• 한국농공학회:학술대회논문집
• /
• 한국농공학회 2001년도 학술발표회 발표논문집
• /
• pp.162-170
• /
• 2001

The majority of important structures are made of concrete. Recently earth canals have increasingly been changed to concrete-based irrigation structures every year for higher efficiency of water conveyance and easier maintenance. Unfortunately these concrete structures for agricultural purpose have serviced to only $15{\sim}20$ years, which amounts to only about one third of target service life and will finally result in natural resources waste and weakening of competitive power of agriculture and farmers. Moreover, recently increased concerns of phil-environment have required reconsideration of the roles, shapes, service lives of the irrigation structures. Hereby, this study is presented to find out suggestions or comments on the solutions to the problems of shorter service life and the resultant environmental impact encountered recently in the hydraulic structures for the prosperity of farmers, agriculture and this country.

• 한국정보시스템학회:학술대회논문집
• /
• 한국정보시스템학회 2005년도 춘계학술대회 발표 논문집
• /
• pp.65-78
• /
• 2005

Nowadays, large amounts of XML documents are available on the Internet. Thus, we need to analyze them multi-dimensionally in the same way as relational data. In this paper, we propose a new frame-work for multidimensional analysis of XML documents, which we call XML-OLAP. We base XML-OLAP on XML warehouses where every fact data as well as dimension data are stored as XML documents. We build XML cubes from XML warehouses. We propose a new multidimensional expression language for XML cubes, which we call XML-MDX. XML-MDX statements target XML cubes and use XQuery expressions to designate the measure data. They specify text mining operators for aggregating text constituting the measure data. We evaluate XML-OLAP by applying it to a U.S. patent XML warehouse. We use XML-MDX queries, which demonstrate that XML-OLAP is effective for multi-dimensionally analyzing the U.S. patents.

• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2006년도 Spring Conference
• /
• pp.95-105
• /
• 2006

Alzheimer's disease (AD) is an irreversible, progressive brain disorder that is characterized by dementia. Amounts of p25 and cdk5 kinase activity are specifically upregulated in AD patient's brain samples. Considerable evidence now points importance of p25/cdk5 in generation of A$\beta$ peptides and hyperphosphorylation of tau linking amyloid plaques and neurofibrillary tangles, two major pathological hallmarks of AD. We demonstrated that P25/CDK5 phosphorylates BACE1, the first step protease to produce A$\beta$. P25/CDK5 inhibitors to reduce BACE1 phosphorylation and the secretion of A$\beta$ are screened through in silica, in vitro, and cell-based assays. Out of 4.3 million chemicals we finally selected two compounds to have IC50 of 10 microM in cell-based assays. The inhibitors block Tau phosphrorylation as well as BACE1 phosphorylation. In conclusion P25 should be one of the best targets for AD therapeutics.

• 유체기계공업학회:학술대회논문집
• /
• 유체기계공업학회 2005년도 연구개발 발표회 논문집
• /
• pp.813-818
• /
• 2005

Cooling seawater of thermal power plant which amounts about 5 cms per 100 MWe has hydro energy of about 3,000 kW at the thermal power plant complex, but this useful hydro energy has not been developed. Therefore, the feasibility study on hydro energy development of three power plants located in the southern and western coast of Korea was performed. Three target power plants are Samcheonpo, Boryeong and Hadong thermal power plant. The design head to discharge cooling water by gravity and the head caused by tidal level in the southwestern coastal area, could be used for the production of electric power. The various alternatives were studied and technical feasibility and economical efficiency were clearly proved.

• 말소리와 음성과학
• /
• 제4권1호
• /
• pp.29-47
• /
• 2012

The purpose of this paper is to show how to convert the label files of the Buckeye Corpus of Spontaneous Speech [1] into Praat format and to introduce some of the Praat scripts that will enable linguists to study various aspects of spoken American English present in the corpus. During the conversion process, several types of errors were identified and corrected either manually or automatically by the use of scripts. The Praat script tools that have been developed can help extract from the corpus massive amounts of phonetic measures such as the VOT of plosives, the formants of vowels, word frequency information and speech rates that span several consecutive words. The script tools can extract additional information concerning the phonetic environment of the target words or allophones.

