• The Journal of Korean Medicine
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• v.43 no.1
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• pp.87-98
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• 2022

Objectives: The purpose of this study was to investigate the effect of weight loss in Korean Medicine (KM) obesity treatment combined with self-monitoring and to identify the relevant factors which are related to successful weight loss. In addition to this, adverse events reported by the patients were analyzed to assess the safety of KM treatments for obesity Methods: This was a retrospective observational study that analyzed the medical records of the patients that participated in the 10-week of KM treatment. All patients took herbal medicine for weight loss and were instructed to reduce calorie intake and adhere to self-monitoring. Clinical data including body weight were collected for evaluating the effect of the treatments. Behavior factors affecting weight loss were collected. The correlation between each factor and weight loss was analyzed. Adverse events (AEs) were collected at each time to evaluate the safety of the intervention. Results: One hundred eighteen patients' records were included in this study. The average weight loss was 7.64kg(74.59kg to 66.95kg). 94.9% of patients lost 5% or more of their initial weight. The degree of weight loss was identified to be related to self-assessment of diet control and self-assessment of appetite control. The average self-weighing frequency significantly increased(2.45 times/week before treatment and 4.70 times/weeks during treatment). Constipation, insomnia, and dizziness were found to be the most frequent AEs, and except for one case, most AEs were mild cases. Conclusion: From this study, we found that KM obesity treatment combined with self-monitoring showed significant weight loss without serious AE.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.5
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• pp.535-542
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• 2023

In order to understand the seismic performance of a bridge, it is common to review through seismic performance evaluation and numerical analysis of the target bridge. Seismic performance evaluation and review through numerical analysis are analysis methods for specific target bridges, and many problems can arise in each management body managing bridges nationwide. Therefore, in this study, research was conducted to estimate the seismic performance of public bridges with various types and characteristics. Seismic performance was estimated by applying the seismic risk assessment method, calculating the seismic fragility curve for the type and specifications of the bridge, and estimating the seismic performance of the bridge in use by applying the domestic seismic design standard. In addition, by installing it on the platform, service items were established so that users can easily review the estimation of seismic performance of domestic bridges.

• Journal of Advanced Navigation Technology
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• v.27 no.2
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• pp.173-181
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• 2023

Aircraft carriers need to maintain an orderly flow of aircraft in order for military ships to conduct combat through aircraft. Maintaining aircraft flow is an important factor in strengthening ship and aviation safety. In order to maintain aircraft flow, it is essential to develop a state-of-the-art air control system that provides higher quality control information by simultaneously accommodating radar-based monitoring information and monitoring information based on CNS integrated technology. Based on this point, this study describes the function and operation method of specific control equipment for the operation of the Aviation Support System and Air Traffic Control System required to operate light aircraft carriers in Korea based on overseas cases.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2020.08a
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• pp.17-17
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• 2020

나고야의정서 발효에 따라 이에 대한 대응이 전세계적인 이슈가 되면서 각 국가들은 자국내 유용자원식물의 주권확립을 위한 움직임을 보이고 있으며 이들의 기원종 확립과 진위 감별을 위한 연구가 활발히 진행되고 있다. 이에 본 연구에서는 전라도 지역 내 생약 자원식물의 분포현황 및 실체를 파악하고자 하였다. 조사시기는 2018년 3월부터 2020년 5월까지 계절별로 해안가, 산지, 농경지 등 다양한 서식환경에 대하여 조사를 실시하였다. 전라도 내에서 확인되 생약자원식물은 106과 243속 405종 31변종 4품종 총 440분류군이 분포하는 것으로 조사되었으며, 한반도 관속식물 4,499분류군(Korea National Arboretum, 2018; Http://www.nature.go.kr/kpni/)의 9.8%에 해당된다. 본 조사지역 내에서 확인된 생약자원 식물 중, 특산식물로는 매미꽃, 할미밀망, 노랑붓꽃 등 11분류군이 확인되었으며, 희귀식물로는 CR등급의 노랑붓꽃을 포함하여, VU등급의 약난초, 흑삼릉 등 25분류군이 확인되었다. 특히 본 조사를 통해 수집된 생약자원식물의 표본, 화상자료, 종자, 생약부위 등은 추후 우리나라의 생약자원에 대한 관리DB를 구축하는데 기초자료로서 유용하게 활용될 것이다.

