• Toxicological Research
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• 제20권2호
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• pp.89-100
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• 2004

The comet assay (also called the single-cell gel electrophoresis assay) has been widely used for detecting DNA damage and repair in individual cells. Since the conventional methods of evaluating comet assay data using frequency statistics are unsatisfactory we developed a new quantitative measure of DNA damage/repair that is based on all information residing in the dose/time-response curves of a comet experiment. Blood samples were taken from 25 breast cancer patients before undergoing radiotherapy. The comet assay was performed under alkaline conditions using isolated lymphocytes. Tail DNA, tail length, tail moment and tail inertia of the comet were measured for each patient at four doses of $\gamma$-rays (0, 2, 4 and 8 Gy) and at four time points after irradiation (0, 10, 20 and 30 min) using 100 cells each. The resulting three-dimensional dose-time response surface was modeled by multiple regression, and the second derivative, termed 2D, on dose and time was determined. A software module was programmed in SAS/AF to compute 2D values. We applied the new method successfully to data obtained from cancer patients to be assessed for their radiation sensitivity. We computed the 2D values for the four damage measures, i.e., tail moment, tail length, tail DNA and tail inertia, and examined the pairwise correlation coefficients of 2D both on the log scale and the unlogged scale. 2D values based on tail moment and tail DNA showed a high correlation and, therefore, these two damage measures can be used interchangeably as far as DNA repair is concerned. 2D values based on tail inertia have a correlation profile different from the other 2D values which may reflect different facets of DNA damage/repair. Using the dose-time response surface, other statistical models, e.g., the proportional hazards model, become applicable for data analysis. The 2D approach can be applied to all DNA repair measures, Le., tail moment, tail length, tail DNA and tail inertia, and appears to be superior to conventional evaluation methods as it integrates all data of the dose/time-response curves of a comet assay.

• Communications for Statistical Applications and Methods
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• 제27권3호
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• pp.327-347
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• 2020

We consider a credit portfolio with highly skewed exposures. In the portfolio, small number of obligors have very high exposures compared to the others. For the Bernoulli mixture model with highly skewed exposures, we propose a new importance sampling scheme to estimate the tail loss probability over a threshold and the corresponding expected shortfall. We stratify the sample space of the default events into two subsets. One consists of the events that the obligors with heavy exposures default simultaneously. We expect that typical tail loss events belong to the set. In our proposed scheme, the tail loss probability and the expected shortfall corresponding to this type of events are estimated by a conditional Monte Carlo, which results in variance reduction. We analyze the properties of the proposed scheme mathematically. In numerical study, the performance of the proposed scheme is compared with an existing importance sampling method.

• Communications for Statistical Applications and Methods
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• 제2권2호
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• pp.336-346
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• 1995

In many problems concerned with statistical inferences, it will be of interest to compute tail areas rather than densities. But, it is often hard to calculate the exact tail probability. Saddlepoint approximation formula to the tail probability of a smooth function of random cector is developed by DiCiccio and Martin(1991). Applications of this method to stress-strength model are considered in this paper. To obtain the generalized p-values suggested by Tsui and Weerahandi(1989), we need to calculate complicated multiple integration. However, DiCiccio and Martin's(1991) results offer a convenient method to approximate these very accurately. For many artificial data sets, we access the accuracy of DiCiccio and Martin's by comparing the approximate value with the exact one.

• 천문학회보
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• 제43권2호
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• pp.57.4-58
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• 2018

It is interesting to find the best exospheric model that can account for the observed characteristics of the lunar coma and tail simultaneously. Recently, the initial abundances of atomic species near surface are found to be different depending on certain local areas. We will present the influence of different initial conditions of localized sources on the characteristics of the lunar exosphere, and also present time-dependent simulations showing the distributions of atomic species around the lunar coma and the final stage of the lunar tail. Based on our updated 3-D lunar model, we will present resulted physical parameters of the lunar sodium coma and tail.