• 동력기계공학회지
• /
• 제3권1호
• /
• pp.38-44
• /
• 1999

Subway is one of the most important transportation and its facilities are increased by the drift of population to cities in these days. But heat generation results from lighting, human and traffic increase in subway, half-closed space, gives uncomfortable sense to the subway passengers. Therefore, natural ventilation by piston effect is done to relieve uncomfortable sense. But train wind by piston effect gives uncomfortable sense to the subway passengers, too. So the numerical calculation of inflow and outflow amounts is important to predict thermal environment and reduce train wind. In case of actual survey of train wind in target station, the amount of train wind are about $3100m^3/train$ at the minimum, about $6000m^3/train$ at the maximum, about $4200m^3/train$ on average. When comparison between simulation for train wind prediction and actual survey for accuracy was done train wind prediction program showed similar results.

• 한국소성가공학회:학술대회논문집
• /
• 한국소성가공학회 2009년도 춘계학술대회 논문집
• /
• pp.252-255
• /
• 2009

The roll gap set-up in the finishing mill is one of the most important technologies in the hot plate rolling process. As the target thickness can be obtained by the correct set-up of the roll gap, improving the roll gap set-up technology is very critical for plate thickness accuracy. The main cause of thickness variation in hot plate mills is the non-uniform temperature distribution along the length of the slab. The objective of this study is to adjust the roll gap set-up for the thickness accuracy of plate in hot rolling process considering top-end temperature drop. Therefore this study has concentrated on determining the correct amounts of roll gap to compensate thickness variation due to top-end temperature drop. The off-line simulation of compensated roil gap significantly decreases top-end thickness variation.

• BMB Reports
• /
• 제47권3호
• /
• pp.122-129
• /
• 2014

Although considerable progress has been made in understanding how tumors evade immune surveillance, measures to counter the same have not kept pace with the advances made in designing effective strategies. 4-1BB (CD137; TNFRS9), an activation-induced costimulatory molecule, is an important regulator of immune responses. Targeting 4-1BB or its natural ligand 4-1BB ligand (4-1BBL) has important implications in many clinical conditions, including cancer. In-depth analysis revealed that 4-1BB-mediated anti-cancer effects are based on its ability to induce activation of cytotoxic T lymphocytes (CTL), and among others, high amounts of IFN-${\gamma}$. In this review, we will discuss the various aspects of 4-1BB-mediated anti-tumor responses, the basis of such responses, and future directions.

• 반도체디스플레이기술학회지
• /
• 제10권1호
• /
• pp.83-89
• /
• 2011

In the case of the tracking system with an active camera, it is very difficult to guarantee real-time processing due to the attribute of vision system which handles large amounts of data at once and has time delay to process. The reliability of the processed result is also badly influenced by the slow sampling time and uncertainty caused by the image processing. In this paper, we figure out dynamic characteristics of pixels reflected on the image plane and derive the mathematical model of the vision tracking system which includes the actuating part and the image processing part. Based on this model, we find a controller that stabilizes the system and enhances the tracking performance to track a target rapidly. The centroid is used as the position index of moving object and the DC motor in the actuating part is controlled to keep the identified centroid at the center point of the image plane.

• 미생물학회지
• /
• 제27권4호
• /
• pp.317-322
• /
• 1989

A gene can be selectively overexpressed in E. coli by utilizing the phage T7 RNA polymerase's stringent recognition and active transcription of the T7 promoter. The T7 expression system was constructed such that the T7 RNA polymerase gene is under the control of lacUV5 promoter in one plasmid, and that the target gene, the promoterless chloramphenicol acetyltransferase (CAT) gene with E. coli ribosome binding site is under the control of T7 promoter in the other plasmid. Only the E. coli cells containing both plasmids show high resistance to chloramphenicol. When the copy number of the runaway plasmid containing the polymerase gene was varied by a temperature shift, amounts of the CAT protein synthesized upon induction was correspondingly changed as shown in SDS gel electrophoresis.