• Korean Circulation Journal
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• v.54 no.2
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• pp.78-90
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• 2024

Background and Objective: We aimed to investigate long-term clinical and echocardiographic outcomes, including tricuspid valve durability, annular growth, and left ventricular reverse remodeling, after modified cone reconstruction in patients with Ebstein's anomaly. Methods: This was a retrospective analysis of all pediatric patients who underwent modified cone reconstruction for Ebstein's anomaly at a single tertiary center between January 2005 and June 2021. Results: A total of 14 pediatric patients underwent modified cone reconstruction for Ebstein's anomaly; the median age was 5.8 years (range, 0.01-16.6). There were three patients (21.4%) with Carpentier type B, ten patients with Carpentier type C (71.4%), and one patient with Carpentier type D (7.1%). There was no early or late mortality, arrhythmia, or readmission for heart failure at a 10-year follow-up. There were no cases of more than mild tricuspid stenosis or more than moderate tricuspid regurgitation during the study period, except for one patient with severe tricuspid regurgitation who underwent reoperation. The z value for tricuspid valve annular size significantly decreased immediately after the operation (2.46 vs. -1.15, p<0.001). However, from 1 year to 7 years after surgery, the z values were maintained between -1 and +1. Left ventricular end-systolic volume, end-diastolic volume, and stroke volume increased after surgery and remained elevated until seven years postoperatively. Conclusions: Ebstein's anomaly in children can be repaired by modified cone reconstruction with low mortality and morbidity, good tricuspid valve durability, and annular growth relative to somatic growth.

• International Journal of Molecular Medicine
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• v.44 no.1
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• pp.125-134
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• 2019

Mutations in myelin protein zero (MPZ) cause inherited peripheral neuropathies, including Charcot-Marie-Tooth disease (CMT) and Dejerine-Sottas neuropathy. Mutant MPZ proteins have previously been reported to cause CMT via enhanced endoplasmic reticulum (ER) stress and Schwann cell (SC) death, although the pathological mechanisms have not yet been elucidated. In this study, we generated an in vitro model of rat SCs expressing mutant MPZ (MPZ V169fs or R98C) proteins and validated the increase in cell death and ER stress induced by the overexpression of the MPZ mutants. Using this model, we examined the efficacy of 3 different aminosalicylic acids (ASAs; 4-ASA, sodium 4-ASA and 5-ASA) in alleviating pathological phenotypes. FACS analysis indicated that the number of apoptotic rat SCs, RT4 cells, induced by mutant MPZ overexpression was significantly reduced following treatment with each ASA. In particular, treatment with 4-ASA reduced the levels of ER stress markers in RT4 cells induced by V169fs MPZ mutant overexpression and relieved the retention of V169fs mutant proteins in the ER. Additionally, the level of an apoptotic signal mediator (p-JNK) was only decreased in the RT4 cells expressing R98C MPZ mutant protein following treatment with 4-ASA. Although 4-ASA is known as a free radical scavenger, treatment with 4-ASA in the in vitro model did not moderate the level of reactive oxygen species, which was elevated by the expression of mutant MPZ proteins. On the whole, the findings of this study indicate that treatment with 4-ASA reduced the ER stress and SC death caused by 2 different MPZ mutants and suggest that ASA may be a potential therapeutic agent for CMT.

• 한국학연구
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• no.48
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• pp.315-350
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• 2018

이 연구는 『추악한 미국인』을 포함한 '추악한 시리즈'가 '한국'에서 번역되는 맥락과 의미를 분석하고자 했다. 이를 통해 『The Ugly American』이 동아시아 각국에 번역되고 전유되어 '추악한 시리즈'를 창출하고 그것이 한국에 번역되는 맥락을 파악할 수 있다. 『The Ugly American』(1958)은 윌리암 J. 레더러(Lederer, William J), 유진 버딕크(Burdick, Eugene) 공저의 풍자소설이다. 이 소설은 1959년 한국에 『추악한 미국인』으로 번역되면서 알려지기 시작하는데 베트남전쟁에서 미국인의 실수와 추태를 다룬 작품이다. 이 작품이 중요한 것은 월남전의 미국의 과오를 비판한 수준을 넘어 글쓰기의 아이디어와 방식이 미친 영향력이다. 제목이 함의하듯 이러한 책의 발상은 특정 국가와 그 민족구성원의 문제점을 지적하는 글쓰기 형식이기 때문에 민족(성) 비판과 맥이 닿아 있다. 『The Ugly American』의 수용과 전유는 한국뿐만 아니라 중국, 일본, 대만 등 동아시아 각국의 역사적 관계와 문명의 격차에서 기인하는 자기인식과 상대국에 대한 평가를 파악할 수 있게 한다. 소속 공동체에 대한 자긍심과 (민족)주체의 내적 발전 및 동태적 역동성의 발견 및 재인식 작업으로서의 민족문화론은 개인과 국가의 자기지식과 아이덴티티의 필수불가결한 구축 과정이며 진보와 지체를 둘러싼 일종의 자기반응이다. 이처럼 자신과 세계인식의 재갱신은 서구제국주의의 관점과 적자생존론, 민족주의를 경유해온 우리의 인식론적 성찰의 현실과 긴밀하게 관련된다는 점에서 '추악한' 시리즈는 그 실상과 강박을 접근할 수 있는 중요한 참조점이 될 것이다.