• 한국가시화정보학회지
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• 제13권1호
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• pp.9-14
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• 2015

There have been many attempts to reduce the cost of transportation. Especially, drag reduction of heavy vehicles has enormous influence on energy saving by reducing the driving power of the vehicles. In this study, the effects of drag-reducing additive devices such as side skirt, boat tail and cab-roof fairing on the drag reduction of a 5 ton truck model were experimentally investigated. The aerodynamic performance of these flow-control devices attached to heavy vehicle was evaluated through wind tunnel test. In addition, flow patterns around the truck model were visualized by using smoke tube method. The drag coefficient is reduced by up to 5.7%, 7.16% and 22.2% by the side skirt, boat tail and cab-roof fairing, respectively. The interactive effect of the side skirt and boat tail was also investigated.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2010년도 학술발표회
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• pp.571-575
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• 2010

Drought is a natural hazard with different properties that are usually dependent to each other. Therefore, a multivariate model is often used for drought frequency analysis. The Copula based bivariate drought severity and duration frequency analysis is applied in the current study in order to show the effect of tail behavior of drought severity and duration on the selection of a copula function for drought bivariate frequency analysis. Four copula functions, namely Clayton, Gumbel, Frank and Gaussian, were fitted to drought data of four stations in Iran and Canada in different climate regions. The drought data are calculated based on standardized precipitation index time series. The performance of different copula functions is evaluated by estimating drought bivariate return periods in two cases, [$D{\geq}d$ and $S{\geq}s$] and [$D{\geq}d$ or $S{\geq}s$]. The bivariate return period analysis indicates the behavior of the tail of the copula functions on the selection of the best bivariate model for drought analysis.

• Nuclear Engineering and Technology
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• 제55권12호
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• pp.4350-4356
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• 2023

Radiation detection systems working at high count rates suffer from the overlapping of their output electric pulses, known as pulse pile-up phenomenon, resulting in spectrum distortion and degradation of the energy resolution. Pulse tail extrapolation is a pile-up correction method which tries to restore the shifted baseline of a piled-up pulse by extrapolating the overlapped part of its preceding pulse. This needs a mathematical model which is almost always nonlinear, fitted usually by a nonlinear least squares (NLS) technique. NLS is an iterative, potentially time-consuming method. The main idea of the present study is to replace the NLS technique by an integration-based non-iterative method (NIM) for pulse tail extrapolation by an exponential model. The idea of linear extrapolation, as another non-iterative method, is also investigated. Analysis of experimental data of a NaI(Tl) radiation detector shows that the proposed non-iterative method is able to provide a corrected spectrum quite similar with the NLS method, with a dramatically reduced computation time and complexity of the algorithm. The linear extrapolation approach suffers from a poor energy resolution and throughput rate in comparison with NIM and NLS techniques, but provides the shortest computation time.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 1999년도 봄 학술발표회 논문집
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• pp.177-184
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• 1999

In soft ground tunneling, shield method is very good for safety of neighboring structures. Although shield tunnel method has the merits to minimize the deformation of ground around tunnel, ground deformations occurred until the material grouted in tail void hardens are inevitable. In this study, the effects of micropile used as one method to restrain the settlement of neighboring structures by the tail void are studied by laboratory model tests. As a basic test result, the effective direction of micropile and the restraint rate of settlement by micropile reinforcement are known.

• 유공압시스템학회논문집
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• 제7권2호
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• pp.19-26
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• 2010

The typical trunk lid system for vehicle is composed of a hinge having 4-bar link and gas lifter. Here, the energy regenerative brake of hydraulic driven systems is applied to the tail gate system for vehicle and removed the gas lifter. The new tail gate system is composed of a hydraulic pump by electric motor, a hydraulic motor, four check valves, an accumulator, a relief valve and a directional control valve. The dynamic characteristics of the hydraulic motor system, such as the surge pressure and response time, are investigated in both brake action and acceleration action. The capacity selection method of accumulator by mathematical model is based upon trial and error approach and computer simulation by AMEsim software is carried out.

• 대한조선학회 특별논문집
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• 대한조선학회 2007년도 특별논문집
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• pp.32-42
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• 2007

Container vessels are required to have a large KMT to load many containers which requires a wide transom stern form. The wide transom stern generates large stern waves particularly at the scantling draft. This means that reducing the stern wave leads to resistance reduction. Numerical analyses and Model tests for duck-tail of the stern part have been performed to reduce the resistance of the container vessel having the wide transom on the scantling draft and optimize the form of duck-tail with the change of the design parameter i.e. length and edge height. The optimized duck-tail increases the speed by 0.8 % at scantling draft.