10^{-4}/yr$. Therefore, a layer of protection analysis has been applied. As a result, it is suggested to introduce inherently safer design to avoid catalytic reaction, a safety instrumented function to prevent overheating, and a relief system that prevents explosion even if a decomposition reaction occurs. The proposed method is expected to contribute to developing safety management systems for various chemical processes including concentration of hydrogen peroxide.

Safety Data Sheets as a Hazard Communication Tool: An Assessment of Suitability and Readability

  • Kevin Ho;Thomas Tenkate
    • Safety and Health at Work
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    • v.15 no.2
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    • pp.192-199
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    • 2024
  • Background: Safety data sheets (SDSs) are hazard communication materials that accompany chemicals/hazardous products in the workplace. Many SDSs contain dense, technical text, which places considerable comprehension demands on workers, especially those with lower literacy skills. The goal of this study was to assess SDSs for readability, comprehensibility, and suitability (i.e., fit to the target audience). Methods: The Suitability Assessment of Materials (SAM) tool assessed SDSs for suitability and readability. We then amended the SAM tool to further assess SDSs for comprehensibility factors. Both the original and amended SAM tool were used to score 45 randomly selected SDSs for content, literacy demand, graphics, and layout/typography. Results: SDSs performed poorly in terms of readability, suitability, and comprehensibility. The mean readability scores were Flesch-Kincaid Grade Level (9.6), Gunning Fog index (11.0), Coleman-Liau index (13.7), and Simple Measure of Gobbledygook index (10.7), all above the recommended reading level. The original SAM graded SDSs as "not suitable" for suitability and readability. When the amended SAM was used, the mean total SAM score increased, but the SDSs were still considered "not suitable" when adding comprehensibility considerations. The amended SAM tool better identified content-related issues specific to SDSs that make it difficult for a reader to understand the material. Conclusions: In terms of readability, comprehensibility, and suitability, SDSs perform poorly in their primary role as a hazard communication tool, therefore, putting workers at risk. The amended SAM tool could be used when writing SDSs to ensure that the information is more easily understandable for all audiences.

RELIABILITY-BASED DESIGN OPTIMIZATION OF AN AUTOMOTIVE SUSPENSION SYSTEM FOR ENHANCING KINEMATIC AND COMPLIANCE CHARACTERISTICS

  • CHOI B.-L.;CHOI J.-H.;CHOI D.-H.
    • International Journal of Automotive Technology
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    • v.6 no.3
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    • pp.235-242
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    • 2005
  • This study introduces the Reliability-Based Design Optimization (RBDO) to enhance the kinematic and compliance (K & C) characteristics of automotive suspension system. In previous studies, the deterministic optimization has been performed to enhance the K & C characteristics. Unfortunately, uncertainties in the real world have not been considered in the deterministic optimization. In the design of suspension system, design variables with the uncertainties, such as the bushing stiffness, have a great influence on the variation of the suspension performances. There is a need to quantify these uncertainties and to apply the RBDO to obtain the design, satisfying the target reliability level. In this research, design variables including uncertainties are dealt as random variables and reliability of the suspension performances, which are related the K & C characteristics, are quantified and the RBDO is performed. The RBD-optimum is compared with the deterministic optimum to verify the enhancement in reliability. Thus, the reliability of the suspension performances is estimated and the RBD-optimum, satisfying the target reliability level, is determined.

The Effect of the DIC Speckle Patterns for a Microcrack Measurement (미소균열 측정에 대한 DIC 스펙클 형상의 영향)

  • Lee, Jun Hyuk;Kwon, Oh Heon
    • Journal of the Korean Society of Safety
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    • v.34 no.4
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    • pp.15-21
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    • 2019
  • In order to secure the safety of various machinery, it is very important to develop a technique for accurately and quickly measuring the cracks generated in the mechanical equipment and evaluating the mechanical characteristics. The evaluation of the mechanical properties is accompanied by an appropriate strain measurement according to the material and crack occurrence of the target structure. Especially, when micro cracks are generated, the evaluation method is very important. Digital image correlation is an optical full field displacement measuring method which is using currently with speckles in the interested area. However the evaluation method and conditions of image distributions have to be considered carefully to measure the crack occurrence because the images of the speckle patterns affect the quality of displacement results. In this study, the speckle pattern density is characterized to improve the accuracy of the measurement method. And also the micro crack initiation is detected by the measured displacement in the adopted speckle pattern distribution. It is shown that the proposed method is useful to determine the density pattern distribution for the accurate measurement and crack detection.

Development of simulation-based testing environment for safety-critical software

  • Lee, Sang Hun;Lee, Seung Jun;Park, Jinkyun;Lee, Eun-chan;Kang, Hyun Gook
    • Nuclear Engineering and Technology
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    • v.50 no.4
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    • pp.570-581
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    • 2018
  • Recently, a software program has been used in nuclear power plants (NPPs) to digitalize many instrumentation and control systems. To guarantee NPP safety, the reliability of the software used in safetycritical instrumentation and control systems must be quantified and verified with proper test cases and test environment. In this study, a software testing method using a simulation-based software test bed is proposed. The test bed is developed by emulating the microprocessor architecture of the programmable logic controller used in NPP safety-critical applications and capturing its behavior at each machine instruction. The effectiveness of the proposed method is demonstrated via a case study. To represent the possible states of software input and the internal variables that contribute to generating a dedicated safety signal, the software test cases are developed in consideration of the digital characteristics of the target system and the plant dynamics. The method provides a practical way to conduct exhaustive software testing, which can prove the software to be error free and minimize the uncertainty in software reliability quantification. Compared with existing testing methods, it can effectively reduce the software testing effort by emulating the programmable logic controller behavior at the machine level.

A Study on the Test Method of Autonomous Vehicle for Fixed Targets (고정목표에 대한 자율주행자동차 시험방법에 관한 연구)

  • Kim, Bong-Ju;Lee, Seon-Bong
    • Journal of Auto-vehicle Safety Association
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    • v.14 no.3
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    • pp.6-16
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    • 2022
  • Recent, the issue of the fourth industrial revolution triggered by technological advances has changed the automobile industry centered on internal combustion engines, and quantitative growth of the global automobile market, which has grown rapidly, has been slowing since 2015. These advances in technology are expected to develop beyond the advanced driver assistance system to autonomous driving technology. According to SAE-J3016 published by the Society of Automotive Engineers, the technology of autonomous vehicles is divided into a total of six stages according to the driver's intervention and automation level from 0 to 5. Securing safety for autonomous vehicles is important. But, research on safety evaluation theory and autonomous vehicle evaluation method based on real vehicle test is insufficient. In this study, the longitudinal distance theory equation and continuous test scenario were proposed for the test method of autonomous vehicles for fixed targets, and the real vehicle test was conducted. When comparing the theoretical values compared to the measured values, it was determined that it was reliable with a minimum error rate of 0.484% and a maximum error rate of 7.391%. Using the proposed theoretical equation, it is judged that it can be used as a safety evaluation method in an environment where real vehicle test is not possible because it can grasp the trend in the longitudinal direction in the development stage.