• The Journal of Internal Korean Medicine
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• v.31 no.3
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• pp.578-585
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• 2010

Objectives : Coldness of hands and feet has been regarded to be associated with blood circulation. This study was performed to assess the correlation between erythrocyte deformability and coldness of hands and feet. Methods : 145 patients who had taken an erythrocyte deformability test were selected for this study among hospitalized patients within 4 weeks after their cerebral infarction at the Internal Medical Department at Kyunghee Oriental Medical Center from August 2008 to August 2009. We divided the selected patients into two groups, with and without of coldness of hands and feet groups. The two groups were compared on risk factors for atherosclerosis and examined for variables including erythrocyte deformability. Results : 1. On demographic variables of the patients, only body mass index was significantly lower in the coldness of hands and feet group than the control group. There was no significant difference of the rate of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, smoking, drinking and carotid artery stenosis between the two groups. 2. According to blood test, the coldness of hands and feet group showed significantly lower erythrocyte deformability index than the control group. 3. Body mass index and erythrocyte deformability index showed a close relationship with coldness of hands and feet in multivariate analysis. Conclusions : The correlation between the erythrocyte deformability and coldness of hands and feet in cerebral infarction patients were decreased erythrocyte deformability participated in the mechanism of coldness of hands and feet.

• Journal of Digital Convergence
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• v.14 no.7
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• pp.309-319
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• 2016

There is a need to develop a data quality management algorithm in order to improve the quality of health care data. In this study, we developed a data quality control algorithms associated diseases related to diabetes in patients with hypertension. To make a data quality algorithm, we extracted hypertension patients from 2011 and 2012 discharge damage survey data. As the result of developing Data quality management algorithm, significant factors in hypertension patients with diabetes are gender, age, Glomerular disorders in diabetes mellitus, Diabetic retinopathy, Diabetic polyneuropathy, Closed [percutaneous] [needle] biopsy of kidney. Depending on the decision tree results, we defined Outlier which was probability values associated with a patient having diabetes corporal with hypertension or more than 80%, or not more than 20%, and found six groups with extreme values for diabetes accompanying hypertension patients. Thus there is a need to check the actual data contained in the Outlier(extreme value) groups to improve the quality of the data.

• Korean Journal of Agricultural Science
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• v.49 no.3
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• pp.539-545
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• 2022

The aim of this study was to evaluate the effect of beekeeping by-products added to drinking water on the growth performance and intestinal and fecal microflora of Institute of Cancer Research (ICR) mice. A total of 72 five-week-old ICR mice with an initial body weight (BW) of 24.57 ± 0.60 g were used in a two-week experiment. The four treatment groups were as follows; 1) CON, normal distilled water; 2) T1, CON with 0.7% beehive extract; 3) T2, CON with 0.7% propolis (PRO); and 4) T3, CON with 0.7% royal jelly (RJ). Each treatment consisted of 6 replicate cages with 3 mice per cage. At 0 - 1 week, T3 showed a significantly higher (p < 0.05) body weight gain (BWG) and feed efficiency (G : F) than that of CON. Compared with CON, T2 showed a significantly higher (p < 0.05) BWG and feed intake at 1 - 2 weeks. During the entire period, T2 and T3 showed a significantly higher (p < 0.05) BWG and G : F compared to CON. The amount of Salmonella and Lactobacillus in the large intestine was significantly decreased and increased (p < 0.05) in T2 and T3, respectively, compared to CON. The amount of Escherichia coli in the fecal matter was significantly reduced (p < 0.05) compared to CON in all treatment groups to which beekeeping by-products were added. In conclusion, the addition of PRO or RJ to the drinking water of ICR mice had a positive effect on the growth performance and the intestinal and fecal microflora.